Crystal structure of an angiotensin-converting enzyme (ACE) and uses thereof

ABSTRACT

The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of ACE crystal and the structure coordinates thereof.

This application is a U.S. National Phase Application pursuant to 35U.S.C. 371 of International Application No. PCT/GB2003/003966 which wasfiled Sep. 12, 2003, claiming benefit of priority of British PatentApplication No. 0221169.6 filed Sep. 12, 2002. The entire disclosure ofeach of the foregoing applications is incorporated herein by reference.

FIELD OF INVENTION

The present invention relates to a crystal. In particular, the presentinvention relates to a crystal of ACE protein.

The present invention further relates to methods, processes, ACEmodulators, pharmaceutical compositions and uses of the ACE crystal andthe structure co-ordinates thereof.

BACKGROUND TO THE INVENTION

Angiotensin converting enzyme (peptidyl dipeptidase A, EC 3.4.15.1, ACE)is a membrane-anchored dipeptidyl carboxypeptidase that is essential forblood pressure regulation and electrolyte homeostasis via therenin-angiotensin-aldosterone system. The enzyme is a zincmetalloprotease that converts the inactive peptide angiotensin I toangiotensin II, a potent vasoconstrictor. ACE, like many diversemembrane-bound ectoproteins, is released from the membrane by a membraneprotease or secretase (1). An understanding of this cleavage-secretionmechanism is important for the development of therapeutic strategies toaddress the different pathologies caused by defects in the function ofthe secretase. Substrate determinants that specify cleavage bysecretases remain incompletely characterised, but may include thephysico-chemical properties of the juxtamembrane (“stalk”) sequence orunidentified recognition motifs of the stalk or the extracellulardomain. Cleavage of ACE occurs in the stalk sequence and thesolubilizing protease is constrained topologically, in terms of thenumber of residues between the cleavage site and the proximalextracellular domain of ACE. However, the ACE secretase appears to beremarkably versatile in terms of its substrate specificity (2,3).

The active sites of ACE and carboxypeptidase A, a prototypic zincmetalloprotease, are understood to be very similar and this similarityis exploited in the design of the first generation of ACE inhibitors.The clinical success of these inhibitors—such as captopril andenalapril—in the treatment of hypertension and congestive heart failureis well established. However, the side effects such as persistent coughwhich effects up to 20% of patients and angioedema which is less common,together with limitations such as their contraindication in patientswith impaired renal function and decreased efficacy in patients withlow-renin hypertension, underscore the need for more specific andselective inhibitors.

There are two isoforms of ACE that are transcribed from the same gene ina tissue specific manner. In somatic tissues it exists as a glycoproteincomposed of a single large polypeptide chain of 1277 amino acids whereasthe germinal form is synthesised as a lower molecular mass isozyme andis thought to play a role in sperm maturation and the binding of spermto the oviduct epithelium. The somatic form consists of two domains (N-and C-domain), each containing an active site with a conserved HEXXHzinc-binding motif and a glutamate some 24 residues downstream whichforms the third zinc ligand (Williams et al., 1994). The two domainsdiffer in their substrate specificities; inhibitor and chlorideactivation profiles; and physiological functions. There are twoN-domain-specific substrates: the hemoregulatory peptideN-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) which controlshematopoietic stem cell differentiation and proliferation; and thebradykinin potentiating peptide angiotensin-(1-7). On the other hand,both active sites catalyse the hydrolysis of angiotensin I and thevasodilator bradykinin with similar efficiency. However, inhibition ofthe N-domain with a phosphinic peptide RXP407 has no effect on bloodpressure regulation (Junot et al., 2001) and, furthermore, expression ofthe N-domain only, in transgenic mice produced a phenotype similar tothe ACE knockout mice (Esther et al., 1997). Thus, the C-domain appearsto be necessary and sufficient for controlling blood pressure andcardiovascular function. Testis ACE (tACE) is identical to theC-terminal half of somatic ACE, except for a unique 36-residue sequenceconstituting its amino terminus, thus this isoform is selected forinitial efforts to obtain a three-dimensional structure.

The cDNA sequence of human testicular ACE has been described (Ehlers etal. (1989) Proc. Nat. Acad. Sci. 86: 7741-7745) and the predictedprotein consists of a 732-residue preprotein including a 31-residuesignal peptide. The mature polypeptide has a molecular weight of 80,073(unglycosylated form).

Despite the pivotal role of ACE, there have been no reports disclosingthat suitable crystals have been or could be obtained for this enzymeand so the X-ray crystallographic analysis of such proteins has beenimpossible.

SUMMARY OF THE INVENTION

The present invention is based upon the seminal finding of the firstthree-dimensional structure of the ACE protein.

Peptidases, for example, thermolysin and carboxypeptidase A that havebeen used in comparative molecular field analysis and 3D quantitativestructure-activity relationship studies of ACE (Waller & Marshall, 1993)show no homology with the structure of ACE described herein.Surprisingly, ACE shows significant structural homology with that ofneurolysin, a member of the M3 family of thimet oligopeptidases. The twoproteins do not share any amino acid sequence identity (close to randomscore), yet when the two structures are optimally superimposed usingDALI server (Hohn & Sander, 1999), there is noticeable match with a rootmean square (r.m.s.) deviation of 4.0 Å for 143 C_(α) atoms.Accordingly, the structure presented herein may be used for thedevelopment of novel, highly selective ACE modulators with the potentialfor greater efficacy, fewer side effects and treatment of newindications.

Thus, in a first aspect, the present invention relates to a crystal ofACE protein.

Preferably, the ACE protein is underglycosylated.

Preferably, the ACE protein is underglycosylated by removing one or moreglycosylation sites and/or one or more partially glycosylated sites.More preferably, the underglycosylated ACE protein is deglycosylated atamino acids 337 and 586 or amino acids 90, 109, 155, 337 and 586 of SEQID No 2.

Preferably, the crystal comprises atoms arranged in a spatialrelationship represented by at least a portion of the structureco-ordinates of Table A or Table B.

Preferably, the crystal belongs to the space group P2₁2₁2₁.

Preferably, the crystal has the unit cell dimensions: a=56.47 Å, b=84.90Å and c=133.99 Å.

Preferably, the crystal is a crystal of human ACE protein.

Preferably, the crystal further comprises an entity bound to the ACEprotein or a portion thereof. More preferably, the entity is bound tothe ACE protein or a portion thereof by contacting one or more residuesof the ACE protein selected from: His384, Ala385, Lys542, Tyr551,Tyr554, Glu415 and His544. More preferably, the entity modulates theactivity of ACE. More preferably, the entity is an inhibitor of ACE—suchas lisinopril or a derivative thereof.

In a second aspect, the present invention relates to a method ofpreparing a crystal of ACE protein comprising the steps of: (a)culturing host cells comprising an underglycosylated ACE protein; (b)purifying the underglycosylated ACE protein; and (c) crystallising theunderglycosylated ACE protein.

Preferably, the ACE protein is underglycosylated by removing one or moreglycosylation sites and/or one or more partially glycosylated sites.More preferably, the underglycosylated ACE protein is deglycosylated atamino acids 337 or amino acids 90, 109, 155, 337 and 586 of SEQ ID No 2.

Preferably, the ACE protein is crystallised using about 10 mM HEPES andabout 0.1% PMSF with an equal volume of a reservoir solution containingabout 15% PEG 4000, about 50 mM CH₃COONa.3H₂O pH 4.7 and about 10 μMZnSO₄.7H₂O.

Preferably, the crystal that is prepared has a structure defined by atleast a portion of the structure co-ordinates of Table A or Table B.

Preferably, the crystal belongs to the space group P2₁2₁2₁.

Preferably, the crystal has the unit cell dimensions: a=56.47 Å, b=84.90Å and c=133.99 Å.

Preferably, the ACE protein is human ACE protein.

Preferably, the crystal further comprises an entity bound to the ACEprotein. More preferably, the entity modulates the activity of ACE. Morepreferably, the entity is an inhibitor of ACE—such as lisinopril or aderivative thereof. More preferably, the crystal that is prepared has astructure defined by at least a portion of the structure co-ordinates ofTable B.

In a third aspect, the present invention relates to a method ofscreening for a modulator of ACE wherein the method comprises the use ofa crystal according to the present invention. Preferably, the methodcomprises the steps of: (a) providing at least a portion of thestructure co-ordinates of Table A or Table B; (b) employing at least aportion of the structure co-ordinates of Table A or Table B to design orselect or synthesise a putative modulator of ACE; (c) contacting theputative modulator of ACE with ACE or a mutant, variant, homologue,derivative or fragment thereof in the presence of a substrate; and (d)screening the putative modulator of ACE in an assay for the potential tomodulate ACE.

Preferably, at least a portion of the structure co-ordinates of Table Aor Table B and/or the putative modulator of ACE and/or the substrate areprovided on a machine-readable data storage medium comprising a datastorage material encoded with machine readable data.

Preferably, the putative ACE modulator is from a library of compounds.

Preferably, the putative ACE modulator is selected from a database.

Preferably, the putative ACE modulator is designed de novo.

Preferably, the putative ACE modulator is designed from a known ACEmodulator.

Preferably, the design or selection of the putative ACE modulator isperformed in conjunction with computer modelling.

Preferably, the putative ACE modulator is useful in the preventionand/or treatment of an ACE related disorder. More preferably, the ACErelated disorder is hypertension.

In a fourth aspect, the present invention relates to a processcomprising the steps of: (a) performing the method according to thethird aspect of the present invention; (b) identifying one or moremodulators of ACE; and (c) preparing a quantity of those one or more ACEmodulators.

In a fifth aspect, the present invention relates to a process comprisingthe steps of: (a) performing the method according to the third aspect ofthe present invention; (b) identifying one or more ACE modulators; and(c) preparing a pharmaceutical composition comprising those one or moreidentified ACE modulators.

In a sixth aspect, the present invention relates to a process comprisingthe steps of: (a) performing the method according to the third aspect ofthe present invention; (b) identifying one or more ACE modulators; (c)modifying those one or more ACE modulators; and (d) optionally preparinga pharmaceutical composition comprising those one or more ACEmodulators.

In a seventh aspect, the present invention relates to a method ofobtaining structural information about a molecule or a molecular complexof unknown structure by using at least a portion of the structureco-ordinates of ACE, comprising the steps of: (a) generating X-raydiffraction data from a crystallised molecule or molecular complex; (b)applying at least a portion of the structure co-ordinates of ACE to saidX-ray diffraction pattern to generate a three dimensional electrondensity map of at least a portion of the molecule or molecular complex;and (c) using all or a portion of the structure co-ordinates of ACE togenerate homology models of ACE.

In an eighth aspect, the present invention relates to an ACE modulatoridentified by the method according to the third aspect of the presentinvention. Preferably, the ACE modulator inhibits ACE.

In a ninth aspect, the present invention relates to a pharmaceuticalcomposition comprising an ACE modulator according to the seventh aspectof the present invention and a pharmaceutically acceptable carrier,diluent, excipient or adjuvant or any combination thereof.

In a tenth aspect, the present invention relates to a method ofpreventing and/or treating an ACE related disorder comprisingadministering a modulator of ACE according to the seventh aspect of thepresent invention and/or a pharmaceutical according to the eighth aspectof the present invention, wherein said modulator of ACE or saidpharmaceutical is capable of causing a beneficial preventative and/ortherapeutic effect.

In an eleventh aspect, the present invention relates to a computer forproducing a three-dimensional representation of ACE wherein saidcomputer comprises: (a) a computer-readable data storage mediumcomprising a data storage material encoded with computer-readable data,wherein said data comprises the structure co-ordinates of ACE; (b) aworking memory for storing instructions for processing saidcomputer-readable data; (c) a central-processing unit coupled to saidworking memory and to said computer-readable data storage medium forprocessing said computer-machine readable data into saidthree-dimensional representation; and (d) a display coupled to saidcentral-processing unit for displaying said three-dimensionalrepresentation.

In a twelfth aspect, the present invention relates to a machine-readabledata storage medium comprising a data storage material encoded withmachine-readable data, wherein the data is defined by at least a portionof the structure co-ordinates of ACE in Table A or Table B.

In a thirteenth aspect, the present invention relates to the use of anACE crystal in the preparation of a medicament to prevent and/or treatan ACE related disorder. Preferably, the ACE related disorder ishypertension.

In a fourteenth aspect, the present invention relates to the use of atleast a portion of the structure co-ordinates of Table A or Table B toscreen for modulators of ACE.

In a fifteenth aspect, the present invention relates to the use of atleast a portion of the structure co-ordinates of Table A or Table B tosolve the structure of the crystalline form of any other protein withsignificant amino acid sequence homology to any functional domain ofACE.

In a sixteenth aspect, the present invention relates to the use of atleast a portion of the structure co-ordinates of Table A or Table B inmolecular design techniques to design, select and synthesise modulatorsof ACE.

In a seventeenth aspect, the present invention relates to the use of atleast a portion of the structure co-ordinates of Table A or Table B inthe development of compounds that can isomerise to reactionintermediates in the chemical reaction of a substrate or other compoundthat binds to ACE.

In an eighteenth aspect, the present invention relates to the use of atleast a portion of the structure co-ordinates of Table A or Table B toscreen small molecule databases for chemical entities or compounds thatmodulate ACE.

In a nineteenth aspect, the present invention relates to the use of atleast a portion of the structure co-ordinates of Table A or Table B tosolve the structure of the crystalline form of any other protein withsignificant amino acid sequence homology to any functional domain ofACE. Preferably, the structure of the crystalline form of any otherprotein with significant amino acid sequence homology to any functionaldomain of ACE is solved using molecular replacement.

In a twentieth aspect, the present invention relates to the expressionvectors pLEN-tACEΔ36g(1, 2, 3, 4) and pLEN-tACEΔ36g(1,3).

DETAILED DESCRIPTION OF THE INVENTION

ACE Protein

ACE (EC 3.4.15.1) is a peptidyldipeptide hydrolase. It catalyzes thehydrolysis of the penultimate peptide bond at the C-terminal end of avariety of acylated tripeptides and larger polypeptides having anunblocked alpha-carboxy group having a free C-terminus. The reactivityof the enzyme varies markedly depending on the substrate.

As used herein, the term “ACE protein” includes all vertebrate andmammalian forms and is intended to cover mutants, variants, homologues,derivatives and fragments thereof. Preferably, the mutants, variants,homologues, derivatives and fragments thereof have the activity of thenaturally occurring ACE.

There are two isoforms of ACE that are transcribed from the same gene ina tissue specific manner. In somatic tissues, it exists as aglycoprotein composed of a single large polypeptide chain of 1277 aminoacids whereas the germinal form is synthesised as a lower molecular massisozyme and is thought to play a role in sperm maturation and thebinding of sperm to the oviduct epithelium. The somatic form consists oftwo domains (N- and C-domain), each containing an active site with aconserved HEXXH zinc-binding motif and a glutamate some 24 residuesdownstream which forms the third zinc ligand (Williams et al., 1994).The two domains differ in their substrate specificities; inhibitor andchloride activation profiles; and physiological functions. There are twoN-domain-specific substrates: the hemoregulatory peptideN-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) which controlshematopoietic stem cell differentiation and proliferation; and thebradykinin potentiating peptide angiotensin-(1-7). On the other hand,both active sites catalyse the hydrolysis of angiotensin I and thevasodilator bradykinin with similar efficiency. However, inhibition ofthe N-domain with a phosphinic peptide RXP407 had no effect on bloodpressure regulation (Junot et al., 2001) and, furthermore, expression ofthe N-domain only, in transgenic mice produced a phenotype similar tothe ACE knockout mice Esther et al., 1997). Thus, the C-domain appearsto be necessary and sufficient for controlling blood pressure andcardiovascular function. Testis ACE (tACE) is identical to theC-terminal half of somatic ACE, except for a unique 36-residue sequenceconstituting its amino terminus.

Further background teachings on ACE have been presented by Victor A.McKusick et al. at http://www3.ncbi.nlm.nih.gov/Omim/searchornim.htm.The following information concerning ACE has been extracted from thatsource.

-   -   Angiotensin I-converting enzyme or kininase II, is a dipeptidyl        carboxypeptidase that plays an important role in blood pressure        regulation and electrolyte balance by hydrolyzing angiotensin I        into angiotensin II, a potent vasopressor, and        aldosterone-stimulating peptide. The enzyme is also able to        inactivate bradykinin, a potent vasodilator.    -   Ehlers et al. (1989) Proc. Nat. Acad. Sci. 86: 7741-7745        determined the cDNA sequence for human testicular ACE. The        predicted protein is identical, from residue 37 to its C        terminus, to the second half or C-terminal domain of the        endothelial ACE sequence. The inferred protein sequence consists        of a 732-residue preprotein including a 31-residue signal        peptide. The mature polypeptide has a molecular weight of        80,073.    -   Howard et al. (1990) Mol. Cell. Biol. 10: 4294-4302, found that        the testis-specific form of ACE has its own promoter within        intron 12, is encoded by the 3-prime region of the gene, and is        found only in postmeiotic spermatogenic cells and sperm.    -   Although angiotensin-converting enzyme has been studied        primarily in the context of its role in blood pressure        regulation, this widely distributed enzyme has many other        physiologic functions. The ACE gene encodes 2 isoymes. The        somatic ACE isozyme is expressed in many tissues, including        vascular endothelial cells, renal epithelial cells, and        testicular Leydig cells, whereas the testicular or germinal ACE        isozyme is expressed only in sperm Ramaraj et al., (1998) J.        Clin. Invest. 102: 371-378.    -   Brown et al. (1996) Clin. Pharmacol. Therapeutics 60: 8-13 found        an association between the use of certain ACE inhibitors        (lisinopril or enalapril vs captopril) and emergent angioedema        in the African-American population of Tennessee. The adjusted        relative risk of angioedema was 4.5 (95% CI, 2.9-6.8) in blacks        compared to whites. The African-American patients were more        severely affected: 7 of the 8 patients admitted to the intensive        care unit were black, as were all patients who required        intubation. African-American users of ACE inhibitors tended to        be younger and female when compared to their white counterparts.        The rate of angioedema was highest within the first 30 days of        use (5.79 per 1000 patient-years) compared to long-term use        (1.04 per 1000 patient-years).    -   Large-scale trials of therapy for heart failure showed        improvements in outcome with ACE inhibitors and beta-blockers.        These results led to the recommendation that all patients who        have heart failure accompanied by a low ejection fraction and        who can tolerate ACE inhibitors and beta-blockers should be        treated with both agents. Exner et al. (2001) New Eng. J. Med.        344: 1351-1357 focused on the fact that black patients with        heart failure have a poorer prognosis than white patients and        performed a study comparing racial groups. They found that        whereas therapy with enalapril is associated with significant        reduction in the risk of hospitalization for heart failure among        white patients with left ventricular function, it had no such        effect in similar black patients. The explanation for the lesser        response to the ACE inhibitor in black patients was not clear.    -   Mattei et al. (1989) Cytogenet. Cell Genet. 51: 1041 assigned        the ACE gene to 17q23 by in situ hybridization. Using a DNA        marker at the growth hormone gene locus, which they        characterized as ‘extremely polymorphic’ and which showed no        recombination with ACE, Jeunemaitre et al. (1992) Nature Genet.        1: 72-75, mapped ACE to 17q22-q24, consistent with the in situ        hybridization mapping to 17q23. A demonstration of linkage        between the ACE locus and elevated blood pressure in a rat model        of hypertension pointed to ACE as a candidate gene in human        hypertension. In studies of hypertensive families, they found no        evidence to support linkage between the ACE locus and the        disease, however.    -   Krege et al. (1995) Nature 375: 146-148 investigated the role of        the ACE gene in blood pressure control and reproduction using        mice generated to carry an insertional mutation that was        designed to inactivate both forms of Ace. All homozygous female        mutants were found to be fertile, but the fertility of        homozygous male mutants was greatly reduced. Heterozygous males        but not females had blood pressures that were 15 to 20 mm Hg        less than normal, although both male and female heterozygotes        had reduced serum Ace activity.    -   Although significant ACE activity is found in plasma, the        majority of the enzyme is bound to tissue such as vascular        endothelium. Esther et al. (1997), J. Clin. Invest. 99:        2375-2385, used targeted homologous recombination to create mice        expressing a form of ACE that lacks the C-terminal half of the        molecule. This modified ACE protein was catalytically active but        entirely secreted from cells. Mice that expressed only this        modified ACE had significant plasma ACE activity but no        tissue-bound enzyme. These animals had low blood pressure, renal        vascular thickening, and a urine-concentrating defect. The        phenotype was very similar to that of completely ACE-deficient        mice previously reported, except that the renal pathology was        less severe. These studies strongly supported the concept that        the tissue-bound ACE is essential for the control of blood        pressure and the structure and function of the kidney.    -   ACE gene knockout mice lack both isozymes and exhibit low blood        pressure, kidney dysfunctions, and male infertility. Ramaraj et        al. (1998) J. Clin. Invest. 102: 371-378, reported the use of a        sperm-specific promoter and interbreeding of transgenic and gene        knockout mice for generating a mouse strain that expressed ACE        only in sperm. The experimental mice maintained the kidney        defects of ACE −/− mice, but unlike the knockout strain, the        males were fertile. Thus, Ramaraj et al. (1998) established that        the role of ACE in male fertility is completely dependent on its        exclusive expression in sperm. Their study demonstrated how        transgenic and knockout techniques can be combined for ascribing        a specific physiologic function to the expression of a        multifunctional protein in a given tissue.    -   Hagaman et al. (1998) Proc. Nat. Acad. Sci. 95: 2552-2557 used        transgenic mice lacking somatic and testis ACE to investigate        the male fertility defect They demonstrated that mice lacking        both somatic and testis ACE isozymes have defects in sperm        transport within the oviducts and in binding to zonae        pellucidae. Males generated by gene targeting experiments that        lack somatic ACE but retain testis ACE are fertile. Both male        and female mice lacking angiotensinogen have normal fertility.        The authors found that males heterozygous for the mutation        inactivating both ACE enzymes had offspring of wildtype and        heterozygous genotypes at the same frequency, suggesting that        sperm carrying the mutation are not at a selective disadvantage.

Nephropathy of type I diabetes is associated with the D allele of theinsertion/deletion (I/D) polymorphism in intron 16 of the ACE gene. TheD allele determines higher enzyme levels. To address causalityunderlying this association, Huang et al. (2001) Proc. Nat. Acad. Sci.98: 13330-13334 induced diabetes in mice having 1, 2, or 3 copies of theAce gene, normal blood pressure, and an enzyme level range (65-162% ofwildtype) comparable to that seen in humans. Twelve weeks later, the3-copy diabetic mice had increased blood pressures and overtproteinuria. Proteinuria was correlated to plasma ACE level in the3-copy diabetic mice. Thus, a modest genetic increase in ACE levels wassufficient to cause nephropathy in diabetic mice.

Crystal

In one aspect of the present invention, there is provided a crystal ofACE protein.

As used herein, the term “crystal” means a structure (such as a threedimensional (3D) solid aggregate) in which the plane faces intersect atdefinite angles and in which there is a regular structure (such asinternal structure) of the constituent chemical species. Thus, the term“crystal” can include any one of: a solid physical crystal form such asan experimentally prepared crystal, a 3D model based on the crystalstructure, a representation thereof—such as a schematic representationthereof, a diagrammatic representation thereof, or a data set thereoffor a computer.

The crystals of the present invention may be prepared by purifying ACEprotein and then crystallising the purified protein. The ACE protein mayalso be prepared by expressing a nucleotide sequence encoding the ACEprotein in a suitable host cell.

In a preferred embodiment, the crystals of the present invention areprepared by purifying underglycosylated ACE protein and thencrystallising the purified underdeglycosylated protein. Theunderdeglycosylated ACE protein may also be prepared by expressing anucleotide sequence encoding the underdeglycosylated ACE protein in asuitable host cell.

ACE may be purified using various methods known to a person skilled inthe art, for example, from conditioned media by affinity chromatographyon a Sepharose-28-lisinopril affinity resin (Yu et al. 1997). Theprotein may be quantified by amino acid analysis and assayed foractivity using the substrate hippuryl-L-histidyl-L-leucine, as describedpreviously (Ehlers, M R E, Chen, Y-N, Riordan, J F (1991) Proc. Natl.Acad. Sci. USA 88, 1009-1013).

The purified ACE proteins may be stored at −20° C. in 10 mM HEPES and0.1% PMSF.

Concentration may be performed with the aid of a filtration system andthe protein concentrate may be immediately used for crystallisationpurposes. The protein concentrate may be crystallised using, forexample, the vapour diffusion hanging drop method at a temperature offrom about 1° C. to about 30° C., preferably from about 4° C. to about20° C., more preferably at about 16° C. The crystallisation temperaturemay be dependent on the additives present in the protein solution.

Typically, the best crystals for ACE proteins are grown at 16° C. by thevapour diffusion hanging drop method by mixing 2 μl of the proteinsolution at ˜11.5 mg/ml in 10 mM HEPES and 0.1% PMSF with an equalvolume of a reservoir solution containing 15% PEG 4000, 50 mMCH₃COONa.3H₂O pH 4.7 and 10 μM ZnSO₄.7H₂O. Crystals usually appearwithin 2 weeks and grow to their maximum size after about a month.

The design of ACE inhibitors has been based upon the assumption that thestructure of ACE is related to that of peptidases—such as thermolysin(MA clan, M2 family) and carboxypeptidase A (MC clan, M14 family) asevidenced by comparative molecular field analysis and 3D quantitativestructure-activity relationship studies of ACE (Waller & Marshall,1993). Marshall & Cramer (1988) Trends Pharamacol. Sci. 9, 285-289 havealso reported the development of predictive models for inhibitors of ACEand thermolysin. Surprisingly, the structure of ACE described herein,shows no structural homology with thermolysin but shows significantstructural homology with neurolysin, a member of the M3 family of thimetoligopeptidases. Therefore, the structure presented herein, may beeffectively used for the development of novel, highly selective ACEmodulators with the potential for greater efficacy, fewer side effectsand treatment of new indications. In addition, the unanticipatedsimilarity with neurolysin has shown the structural conservation amongstan merging family of peptidases with a common evolutionary origin.

Without wishing to be bound by theory, it appears that the corestructure of the two proteins is highly similar with different loopstructures on the outer surface in the case of neurolysin. Indeed likeACE, neurolysin also belongs to the family of metallopeptidases bearingthe HEXXH active site motif (Rawlings and Barrett, 1995; Brown et al.,2001). The striking similarity also extends to the active site region inneurolysin consisting of a deep narrow channel that divides the moleculeinto two halves. It has been speculated that using the flexiblesecondary structure elements in the active site cavity, theneuropeptidase can effectively cleave a variety of small peptides.Likewise in ACE, the geometry of the active site groove clearly accountsfor ACE's inability to hydrolyse large, folded substrates. Furthermore,the enzyme's preference for oligopeptide substrates of about thirteenresidues or less suggests that the substrate does not have the samefreedom to extend outside of the channel during catalysis.Peptidases—such as thermolysin (MA clan, M4 family) and carboxypeptidaseA (MC clan, M14 family)—which have been used in comparative molecularfield analysis and 3D quantitative structure-activity relationshipstudies (Waller & Marshall, 1993) show no structural homology with ACE.

A crystal according to any one of the preceding claims comprising atomsarranged in a spatial relationship represented by at least a portion ofthe structure co-ordinates of Table A or Table B.

Preferably, the crystal belongs to the space group P2₁2₁2₁ and has aunit cell with dimensions of: a=56.47 Å, b=84.90 Å, c=133.99 Å.

Preferably, the crystal is a crystal of human ACE protein.

Complexes may be obtained by growing the crystals in the presence of anentity—such as a test compound. In these experiments the proteinsolution is mixed with the entity and an equal volume of the reservoirsolution before setting up the crystallisation. Single crystals suitablefor diffraction work typically appear after about 4 weeks.

Typically, the protein comprising ACE is purified to homogeneity forcrystallisation. Purity of ACE may be measured by typical techniquessuch as SDS-PAGE, mass spectrometry and hydrophobic HPLC.

The crystal structure of the invention may contain a portion—such as atleast 25%, at least 50%, at least 75%, or preferably at least 90%, atleast 95%, at least 98%, or at least 99%—of the co-ordinates listed inTable A or Table B. Preferably, the crystal structure of the inventioncontains all of the co-ordinates listed in Table A or Table B.

Preferably, the crystal is usable in X-ray crystallography techniques.

Preferably, the crystals used can withstand exposure to X-ray beams usedto produce diffraction pattern data necessary to solve the X-raycrystallographic structure.

Preferably, prior to data collection, the crystals are flash-cooled atabout 100 K in a cryoprotectant. More preferably, cryoprotectantcontains 15% PEG 4000, 50 mM CH₃COONa.3H₂O pH 4.7, 10 μM ZnSO₄.7H₂O and25% glycerol.

The X-ray data may be collected at a Synchrotron Radiation Source.Preferably, the X-ray data are collected at a Synchrotron RadiationSource at 100° K.

Preferably, the crystal has a resolution determined by X-raycrystallography of about 3.5 Å or less, more preferably a resolution ofabout 2.8 Å or less, more preferably, a resolution of about 2 Å or less,more preferably, a resolution of about 1.5 Å or less, most preferably, 1Å or less.

Deglycosylation and Underglycosylated

Many proteins in eukaryotic cells are glycoproteins that containoligosaccharide chains covalently linked to certain amino acids.Glycosylation is known to affect protein folding, localisation andtrafficking, protein solubility, antigenicity, biological activity andhalf-life, as well as cell-cell interactions.

Protein glycosylation can be divided into four main categories mainlydepending on the linkage between the amino acid and the sugar. These areN-linked glycosylation, O-linked glycosylation, C-mannosylation and GPIanchor attachments. N-glycosylation is characterised by the addition ofa sugar to the amino group of an asparagine. In O-glycosylation, a sugaris attached to the hydroxyl group of a serine or threonine residue.

For N-glycosylation, the sequence motif Asn-Xaa-Ser/Thr (wherein Xaa isany amino acid other than Pro) has been defined as a prerequisite forglycosylation. Although rare, the sequence motif Asn-Xaa-Cys can also bean acceptor site. N-glycans can be subdivided into three distinct groupscalled ‘high mannose type’, ‘hybrid type’, and ‘complex type’, with thecommon pentasaccharidecore—Manp(alpha1,6)-(anp(alpha1,3))-Manp(beta1,4)-GlcpNAc(beta1,4)GlcpNAc(beta1,N)-Asn—occurring in all three groups. The relationshipbetween all three types can be ascribed to the fact that they originatefrom one precursor oligosaccharide which contains the described commonpentasaccharide core Man3-GlcNAc2, and some additional sugar residuesand the non-reducing end, and is then processed enzymatically to yieldthese three types. Since the hydroxyl group of Ser/Thr is thought to beinvolved in hydrogen bonding during the enzymatic attachment of theoligosaccharide precursor molecule to yield a favourable conformationfor the action of the oligosaccharyltransferase, it has been suggestedfor proline that the steric hindrance might be too large (Kornfeld(1985) Ann. Rev. Biochem. 54: 631-64), preventing glycosylation at Procontaining sites. The negative influence of aspartic acid towardsglycosylation can be ascribed to the negative charge on the side chainof this residue. In addition some cases have been reported where Ser/Thris replaced by cysteine. While Ser replacement by Cys generally leads todecreased glycosylation, it has been shown (Kasturi 1995 J. Biol. Chem.270: 14756-61) that substitution by Thr at a given potentialglycosylation site can lead to increased glycosylation. This is inaccordance with the model of hydrogen bonding being an important factorduring the attachment of the precursor molecule to the protein. Althoughthere are usually many potential glycosylation sites in a protein it hasbeen estimated that glycosylation occurs only at one third of them.Mostly at those sites where the surrounding amino acids allow theformation of a beta turn.

Various glycoforms of ACE have been described. By way of example,Sadhukhan & Sen (3a) disrupted specific glycosylation sites in rabbittACE to elucidate the glycosylation requirements for the expression andprocessing of active testis ACE. There are five potential N-linkedglycosylation sites in the rabbit tACE sequence, with an additional sixin the somatic form (4a). A null mutant, where all five sites had beendisrutpted, behaved similarly to wild-type tACE expressed in thepresence of the glycosylation-inhibitor, tunicamycin. It was degradedintracellularly and failed to be detected in culture medium, confirmingprevious findings that tACE requires N-linked glycosylation to beexpressed in an active form (5a and 3a). Expression of the remainingmutants showed a preference for N-linked glycosylation at the N-terminusand that the presence of sugars at a single N-terminal site wasnecessary and sufficient to produce enzymatically-active tACE that wassolubilised. The presence of glycosylation is not site-specific, asmutants that have either the first site or second site intact areexpressed and active. However, glycosylation at the third site alone isnot sufficient to produce active protein in HeLa cells, albeit thismutant was expressed in yeast (3a), indicating that the requirements forglycosylation are cell-specific.

In human testis ACE O-linked sugars are not necessary for expression,implicating the N-linked sugars in this role (6a). N-linkedglycosylation of human tACE expressed in CHO cells at each site has beenidentified by MALDI-TOF mass spectrometry (7a). There are sevenpotential N-linked sites in human tACE, five of which are complementaryto the sites in rabbit tACE (7a). The unique sites lie within theectodomain (the fourth site) and in the juxtamembrane stalk region,adjacent to the cleavage site (the seventh site). As with the rabbitform, there appears to be a preference for glycosylation at theN-terminus as evidenced by MALDI-TOF mass spectrometry of glyosylationsites (7a). Inhibition of complex oligosaccharide formation using aglucosidase I inhibitor N-butyldeoxynojirimycin (NB-DNJ) led to theproduction of an active glycoform that was electrophoreticallyhomogeneous (7a).

Suitably, the crystal of the ACE protein may comprise de-glycosylatedACE protein or a fragment thereof. For example, the deglycosylated ACEmay comprise the sequence presented as SEQ ID No. 2.

To deglycosylate the ACE protein, various methods known to a personskilled in the art may be used. Both chemical and enzymatic methods maybe used for removing oligosaccharides from glycoproteins. Hydrazinolysisof glycoproteins (Kuraya, N & Hase (1992) J Biochem (Tokyo)112:122-126), is capable of removing both N- and O-linked sugars,although this results in the complete destruction of the proteincomponent and is therefore not suitable if recovery of the protein isdesirable. Milder chemical methods such as trifluoromethanesulphonicacid (TFMS) may be used, however this may result in incomplete sugarremoval and partial protein destruction. Other methods—such as sitedirected mutagenesis of glycosylated amino acids may also be used.

Suitably, enzymatic methods may be used which provide for complete sugarremoval with no protein degradation.

Use of the enzyme PNGase F is an effective method of removing virtuallyall N-linked oligosaccharides from glycoproteins (Tarentino & Plummer(1994). Methods in Enzymol 230: 44-57). The oligosaccharide is leftintact and therefore suitable for further analysis (the asparagineresidue from which the sugar was removed is deaminated to aspartic acid,the only modification to the protein).

Other commonly used endoglycosidases include Endoglycosidase H (Kobata(1979) Anal Biochem 100:1-14) and Endoglycosidase F (Trimble & Tarentino(1991) J. Biochem. 266:1646-1651). In a preferred method, the ACEprotein is digested with Endoglycosidase H (30 mU) in a suitablebuffer—such as 100 mM sodium phosphate, 0.1 mM ZnCl₂ and 1% BSA, pH 6.0for 16 h at 37° C. The endo H-treated protein is passed through a lectinaffinity column consisting of equal parts of concanavalin A, wheat germ,and lentil lectin, after equilibration with 20 mM Tris-HCl, 0.5 M NaClat pH 7.4. The deglycosylated ACE is collected in the flowthrough. Freeoligosaccharides and any other impurities are removed from theflowthrough fraction by a final lisinopril-Sepharose affinitychromatography step. The homogeneity of the ACE protein afterdeglycosylation is confirmed by SDS-PAGE on a 4-20% acrylamide gel andMALDI-TOF mass spectrometry.

Commercially available kits may also be used—such as the E-DEGLY kit(Sigma-Aldrich, UK) and the GlycoFree Deglycosylation Kit (Glyco,Novato, USA) which removes both N- and O-linked glycans fromglycoproteins.

Preferably, ACE is crystallised using underglycosylated ACE protein.

As used herein, the term “underglycosylated” means that one or more ofthe oligosaccharide chains covalently linked to amino acids in theglycosylated protein are no longer present.

By way of example only, testis ACE is glycosylated at amino acids 72, 90and 109 and glycosylated partially at amino acids 155, 337 and 586.Accordingly, the “underglycosylated” testis ACE may not be glycosylateda one or more of amino acids 72, 90, 109, 155, 337 and 586.

The underglycosylated ACE protein may be prepared using variousmethods—such as site directed mutagenesis and glycosylation inhibitionmethods. For example, glycosylation inhibition methods using NB-DNJ mayprevent the formation of complex oligosaccharides. NB-DNJ inhibitsglucosidase I and prevents maturation of the sugars.

Preferably, the underglycosylated ACE protein is prepared by culturinghost cells in the presence of N-butyldeoxynojirimycin (NB-DNJ).

Preferably, underglycosylated ACE protein is prepared usingsite-directed mutagenesis. More preferably, the underglycosylated ACEprotein comprises a mutation at amino acid 337 of SEQ ID No. 2 or aminoacids 90, 109, 155, 337 and 586 of SEQ ID No. 2.

Underglycosylated mutants may yield crystals in the orthorhombic,P2₁2₁2₁ space group that diffract to 2.8 Å or less. Moreover, crystalsfrom a truncated mutant of tACE that only have simple high mannoseoligosaccharides are also grown in the orthorhombic space group P2₁2₁2₁which may diffract to better than 2.0 Å resolution.

Preparing a Crystal of Ace Protein

In another aspect, the present invention relates to a method ofpreparing a crystal of ACE protein, comprising the steps of (a)culturing host cells comprising an underglycosylated ACE protein; (b)purifying the underglycosylated ACE protein; and (c) crystallising theunderglycosylated ACE protein.

Preferably, the ACE protein is underglycosylated by removing one or moreglycosylation sites and/or one or more partially glycosylated sites.More preferably, the underglycosylated ACE protein comprises a mutationat amino acid 337 of SEQ ID No 2 or amino acids 90, 109, 155, 337 and586 of SEQ ID No 2.

The ACE protein may be underglycosylated and purified using the methodsdescribed herein.

Preferably, the ACE protein is crystallised using about 10 mM HEPES andabout 0.1% PMSF with an equal volume of a reservoir solution containingabout 15% PEG 4000, about 50 mM CH₃COONa.3H₂O pH 4.7 and about 10 μMZnSO₄.7H₂O.

Preferably, the ACE protein is crystallised in the presence of anentity, for example, a modulator of ACE.

Modulators of Ace

The role of ACE in the pathogenesis of hypertension has resulted in asearch for modulators (eg. inhibitors) of the enzyme that could act asantihypertensive drugs (eg. U.S. Pat. No. 3,891,616, U.S. Pat. No.3,947,575, U.S. Pat. No. 4,052,511 and U.S. Pat. No. 4,053,651).Therapeutic vasodepressors—such as Captopril andD-2-methyl-3-mercaptopropanoyl-L-proline—have been synthesised as ACEinhibitors. Numerous synthetic peptide derivatives have also been shownto be ACE inhibitors as disclosed in U.S. Pat. No. 3,832,337.

Natural substances that inhibit ACE include snake venom and thosederived from foodstuffs—such as ACE inhibiting peptides produced byenzymatic hydrolysis of proteins, such as casein or fish meat protein(by Hiroyuki Ukeda, Nippon Nogei Kagaku Kaishi (Journal of Japan Societyfor Bioscience, Biotechnology, and Agrochemistry, 66(1), 25-29 (1992)).

ACE inhibiting synthetic substances include captopril(D-2-methyl-3-mercaptopropanoyl-L-proline) which has already been put topractical application as an orally administered vasodepressor.

However, many ACE inhibiting substances exhibit side effects in manycases and special attention needs be exercised in safety aspects.

The present invention permits the use of molecular design techniques todesign, select and synthesise chemical entities and compounds, includingACE modulating compounds, capable of binding to ACE, in whole or inpart.

Thus, in a further aspect, the present invention relates to a method ofscreening for a modulator of ACE wherein the method comprises the use ofa crystal of ACE.

Preferably, the method comprises the steps of: (a) providing at least aportion of the structure co-ordinates of Table A or Table B; (b)employing at least a portion of the structure co-ordinates of Table A orTable B to design or select or synthesise a putative modulator of ACE;(c) contacting the putative modulator of ACE with ACE or a mutant,variant, homologue, derivative or fragment thereof in the presence of asubstrate; and (d) screening the putative modulator of ACE in an assayfor the potential to modulate ACE.

By way of example, the structure co-ordinates may be used to designcompounds that bind to the enzyme and may alter the physical propertiesof the compounds (eg. solubility) or the enzyme itself. This inventionmay be used to design compounds that act as modulators—such ascompetitive inhibitors—of ACE by binding to all or a portion of theactive site of ACE. Compounds may also be designed that act asnon-competitive inhibitors of ACE. These as non-competitive inhibitorsmay bind to all or a portion of ACE already bound to its substrate andmay be more potent and specific than known ACE inhibitors that competeonly for the ACE active site. Similarly, non-competitive inhibitors thatbind to and inhibit ACE whether or not it is bound to another chemicalentity may be designed using the structure co-ordinates of ACE asdescribed herein.

By way of example, it may be found that the COOH-binding active siteresidue differs between the N and C domain active sites and/or that itmay be amenable to the incorporation of a functionality that cancovalently modify this residue to produce an irreversible inhibitordesign. It has long been assumed that the COOH-binding residue is apositively charged arginine (M. A. Ondetti & D. W. Cushman (1981) inBiochemical Regulation of Blood Pressure (R. L. Soffer, ed.), Wiley, NewYork, 165-204), but the ACE-lisinopril X-ray crystal structure describedherein, shows that it is a lysine, in the case of the C-domain activesite. This may present an opportunity for covalent modification, by, forexample, the introduction of an alkyl halide or halo-ketonefunctionality into the inhibitors that can alkylate the lysine amine, orα-ketone or aldehyde that can form a Schiff's base with the lysineamine, or the use of activated ester or thioester groups, or othermodified carboxyl groups susceptible to nucleophilic attack.

In a preferred embodiment, at least a portion of the structureco-ordinates of Table A or Table B and/or the putative modulator of ACEand/or the substrate are provided on a machine-readable data storagemedium comprising a data storage material encoded with machine readabledata.

An ACE crystal may be probed with a variety of different chemicalentities or test compounds to determine optimal sites for interactionbetween modulators of ACE and the enzyme. For example, X-ray diffractiondata collected from crystals grown in the presence of chemical entitiesor test compounds may allow the elucidation of how the chemical entitiesor test compounds interact with ACE. Molecules that bind to those sitescan then be designed and synthesised and tested for their ACE modulatingactivity.

The present invention may also allow the development of compounds thatcan isomerise to reaction intermediates in the chemical reaction of asubstrate or other compound that binds to ACE. Thus, the time-dependentanalysis of structural changes in ACE during its interaction with othermolecules may be performed. The reaction intermediates of ACE may alsobe deduced from the reaction product in co-complex with ACE. Suchinformation is especially useful to design improved analogues of knownACE modulators or to design new ACE modulators based on the reactionintermediates of the ACE enzyme and ACE-modulator complex. This mayprovide a new route for designing ACE modulators with high specificityand stability. Preferably, this provides a new route for designing ACEmodulators with high specificity, high stability and low toxicity.

Small molecule databases or test compounds may be screened for chemicalentities or compounds that can bind in whole, or in part, to ACE. Thus,in a preferred embodiment, the putative ACE modulator is from a libraryof compounds or a database. In this screening, the quality of fit ofsuch entities or compounds to the binding site may be judged by variousmethods—such as shape complementarity or estimated interaction energy(Meng, E. C. et al., J. Comp. Chem., 13, pp. 505-524 (1992)).

Because ACE protein or a mutant, variant, homologue, derivative orfragment thereof may crystallise in more than one crystal form, thestructure co-ordinates of ACE, or portions thereof, may be particularlyuseful to solve the structure of other crystal forms of ACE. They mayalso be used to solve the structure of ACE mutants, ACE variants, ACEhomologues, ACE derivatives, ACE fragments and ACE complexes.

Preferably, the structure co-ordinates of ACE are used to solve thestructure of the crystalline form of any other protein with significantamino acid sequence homology to any functional domain of ACE. By way ofexample, molecular replacement may be used. In this method, the unknowncrystal structure, whether it is another crystal form of ACE, an ACEmutant, an ACE variant, an ACE homologue (eg. another protein withsignificant amino acid sequence homology to any functional domain ofACE), an ACE derivative, an ACE fragments or an ACE co-complex may bedetermined using the ACE structure co-ordinates of the presentinvention. This method will provide a more accurate structural form forthe unknown crystal more quickly and efficiently than attempting todetermine such information ab initio.

In a preferred embodiment of the present invention, the ACE crystalfurther comprises an entity bound to the ACE protein or a portionthereof. For example, ACE may be crystallised in complex with an entitythat is an inhibitor of ACE eg. lisinopril.

Preferably, the entity is bound to the ACE protein or a portion thereofby contacting one or more residues of the ACE protein selected from:His384, Ala385, Lys542, Tyr551, Tyr554, Glu415 and His544.

The crystal structures of a series of such complexes may then be solvedby molecular replacement or in combination with MAD (MultiwavelengthAnomalous Dispersion) and/or MIRAS (Multiple Isomorphous Replacementwith Anomalous Scattering) procedures—and compared with that ofwild-type ACE. Potential sites for modification within the binding sitesof the enzyme may thus be identified. This information provides anadditional tool for determining the most efficient binding interactions,for example, increased hydrophobic interactions, between ACE and achemical entity or compound.

The structures and complexes of ACE may be refined using computersoftware—such as X-PLOR (Meth. Enzymol., vol. 114 & 115, H. W. Wyckoffet al., eds., Academic Press (1985)), MLPHARE (Collaborativecomputational project Number 4. The CCP4 Suite: Programs for ProteinCrystallography (1994) Acta Crystallogr. D 50, 760-763) and SHARP [De LaFortelle, E. & Bricogne, G. Maximum-likelihood heavy-atom parametersrefinement in the MIR and MAD methods (1997) Methods Enzymol. 276,472-494). Preferably, the complexes are refined using the program CNS(Brünger et al. (1998) Acta Crystallogr. D 54, 905-921). During thefinal stages of refinement water molecules, ions and inhibitor moleculesmay be inserted in the structure. This information may thus be used tooptimise known classes of ACE modulators, eg. ACE inhibitors, and moreimportantly, to design and synthesise novel classes of ACE modulators.

The overall figure of merit may be improved by iterative solventflattening, phase combination and phase extension with the programSOLOMON [Abrahams, J. P. & Leslie, A. G. W. Methods used in structuredetermination of bovine mitochondrial F1 ATPase. (1996) ActaCrystallogr. D 52, 110-119].

The structure co-ordinates of ACE mutants provided in this inventionalso facilitate the identification of related proteins or enzymesanalogous to ACE in function, structure or both, thereby further leadingto novel therapeutic modes for treating or preventing ACE relateddiseases.

The design of compounds that bind to or modulate ACE according to thepresent invention generally involves consideration of two factors.First, the compound must be capable of physically and structurallyassociating with ACE. Non-covalent molecular interactions important inthe association of ACE with its substrate may include hydrogen bonding,van der Waals and hydrophobic interactions. Second, the compound must beable to assume a conformation that allows it to associate with ACE.Although certain portions of the compound may not directly participatein the association with ACE, those portions may still influence theoverall conformation of the molecule. This may have a significant impacton potency. Such conformational requirements include the overallthree-dimensional structure and orientation of the chemical entity orcompound in relation to all or a portion of a binding site of ACE, orthe spacing between functional groups of a compound comprising severalchemical entities that directly interact with ACE.

The potential modulating or binding effect of a chemical compound on ACEmay be analysed prior to its actual synthesis and testing by the use ofcomputer modelling techniques. If the theoretical structure of the givencompound suggests insufficient interaction and association with ACE,then synthesis and testing of the compound may be obviated. However, ifcomputer modelling indicates a strong interaction, the molecule may besynthesised and tested for its ability to bind to ACE and modulate (eg.inhibit) using the fluorescent substrate assay of Thronberry et al.(2000) Methods Enzymol. 322, pp 100-110. In this manner, synthesis ofinactive compounds may be avoided.

A modulating or other binding compound of ACE may be computationallyevaluated and designed by means of a series of steps in which chemicalentities or test compounds are screened and selected for their abilityto associate ACE.

A person skilled in the art may use one of several methods to screenchemical entities or test compounds for their ability to associate withACE and more particularly with the individual binding sites of ACE. Thisprocess may begin by visual inspection of, for example, the active siteon the computer screen based on the ACE co-ordinates of the presentinvention. Selected chemical entities or test compounds may then bepositioned in a variety of orientations, or docked, with ACE. Dockingmay be accomplished using software such as Quanta and Sybyl, followed byenergy minimisation and molecular dynamics with standard molecularmechanics force fields—such as CHARMM and AMBER.

Specialised computer programs may also assist in the process ofselecting chemical entities or test compounds. These include but are notlimited to MCSS (Miranker and Karplus (1991) Proteins: Structure,Function and Genetics, 11, pp. 29-34); GRID (Goodford (1985) J. Med.Chem., 28, pp. 849-857) and AUTODOCK (Goodsell and Olsen (1990),Proteins: Structure. Function, and Genetics, 8, pp. 195-202.

Once suitable chemical entities or test compounds have been selected,they may be assembled into a single compound—such as an ACE modulator.Assembly may proceed by visual inspection of the relationship of thechemical entities or test compounds in relation to the structureco-ordinates of ACE. This may be followed by manual model building usingsoftware—such as Quanta, Sybyl or O [Jones, T. A., Zou, J. Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for building protein models inelectron density maps and the location of errors in these models (1991)Acta Crystallogr. A 47, 110-119].

Refinement of the model may be carried out using the program CNS[Brünger, A. T. et al. Crystallography & NMR System: A new softwaresuite for macromolecular structure determination. (1998) ActaCrystallogr. D 54, 905-921].

Various programs may be used by a skilled person to connect theindividual chemical entities or test compounds—such as 3D Databasesystems (Martin (1992) J. Med. Chem., 35, pp. 2145-2154) and CAVEAT(Bartlett et al. (1989) Royal Chem. Soc. 78, pp. 182-196).

Rather than build an ACE inhibitor one chemical entity at a time,modulating or other ACE binding compounds may be designed as a whole orde novo using either an empty binding site or optionally including someportion(s) of a known inhibitor(s). Such compounds may be designed usingprograms that may include but are not limited to LEGEND (Nishibata andItai (1991) Tetrahedron, 47, p. 8985) and LUDI (Bohm (1992) J. Comp.Aid. Molec. Design, 6, pp. 61-78).

Other molecular modelling techniques may also be employed in accordancewith this invention—such as those described by Cohen et al., J. Med.Chem., 33, pp. 883-894 (1990); Navia and Murcko (1992) Current Opinionsin Structural Biology, 2, pp. 202-210 (1992).

Once a compound has been designed or selected by the above methods, theefficiency with which that compound may bind to ACE may becomputationally evaluated. Specific computer software may be used toevaluate the efficiency of binding (eg. to evaluate compound deformationenergy and electrostatic interaction)—such as QUANTA/CHARMM (AccelrysInc., USA) and Insight II/Discover (Biosym Technologies Inc., San Diego,Calif., USA). These programs may be implemented, for instance, using asuitable workstation. Other hardware systems and software packages willbe known to those persons skilled in the art.

Once an ACE-modulating compound has been selected or designed, asdescribed above, substitutions may be made (eg. in atoms or side groups)to improve or modify the binding properties. The substitutions may beconservative ie. the replacement group may have approximately the samesize, shape, hydrophobicity and charge as the original group. Suchsubstituted chemical compounds may then be analysed for efficiency ofbinding to ACE by the same computer methods described above.

Test compounds and modulators of ACE etc. which are identified using thecrystal and the methods of the present invention may be screened inassays. Screening can be, for example in vitro, in cell culture, and/orin vivo. Biological screening assays preferably centre on activity-basedresponse models, binding assays (which measure how well a compoundbinds), and bacterial, yeast and animal cell lines (which measure thebiological effect of a compound in a cell). The assays can be automatedfor high capacity-high throughput screening (HTS) in which large numbersof compounds can be tested to identify compounds with the desiredactivity.

Current screening technologies are described in Handbook of DrugScreening, edited by Ramakrishna Seethala, Prabhavathi B. Fernandes. NewYork, N.Y., Marcel Dekker, (2001).

Ace Related Disorders

ACE related disorders include, but are not limited to, treatment of highblood pressure; treatment of heart failure; prolonging survival ofpatients who have had a heart attack; preventing death by heart attackand stroke in patients with vascular disease and in diabetics with othervascular risk factors; prolonging survival of patients with weak heartmuscle; helping leaking heart valves; preserving kidney function indiabetics; and the treatment of new indications (e.g. polycythemia).Special groups of patients may also be treated with ACE inhibitors,including: patients with chronic pulmonary disease; patients withschleroderma; patients with atherosclerosis; and patients withhyperuricemia.

Ace Constructs

The ACE proteins produced by a host recombinant cell may be secreted ormay be contained intracellularly depending on the nucleotide sequenceand/or the vector used.

As will be understood by those of skill in the art, expression vectorscontaining an ACE encoding nucleotide sequence or a mutant, variant,homologue, derivative or fragment thereof, may be designed with signalsequences which direct secretion of the ACE coding sequences through aparticular prokaryotic or eukaryotic cell membrane.

The ACE encoding sequence may be fused (eg. ligated) to nucleotidesequences encoding a polypeptide domain which will facilitatepurification of soluble proteins (Kroll D J et al (1993) DNA Cell Biol12:441-53). Preferably, the polypeptide domain which facilitatespurification of soluble proteins is fused in frame with the ACE encodingsequence. Such purification facilitating domains include, but are notlimited to, metal chelating peptides—such as histidine-tryptophanmodules that allow purification on immobilised metals (Porath J (1992)Protein Expr Purif 3, 263-281), protein A domains that allowpurification on immobilised immunoglobulin, and the domain utilised inthe FLAGS extension/affinity purification system (Immunex Corp, Seattle,Wash.). The inclusion of a cleavable linker sequence such as Factor XAor enterokinase (Invitrogen, San Diego, Calif.) between the purificationdomain and ACE is useful to facilitate purification.

Preferably, the ACE construct is pEE-ACEΔNJ which encodes human tACEthat lacks the heavily O-glycosylated, 36-residue N-terminal sequenceand is truncated after Ser625, thereby lacking most of the juxtamembranestalk as well as the transmembrane and cytoplasmic domains as describedin (7a).

In another preferred embodiment, the ACE construct comprises anunderglycosylated ACE, constructed by the removal of one or moreglycosylation sites—such as one or more N-linked glycosylation sites.Glycosylation may be abolished using various methods known to a personskilled in the art as previously described. Preferably, a truncated formof tACE (tACEΔ36 lacking the first N-terminal 36 residues as well as thecytoplasmic domain is used for the construction of mutants (7a) andmutagenic oligonucleotides then used for altering the sites that areglycosylated. Preferably, the nucleotide sequence of each fragment isconfirmed by DNA sequencing to ensure that only the desired mutation iscreated.

Preferably, the ACE construct comprising underglycosylated ACE ispLEN-tACEΔ36g(1, 2, 3, 4) or is pLEN-tACEΔ36g(1, 3).

Host Cells

As used herein, the term “host cell” refers to any cell that comprisesnucleotide sequences that are of use in the present invention, forexample, nucleotide sequences encoding ACE.

Host cells may be transformed or transfected with a nucleotide sequencecontained in a vector e.g. a cloning vector. Preferably, said nucleotidesequence is carried in a vector for the replication and/or expression ofthe nucleotide sequence. The cells will be chosen to be compatible withthe said vector and may for example be prokaryotic (for examplebacterial), fungal, yeast or plant cells.

The gram-negative bacterium E. coli is widely used as a host for cloningnucleotide sequences. This organism is also widely used for heterologousnucleotide sequence expression. However, large amounts of heterologousprotein tend to accumulate inside the cell. Subsequent purification ofthe desired protein from the bulk of E. coli intracellular proteins cansometimes be difficult.

In contrast to E. coli, bacteria from the genus Bacillus are verysuitable as heterologous hosts because of their capability to secreteproteins into the culture medium. Other bacteria suitable as hosts arethose from the genera Streptomyces and Pseudomonas.

Depending on the nature of the polynucleotide and/or the desirabilityfor further processing of the expressed protein, eukaryotic hostsincluding yeasts or other fungi may be preferred. In general, yeastcells are preferred over fungal cells because yeast cells are easier tomanipulate. However, some proteins are either poorly secreted from theyeast cell, or in some cases are not processed properly (e.g.hyperglycosylation in yeast). In these instances, a different fungalhost organism should be selected.

Examples of expression hosts are fungi—such as Aspergillus species (suchas those described in EP-A-0184438 and EP-A-0284603) and Trichodermaspecies; bacteria—such as Bacillus species (such as those described inEP-A-0134048 and EP-A-0253455), Streptomyces species and Pseudomonasspecies; yeasts—such as Kluyveromyces species (such as those describedin EP-A-0096430 and EP-A-0301670) and Saccharomyces species; andmammalian cells—such as CHO-K1 cells.

The use of host cells may provide for post-translational modifications(eg. glycosylation) as may be needed to confer optimal biologicalactivity on recombinant expression products of the present invention.

Aspects of the present invention also relate to host cells comprisingthe ACE constructs of the present invention. The ACE constructs maycomprise a nucleotide sequence for replication and expression of thesequence. The cells will be chosen to be compatible with the vector andmay for example be prokaryotic (for example bacterial), fungal, yeast orplant cells.

In a preferred embodiment, the host cells are mammalian cells—such asCHO-K1 cells. CHO-K1 cells expressing ACE may be grown and maintained inaccordance with Yu et al. (1997).

Nucleotide Sequences

As used herein, the term “nucleotide sequence” refers to nucleotidesequences, oligonucleotide sequences, polynucleotide sequences andvariants, homologues, fragments and derivatives thereof (such asportions thereof) which comprise the nucleotide sequences encoding ACE,for example, testis ACE or somatic ACE.

The nucleotide sequence may be DNA or RNA of genomic or synthetic orrecombinant origin, which may be double-stranded or single-strandedwhether representing the sense or antisense strand or combinationsthereof.

Preferably, the term nucleotide sequence is prepared by use ofrecombinant DNA techniques (e.g. recombinant DNA). The nucleotidesequences may include within them synthetic or modified nucleotides. Anumber of different types of modification to oligonucleotides are knownin the art. These include methylphosphonate and phosphorothioatebackbones, addition of acridine or polylysine chains at the 3′ and/or 5′ends of the molecule. For the purposes of the present invention, it isto be understood that the nucleotide sequences described herein may bemodified by any method available in the art.

It will be understood by a skilled person that numerous differentnucleotide sequences can encode the same protein as a result of thedegeneracy of the genetic code. In addition, it is to be understood thatskilled persons may, using routine techniques, make nucleotidesubstitutions that do not substantially affect the activity encoded bythe nucleotide sequence of the present invention to reflect the codonusage of any particular host organism in which the target is to beexpressed. Thus, the terms “variant”, “homologue” or “derivative” inrelation to nucleotide sequences include any substitution of, variationof, modification of, replacement of, deletion of or addition of one (ormore) nucleic acids from or to the sequence providing the resultantnucleotide sequence encodes a functional protein according to thepresent invention (or even a modulator of ACE according to the presentinvention if said modulator comprises a nucleotide sequence or an aminoacid sequence).

Amino Acid Sequences

As used herein, the term “amino acid sequence” is synonymous with theterm “polypeptide” and/or the term “protein”. In some instances, theterm “amino acid sequence” is synonymous with the term “peptide”. Insome instances, the term “amino acid sequence” is synonymous with theterm “protein”.

Aspects of the present invention concern the use of amino acidsequences, which may be available in databases. These amino acidsequences may comprise ACE proteins.

The amino acid sequence may be isolated from a suitable source, or itmay be made synthetically or it may be prepared by use of recombinantDNA techniques.

Preferably, ACE comprises SEQ ID No. 1 or SEQ ID No. 2, or a mutant,variant, homologue, derivative or fragment thereof. More preferably, ACEcomprises SEQ ID No. 2, or a mutant, variant, homologue, derivative orfragment thereof.

Purity

Preferably the protein solution used for crystallisation is at least97.5% pure. More preferably, the protein solution used forcrystallisation is at least 99.0% pure. Most preferably, the proteinsolution used for crystallisation is at least 99.5% pure.

Model

As used herein, the term “model” refers to a structural model such as athree dimensional (3D) structural model (or representation thereof)comprising ACE.

Test compounds can be modelled that bind spatially and preferentially toACE—such as to bind spatially and preferentially to ACE—for example, theactive site of ACE.

Preferably, the crystal model comprising ACE is built from all or aportion of the structure co-ordinates presented in Table A or Table B.

Mutant

As used herein, the term “mutant” refers to ACE comprising any one ormore changes in the wild-type ACE sequence shown as SEQ ID No. 1 or oneor more changes in the native ACE sequence shown as SEQ ID No. 2.

The term “mutant” is not limited to any of the mutations describedherein which are reflected in amino acid substitutions of the amino acidresidues in ACE, but may also include, but are not limited to, otherdeletions or insertions of nucleotides which may result in changes inthe amino acid residues in the amino acid sequence of ACE.

In a preferred embodiment, mutations are located at amino acids 337 ofSEQ ID No. 2 or amino acids 90, 109, 155, 337 and 586 of SEQ ID No. 2.

The present invention also enables the solving of the crystal structureof ACE mutants. More particularly, by virtue of the present invention,the location of the active site of ACE based on its crystal structurepermits the identification of desirable sites for mutation. For example,one or more mutations may be directed to a particular site—such as theactive site—or combination of sites of ACE. Similarly, only a locationon, at or near the enzyme surface may be replaced, resulting in analtered surface charge of one or more charge units, as compared to thewild-type enzyme. Alternatively, an amino acid residue in ACE may bechosen for replacement based on its hydrophilic or hydrophobiccharacteristics.

Such mutants may be characterised by any one of several differentproperties as compared with wild-type ACE. For example, such mutants mayhave altered surface charge of one or more charge units, or have anincreased stability to subunit dissociation, or an altered substratespecificity in comparison with, or a higher specific activity than,wild-type ACE.

The mutants may be prepared in a number of ways that are known by aperson skilled in the art. For example, mutations may be introduced bymeans of oligonucleotide-directed mutagenesis or other conventionalmethods. Alternatively, mutants of ACE may be generated by site specificreplacement of a particular amino acid with an unnaturally occurringamino acid. This may be achieved by growing a host organism capable ofexpressing either the wild-type or mutant polypeptide on a growth mediumdepleted of one or more natural amino acids but enriched in one or morecorresponding unnaturally occurring amino acids.

The expression, activity (eg. kinetic constants) and/or thecrystallisation properties of the mutants may be determined using themethods described herein.

Variants/Homologues/Derivatives/Fragments

The ACE described herein is intended to include any polypeptide, whichhas the activity of the naturally occurring ACE and includes allvertebrate and mammalian forms. Such terms also include polypeptidesthat differ from naturally occurring forms of ACE by having amino aciddeletions, substitutions, and additions, but which retain the activityof ACE.

The term “variant” is used to mean a naturally occurring polypeptide ornucleotide sequences which differs from a wild-type or a nativesequence.

The term “fragment” indicates that a polypeptide or nucleotide sequencecomprises a fraction of a wild-type or a native sequence. It maycomprise one or more large contiguous sections of sequence or aplurality of small sections. The sequence may also comprise otherelements of sequence, for example, it may be a fusion protein withanother protein. Preferably the sequence comprises at least 50%, morepreferably at least 65%, more preferably at least 80%, most preferablyat least 90% of the wild-type sequence.

The present invention also encompasses the use of variants, homologuesand derivatives of nucleotide and amino acid sequences. Here, the term“homologue” means an entity having a certain homology with amino acidsequences or nucleotide sequences. Here, the term “homology” can beequated with “identity”.

In the present context, an homologous sequence is taken to include anamino acid sequence which may be at least 75, 85 or 90% identical,preferably at least 95 or 98% identical to the subject sequence—such asACE or a functional domain thereof.

Although homology can also be considered in terms of similarity (i.e.amino acid residues having similar chemical properties/functions), it ispreferred to express homology in terms of sequence identity.

A significantly homologous amino acid sequence is taken to include anamino acid sequence which may be at least 75, 85 or 90% identical,preferably at least 95 or 98% identical to the subject sequence—such asACE or a functional domain thereof.

An homologous sequence is taken to include a nucleotide sequence whichmay be at least 75, 85 or 90% identical, preferably at least 95 or 98%identical to the subject sequence—such as ACE or a functional domainthereof.

Homology comparisons can be conducted by eye, or more usually, with theaid of readily available sequence comparison programs. Thesecommercially available computer programs can calculate % homologybetween two or more sequences.

% homology may be calculated over contiguous sequences, i.e. onesequence is aligned with the other sequence and each amino acid in onesequence is directly compared with the corresponding amino acid in theother sequence, one residue at a time. This is called an “ungapped”alignment. Typically, such ungapped alignments are performed only over arelatively short number of residues.

Although this is a very simple and consistent method, it fails to takeinto consideration that, for example, in an otherwise identical pair ofsequences, one insertion or deletion will cause the following amino acidresidues to be put out of alignment, thus potentially resulting in alarge reduction in % homology when a global alignment is performed.Consequently, most sequence comparison methods are designed to produceoptimal alignments that take into consideration possible insertions anddeletions without penalising unduly the overall homology score. This isachieved by inserting “gaps” in the sequence alignment to try tomaximise local homology.

However, these more complex methods assign “gap penalties” to each gapthat occurs in the alignment so that, for the same number of identicalamino acids, a sequence alignment with as few gaps aspossible—reflecting higher relatedness between the two comparedsequences—will achieve a higher score than one with many gaps. “Affinegap costs” are typically used that charge a relatively high cost for theexistence of a gap and a smaller penalty for each subsequent residue inthe gap. This is the most commonly used gap scoring system. High gappenalties will of course produce optimised alignments with fewer gaps.Most alignment programs allow the gap penalties to be modified. However,it is preferred to use the default values when using such software forsequence comparisons. For example when using the GCG Wisconsin Bestfitpackage the default gap penalty for amino acid sequences is −12 for agap and −4 for each extension.

Calculation of maximum % homology therefore firstly requires theproduction of an optimal alignment, taking into consideration gappenalties. A suitable computer program for carrying out such analignment is the GCG Wisconsin Bestfit package (University of Wisconsin,U.S.A.; Devereux et al., 1984, Nucleic Acids Research 12:387). Examplesof other software than can perform sequence comparisons include, but arenot limited to, the BLAST package (see Ausubel et al., 1999 ibid—Chapter18), FASTA (Atschul et al., 1990, J. Mol. Biol., 403-410) and theGENEWORKS suite of comparison tools. Both BLAST and FASTA are availablefor offline and online searching (see Ausubel et al., 1999 ibid, pages7-58 to 7-60). However, for some applications, it is preferred to usethe GCG Bestfit program. A new tool, called BLAST 2 Sequences is alsoavailable for comparing protein and nucleotide sequence (see FEMSMicrobiol Left 1999 174(2): 247-50; FEMS Microbiol Lett 1999 177(1):187-8)

Although the final % homology can be measured in terms of identity, thealignment process itself is typically not based on an all-or-nothingpair comparison. Instead, a scaled similarity score matrix is generallyused that assigns scores to each pairwise comparison based on chemicalsimilarity or evolutionary distance. An example of such a matrixcommonly used is the BLOSUM62 matrix—the default matrix for the BLASTsuite of programs. GCG Wisconsin programs generally use either thepublic default values or a custom symbol comparison table if supplied(see user manual for further details). For some applications, it ispreferred to use the public default values for the GCG package, or inthe case of other software, the default matrix, such as BLOSUM62.

Once the software has produced an optimal alignment, it is possible tocalculate % homology, preferably % sequence identity. The softwaretypically does this as part of the sequence comparison and generates anumerical result.

By way of example, homologous sequences of ACE include, but are notlimited to human ACE_(S) somatic ACE (accession number: J04144), humanACE_(T) testis ACE (accession number: M26657), human ACEH/ACE2(accession numbers: AAF78220; BAB40370; AAF99721), chimp ACE_(T)(accession number: AF193487_(—)2), rabbit ACE_(T) mature protein(accession number: P22968), rabbit ACE_(T) full pre-protein (accessionnumber: P22968), mouse ACE_(T) testis ACE (accession number: P22967),bovine Cdom ACE_(S) C-domain, rat Cdom ACE_(S) C-domain (derived fromaccession number P47820; starting D616), human Ndom ACE_(S) N-domain(derived from accession number P12821 (J04144)), chimp Ndom ACE_(S)N-domain (derived from accession number AF193487_(—)1), rabbit NdomACE_(S) N-domain (derived from P12822), bovine Ndom (Bovine {Bos taurus}ACE_(S) N-domain), mouse Ndom ACE_(S) N-domain (derived from accessionnumber P09470), rat Ndom ACES N-domain (derived from accession numberP47820), chick ACE (partial ACE accession number Q10751), dros AnCE(derived from accession number Q10714), dros ACEr (derived fromaccession number X96913), buffalo fly ACE (derived from accession numberQ10715), and silkworm ACE (derived from accession number BAA97657), tickACE (derived from accession number U62809).

The sequences may also have deletions, insertions or substitutions ofamino acid residues, which produce a silent change and result in afunctionally equivalent substance. Deliberate amino acid substitutionsmay be made on the basis of similarity in polarity, charge, solubility,hydrophobicity, hydrophilicity, and/or the amphipathic nature of theresidues as long as the secondary binding activity of the substance isretained. For example, negatively charged amino acids include asparticacid and glutamic acid; positively charged amino acids include lysineand arginine; and amino acids with uncharged polar head groups havingsimilar hydrophilicity values include leucine, isoleucine, valine,glycine, alanine, asparagine, glutamine, serine, threonine,phenylalanine, and tyrosine.

Conservative substitutions may be made, for example according to theTable below. Amino acids in the same block in the second column andpreferably in the same line in the third column may be substituted foreach other:

ALIPHATIC Non-polar G A P I L V Polar - uncharged C S T M N Q Polar -charged D E K R AROMATIC H F W Y

Homologous substitution (substitution and replacement are both usedherein to mean the interchange of an existing amino acid residue, withan alternative residue) may occur i.e. like-for-like substitution suchas basic for basic, acidic for acidic, polar for polar etc.Non-homologous substitution may also occur i.e. from one class ofresidue to another or alternatively involving the inclusion of unnaturalamino acids such as ornithine (hereinafter referred to as Z),diaminobutyric acid ornithine (hereinafter referred to as B), norleucineomithine (hereinafter referred to as O), pyriylalanine, thienylalanine,naphthylalanine and phenylglycine.

Replacements may also be made by unnatural amino acids include; alpha*and alpha-disubstituted* amino acids, N-alkyl amino acids*, lacticacid*, halide derivatives of natural amino acids such astrifluorotyrosine*, p-Cl-phenylalanine*, p-Br-phenylalanine*,p-I-phenylalanine*, L-allyl-glycine*, β-alanine*, L-α-amino butyricacid*, L-γ-amino butyric acid*, L-α-amino isobutyric acid*, L-ε-aminocaproic acid#, 7-amino heptanoic acid*, L-methionine sulfone#*,L-norleucine*, L-norvaline*, p-nitro-L-phenylalanine*,L-hydroxyproline#, L-thioproline*, methyl derivatives of phenylalanine(Phe) such as 4-methyl-Phe*, pentamethyl-Phe*, L-Phe (4-amino)#, L-Tyr(methyl)*, L-Phe (4-isopropyl)*, L-Tic(1,2,3,4-tetrahydroisoquinoline-3-carboxyl acid)*, L-diaminopropionicacid# and L-Phe (4-benzyl)*. The notation * has been utilised for thepurpose of the discussion above (relating to homologous ornon-homologous substitution), to indicate the hydrophobic nature of thederivative whereas # has been utilised to indicate the hydrophilicnature of the derivative, #* indicates amphipathic characteristics.

The term “derivative” or “derivatised” as used herein includes chemicalmodification of an entity—such as test compound or an ACE modulator.Illustrative of such chemical modifications would be replacement ofhydrogen by a halo group, an alkyl group, an acyl group or an aminogroup.

Variant amino acid sequences may include suitable spacer groups that maybe inserted between any two amino acid residues of the sequenceincluding alkyl groups such as methyl, ethyl or propyl groups inaddition to amino acid spacers such as glycine or β-alanine residues. Afurther form of variation, involves the presence of one or more aminoacid residues in peptoid form, will be well understood by those skilledin the art. For the avoidance of doubt, “the peptoid form” is used torefer to variant amino acid residues wherein the α-carbon substituentgroup is on the residue's nitrogen atom rather than the α-carbon.Processes for preparing peptides in the peptoid form are known in theart, for example Simon R J et al., PNAS (1992) 89(20), 9367-9371 andHorwell D C, Trends Biotechnol. (1995) 13(4), 132-134.

Test Compounds

As used herein, the term “test compound” includes, but is not limitedto, a compound which may be obtainable from or produced by any suitablesource, whether natural or not.

The test compound may be designed or obtained from a library ofcompounds, which may comprise peptides, as well as other compounds, suchas small organic molecules and particularly new lead compounds. By wayof example, the test compound may be a natural substance, a biologicalmacromolecule, or an extract made from biological materials—such asbacteria, fungi, or animal (particularly mammalian) cells or tissues, anorganic or an inorganic molecule, a synthetic test compound, asemi-synthetic test compound, a structural or functional mimetic, apeptide, a peptidomimetics, a derivatised test compound, a peptidecleaved from a whole protein, or a peptide synthesised synthetically(such as, by way of example, either using a peptide synthesiser or byrecombinant techniques or combinations thereof, a recombinant testcompound, a natural or a non-natural test compound, a fusion protein orequivalent thereof and mutants, derivatives or combinations thereof Thetest compound may even be a compound that is a modulator of ACE—such asa known inhibitor of ACE—that has been modified in some way eg. byrecombinant DNA techniques or chemical synthesis techniques.

Typically, the test compound will be prepared by recombinant DNAtechniques and/or chemical synthesis techniques.

Once a test compound capable of interacting ACE has been identified,further steps may be carried out to select and/or to modify the testcompounds and/or to modify existing compounds, such that they are ableto modulate ACE.

Modulating Ace

As herein, the term “modulating” refers to preventing, suppressing,inhibiting, alleviating, restorating, elevating, increasing or otherwiseaffecting ACE.

The term “ACE modulator” may refer to a single entity or a combinationof entities.

The ACE modulator may be an antagonist or an agonist of ACE.

As used herein, the term “agonist” means any entity, which is capable ofinteracting (eg. binding) with ACE and which is capable of increasing aproportion of the ACE that is in an active form, resulting in anincreased biological response.

As used herein, the term “antagonist” means any entity, which is capableof interacting (eg. binding) with ACE and which is capable of decreasing(eg. inhibiting) a proportion of the ACE that is in an active form,resulting in a decreased biological response.

Preferably, the ACE modulators of the present invention are antagonistsof ACE.

The modulator of ACE may be an organic compound or other chemical. Themodulator of ACE may be a compound, which is obtainable from or producedby any suitable source, whether natural or artificial. The modulator ofACE may be an amino acid molecule, a polypeptide, or a chemicalderivative thereof, or a combination thereof. The modulator of ACE mayeven be a polynucleotide molecule—which may be a sense or an anti-sensemolecule. The modulator of ACE may even be an antibody.

The modulator of ACE may be designed or obtained from a library ofcompounds, which may comprise peptides, as well as other compounds, suchas small organic molecules.

By way of example, the modulator of ACE may be a natural substance, abiological macromolecule, or an extract made from biological materialssuch as bacteria, fungi, or animal particularly mammalian) cells ortissues, an organic or an inorganic molecule, a synthetic agent, asemi-synthetic agent, a structural or functional mimetic, a peptide, apeptidomimetic, a derivatised agent, a peptide cleaved from a wholeprotein, or a peptide synthesised synthetically (such as, by way ofexample, either using a peptide synthesiser or by recombinant techniquesor combinations thereof, a recombinant agent, an antibody, a natural ora non-natural agent, a fusion protein or equivalent thereof and mutants,derivatives or combinations thereof).

Typically, the modulator of ACE will be an organic compound. Typically,the organic compounds will comprise two or more hydrocarbyl groups.Here, the term “hydrocarbyl group” means a group comprising at least Cand H and may optionally comprise one or more other suitablesubstituents. Examples of such substituents may include halo-, alkoxy-,nitro-, an alkyl group, a cyclic group etc. In addition to thepossibility of the substituents being a cyclic group, a combination ofsubstituents may form a cyclic group. If the hydrocarbyl group comprisesmore than one C then those carbons need not necessarily be linked toeach other. For example, at least two of the carbons may be linked via asuitable element or group. Thus, the hydrocarbyl group may containhetero atoms. Suitable hetero atoms will be apparent to those skilled inthe art and include, for instance, sulphur, nitrogen and oxygen. Forsome applications, preferably the modulator of ACE comprises at leastone cyclic group. The cyclic group may be a polycyclic group, such as anon-fused polycyclic group. For some applications, the modulator of ACEcomprises at least the one of said cyclic groups linked to anotherhydrocarbyl group.

The modulator of ACE may contain halo groups, for example, fluoro,chloro, bromo or iodo groups.

The modulator of ACE may contain one or more of alkyl, alkoxy, alkenyl,alkylene and alkenylene groups—which may be unbranched- orbranched-chain.

The modulator of ACE may be in the form of a pharmaceutically acceptablesalt—such as an acid addition salt or a base salt—or a solvate thereof,including a hydrate thereof. For a review on suitable salts see Berge etal, (1977) J. Pharm. Sci. 66, 1-19.

The modulator of ACE may be structurally novel modulators of ACE.

The modulators of ACE may be analogues of known modulators of ACE—suchas known inhibitors of ACE (for example, snake venom, peptides producedby enzymatic hydrolysis of casein or fish meat protein, or Benazepril,Captopril, Cilazapril, Enalapril, Fosinopril, Lisinopril, Moexipril,Perindopril, Quinapril, Ramipril, Trandolapril and Enalaprilat.

Preferably, the ACE modulators have improved properties over thosepreviously available, for example, fewer side effects—such as cough (eg.dry, persistent); fever and chills; hoarseness; swelling of face, mouth,hands, or feet; trouble in swallowing or breathing; itching of skin;yellow eyes or skin; dizziness, light-headedness, or fainting; skinrash, with or without itching; fever, or joint pain; abdominal pain,abdominal distention; nausea, or vomiting; chest pain, confusion;irregular heartbeat; nervousness; numbness or tingling in hands, feet,or lips; weakness or heaviness of legs; headache, diarrhoea; loss oftaste; nausea; unusual tiredness.

The modulator of ACE may be a mimetic.

The modulator of ACE may also be chemically modified.

The modulator of ACE may be capable of displaying other therapeuticproperties.

The modulator of ACE may be used in combination with one or more otherpharmaceutically active agents.

If combinations of active agents are administered, then they may beadministered simultaneously, separately or sequentially.

Mimetic

As used herein, the term “mimetic” relates to any chemical whichincludes, but is not limited to, a peptide, polypeptide, antibody orother organic chemical which has the same qualitative activity or effectas a known compound. That is, the mimetic is a functional equivalent ofa known compound.

Stereo and Geometric Isomers

Modulators of ACE may exist as stereoisomers and/or geometricisomers—e.g. they may possess one or more asymmetric and/or geometriccentres and so may exist in two or more stereoisomeric and/or geometricforms. The present invention contemplates the use of all the individualstereoisomers and geometric isomers, and mixtures thereof.

Pharmaceutical Salt

Modulators of ACE may be administered in the form of a pharmaceuticallyacceptable salt.

Pharmaceutically-acceptable salts are well known to those skilled in theart, and for example include those mentioned by Berge et al, (1977) J.Pharm. Sci., 66, 1-19. Suitable acid addition salts are formed fromacids which form non-toxic salts and include the hydrochloride,hydrobromide, hydroiodide, nitrate, sulphate, bisulphate, phosphate,hydrogenphosphate, acetate, trifluoroacetate, gluconate, lactate,salicylate, citrate, tartrate, ascorbate, succinate, maleate, fumarate,gluconate, formate, benzoate, methanesulphonate, ethanesulphonate,benzenesulphonate and p-toluenesulphonate salts.

When one or more acidic moieties are present, suitable pharmaceuticallyacceptable base addition salts can be formed from bases which formnon-toxic salts and include the aluminium, calcium, lithium, magnesium,potassium, sodium, zinc, and pharmaceutically-active amines such asdiethanolamine, salts.

A pharmaceutically acceptable salt of a modulator of ACE may be readilyprepared by mixing together solutions of the modulator of ACE and thedesired acid or base, as appropriate. The salt may precipitate fromsolution and be collected by filtration or may be recovered byevaporation of the solvent.

The modulator of ACE may exist in polymorphic form.

The modulator of ACE may contain one or more asymmetric carbon atoms andtherefore exists in two or more stereoisomeric forms. Where a modulatorof ACE contains an alkenyl or alkenylene group, cis (E) and trans (Z)isomerism may also occur. The present invention includes the individualstereoisomers of the modulator of ACE and, where appropriate, theindividual tautomeric forms thereof, together with mixtures thereof.

Separation of diastereoisomers or cis and trans isomers may be achievedby conventional techniques, e.g. by fractional crystallisation,chromatography or H.P.L.C. of a stereoisomeric mixture of the modulatorof ACE or a suitable salt or derivative thereof An individual enantiomerof the modulator of ACE may also be prepared from a correspondingoptically pure intermediate or by resolution, such as by H.P.L.C. of thecorresponding racemate using a suitable chiral support or by fractionalcrystallisation of the diastereoisomeric salts formed by reaction of thecorresponding racemate with a suitable optically active acid or base, asappropriate.

The modulator of ACE may also include all suitable isotopic variationsof the modulator of ACE or a pharmaceutically acceptable salt thereof.An isotopic variation of an modulator of ACE or a pharmaceuticallyacceptable salt thereof is defined as one in which at least one atom isreplaced by an atom having the same atomic number but an atomic massdifferent from the atomic mass usually found in nature. Examples ofisotopes that can be incorporated into the modulator of ACE andpharmaceutically acceptable salts thereof include isotopes of hydrogen,carbon, nitrogen, oxygen, phosphorus, sulphur, fluorine and chlorinesuch as ²H, ³H, ¹³C, ¹⁴C, ¹⁵N, ¹⁷O, ¹⁸O, ³¹P, ³²P, ³⁵S, ¹⁸F and ³⁶Cl,respectively. Certain isotopic variations of the modulator of ACE andpharmaceutically acceptable salts thereof, for example, those in which aradioactive isotope such as ³H or ¹⁴C is incorporated, are useful indrug and/or substrate tissue distribution studies. Tritiated, i.e., ³H,and carbon-14, i.e., ¹⁴C, isotopes are particularly preferred for theirease of preparation and detectability. Further, substitution withisotopes such as deuterium, i.e., ²H, may afford certain therapeuticadvantages resulting from greater metabolic stability, for example,increased in vivo half-life or reduced dosage requirements and hence maybe preferred in some circumstances. Isotopic variations of the modulatorof ACE and pharmaceutically acceptable salts thereof of this inventioncan generally be prepared by conventional procedures using appropriateisotopic variations of suitable reagents.

It will be appreciated by those skilled in the art that the agent may bederived from a prodrug. Examples of prodrugs include entities that havecertain protected group(s) and which may not possess pharmacologicalactivity as such, but may, in certain instances, be administered (suchas orally or parenterally) and thereafter metabolised in the body toform the modulator of ACE which is pharmacologically active.

It will be further appreciated that certain moieties known as“pro-moieties”, for example as described in “Design of Prodrugs” by H.Bundgaard, Elsevier, 1985 (the disclosured of which is herebyincorporated by reference), may be placed on appropriate functionalitiesof the modulator of ACE. Such prodrugs are also included within thescope of the invention.

Pharmaceutically Active Salt

The modulator of ACE may be administered as a pharmaceuticallyacceptable salt. Typically, a pharmaceutically acceptable salt may bereadily prepared by using a desired acid or base, as appropriate. Thesalt may precipitate from solution and be collected by filtration or maybe recovered by evaporation of the solvent.

Chemical Synthesis Methods

The modulator of ACE of the present invention may be prepared bychemical synthesis techniques.

It will be apparent to those skilled in the art that sensitivefunctional groups may need to be protected and deprotected duringsynthesis of a compound of the invention. This may be achieved byconventional techniques, for example as described in “Protective Groupsin Organic Synthesis” by T W Greene and P G M Wuts, John Wiley and SonsInc. (1991), and by P. J. Kocienski, in “Protecting Groups”, GeorgThieme Verlag (1994).

It is possible during some of the reactions that any stereocentrespresent could, under certain conditions, be racemised, for example if abase is used in a reaction with a substrate having an having an opticalcentre comprising a base-sensitive group. This is possible during e.g. aguanylation step. It should be possible to circumvent potential problemssuch as this by choice of reaction sequence, conditions, reagents,protection/deprotection regimes, etc. as is well-known in the art.

The compounds and salts may be separated and purified by conventionalmethods.

Separation of diastereomers may be achieved by conventional techniques,e.g. by fractional crystallisation, chromatography or H.P.L.C. of astereoisomeric mixture of a compound of formula (I) or a suitable saltor derivative thereof. An individual enantiomer of a compound of formula(I) may also be prepared from a corresponding optically pureintermediate or by resolution, such as by H.P.L.C. of the correspondingracemate using a suitable chiral support or by fractionalcrystallisation of the diastereomeric salts formed by reaction of thecorresponding racemate with a suitably optically active acid or base.

ACE, modulators of ACE or variants, homologues, derivatives, fragmentsor mimetics thereof may be produced using chemical methods to synthesisethe ACE or the modulator of ACE in whole or in part. For example, a ACEpeptide or a modulator of ACE that is a peptide can be synthesised bysolid phase techniques, cleaved from the resin, and purified bypreparative high performance liquid chromatography (e.g., Creighton(1983) Proteins Structures And Molecular Principles, WH Freeman and Co,New York N.Y.). The composition of the synthetic peptides may beconfirmed by amino acid analysis or sequencing (e.g., the Edmandegradation procedure; Creighton, supra).

Synthesis of peptides (or variants, homologues, derivatives, fragmentsor mimetics thereof) may be performed using various solid-phasetechniques (Roberge J Y et al (1995) Science 269: 202-204) and automatedsynthesis may be achieved, for example, using the ABI 43 1 A PeptideSynthesizer (Perkin Elmer) in accordance with the instructions providedby the manufacturer. Additionally, the amino acid sequences comprisingthe modulator of ACE, may be altered during direct synthesis and/orcombined using chemical methods with a sequence from other subunits, orany part thereof, to produce a variant modulator of ACE.

Chemical Modification

The modulator of ACE may be a chemically modified modulator of ACE.

The chemical modification of a modulator of ACE may either enhance orreduce interactions between the modulator of ACE and the target—such ashydrogen bonding interactions, charge interactions, hydrophobicinteractions, van der Waals interactions or dipole interactions.

In one aspect, the modulator of ACE may act as a model (for example, atemplate) for the development of other compounds.

Pharmaceutical Compositions

The components may be administered alone but will generally beadministered as a pharmaceutical composition—e.g. when the componentsare in a mixture with a suitable pharmaceutical excipient, diluent orcarrier selected with regard to the intended route of administration andstandard pharmaceutical practice.

For example, the components can be administered in the form of tablets,capsules, ovules, elixirs, solutions or suspensions, which may containflavouring or colouring agents, for immediate-, delayed-, modified-,sustained-, pulsed- or controlled-release applications.

If the pharmaceutical is a tablet, then the tablet may containexcipients such as microcrystalline cellulose, lactose, sodium citrate,calcium carbonate, dibasic calcium phosphate and glycine, disintegrantssuch as starch (preferably corn, potato or tapioca starch), sodiumstarch glycollate, croscarmellose sodium and certain complex silicates,and granulation binders—such as polyvinylpyrrolidone,hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose (HPC),sucrose, gelatin and acacia. Additionally, lubricating agents—such asmagnesium stearate, stearic acid, glyceryl behenate and talc may beincluded.

Solid compositions of a similar type may also be employed as fillers ingelatin capsules. Preferred excipients in this regard include lactose,starch, a cellulose, milk sugar or high molecular weight polyethyleneglycols. For aqueous suspensions and/or elixirs, the modulator of ACEmay be combined with various sweetening or flavouring agents, colouringmatter or dyes, with emulsifying and/or suspending agents and withdiluents such as water, ethanol, propylene glycol and glycerin, andcombinations thereof.

The routes for administration (delivery) may include, but are notlimited to, one or more of oral (e.g. as a tablet, capsule, or as aningestable solution), topical, mucosal (e.g. as a nasal spray or aerosolfor inhalation), nasal, parenteral (e.g. by an injectable form),gastrointestinal, intraspinal, intraperitoneal, intramuscular,intravenous, intraventricular, intrauterine, intraocular, intradermal,intracranial, intratracheal, intravaginal, intracerebroventricular,intracerebral, subcutaneous, ophthalmic (including intravitreal orintracameral), transdermal, rectal, buccal, vaginal, epidural,sublingual.

Pharmaceutical compositions of the present invention may comprise atherapeutically effective amount of ACE, one or more modulators of ACEor combinations thereof.

The pharmaceutical compositions may be for human or animal usage inhuman and veterinary medicine and will typically comprise any one ormore of a pharmaceutically acceptable diluent, carrier, or excipient.Acceptable carriers or diluents for therapeutic use are well known inthe pharmaceutical art, and are described, for example, in Remington'sPharmaceutical Sciences, Mack Publishing Co. (A. R. Gennaro edit. 1985).The choice of pharmaceutical carrier, excipient or diluent can beselected with regard to the intended route of administration andstandard pharmaceutical practice. The pharmaceutical compositions maycomprise as—or in addition to—the carrier, excipient or diluent anysuitable binder(s), lubricant(s), suspending agent(s), coating agent(s),solubilising agent(s).

Preservatives, stabilizers, dyes and even flavouring agents may beprovided in the pharmaceutical composition. Examples of preservativesinclude sodium benzoate, sorbic acid and esters of p-hydroxybenzoicacid. Antioxidants and suspending agents may be also used.

There may be different composition/formulation requirements dependent onthe different delivery systems. By way of example, the pharmaceuticalcomposition of the present invention may be formulated to beadministered using a mini-pump or by a mucosal route, for example, as anasal spray or aerosol for inhalation or ingestable solution, orparenterally in which the composition is formulated by an injectableform, for delivery, by, for example, an intravenous, intramuscular orsubcutaneous route.

Alternatively, the formulation may be designed to be administered by anumber of routes.

If the modulator of ACE is to be administered mucosally through thegastrointestinal mucosa, it should be able to remain stable duringtransit though the gastrointestinal tract; for example, it should beresistant to proteolytic degradation, stable at acid pH and resistant tothe detergent effects of bile.

Where appropriate, the pharmaceutical compositions may be administeredby inhalation, in the form of a suppository or pessary, topically in theform of a lotion, solution, cream, ointment or dusting powder, by use ofa skin patch, orally in the form of tablets containing excipients suchas starch or lactose, or in capsules or ovules either alone or inadmixture with excipients, or in the form of elixirs, solutions orsuspensions containing flavouring or colouring agents, or thepharmaceutical compositions can be injected parenterally, for exampleintravenously, intramuscularly or subcutaneously. For parenteraladministration, the compositions may be best used in the form of asterile aqueous solution which may contain other substances, for exampleenough salts or monosaccharides to make the solution isotonic withblood. For buccal or sublingual administration the compositions may beadministered in the form of tablets or lozenges which can be formulatedin a conventional manner.

The modulators of ACE may be used in combination with a cyclodextrin.Cyclodextrins are known to form inclusion and non-inclusion complexeswith drug molecules. Formation of a drug-cyclodextrin complex may modifythe solubility, dissolution rate, bioavailability and/or stabilityproperty of a drug molecule. Drug-cyclodextrin complexes are generallyuseful for most dosage forms and administration routes. As analternative to direct complexation with the drug the cyclodextrin may beused as an auxiliary additive, e.g. as a carrier, diluent orsolubiliser. Alpha-, beta- and gamma-cyclodextrins are most commonlyused and suitable examples are described in WO-A-91/11172, WO-A-94/02518and WO-A-98/55148.

If the modulator of ACE is a protein, then said protein may be preparedin situ in the subject being treated. In this respect, nucleotidesequences encoding said protein may be delivered by use of non-viraltechniques (e.g. by use of liposomes) and/or viral techniques (e.g. byuse of retroviral vectors) such that the said protein is expressed fromsaid nucleotide sequence.

Dose Levels

Typically, a physician will determine the actual dosage which will bemost suitable for an individual subject. The specific dose level andfrequency of dosage for any particular patient may be varied and willdepend upon a variety of factors including the activity of the specificcompound employed, the metabolic stability and length of action of thatcompound, the age, body weight, general health, sex, diet, mode and timeof administration, rate of excretion, drug combination, the severity ofthe particular condition, and the individual undergoing therapy.

Formulation

The component(s) may be formulated into a pharmaceutical composition,such as by mixing with one or more of a suitable carrier, diluent orexcipient, by using techniques that are known in the art.

Vector

Aspects of the present invention relate to a vector comprising anucleotide sequence—such as a nucleotide sequence encoding ACE or amodulator of ACE—administered to a subject.

Preferably, ACE or the modulator of ACE is prepared and/or deliveredusing a genetic vector.

As it is well known in the art, a vector is a tool that allows orfacilitates the transfer of an entity from one environment to another.In accordance with the present invention, and by way of example, somevectors used in recombinant DNA techniques allow entities, such as asegment of DNA (such as a heterologous DNA segment, such as aheterologous cDNA segment), to be transferred into a host and/or atarget cell for the purpose of replicating the vectors comprisingnucleotide sequences and/or expressing the proteins encoded by thenucleotide sequences. Examples of vectors used in recombinant DNAtechniques include, but are not limited to, plasmids, chromosomes,artificial chromosomes or viruses.

The term “vector” includes expression vectors and/or transformationvectors.

The term “expression vector” means a construct capable of in vivo or invitrolex vivo expression.

The term “transformation vector” means a construct capable of beingtransferred from one species to another.

Regulatory Sequences

In some applications, nucleotide sequences are operably linked to aregulatory sequence which is capable of providing for the expression ofthe nucleotide sequence, such as by a chosen host cell. By way ofexample, a vector comprising the ACE nucleotide sequence is operablylinked to such a regulatory sequence i.e. the vector is an expressionvector.

The term “operably linked” refers to a juxtaposition wherein thecomponents described are in a relationship permitting them to functionin their intended manner. A regulatory sequence “operably linked” to acoding sequence is ligated in such a way that expression of the codingsequence is achieved under conditions compatible with the controlsequences.

The term “regulatory sequences” includes promoters and enhancers andother expression regulation signals.

The term “promoter” is used in the normal sense of the art, e.g. an RNApolymerase binding site.

Enhanced expression of a nucleotide sequence, for example, a nucleotidesequence encoding ACE—may also be achieved by the selection ofheterologous regulatory regions, e.g. promoter, secretion leader andterminator regions, which serve to increase expression and, if desired,secretion levels of the protein of interest from the chosen expressionhost and/or to provide for the inducible control of the expression ofACE. In eukaryotes, polyadenylation sequences may be operably connectedto the ACE nucleotide sequence.

Preferably, the ACE nucleotide sequence is operably linked to at least apromoter.

Aside from the promoter native to the gene encoding the ACE nucleotidesequence, other promoters may be used to direct expression of the ACEpolypeptide. The promoter may be selected for its efficiency indirecting the expression of the ACE nucleotide sequence in the desiredexpression host.

In another embodiment, a constitutive promoter may be selected to directthe expression of the ACE nucleotide sequence of the present invention.Such an expression construct may provide additional advantages since itcircumvents the need to culture the expression hosts on a mediumcontaining an inducing substrate.

Hybrid promoters may also be used to improve inducible regulation of theexpression construct.

The promoter can additionally include features to ensure or to increaseexpression in a suitable host. For example, the features can beconserved regions such as a Pribnow Box or a TATA box. The promoter mayeven contain other sequences to affect (such as to maintain, enhance,decrease) the levels of expression of the ACE nucleotide sequence. Forexample, suitable other sequences include the Sh1-intron or an ADHintron. Other sequences include inducible elements—such as temperature,chemical, light or stress inducible elements. Also, suitable elements toenhance transcription or translation may be present.

Expression Vector

Preferably, nucleotide sequences—such as nucleotide sequences encodingACE or modulators of ACE—are inserted into a vector that is operablylinked to a control sequence that is capable of providing for theexpression of the coding sequence by the host cell.

Nucleotide sequences produced by a host recombinant cell may be secretedor may be contained intracellularly depending on the sequence and/or thevector used. As will be understood by those of skill in the art,expression vectors can be designed with signal sequences, which directsecretion of the nucleotide sequence through a particular prokaryotic oreukaryotic cell membrane.

The expression vector may be pEE-tACEΔ36NJ which encodes human tACE thatlacks the heavily O-glycosylated, 36-residue N-terminal sequence and istruncated after Ser⁶²⁵, thereby lacking most of the juxtamembrane stalkas well as the transmembrane and cytoplasmic domains.

In a preferred aspect, the expression vector is pLEN-tACEΔ36g(n), wheren is a set of numbers defining the available N-linked glycosylationsites.

Preferably, the expression vectors are stably expressed in CHO cells asdescribed previously (Ehlers et al. (1996) Biochemistry 35, 9549-9559).More preferably, the expression vectors are pLEN-tACEΔ36g(1, 2, 3, 4)and pLEN-tACEΔ36g(1,3).

Fusion Proteins

ACE or a modulator of ACE may be expressed as a fusion protein to aidextraction and purification and/or delivery of the modulator of ACE orthe ACE protein to an individual and/or to facilitate the development ofa screen for modulators of ACE.

Examples of fusion protein partners include glutathione-S-transferase(GST), 6×His, GAL4 (DNA binding and/or transcriptional activationdomains) and β-galactosidase.

It may also be convenient to include a proteolytic cleavage site betweenthe fusion protein partner and the protein sequence of interest to allowremoval of fusion protein sequences. Preferably, the fusion protein willnot hinder the activity of the protein of interest.

The fusion protein may comprise an antigen or an antigenic determinantfused to the substance of the present invention. In this embodiment, thefusion protein may be a non-naturally occurring fusion proteincomprising a substance, which may act as an adjuvant in the sense ofproviding a generalised stimulation of the immune system. The antigen orantigenic determinant may be attached to either the amino or carboxyterminus of the substance.

Organism

The term “organism” in relation to the present invention includes anyorganism that could comprise ACE and/or modulators of ACE. Examples oforganisms may include mammals, fungi, yeast or plants.

Preferably, the organism is a mammal. More preferably, the organism is ahuman.

Transformation

As indicated earlier, the host organism can be a prokaryotic or aeukaryotic organism. Examples of suitable prokaryotic hosts include E.coli and Bacillus subtilis. Teachings on the transformation ofprokaryotic hosts are well documented in the art, for example seeSambrook et al Molecular Cloning: A Laboratory Manual, 2nd edition,1989, Cold Spring Harbor Laboratory Press) and Ausubel et al., CurrentProtocols in Molecular Biology (1995), John Wiley & Sons, Inc. Examplesof suitable eukaryotic hosts include mammalian cells.

If a prokaryotic host is used then the nucleotide sequence—such as theACE nucleotide sequence—may need to be suitably modified beforetransformation—such as by removal of introns.

Thus, the present invention also relates to the transformation of a hostcell with a nucleotide sequence—such as ACE or a modulator of ACE. Hostcells transformed. with the nucleotide sequence may be cultured underconditions suitable for the expression and recovery of the encodedprotein from cell culture. The protein produced by a recombinant cellmay be secreted or may be contained intracellularly depending on thesequence and/or the vector used. As will be understood by those of skillin the art, expression vectors containing coding sequences can bedesigned with signal sequences which direct secretion of the codingsequences through a particular prokaryotic or eukaryotic cell membrane.Other recombinant constructions may join the coding sequence tonucleotide sequence encoding a polypeptide domain, which will facilitatepurification of soluble proteins (Kroll D J et al (1993) DNA Cell Biol12:441-53) e.g. 6-His or Glutathione-S-transferase.

Transfection

Vectors comprising for example, the ACE nucleotide sequence, may beintroduced into host cells, for example, mammalian cells, using avariety of methods.

Typical transfection methods include electroporation, DNA biolistics,lipid-mediated transfection, compacted DNA-mediated transfection,liposomes, immunoliposomes, lipofectin, cationic agent-mediated,cationic facial amphiphiles (CFAs) (Nature Biotech. (1996) 14, 556),multivalent cations such as spermine, cationic lipids or polylysine,1,2,-bis(oleoyloxy)-3-(trimethylammonio)propane (DOTAP)-cholesterolcomplexes (Wolff and Trubetskoy 1998 Nature Biotechnology 16: 421) andcombinations thereof.

Uptake of nucleic acid constructs by mammalian cells is enhanced byseveral known transfection techniques for example those including theuse of transfection agents. Example of these agents include cationicagents (for example calcium phosphate and DEAE-dextran) and lipofectants(for example lipofectam™ and transfectam™). Typically, nucleic acidconstructs are mixed with the transfection agent to produce acomposition.

Such methods are described in many standard laboratory manuals—such asSambrook et al., Molecular Cloning: A Laboratory Manual, 2d ed. (1989)Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.

General Recombinant DNA Methodology Techniques

The present invention employs, unless otherwise indicated, conventionaltechniques of chemistry, molecular biology, microbiology, recombinantDNA and immunology, which are within the capabilities of a person ofordinary skill in the art. Such techniques are explained in theliterature. See, for example, J. Sambrook, E. F. Fritsch, and T.Maniatis, 1989, Molecular Cloning: A Laboratory Manual, Second Edition,Books 1-3, Cold Spring Harbor Laboratory Press; Ausubel, F. M. et al.(1995 and periodic supplements; Current Protocols in Molecular Biology,ch. 9, 13, and 16, John Wiley & Sons, New York, N.Y.); B. Roe, J.Crabtree, and A. Kahn, 1996, DNA Isolation and Sequencing: EssentialTechniques, John Wiley & Sons; J. M. Polak and James O'D. McGee, 1990,In Situ Hybridization: Principles and Practice; Oxford University Press;M. J. Gait (Editor), 1984, Oligonucleotide Synthesis: A PracticalApproach, Irl Press; and, D. M. J. Lilley and J. E. Dahlberg, 1992,Methods of Enzymology: DNA Structure Part A: Synthesis and PhysicalAnalysis of DNA Methods in Enzymology, Academic Press. Each of thesegeneral texts is herein incorporated by reference.

DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic presentation of wild-type tACE (tACE) and tACEΔ36glycosylation mutants. Glycosylation sites are shown with boxes,glycosylated always (black box), glycosylated partially (grey box) andunglycosylated (open box). The O-glycosylated region at the N-terminusof (tACE), which is absent in tACEΔ36, is shown with a stippled box. TMis the transmembrane domain.

FIG. 2 illustrates the expression of tACE glycosylation mutants.Proteins are immunodetected from detergent-solubilised cells (A) andfrom harvested medium (B) with rabbit anti-human tACE antibody (at1:2000). The estimated protein size is indicated. Lanes contain tACEΔ36(A36), untreated CHO cells (CHO) and ACE glycosylation mutantstACEΔ36-g(n) where n equals the number of sites that are glycosylated.

FIGS. 3 illustrates the effect of tunicamycin on the expression andprocessing of tACE. CHO cells expressing wild-type tACE are treated withthe glycosylation inhibitor tunicamycin for up to 24 h. Cell lysate fromuntreated (a) and treated (b) cells are analysed at the indicated timesby Western blotting, protein molecular weights are given.

FIG. 4 illustrates the effect of phorbol ester on the levels of ACEactivity. Results are expressed as percentage soluble of total (solubleplus cell associated) ACE activity. Lanes show wild-type tACE (tACE),tACEΔ36 (Δ36) and glycosylation mutants tACEΔ36 g(n), where n gives thenumber of sites that are glycosylated. CHO cells were grown either inthe absence (open bars) or the presence (filled bars) of phorbol 12,13-butyrate.

FIG. 5 represents the orthorhombic crystals of tACEΔ36.

FIG. 6 schematically illustrates a general purpose computer (132) of thetype that may be used in accordance with the present invention. Thecomputer (132) includes a central processing unit (134), a read onlymemory (136), a random access memory (138), a hard disk drive (140), adisplay driver (142) and display (144) and a user input/output circuit(146) with a keyboard (148) and mouse (150) all connected via a commonbus (152). The central processing unit (134) may execute programinstructions stored within the ROM (136), the RAM (138) or the hard diskdrive (140) to carry out processing of signal values that may be storedwithin the RAM (138) or the hard disk drive (140). The program may bewritten in a wide variety of different programming languages. Thecomputer program itself may be stored and distributed on a recordingmedium, such as a compact disc, or may be downloaded over a network link(not illustrated). The general purpose computer (132) when operatingunder control of an appropriate computer program effectively forms anapparatus for performing aspects of the present invention.

FIG. 7 illustrates the overview of the testis ACE structure. (a) Ribbondiagram of the molecule looking down on the active site. The moleculecan be divided into 2 halves as domains I and II show in cyan and pinkrespectively. The active site zinc ion and the lisinopril molecule areshown in yellow. The two chloride ions are shown as black spheres. (b)The molecular surface representation showing the active site groove. (c)The structure-sequence relationship in ACE (SEQ ID NO: 2). The secondarystructure elements (domain I-cyan; domain II-pink) follow the samecolour code as in (a). The important residues which are involved inbinding are marked-zinc ligands (yellow), chloride binding residues(C11-light green, C12-dark green), lisinopril binding residues (cyan)and glycosylation sites (open boxes).

FIG. 8 illustrates details of the active site. (a) Zinc co-ordination inthe native structure. Bound zinc ion, acetate ion (AC) and part of thebutyl succinate moiety (LIG) are shown. (b) Details of lisinopril (LIS)interactions. Bound zinc ion is also shown.

FIG. 9 illustrates the comparison of (a) ACE and (b) Neurolysin folds.The same view as in FIG. 7 a has been retained.

The invention will now be further described by way of Examples, whichare meant to serve to assist one of ordinary skill in the art incarrying out the invention and are not intended in any way to limit thescope of the invention.

EXAMPLES Example 1

Materials & Methods

Materials

Endoproteinase Lys-C and Asp-N, peptide-N-glycosidase F (PNGase F),endoglycosidase H (endo H), neuraminidase, and O-glycosidase arepurchased from Roche Biochemicals. Cyanogen bromide, trifluoroaceticacid, and calibration standards (angiotensin, insulin, myoglobin,oxidised insulin B-chain, and TPCK-treated trypsin) are from SigmaChemical Co. Glycosylation inhibitor N-butyldeoxynojirimycin (NB-DNJ)was a kind gift from Dr. F. Platt, University of Oxford, UK.

Construction of Expression Vectors

pEE-ACEΔ36NJ encodes human tACE that lacks the heavily O-glycosylated,36-residue N-terminal sequence and is truncated after Ser⁶²⁵, therebylacking most of the juxtamembrane stalk as well as the transmembrane andcytoplasmic domains, and is constructed as follows. The 5′ half of theACE cDNA in the plasmid pLEN-ACE-JMΔ24 is excised by digestion withBamHI and NheI and replaced with the similarly digested fragment fromplasmid pLEN-ACEΔ36N. pLEN-ACE-JMΔ24 has an engineered EcoRI site atnucleotide (nt) 1984 in the ACE cDNA. The sequence between nt 1854 (thestart of the unique BclI site) and nt 1990 (the end of the codon forSer⁶²⁵) in the native ACE cDNA are amplified by the polymerase chainreaction, using a 3′ primer that contains two stop codons (TAA and TAG)after the Ser⁶²⁵ codon, followed by an EcoRI site. The recombinantsequence is inserted into the pLEN-ACE_(—)36N/JMΔ24 hybrid cut with BclIand EcoRI, to generate pLEN-ACEΔ36NJ. The ACEΔ36NJ coding sequence isexcised by digestion of unique XbaI (generated after first subcloning inpBluescript) and EcoRI sites and inserted into the polylinker of theexpression vector pEE14, to generate pEE-ACEΔ36NJ.

Cell Culture and Transfections

CHO-K1 cells stably transfected with pLEN-ACE glycosylation mutants aregrown and maintained in standard media (50% Ham's F-12/50% DME mediumsupplemented with 20 mM Hepes, pH 7.3) containing 2% fetal bovine serum(heated to 65° C. for 15 mins before use) and 40 μM Zn Cl₂. In addition,native CHO-K1 cells are cotransfected with pEE-ACEΔ36NJ (10 μg) andpSV2NEO (1 μg) by the calcium phosphate precipitate method and clonesstably resistant to G418 (Geneticin, Gibco-BRL) are selected and assayedfor ACE activity, by procedures detailed previously (9,11). Clonesstably expressing pEE-ACEΔ36NJ are further selected for resistance tomethionine sulfoximine and then amplified, as described (Davis, S J,Davies, E A, Barclay, A N, Daenke, S, Bodian, D L, Jones, E Y, Stuart, DI, Butters, T D, Dwek, R A, and van der Merwe, P A (1995) J Biol Chem270, 369-375). Methionine sulfoximine-amplified cells are grown first inGMEM-10 (Gibco-BRL) containing 10% dialyzed fetal bovine serum (FBS)(Gibco-BRL) and 1.5 mM NB-DNJ for 3 days and then refed with GMEM-10, 5%dialyzed FBS, 2 mM NB-DNJ. This medium is changed twice over a period of9 days before harvesting.

Enzyme Purification

Soluble, recombinant tACE (wild-type, ACEΔ36NJ and ACE glycosylationmutants), is purified from conditioned media by affinity chromatographyon a Sepharose-28-lisinopril affinity resin. The protein is quantitatedby amino acid analysis and assayed for activity using the substratehippuryl-L-histidyl-L-leucine, as described (Ehlers, MRE, Chen, Y-N,Riordan, J F (1991) Proc Natl Acad Sci USA 88, 1009-1013).

Deglycosylation of ACE

tACEΔ36NJ (12.5 nmol) purified from cultures treated with NB-DNJ isdigested with endo H (30 mU) in 100 mM sodium phosphate, 0.1 mM ZnCl₂,1% BSA, pH 6.0 for 16 h at 37° C. The endo H-treated ACE is passedthrough a lectin affinity column consisting of equal parts ofconcanavalin A, wheat germ, and lentil lectin, after equilibration with20 mM Tris-HCl, 0.5 M NaCl at pH 7.4. The deglycosylated ACE iscollected in the flowthrough. Free oligosaccharides and any otherimpurities are removed from, the flowthrough fraction by a finallisinopril-Sepharose affinity chromatography step. The homogeneity ofthe tACEΔ36NJ after deglycosylation is confirmed by SDS-PAGE on a 4-20%acrylamide gel and MALDI-TOF mass spectrometry.

Construction of Glycosylation Mutants

Minimally glycosylated isoforms of human testis ACE are constructed bythe removal of a combination of N-linked glycosylation sites.Glycosylation is abolished by site-directed mutagenesis of the site ofattachment in the recognition sequon (Asn-X-Ser/Thr) through a conservedtransition of the Asn to a Gln residue. A truncated form of tACE(tACEΔ36 lacking the first N-terminal 36 residues is used for theconstruction of all mutants. tACEΔ36 cDNA is divided into four fragmentsand introduced into pGEM-11Zf(+) to facilitate site-directedmutagenesis. An Eco47III site is introduced into pGEM-11Zf(+) forcloning of the first and second tACEΔ36 fragments. A 146 bp BamHI/NheIdigested pBR329 fragment that contains an Eco47III site is ligated toBamHI/XbaI digested pGEM. The following mutagenic oligonucleotides areused for altering the consensus sites for N-linked glycosylation: g1-F,g2-F, g3-F, g4-F, g5-F, g6-F, g1-R, g2-R and g3-R, with the numberreferring to each complementary recognition sequon. The mutagenicoligonucleotides encode the Asn to Gln transition (underlined) at theglycosylation sites and a silent mutation that alters a restrictionenzyme recognition site (highlighted in italics). Mutated residues areindicated by bold type:

Forward primers:

g1-F (40-mer): 5′-GAGGCCA

TTGGAACTACAACACC CAG ATCACCACAGAG-3′ (SEQ ID NO: 3) g2-F (36-mer):5′-ATGCAAATAGCC CAG CACACCCT

AAGTACGGCACC-3′ (SEQ ID NO: 4) g3-F (40-mer): 5′-GAAGTTTGATGT

AACCAGTTGCAG CAG ACCACTATCAAG-3′ (SEQ ID NO: 5) g4-F (30-mer):5′-GTGTGCCACCCG CAA GG

AGCTGCCTGCAG-3′ (SEQ ID NO: 6) g5-F (36-mer): 5′-CCGTGCCTCCTGA

TTCTGG CAG AAGTCGATGCTGG-3′ (SEQ ID NO: 7) g6-F (36-mer):5′-ACGGGCCAGCCC CAG ATGAGCGC

TCGGCC-3′ (SEQ ID NO: 8)

Reverse primers are complementary to the forward primers:

g1-R (40-mer): 5′-CTCTGTGGTGAT CTG GGTGTTGTAGTTCCAATTGGCCTCG-3′ (SEQ IDNO: 9) g2-R (36-mer): 5′-GGTGCCGTACTTAAGGGTGTG CTG GGCTATTTGCAT-3′ (SEQID NO: 10) g3-R (40-mer): 5′-CTTGATAGTGGT CTGCTGCAACTGGTTAACATCAAACTTC-3′ (SEQ ID NO: 11)

In the first fragment a cDNA-containing mutation at one site served as atemplate for the mutagenesis of the second site thus generating fivevariants with either one or two sites out of the firs three eliminated.The fourth, fifth and sixth sites (N155, N337 and N586) are eliminatedfrom fragments 2, 3 and 4 respectively using primers g4-F, g5-F, g6-F.The nucleotide sequence of each fragment is confirmed by sequencing toensure that only the desired mutation has been created. The fourfragments are reassembled to produce eight tACEΔ36 glycosylation mutants(FIG. 1).

The mutants are introduced into the mammalian expression vector, pLEN,to facilitate the production of underglycosylated tACEΔ36 protein. Theexpression vectors pLEN-tACEΔ36g(n), where n is a set of numbersdefining the available N-linked glycosylation sites, are stablyexpressed in CHO cells as described previously Ehlers et al. (1996)Biochemistry 35, 9549-9559). Similarly, wild-type tACE (tACE-wt),retaining its 36-residue N-terminus as well as the transmembrane regionand juxtamembrane stalk, is stably expressed in CHO cells. A deletionmutant, tACEΔ36NJ, truncated after Ser625, and thus lacking thecytoplasmic and TM domains as well as most of the juxtamembrane stalk,is constructed (Yu et al. (1997) J. Biol. Chem. 272, 3511-3519). Thevector pEE14-ACEΔ36NJ is transfected into CHO cells and clones stablyexpressing the mutant are amplified using methionine sulfoxamine, asdescribed (Yu et al. (1997) J. Biol. Chem. 272, 3511-3519).

Inhibition of tACE Glycosylation in Presence of Tunicamycin

CHO cells expressing tACE-wt are grown to confluence in 6-well platesand induced overnight in 2% medium in the absence and presence of 5μg/ml tunicamycin. Fresh medium is added and cells are grown in theabsence and presence of 5 μg/ml tunicamycin. At 6, 8, 12, 16, 20 and 24hours detergent-solubilised cell samples are collected. After separatingthe proteins on 10% SDS-PAGE they are immunodetected by Westernblotting.

Western Blot Analysis of Glycosylation Mutants

tACE-wt, tACEΔ36, tACEΔ36-g1, -g2, -g3, -g12, -g13, -g23, -g123 and-g1234 are immunodetected by Western blotting of cell lysates andharvested medium from transfected CHO cells. Proteins are separated on10% SDS-PAGE and transferred to nitrocellulose membrane (Hybond-C,Amersham). The membrane is probed with a polyclonal rabbit anti-humantACE antibody. The membrane is developed using the ECL chemiluminescencekit (Amersham) and visualised on autoradiographic film, as perinstructions.

Analysis of Release Kinetics and Cleavage Sites

After selection for stable transfectants, kinetic analyses of rates ofaccumulation of soluble (released) ACE activity and changes inmembrane-bound ACE activity are performed in the presence and absence of1 μM phorbol 12,13 dibutyrate (Schwager et al. (1998) Biochemistry 37,15449-15456). Identification of the stalk cleavage sites and analysis ofthe C-terminal glycosylation site in the released (soluble) protein iscarried out using limited proteolysis and MALDI-TOF mass spectrometry bymethods described previously (Schwager et al. (1998) Biochemistry 37,15449-15456).

Determination of Kinetic Constants for tACE Hydrolysis ofHippuryl-L-histidyl-L-leucine (Hip-His-Leu)

The enzyme is purified from harvest medium via lisinopril affinitychromatography and rates of substrate hydrolysis are determined. Assaysare performed in 100 mM potassium phosphate pH 8.3 containing 300 mMNaCl. Initial velocities are calculated over a range of Hip-His-Leuconcentrations (0.2-5.0 mM) under initial rate conditions and fit to theMichaelis-Menten equation. K_(m) and V_(max) values are determined bynon-linear regression analysis. Turnover numbers (k_(cat)) andspecificity constants (k_(cat)/K_(m)) are determined using a calculatedmolecular mass of 100 kDa.

Mass Spectrometry

Mass spectrometry is used to verify the glycan occupancy of some of theglycosylation sites of the mutant proteins. All mass spectra areobtained on a MALDI/TOF/MS instrument (Voyager-Elite BiospectrometryWorkstation, PerSeptive Biosystems, Inc.). A nitrogen laser (337 nm) isused for desorption ionization. Measurements are carried out either inthe linear or reflectron mode with mass accuracies of 0.1% and 0.01%,respectively. Spectra are collected over a hundred laser shots.

Typical matrices used in these experiments are3,5-dimethoxy-4-hydroxycinnamic acid (sinapinic acid) andα-cyano-4-hydroxycinnamic acid (Aldrich). About 1 μl of sample solutionwas mixed with 2 μl of the matrix solution (10 mg/ml in 50% v/v CH₃CNand H₂O). A 0.5 μl volume (containing 1-10 pmol of peptide or peptidemixture) of the above solution is loaded on the sample plate and allowedto dry.

Crystallisation

The purified tACE-ACEΔ36NJ and ACE glycosylation mutants are stored at−20° C. in 10 mM HEPES and 0.1% PMSF. Extensive crystallisation trialsusing commercially available crystal screen conditions (HamptonResearch) are tried. In addition ammonium sulphate, PEG and MPD matricesare also tried. The best crystals for these proteins are grown at 16° C.by the vapour diffusion hanging drop method by mixing 2 μl of theprotein solution at ˜11.5 mg/ml in 10 mM HEPES and 0.1% PMSF with anequal volume of a reservoir solution containing 15% PEG 4000 (Fluka), 50mM CH₃COONa.3H₂O (Sigma Chemical Company) pH 4.7 and 10 μM ZnSO₄.7H₂O(Aldrich Chemical Company). Crystals usually appear within 2 weeks andgrow to their maximum size after about a month. The crystals belong toP2₁2₁2₁ space group, with 1 molecule in the crystallographic asymmetricunit and some 49% of the crystal volume occupied by the solvent (celldimensions: a=56.47 Å, b=84.90 Å, c=133.99 Å, Δ=90°, β=90° and γ=90°).tACE-ACEΔ36NJ crystals diffract to 2 Å while tACE-ACEΔ36NJ-g13 andtACE-ACEΔ36NJ-g1234 crystals diffract to 3.0 Å and 2.8 Å respectively ona Synchrotron Radiation Source. All crystals are isomorphous.

The tACE-lisinopril (lisinopril.dihydrate) inhibitor complex is obtainedby growing the crystals in the presence of inhibitor. In theseexperiments the protein solution is mixed with 10 mM of the inhibitorand mixed with an equal volume of the reservoir solution before settingup the crystallisation. Single crystals belonging to the P2₁2₁2₁orthorhombic space group (isomorphous with the native crystals) suitablefor diffraction work appear after about 4 weeks.

X-Ray Diffraction Data Collection

Before data collection, all crystals are flash-cooled at 100 K in acryoprotectant containing 15% PEG 4000, 50 mM CH₃COONa.3H₂O pH 4.7, 10μM ZnSO₄.7H₂O and 25% glycerol with and without respective entities—suchas ACE inhibitors. All the X-ray data are collected at 100° K. using aSynchrotron Radiation Source (ESRF-Grenoble, France). Multi-wavelengthanomalous dispersion (MAD) data are collected with crystals oftACE-lisinopril complex at peak of Zn K-edge (1.2825 Å), inflection(1.28322 Å) and remote (0.95373 Å) wavelengths. An anomalous dataset atlong wavelength (1.7712 Å), the closest possible wavelength to SulphurK-edge is also collected. All other heavy atom data sets are collectedat the SRS-Daresbury (UK) and processed with anomalous signal. Out ofmore than 32 soaks with different heavy atoms, only three are found tobe useful in phasing. These three (Pt, Pd & Os) derivatives are preparedby soaking the tACE-lisinopril complex crystals for ˜10 to 60 minutes inthe presence of 1-5 mM heavy atom solutions. Raw data images are indexedand scaled using the DENZO and SCALEPACK modules of the HKL suite[Otwinowski M and Minor W. (1997) Methods Enzymol 276, 307-326].

Example 2

Expression of Glycosylation Mutants in CHO Cells and the Kinetics ofRelease

The role of N-linked glycosylation in the expression and processing oftACEΔ36 is investigated to establish the minimal glycosylationrequirements for the expression of correctly folded enzymatically-activeprotein. The eight glycosylation mutants constructed are transfectedinto CHO cells and the effect of deglycosylation on the activity,expression and processing of tACEΔ36 is assessed by enzyme assays,immunodetection and cleavage site analysis.

Western blot analysis of cellular and soluble tACEΔ36 glycoforms revealproteins with increased mobility relative to glycosylated wild type tACE(tACE-wt) (FIG. 2) and which is dependent upon on their degree ofglycosylation. Furthermore, differences are detected in the expressionand processing of the various glycoforms. Comparatively low levels oftACEΔ36-g2 protein in cellular extracts (FIG. 2A), and its absence inthe harvest medium (FIG. 2B), may suggest intracellular degradationand/or deficient processing of the protein. Whilst tACEΔ36-g1demonstrates comparable levels of expression to the other proteins (FIG.2A), processing and solubilisation appears to be less efficient thantACEΔ36-g3, -g123, and -g1234 (FIG. 2B). Tunicamycin partially inhibitsthe formation of mature, glycosylated tACE-wt. Western blot analysis ofcellular tACE-wt in the absence of tunicamycin reveals a 105 kDa mature,glycosylated protein (FIG. 3). In the presence of tunicamycin anadditional smaller, deglycosylated 85 kDa protein is detected (FIG. 3).

The K_(m) and k_(cat) values obtained for the hydrolysis of Hip-His-Leuby tACE (Table 3) are in agreement with those previously published forthe C-fragment of the human endothelial isoform (K_(m)=2.0 mM) (10).Differences in the kinetic constants of glycosylated andunder-glycosylated tACEΔ36 mutants are negligible and are not consideredsufficiently different to reflect major alterations in the conformationand activity of the protein. Glycosylation of tACEΔ36 at one(tACEΔ36-g3) or two (tACEΔ36-g13) N-terminal glycosylation sequons issufficient in maintaining the functional integrity of the enzyme.Furthermore, treatment of cells expressing tACEΔ36NJ with theglucosidase I inhibitor NB-DNJ, do not alter the kinetic properties ofthe expressed enzymes.

Example 3

Kinetics of Release and Analysis of Juxtamembrane Cleavage Sites

Independent transfections of CHO cells with tACEΔ36-g1, -g12, -g123 and-g1234 are performed which yield consistent results for each mutant(FIG. 4). All glycosylation mutants show similar levels of phorbol esterstimulation. Thus, N-linked glycosylation does not appear to affectsolubilisation of the membrane-anchored enzyme. Further protein analysisis performed to: 1) identify the C-terminal peptide to determine whethercleavage of tACEΔ36-g1, -g13 and -g1234 occurs at the same residues astACE and 2) to investigate the glycosylation status of the seventhrecognition sequon which lies seven residues proximal to the tACEcleavage site. The mass spectra of endoproteinase Lys-C digestedpeptides of tACEΔ36-g1, -g13 and -g1234 reveal three [M+H]⁺ ions of m/z1698.7, 1690.5 and 1690.9, respectively (Table 2), which are in closeagreement with the theoretical mass of the C-terminal peptide(calculated m/z 1690.8).

Thus, tACEΔ36-g1, -g13 and -g1234 proteolysis occurs between Arg627 andSer628, which is at the same site as tACE-wt. The spectra of the mutanttACEΔ36NJ reveals a [M+H]⁺ ion at m/z 1463.1 which corresponds to thecalculated mass of the peptide Leu614 to Ser625 confirming thattruncation occurs at Ser625 and that there is no further limitedproteolysis of the C-terminus (Table 2).

Example 4

Structure of ACE

The crystal structure of the native ACE enzyme is determined to 2.0 Åresolution. The structure from residues 71-648 adopts an overallellipsoid shape (dimensions ˜72 Å×57 Å×48 Å) with a central groove thatextends for about 30 Å into the molecule and effectively divides theprotein into two “domains” (labelled I and II, FIG. 7 a,b). On top ofthe molecule there is a N-terminal “flap” that allows access to theactive site cleft Like the recently determined zinc-peptidasestructure-neurolysin, ACE is also bristling with helices and iscomprised of twenty α-helices (with almost equal distribution of helicesin both domains) and seven 3₁₀-helices (FIG. 7 c). This makes themolecular architecture very compact and rigid as observed from thethermal parameters (crystallographic B-factors) for the structure. Theonly β-structure which accounts for 4% of all residues occurs as sixrelatively short strands, two of which are located near the active site(FIG. 7 a). The boundaries of the groove are provided by domain II (α13,α14, α15, α17, β4) with part of the domain I forming the flap (α1, α2,α3). In addition the base of the scaffold is formed by helices α6 and α8and helix α15 serves as an anchor.

Eight C-terminal residues are disordered in the crystal structure andmost of this flexible region constitutes the unconstrained juxtamembraneregion distal to the wild-type ACE cleavage site. The α-helix from Ala620 to His 641(α20) defines the C-terminal boundary of the ectodomainand this is in agreement with previous ACE mutagenesis andcleavage-secretion studies (Ehlers et al., 1996; Chubb et al., 2002).Residues Ser 466-Gly 469 are disordered in the structure. Five hundredand four ordered water molecules were identified in the nativestructure. All six glycosylation sites (g1-6, FIG. 7 c) are exposed andg1 site is closest to the N-terminus of the molecule. Sketchy densitywas observed for N-linked carbohydrates in all the glycosylation sites(FIG. 7 c) and modelled as N-acetylglucosamine (NAG) in the nativestructure. The co-ordinates of underglycosylated tACEΔ36NJ ACE are shownin Table A.

Example 5

Zinc Co-ordination

ACE belongs to the gluzincin family of metalloproteases (Hooper, 1994).Zinc is known to be an important catalytic component of ACE. In thestructure, the active site helices α13 and α14 define the substratebinding cleft of this peptidase. One highly ordered zinc ion(B-factor-16.34 Å²) is bound at the active site. The helix α13 containsthe HEXXH zinc binding motif (known to be important for the catalyticactivity of ACE, Wei et al., 1991), with its two zinc coordinatinghistidines (His 414 and His 418) and Glu 442 (from α14 helix) acts asthe third ligand (FIG. 7 c). Additional coordination is provided by anacetate ion (from the crystallization medium) bound at the active siteof the native enzyme (FIG. 8 a). It has been reported previously thatthe recruitment of zinc ion in ACE catalysis is analogous to that inthermolysin (Williams et al., 1994; Corvol et al., 1995) and ourstructural data shows that the zinc binding sites in both proteins areindeed very similar (r.m.s. deviation 1.52 Å) except the acetate ionwhich is replaced by a water molecule in the coordination sphere inthermolysin. The active site pocket in ACE is occupied by 3 orderedwater molecules. In addition, a stretch of clear electron density (at 3σlevel) was observed (˜5 Å away from the zinc ion) at the active sitewhich is interpreted as part of butyl succinate (FIG. 8 a).

Example 6

Activation of ACE by Chloride Ions

Substrate hydrolysis by ACE is activated by chloride anions and, whereassome substrates can be cleaved in the absence of chloride, it is anabsolute requirement for angiotensin I (Bunning and Riordan, 1983;Shapiro et al., 1983). Our structure revealed the location of twochloride ions (FIG. 7a, c). The first chloride ion (Cl1, 20.7 Å awayfrom the zinc ion) is bound to three ligands, Arg 520 (NH1), Arg 217(NE), Trp 516 (NE1) and water and is surrounded by a hydrophobic shellof four tryptophans. The second anion (C12, 10.4 Å away from the zincion) is bound to Arg 553 (NE) in agreement with previous report showingArg 1098 (the analogous Arg residue in the C-domain of somatic ACE) iscritical for chloride dependence of ACE activity (Liu et al., 2001). Tyr255 and a water molecule are the other two C12 ligands. The two chlorideions (separated by 20.3 Å) in ACE are bound almost in a triangularconformation—in accordance with the near equatorial coordination andaccommodation of planar trigonal anions in α-amylase where the chlorideions are involved in the allosteric activation (Aghajari et al., 2002).In addition, the anchoring of Domain II on Domain I scaffold appears tobe mediated by the chloride ions.

Mutating Arg 1098 to a lysine resulted in a 100-fold reduction inchloride binding affinity as well as a decrease in substrate affinity(Liu et al., 2001). This might be due to the contact with the NE atom ofarginine as opposed to an NH1 or NH2 atom with lysine which would permitfree rotation of the basic terminal nitrogens. Recent studies suggestthat the affinity of chloride binding to ACE is directly related to theinteractions between the chloride and enzyme as well as the substrate(Liu et al., 2001). However, based on the location of both chloride ionsin the 3D structure make the latter interaction unlikely. Nevertheless,there is a van der Waals contact between C12 and Pro 438 (α14) thatcould be responsible for maintaining the active site cleft in aconformation which favours substrate accessibility and binding. Indeedα14 contain the third zinc co-ordinating ligand Glu 442. Thus, thechloride interactions likely cause the enzyme to adopt conformationsthat permit higher affinity substrate binding and that it is notimportant in substrate binding per se.

Example 7

Structure Determination and Refinement of an ACE-lisinopril Complex

The crystal structure of tACE bound to the potent lisinopril inhibitor(K_(i)=27×10¹⁰M, Wei et al., 1991) complex is determined by acombination of MAD and MIRAS (Multiple Isomorphous Replacement withAnomalous Scattering) procedures. The position of zinc atom isunambiguously identified using the anomalous difference Patterson mapscalculated using diffractions data at peak wavelength. The MAD phasesthus obtained are not very strong and thus additional phase informationis obtained using MIRAS procedures with three—Platinum (K₂PtCl₄),Palladium (K₂PdCl₄) and Osmium (OsCl₃) heavy atom derivatives. Theidentified Zn site is used to obtain the starting phases in eachderivative. Double difference Fourier maps calculated using FFT routinein CCP4 program [Collaborative computational project Number 4. The CCP4Suite: Programs for Protein Crystallography (1994) Acta Crystallogr. D50, 760-763] gave the first major binding site and the phases from thecombined Zn and first major site are used to get additional major/minorsites for each derivative. All heavy atom binding sites and the Zn siteare refined to 2.8 Å resolution using the program MLPHARE [Collaborativecomputational project Number 4. The CCP4 Suite: Programs for ProteinCrystallography (1994) Acta Crystallogr. D 50, 760-763] and SHARP [De LaFortelle, E. & Bricogne, G. Maximum-likelihood heavy-atom parametersrefinement in the MIR and MAD methods (1997) Methods Enzymol. 276,472-494]. The overall figure of merit from SHARP is 0.38 (at 2.8 Åresolution) and is improved to 0.89 (at 2.0 Å) by iterative solventflattening, phase combination and phase extension with the programSOLOMON [Abrahams, J. P. & Leslie, A. G. W. Methods used in structuredetermination of bovine mitochondrial F1 ATPase. (1996) ActaCrystallogr. D 52, 110-119]. Model building is carried out manuallyusing the program O [Jones, T. A., Zou, J. Y., Cowan, S. W. &Kjeldgaard, M. Improved methods for building protein models in electrondensity maps and the location of errors in these models (1991) ActaCrystallogr. A 47, 110-119]. Refinement of the model is carried outusing the program CNS [Brünger, A. T. et al. Crystallography & NMRSystem: A new software suite for macromolecular structure determination.(1998) Acta Crystallogr. D 54, 905-921]. During the final stages ofrefinement water molecules, zinc ion and the inhibitor molecule areinserted in the respective structure. Both the native and inhibitorcomplex structures are refined at 2.0 Å resolution with ˜94% residues inthe maximum allowed region and no residue in the disallowed region ofthe Ramachandran map. The final structure of the tACE and ACE-lisinoprilcomplex has an R_(free) [Brünger, A. T. Free R value: a novelstatistical quantity for assessing the accuracy of crystal structure.(1992) Nature 355, 472-475] of 22.08 and 21.88%, and a final R_(cryst)of 18.29 and 18.14% respectively.

Highly ordered binding of the inhibitor (overall B-factor 15.26 Å²) inan extended conformation with the aromatic phenyl group stretchingtowards the flap (FIG. 7 a) and its lysine side chain parallel to theHEXXH motif (Table 1). Upon complex formation no significantrearrangement of active site residues was observed. The P₁ carboxylateof lisinopril which is substituted for the normal substrate scissileamide carbonyl is well positioned to bind to the active site zinc(located between subsites S₁ and S₁′). Thus lisinopril provides acoordinating atom (provided by an acetate ion in the native structure,FIG. 8 a), while the other three (two histidines and a glutamic acid)being the same as in the native structure (FIG. 8 b). The phenyl ethylgroup binds to the S₁ subsite and the lysyl amine to Glu 193 via van derWaals interactions at the S₁′ subsite of ACE. Surprisingly, theC-terminal carboxylate which is thought to interact with a positivelycharged arginine residue instead binds to a lysine (Lys 542) as well asTyr 551. The high affinity is attributable to the presence of theS-configuration aromatic, aralkyl or aliphatic groups able to bind tothe S₁ site (Brenner et al., 1990). The contact residues for thelisinopril complex are shown in Table 1. The co-ordinates of theunderglycosylated tACEΔ36NJ ACE-lisinopril complex are shown in Table B.

Example 8

The Homology of ACE with Other Metallopeptidases

ACE belongs to the M2 family of zinc binding metallopeptidases whichfalls under the umbrella of the MA clan. Outside the HEXXH metalcoordinating signature sequence of this family there is little sequencesimilarity between ACE and other members of the family. Surprisingly,peptidases such as thermolysin (MA clan, M4 family) and carboxypeptidaseA (MC clan, M14 family) which have been used in comparative molecularfield analysis and 3D quantitative structure-activity relationshipstudies (Waller & Marshall, 1993) showed no structural homology withACE.

Surprisingly, structural comparison of ACE with other protein structuresusing the DALI server (Holm and Sander, 1999) showed significantstructural homology with that of neurolysin (Brown et al., 2001), aprotein involved in neurotensin metabolism (FIG. 3 a, b). Neurolysin isa member of the M3 family of thimet oligopeptidases and like ACE,belongs to the family of metallopeptidases bearing the HEXXH active sitemotif (Rawlings and Barrett, 1995; Brown et al., 2001). It alsocomprises of an abundance of α-helices with the β-structure accountingfor only 6% of all residues. The two proteins do not exhibit any aminoacid sequence similarity (close to random score), yet when the twostructures are optimally superimposed (using DALI server), there isnoticeable match with an r.m.s. deviation of 4.0 Å for 143 C_(α) atoms.It appears that the core structure for the two proteins are highlysimilar with significant differences in loops on the outer surface inthe case of neurolysin (FIG. 3 a,b). The striking similarity alsoextends to the active site region in neurolysin consisting of a deepnarrow channel that divides the molecule into two halves. It has beenspeculated that using the flexible secondary structure elements in theactive site cavity, the neuropeptidase can effectively cleave a varietyof small peptides. Likewise in ACE, the geometry of the active sitegroove clearly accounts for ACE's inability to hydrolyse large, foldedsubstrates. Furthermore, the enzyme's preference for oligopeptidesubstrates of about thirteen residues or less suggests that thesubstrate does not have the same freedom to extend outside of thechannel during catalysis.

Example 9

Substrate Specificity

The geometry of the active site channel clearly accounts for ACE'sinability to hydrolyse large, folded substrates. Furthermore, theenzyme's preference for oligopeptide substrates of about thirteenresidues or less suggests that the substrate does not have the samefreedom to extend outside of the channel during catalysis.

Example 10

Crystallization of ACE Mutants

tACEΔ36-g1234 and tACEΔ36-g1,3 mutants are successfully crystallisedunder similar conditions as tACEΔ36NJ protein (FIG. 5). Preliminarydiffraction experiments show that tACEΔ36-g1234 crystals diffract to atleast 2.8 Å and tACEΔ36-g1,3 crystals diffract to 3.0 Å respectively andthese crystals are isomorphous with tACEΔ36 crystals.

CONCLUSIONS

The minimal glycosylation requirements for the expression and processingof enzymatically-active human tACE are determined by progressivedeglycosylation. To investigate which sugars are vital for tACEexpression, a series of mutants are constructed that contain a limitednumber of sites for N-linked glycosylation. N-glycan recognition sequonswithin the protein sequence are disrupted by mutagenesis of the Asn to aGln within the recognition sequon.

The removal of a large percentage of glycans does not hamper theexpression of enzymatically-active tACEΔ36 and the presence of glycansat two of the three N-terminal sites is sufficient to produce proteinthat retain the kinetic properties of the native enzyme. Furthermore,the minimum N-linked glycosylation that allowed for enzymatically-activetACE to be expressed is the presence of glycans at the first or thirdsite. Glycosylation at either of these sites appears to be sufficientfor protein folding, whereas glycosylation of the second site only,results in rapid intracellular degradation. This is in agreement withthe glycosylation requirements of active rabbit ACE expressed inmammalian cells and yeast which also has a minimal requirement of atleast one of the three N-terminal sites (3a).

In the construction of the tACEΔ36 glycosylation mutants, the seventhsite which is not present in rabbit tACE is not targeted as it has beenshown to be unglycosylated (7a). With the removal of the glycosylatedsequons, it is possible that this site may be glycosylated in order tocompensate for the loss of oligosaccharide chains. However, this is notthe case and that even when there is only one N-linked oligosccharide,this does not occur.

There is a preference for oligosaccharides to be attached to sequonscontaining threonine residues rather than serine residues. This isobserved in human tACE, where all sequons with a serine in the thirdposition are partially glycosylated and those with threonine are fullyglycosylated, except for the seventh site, which has a threonine in thethird position (7a).

The fact that glycosylation at the seventh site appears to be occludedby the presence of the tryptophan, rather than the structure of thejuxtamembrane region, is supported by the findings that a tACE deletionmutant, tACEΔ6, which generates a novel Asn-Arg-Ser sequon adjacent tothe wild-type cleavage site, is glycosylated (14a). The extendedconformation of oligosaccharides may prevent access of the secretase atthis point resulting in displacement of the wild-type cleavage site 13residues towards the C-terminus (14a).

CHO cells expressing wild-type tACE (tACE-wt) are exposed totunicamycin, which inhibits N-linked glycosylation, to determine theeffect of complete deglycosylation on the expression and activity oftACE over time. Cellular tACE-wt activity in cells treated withtunicamycin is approximately three-fold lower than that of untreatedcells (data not shown) and a smaller immature form of the protein isobserved by Western blot analysis. These results are consistent with theinterpretation that the smaller 85 kDa-protein is the deglycosylatedform and the 105 kDa-protein, the mature glycosylated form (7a), (9a),(14a). Thus, tunicamycin inhibits the formation of mature glycosylatedtACE-wt, to a certain degree, resulting in the accumulation ofunglycosylated tACE-wt in the cell, without a significant decrease inthe total amount of protein compared to untreated cells. Our datasuggest that unglycosylated tACE-wt is not solubilised and that itrequires the presence of N-glycans for proper expression, maturation andprocessing.

The enzymatically-active tACE-wt present in cells treated withtunicamycin is most likely the product of a pool of glycosylatedtACE-wt, which is either produced prior to tunicamycin treatment or isresistant to tunicamycin. Tunicamycin may therefore not be completelyeffective in CHO cells, whereas in HeLa cells, Kasturi et al. found thattunicamycin-treatment resulted in the generation of deglycosylatedprotein that is degraded intracellularly within three-hours, with nosoluble tACE being detected (5a). Thus, it appears that the effect oftunicamycin on tACE glycosylation appears to be cell-specific.

Enzymatic removal of N-linked glycans is used to produce crystals of CD2glycoprotein that diffracted to 2.5 Å (15a). However, crystallisationtrials with deglycosylated tACEΔ36NJ that has a single GlcNAc residueattached to the asparagine residue of the N-linked site only producedneedle-like crystals that are not suitable for further diffractionstudies. Surprisingly, tACEΔ36NJ expressed in the presence of NB-DNJ,but retaining the simple high mannose oligosaccharides (Glc₃Man₇GlcNAc₂)yielded the best crystals for X-ray diffraction studies and subsequentsuccessful 3D structure determination at 2.0 Å resolution

Interestingly, the presence of the membrane anchor increased the extentof human CD59 glycan processing (16a). Possible reasons for thisdifference are, that the ectodomain is held closer to theglycan-processing enzymes and/or the longer exposure to theglycosyltransferases. The oligosaccharide processing of solubletACEΔ36NJ protein may also differ from the membrane-bound form however,expressing the protein in the presence of a glucosidase inhibitor wouldprevent the production of complex oligosaccharides.

Furthermore, the kinetic properties of this mutant are not influenced byNB-DNJ treatment. Similarly, Yu et al. reported identical K_(m) valuesfor glycosylated and deglycosylated forms of tACEΔ36NJ, in agreementwith that of tACE-wt, using furanacryloyl-Phe-Gly-Gly as a substrate(7a). Glucosidase inhibitors, at concentrations required to blocktrimming of the terminal glucose residues and subsequent complexoligosaccharide formation, can affect cell maturation and apoptosis(Misago M, Tsukada J, Fukuda M N, Eto S (2000) Biochem Biophys ResCommun. 269, 219-225). This treatment also results in a decrease inprotein expression (unpublished data). Thus, mutants lacking some of theC-terminal N-linked glycans are used with the objective of producingprotein with a minimal number of oligosaccharides that would crystallisein a reproducible fashion.

Crystals of glycosylation mutants g13 and g1234 have been grown undersimilar condition as in the case of tACEΔ36NJ. The glycosylation mutantcrystals seem to grow faster than tACEΔ36NJ crystals. However, they aresmaller in size in the first instance, but have been proven to besuitable for diffraction work.

The determination of the 3D structure of ACE and ACE-lisinopril complexmay be effectively used for the development of novel, highly selectiveACE modulators targeted, for example, to either the N or the C domain,by structure-based rational drug design. This may produce a newgeneration of ACE inhibitors with the potential for greater efficacy,fewer side effects and treatment of new indications (e.g. polycythemia).In addition, the unanticipated similarity with neurolysin has shown thestructural conservation amongst an emerging family of peptidases with acommon evolutionary origin.

In a further aspect, the present invention relates to a compositioncomprising ACE in a crystalline form.

In a further aspect, the present invention relates to a scalable 3Dmodel of ACE having at least a portion of the structure co-ordinatesshown in Table A or Table B.

All publications mentioned in the above specification are hereinincorporated by reference. Various modifications and variations of thedescribed methods and system of the invention will be apparent to thoseskilled in the art without departing from the scope and spirit of theinvention. Although the invention has been described in connection withspecific preferred embodiments, it should be understood that theinvention as claimed should not be unduly limited to such specificembodiments. Indeed, various modifications of the described modes forcarrying out the invention which are obvious to those skilled inmolecular biology or related fields are intended to be within the scopeof the following claims.

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TABLE 1 ACE-Lisinopril Contact Residues (hydrogen bonds at the activesite) Ligand atoms Lisinopril atom Interacting atoms Distance (Å) O1 His384 NE2 2.76 N1 His 384 NE2 3.24 N1 Ala 385 O 2.92 O4 Lys 542 NZ 2.93 O4Tyr 551 OH 2.56 O3 Tyr 554 OH 2.77 O2 Wat 2.82 O5 Wat 2.68 N3 Wat 3.01N3 Wat 3.26 O5 Wat 2.77 N3 Wat 3.11 O2 Glu 415 OE2 2.70 O1 His 544 NE23.11 Zinc Coordination-ACE-Lisinopril Complex Coordination Distance (Å)Zn His 414 NE2 2.04 Zn His 418 NE2 2.07 Zn Glu 442 OE1 2.00 Zn Lis O32.14 Lis = Lisinopril

TABLE 2 Data Collection Resolution range^(a) % R_(merge) ^(ab) CrystalWavelength(Å) (Å) completeness^(a) <I>/<σ>^(a) (%) MAD Phasing Zn Peak1.2825 50-2.00(2.07-2.00) 94.7(63.2) 11.54(1.93) 5.4(22.3) data. Zninfl. 1.2832 50-2.01(2.08-2.01) 95.9(72.1) 11.55(1.98) 5.8(23.8) Zn rem.0.9537 50-1.98(2.05-1.98) 94.1(65.8) 15.48(2.63) 4.8(14.9) LongWavelength 50-2.66(2.76-2.66) 99.6(97.0) 22.92(4.94) 8.3(21.8) 1.7712MIRAS Phasing data Pt 0.87 20-2.80(2.9-2.8) 90.2(83.6)  9.94(4.52)11.2(27.1)  Pt25 0.87 20-2.60(2.69-2.6) 89.9(75.9)  13.6(4.17) 8.8(27.8)Pd 0.978 50-2.18(2.26-2.18) 89.4(81.2) 26.14(6.73) 5.8(25.8) Pd2 0.97830-2.60(2.69-2.6) 95.2(86.7) 16.95(5.46) 9.5(35.7) Oscl 1.48850-2.80(2.9-2.8) 96.6(91.4) 18.51(6.16) 13.1(40.4)  Native Data 1.48850-2.00(2.07-2.0) 98.8(95.7) 22.46(4.44) 8.1(43.2) Refinement B factorRmsd (Å²) Rms deviations Bonded Bond Bond Bonded Side ResolutionReflections R_(cryst) ^(c) R_(free) ^(d) length angle Main Chain ChainModel (Å) working/test (%) (%) (Å) (°) Atoms Atoms Native 47.14-2.039727/1675 18.29 22.08 0.005  1.22 1.281 2.126 (ACE) Lisinopril47.14-2.0 76164/3094 18.14 21.88 0.0055 1.24 1.174 2.048 complex(ACE-LIS) ^(a)Values in parentheses are for the outer resolution shell.^(b)R_(merge) = Σ|I − <I>|/Σ I, where I is the observed intensity and<I> is the average intensity obtained from multiple observations ofsymmetry related reflections. ^(c)R_(cryst) = Σ|Fo| − |Fc|/Σ|Fo| whereFo and Fc are observed and calculated structure factors respectively.^(d)R_(free) is obtained for a test set of reflections, consisting of arandomly selected ~4% of reflections.

TABLE 3 Kinetic parameters for the hydrolysis of Hip-His-Leu by varioustACE glycoforms K_(m) (mM) k_(cat) (sec⁻¹) k_(cat)/K_(m) (sec⁻¹mM⁻¹)tACE-wt 2.7 193 72 tACEΔ36-g1 1.6 128 79 tACEΔ36-g3 2.5 111 44tACEΔ36-g13 2.7 170 63 tACEΔ36-g2 inactive inactive inactive tACEΔ36-g122.1 195 94 tACEΔ36-g123 2.7 189 71 tACEΔ36-g1234 1.5  85 56 tACEΔ36-NJ¹2.6 253 99 tACEΔ36-NJ² 4.1 289 70 ¹Expressed in CHO cells treated withNB-DNJ. ²Expressed in NB-DNJ-untreated CHO cells.

TABLE 4 Mass Spectral Analysis of C-Terminal Endoproteinase Lys-CPeptides^(a) Peptide (residue no.^(b)) tACEΔ36-g1 tACEΔ36g-1tACEΔ36-g1234 tACEΔ36NJ 598-613^(c) 1951.6 (1951.2) 1950.6 (1951.2)1950.2 (1951.2) 1951.5 (1951.2) 614-627^(d) 1689.7 (1690.8) 1690.5(1690.8) 1690.9 (1690.5) 614-625^(d) 1463.1 (1463.5) ^(a)Soluble (shed)ACE proteins were purified from conditioned medium of transfected cells,digested with endoproteinase Lys-C and analyzed by MALDI-TOF massspectrometry. ^(b)Amino acid residue numbering refers to wild type tACE(Ehlers et al 1989). Shown are the masses of the penultimate ^(c) andultimate ^(d) C-terminal peptides. All values are calculated forprotonated isotopically averaged molecular masses m/z. In parenthesesare expected masses.

TABLE A Co-ordinates of underglycosylated tACEΔ36NJ ACE REMARKcoordinates from minimization refinement REMARK refinement resolution:47.14-2.0 A REMARK starting r= 0.1829 free_r= 0.2206 REMARK final  r=0.1829 free_r= 0.2208 REMARK rmsd bonds= 0.005706 rmsd angles= 1.22440REMARK wa= 0.837519 REMARK target= mlf cycles= 1 steps= 20 REMARK sg=P2(1)2(1)2(1) a= 56.621 b= 85.062 c= 133.791 alpha= 90 beta= 90 gamma=90 REMARK ncs= none REMARK B-correction resolution: 6.0-2.0 REMARKinitial B-factor correction applied to fobs: REMARK  B11=  2.826 B22=−1.896 B33= −0.930 REMARK  B12=  0.000 B13=  0.000 B23=  0.000 REMARKB-factor correction applied to coordinate array B:  0.207 REMARK bulksolvent: density level= 0.355826 e/A{circumflex over ( )}3, B-factor=50.0907 A{circumflex over ( )}2 REMARK reflections with |Fobs|/sigma_F <0.0 rejected REMARK reflections with |Fobs| > 10000 * rms(Fobs) rejectedREMARK theoretical total number of refl. in resol. range: 44472 (100.0%)REMARK number of unobserved reflections (no entry or |F|=0): 3070 (6.9%)REMARK number of reflections rejected:   0 (  0.0% ) REMARK total numberof reflections used: 41402 ( 93.1% ) REMARK number of reflections inworking set: 39727 ( 89.3% ) REMARK number of reflections in test set: 1675 (  3.8% ) CRYST1  56.621  85.062 133.791 90.00 90.00 90.00 P 21 2121 REMARK VERSION: 1.1 ATOM 1 CB ALA 71 34.205 71.662 65.620 1.00 47.11ATOM 2 C ALA 71 36.244 70.263 65.985 1.00 47.34 ATOM 3 O ALA 71 36.11769.044 65.862 1.00 47.51 ATOM 4 N ALA 71 35.784 72.211 67.437 1.00 47.96ATOM 5 CA ALA 71 35.164 71.098 66.663 1.00 47.50 ATOM 6 N GLU 72 37.30770.929 65.547 1.00 46.68 ATOM 7 CA GLU 72 38.419 70.260 64.882 1.0046.09 ATOM 8 CB GLU 72 39.315 71.298 64.200 1.00 46.87 ATOM 9 CG GLU 7240.370 70.727 63.262 1.00 47.65 ATOM 10 CD GLU 72 39.776 70.111 62.0051.00 48.95 ATOM 11 OE1 GLU 72 38.997 70.801 61.309 1.00 48.20 ATOM 12OE2 GLU 72 40.096 68.939 61.708 1.00 49.03 ATOM 13 C GLU 72 39.22369.474 65.916 1.00 45.81 ATOM 14 O GLU 72 39.862 68.466 65.594 1.0045.67 ATOM 15 N ALA 73 39.184 69.941 67.161 1.00 43.82 ATOM 16 CA ALA 7339.905 69.292 68.249 1.00 42.35 ATOM 17 CB ALA 73 39.995 70.229 69.4461.00 42.98 ATOM 18 C ALA 73 39.210 67.996 68.646 1.00 40.96 ATOM 19 OALA 73 39.863 66.990 68.926 1.00 39.62 ATOM 20 N GLU 74 37.881 68.02868.680 1.00 40.60 ATOM 21 CA GLU 74 37.104 66.844 69.025 1.00 40.79 ATOM22 CB GLU 74 35.620 67.190 69.157 1.00 42.97 ATOM 23 CG GLU 74 35.13867.389 70.581 1.00 48.05 ATOM 24 CD GLU 74 33.642 67.644 70.649 1.0051.91 ATOM 25 OE1 GLU 74 32.869 66.798 70.142 1.00 53.53 ATOM 26 OE2 GLU74 33.239 68.687 71.210 1.00 53.71 ATOM 27 C GLU 74 37.272 65.799 67.9311.00 38.90 ATOM 28 O GLU 74 37.217 64.597 68.192 1.00 38.20 ATOM 29 NALA 75 37.482 66.273 66.706 1.00 37.33 ATOM 30 CA ALA 75 37.643 65.39565.552 1.00 35.44 ATOM 31 CB ALA 75 37.619 66.217 64.268 1.00 34.80 ATOM32 C ALA 75 38.917 64.558 65.613 1.00 33.72 ATOM 33 O ALA 75 38.87163.343 65.434 1.00 34.25 ATOM 34 N SER 76 40.053 65.204 65.856 1.0032.28 ATOM 35 CA SER 76 41.319 64.486 65.932 1.00 32.11 ATOM 36 CB SER76 42.486 65.468 66.012 1.00 33.65 ATOM 37 OG SER 76 42.391 66.26667.175 1.00 40.00 ATOM 38 C SER 76 41.326 63.562 67.148 1.00 30.77 ATOM39 O SER 76 41.948 62.501 67.126 1.00 30.49 ATOM 40 N LYS 77 40.63163.974 68.204 1.00 29.20 ATOM 41 CA LYS 77 40.534 63.179 69.424 1.0029.11 ATOM 42 CB LYS 77 39.924 64.021 70.547 1.00 32.76 ATOM 43 CG LYS77 39.438 63.219 71.745 1.00 35.84 ATOM 44 CD LYS 77 38.889 64.13572.830 1.00 42.05 ATOM 45 CE LYS 77 38.072 63.355 73.847 1.00 44.16 ATOM46 NZ LYS 77 36.868 62.741 73.208 1.00 47.21 ATOM 47 C LYS 77 39.66261.952 69.160 1.00 28.16 ATOM 48 O LYS 77 39.966 60.844 69.613 1.0025.92 ATOM 49 N PHE 78 38.573 62.163 68.427 1.00 26.59 ATOM 50 CA PHE 7837.661 61.079 68.083 1.00 26.14 ATOM 51 CB PHE 78 36.495 61.610 67.2501.00 26.37 ATOM 52 CG PHE 78 35.634 60.527 66.657 1.00 28.09 ATOM 53 CD1PHE 78 34.772 59.788 67.459 1.00 27.07 ATOM 54 CD2 PHE 78 35.700 60.23865.297 1.00 27.78 ATOM 55 CE1 PHE 78 33.983 58.776 66.916 1.00 28.93ATOM 56 CE2 PHE 78 34.914 59.224 64.745 1.00 29.96 ATOM 57 CZ PHE 7834.055 58.493 65.558 1.00 27.46 ATOM 58 C PHE 78 38.407 60.018 67.2811.00 24.51 ATOM 59 O PHE 78 38.293 58.825 67.555 1.00 25.03 ATOM 60 NVAL 79 39.174 60.460 66.290 1.00 24.17 ATOM 61 CA VAL 79 39.928 59.53965.448 1.00 25.75 ATOM 62 CB VAL 79 40.647 60.296 64.315 1.00 27.26 ATOM63 CG1 VAL 79 41.588 59.362 63.574 1.00 29.96 ATOM 64 CG2 VAL 79 39.61860.868 63.352 1.00 26.11 ATOM 65 C VAL 79 40.944 58.732 66.255 1.0026.10 ATOM 66 O VAL 79 41.109 57.527 66.030 1.00 26.21 ATOM 67 N GLU 8041.624 59.390 67.191 1.00 25.41 ATOM 68 CA GLU 80 42.605 58.707 68.0311.00 26.15 ATOM 69 CB GLU 80 43.302 59.699 68.974 1.00 30.36 ATOM 70 CGGLU 80 44.036 60.832 68.267 1.00 34.75 ATOM 71 CD GLU 80 44.759 61.76069.233 1.00 39.99 ATOM 72 OE1 GLU 80 44.149 62.161 70.251 1.00 41.71ATOM 73 OE2 GLU 80 45.934 62.096 68.971 1.00 40.92 ATOM 74 C GLU 8041.910 57.627 68.858 1.00 23.94 ATOM 75 O GLU 80 42.408 56.504 68.9791.00 22.22 ATOM 76 N GLU 81 40.759 57.969 69.431 1.00 22.01 ATOM 77 CAGLU 81 40.011 57.013 70.237 1.00 22.46 ATOM 78 CB GLU 81 38.831 57.70670.927 1.00 25.23 ATOM 79 CG GLU 81 39.227 58.391 72.231 1.00 29.28 ATOM80 CD GLU 81 38.161 59.326 72.773 1.00 32.89 ATOM 81 OE1 GLU 81 36.96058.986 72.693 1.00 34.63 ATOM 82 OE2 GLU 81 38.531 60.399 73.298 1.0035.89 ATOM 83 C GLU 81 39.524 55.860 69.369 1.00 21.38 ATOM 84 O GLU 8139.678 54.686 69.725 1.00 19.63 ATOM 85 N TYR 82 38.948 56.197 68.2201.00 19.43 ATOM 86 CA TYR 82 38.461 55.179 67.303 1.00 19.72 ATOM 87 CBTYR 82 37.927 55.832 66.024 1.00 19.77 ATOM 88 CG TYR 82 37.545 54.83764.951 1.00 20.35 ATOM 89 CD1 TYR 82 36.376 54.078 65.054 1.00 19.98ATOM 90 CE1 TYR 82 36.033 53.145 64.074 1.00 20.16 ATOM 91 CD2 TYR 8238.363 54.638 63.842 1.00 20.13 ATOM 92 CE2 TYR 82 38.033 53.708 62.8581.00 21.53 ATOM 93 CZ TYR 82 36.866 52.967 62.980 1.00 20.57 ATOM 94 OHTYR 82 36.538 52.053 62.011 1.00 19.33 ATOM 95 C TYR 82 39.581 54.20166.940 1.00 18.48 ATOM 96 O TYR 82 39.382 52.987 66.944 1.00 19.79 ATOM97 N ASP 83 40.760 54.734 66.637 1.00 20.94 ATOM 98 CA ASP 83 41.88953.897 66.236 1.00 23.21 ATOM 99 CB ASP 83 43.052 54.766 65.748 1.0025.46 ATOM 100 CG ASP 83 44.149 53.945 65.092 1.00 31.10 ATOM 101 OD1ASP 83 43.862 53.293 64.065 1.00 33.90 ATOM 102 OD2 ASP 83 45.293 53.94165.597 1.00 31.88 ATOM 103 C ASP 83 42.398 52.937 67.307 1.00 23.85 ATOM104 O ASP 83 42.600 51.751 67.037 1.00 23.74 ATOM 105 N ARG 84 42.61753.431 68.521 1.00 23.48 ATOM 106 CA ARG 84 43.117 52.548 69.565 1.0024.21 ATOM 107 CB ARG 84 43.576 53.351 70.792 1.00 25.95 ATOM 108 CG ARG84 42.574 54.331 71.350 1.00 28.39 ATOM 109 CD ARG 84 43.155 55.06072.557 1.00 29.91 ATOM 110 NE ARG 84 44.269 55.945 72.220 1.00 28.71ATOM 111 CZ ARG 84 44.211 57.273 72.280 1.00 29.24 ATOM 112 NH1 ARG 8443.093 57.877 72.660 1.00 28.18 ATOM 113 NH2 ARG 84 45.278 58.001 71.9821.00 30.94 ATOM 114 C ARG 84 42.107 51.474 69.959 1.00 22.21 ATOM 115 OARG 84 42.489 50.332 70.192 1.00 20.72 ATOM 116 N THR 85 40.824 51.82370.010 1.00 20.97 ATOM 117 CA THR 85 39.796 50.845 70.365 1.00 21.86ATOM 118 CB THR 85 38.457 51.528 70.752 1.00 22.90 ATOM 119 OG1 THR 8537.996 52.349 69.673 1.00 24.14 ATOM 120 CG2 THR 85 38.637 52.389 72.0061.00 22.66 ATOM 121 C THR 85 39.531 49.853 69.227 1.00 22.63 ATOM 122 OTHR 85 39.271 48.671 69.468 1.00 23.06 ATOM 123 N SER 86 39.597 50.33167.988 1.00 22.84 ATOM 124 CA SER 86 39.364 49.467 66.833 1.00 23.43ATOM 125 CB SER 86 39.358 50.290 65.542 1.00 20.63 ATOM 126 OG SER 8638.201 51.101 65.469 1.00 22.91 ATOM 127 C SER 86 40.420 48.375 66.7371.00 23.93 ATOM 128 O SER 86 40.107 47.224 66.431 1.00 26.22 ATOM 129 NGLN 87 41.671 48.739 66.996 1.00 25.11 ATOM 130 CA GLN 87 42.764 47.77766.934 1.00 27.65 ATOM 131 CB GLN 87 44.076 48.441 67.349 1.00 29.31ATOM 132 CG GLN 87 44.611 49.434 66.340 1.00 34.89 ATOM 133 CD GLN 8745.901 50.079 66.797 1.00 38.51 ATOM 134 OE1 GLN 87 46.854 49.392 67.1701.00 39.63 ATOM 135 NE2 GLN 87 45.942 51.407 66.766 1.00 40.39 ATOM 136C GLN 87 42.494 46.575 67.832 1.00 27.47 ATOM 137 O GLN 87 42.700 45.43067.430 1.00 27.09 ATOM 138 N VAL 88 42.027 46.843 69.049 1.00 27.70 ATOM139 CA VAL 88 41.732 45.784 70.009 1.00 27.09 ATOM 140 CB VAL 88 41.45746.363 71.418 1.00 28.38 ATOM 141 CG1 VAL 88 41.137 45.231 72.392 1.0028.68 ATOM 142 CG2 VAL 88 42.666 47.156 71.902 1.00 28.04 ATOM 143 C VAL88 40.531 44.933 69.597 1.00 26.88 ATOM 144 O VAL 88 40.628 43.71169.537 1.00 26.76 ATOM 145 N VAL 89 39.403 45.577 69.318 1.00 25.88 ATOM146 CA VAL 89 38.199 44.852 68.928 1.00 26.99 ATOM 147 CB VAL 89 36.98545.813 68.803 1.00 27.18 ATOM 148 CG1 VAL 89 37.315 46.950 67.862 1.0032.87 ATOM 149 CG2 VAL 89 35.765 45.060 68.306 1.00 31.36 ATOM 150 C VAL89 38.375 44.071 67.616 1.00 27.29 ATOM 151 O VAL 89 37.906 42.93767.497 1.00 25.50 ATOM 152 N TRP 90 39.048 44.674 66.637 1.00 26.45 ATOM153 CA TRP 90 39.273 44.010 65.354 1.00 27.47 ATOM 154 CB TRP 90 39.81745.003 64.325 1.00 29.71 ATOM 155 CG TRP 90 38.809 46.020 63.873 1.0033.63 ATOM 156 CD2 TRP 90 38.891 46.847 62.707 1.00 35.80 ATOM 157 CE2TRP 90 37.752 47.684 62.707 1.00 37.41 ATOM 158 CE3 TRP 90 39.817 46.96561.663 1.00 37.42 ATOM 159 CD1 TRP 90 37.656 46.375 64.513 1.00 34.94ATOM 160 NE1 TRP 90 37.015 47.373 63.819 1.00 36.40 ATOM 161 CZ2 TRP 9037.514 48.629 61.700 1.00 38.33 ATOM 162 CZ3 TRP 90 39.582 47.906 60.6611.00 39.67 ATOM 163 CH2 TRP 90 38.437 48.726 60.690 1.00 40.02 ATOM 164C TRP 90 40.243 42.846 65.510 1.00 27.07 ATOM 165 O TRP 90 40.121 41.83164.824 1.00 27.40 ATOM 166 N ASN 91 41.210 42.991 66.409 1.00 25.74 ATOM167 CA ASN 91 42.167 41.920 66.634 1.00 26.47 ATOM 168 CB ASN 91 43.27142.364 67.597 1.00 26.15 ATOM 169 CG ASN 91 44.156 41.212 68.033 1.0029.44 ATOM 170 OD1 ASN 91 43.840 40.502 68.987 1.00 30.76 ATOM 171 ND2ASN 91 45.261 41.005 67.319 1.00 28.75 ATOM 172 C ASN 91 41.442 40.70567.196 1.00 27.08 ATOM 173 O ASN 91 41.697 39.574 66.780 1.00 26.40 ATOM174 N GLU 92 40.533 40.942 68.138 1.00 26.14 ATOM 175 CA GLU 92 39.76839.858 68.734 1.00 27.35 ATOM 176 CB GLU 92 38.906 40.378 69.888 1.0030.98 ATOM 177 CG GLU 92 39.643 40.460 71.214 1.00 37.75 ATOM 178 CD GLU92 38.847 41.182 72.288 1.00 40.97 ATOM 179 OE1 GLU 92 37.654 40.85572.466 1.00 43.05 ATOM 180 OE2 GLU 92 39.421 42.070 72.955 1.00 41.95ATOM 181 C GLU 92 38.881 39.174 67.705 1.00 25.71 ATOM 182 O GLU 9238.777 37.952 67.689 1.00 25.50 ATOM 183 N TYR 93 38.238 39.961 66.8491.00 25.38 ATOM 184 CA TYR 93 37.367 39.396 65.825 1.00 25.52 ATOM 185CB TYR 93 36.693 40.503 65.012 1.00 25.32 ATOM 186 CG TYR 93 35.79039.961 63.929 1.00 28.08 ATOM 187 CD1 TYR 93 34.578 39.348 64.248 1.0028.32 ATOM 188 CE1 TYR 93 33.761 38.804 63.260 1.00 31.75 ATOM 189 CD2TYR 93 36.165 40.021 62.588 1.00 29.39 ATOM 190 CE2 TYR 93 35.355 39.47761.589 1.00 33.01 ATOM 191 CZ TYR 93 34.155 38.872 61.933 1.00 33.10ATOM 192 OH TYR 93 33.354 38.334 60.952 1.00 36.34 ATOM 193 C TYR 9338.161 38.501 64.878 1.00 23.80 ATOM 194 O TYR 93 37.725 37.404 64.5281.00 24.56 ATOM 195 N ALA 94 39.325 38.984 64.461 1.00 23.33 ATOM 196 CAALA 94 40.184 38.241 63.552 1.00 24.84 ATOM 197 CB ALA 94 41.461 39.03463.274 1.00 22.84 ATOM 198 C ALA 94 40.526 36.876 64.143 1.00 24.40 ATOM199 O ALA 94 40.589 35.876 63.427 1.00 23.49 ATOM 200 N ALA 95 40.73936.840 65.454 1.00 25.55 ATOM 201 CA ALA 95 41.069 35.593 66.136 1.0025.36 ATOM 202 CB ALA 95 41.361 35.864 67.609 1.00 30.67 ATOM 203 C ALA95 39.928 34.593 66.007 1.00 24.83 ATOM 204 O ALA 95 40.138 33.44065.630 1.00 26.02 ATOM 205 N ALA 96 38.718 35.038 66.326 1.00 23.74 ATOM206 CA ALA 96 37.547 34.177 66.244 1.00 23.43 ATOM 207 CB ALA 96 36.32934.904 66.794 1.00 22.21 ATOM 208 C ALA 96 37.284 33.742 64.803 1.0023.35 ATOM 209 O ALA 96 36.934 32.589 64.545 1.00 22.60 ATOM 210 N ASN97 37.451 34.673 63.870 1.00 21.81 ATOM 211 CA ASN 97 37.224 34.38962.456 1.00 22.42 ATOM 212 CB ASN 97 37.308 35.695 61.651 1.00 21.62ATOM 213 CG ASN 97 36.768 35.553 60.241 1.00 22.75 ATOM 214 OD1 ASN 9735.968 34.660 59.955 1.00 22.10 ATOM 215 ND2 ASN 97 37.186 36.450 59.3561.00 21.12 ATOM 216 C ASN 97 38.257 33.373 61.965 1.00 21.42 ATOM 217 OASN 97 37.941 32.480 61.183 1.00 22.56 ATOM 218 N TRP 98 39.490 33.50262.447 1.00 22.34 ATOM 219 CA TRP 98 40.552 32.585 62.059 1.00 22.66ATOM 220 CB TRP 98 41.901 33.085 62.583 1.00 22.16 ATOM 221 CG TRP 9843.016 32.098 62.384 1.00 23.43 ATOM 222 CD2 TRP 98 43.883 32.003 61.2461.00 22.99 ATOM 223 CE2 TRP 98 44.749 30.907 61.470 1.00 24.37 ATOM 224CE3 TRP 98 44.010 32.735 60.055 1.00 21.19 ATOM 225 CD1 TRP 98 43.38131.086 63.229 1.00 25.02 ATOM 226 NE1 TRP 98 44.421 30.365 62.686 1.0025.09 ATOM 227 CZ2 TRP 98 45.733 30.526 60.547 1.00 23.12 ATOM 228 CZ3TRP 98 44.989 32.354 59.134 1.00 21.49 ATOM 229 CH2 TRP 98 45.837 31.25859.389 1.00 20.86 ATOM 230 C TRP 98 40.286 31.170 62.578 1.00 23.96 ATOM231 O TRP 98 40.444 30.190 61.840 1.00 22.16 ATOM 232 N ASN 99 39.87631.071 63.841 1.00 24.47 ATOM 233 CA ASN 99 39.596 29.770 64.455 1.0026.36 ATOM 234 CB ASN 99 39.230 29.936 65.937 1.00 27.31 ATOM 235 CG ASN99 40.368 30.524 66.760 1.00 29.77 ATOM 236 OD1 ASN 99 41.537 30.43266.382 1.00 28.77 ATOM 237 ND2 ASN 99 40.028 31.119 67.899 1.00 30.82ATOM 238 C ASN 99 38.480 29.026 63.724 1.00 25.35 ATOM 239 O ASN 9938.523 27.802 63.588 1.00 23.96 ATOM 240 N TYR 100 37.477 29.762 63.2581.00 24.11 ATOM 241 CA TYR 100 36.380 29.145 62.518 1.00 24.41 ATOM 242CB TYR 100 35.242 30.153 62.308 1.00 27.59 ATOM 243 CG TYR 100 34.34829.829 61.127 1.00 28.29 ATOM 244 CD1 TYR 100 33.375 28.834 61.209 1.0030.33 ATOM 245 CE1 TYR 100 32.581 28.505 60.101 1.00 29.75 ATOM 246 CD2TYR 100 34.508 30.494 59.912 1.00 31.13 ATOM 247 CE2 TYR 100 33.72530.174 58.800 1.00 31.87 ATOM 248 CZ TYR 100 32.765 29.180 58.902 1.0032.09 ATOM 249 OH TYR 100 31.995 28.868 57.799 1.00 31.48 ATOM 250 C TYR100 36.892 28.674 61.157 1.00 24.55 ATOM 251 O TYR 100 36.698 27.52160.770 1.00 23.28 ATOM 252 N ASN 101 37.538 29.588 60.436 1.00 22.98ATOM 253 CA ASN 101 38.083 29.312 59.111 1.00 21.52 ATOM 254 CB ASN 10138.799 30.555 58.573 1.00 22.42 ATOM 255 CG ASN 101 37.883 31.452 57.7661.00 20.70 ATOM 256 OD1 ASN 101 37.843 31.369 56.541 1.00 20.36 ATOM 257ND2 ASN 101 37.131 32.307 58.452 1.00 20.18 ATOM 258 C ASN 101 39.04828.130 59.074 1.00 22.49 ATOM 259 O ASN 101 39.092 27.398 58.085 1.0022.22 ATOM 260 N THR 102 39.821 27.953 60.144 1.00 21.87 ATOM 261 CA THR102 40.799 26.866 60.209 1.00 23.29 ATOM 262 CB THR 102 42.153 27.36460.773 1.00 22.46 ATOM 263 OG1 THR 102 41.985 27.779 62.132 1.00 21.26ATOM 264 CG2 THR 102 42.675 28.544 59.956 1.00 22.88 ATOM 265 C THR 10240.332 25.682 61.055 1.00 25.33 ATOM 266 O THR 102 41.100 24.755 61.3121.00 26.63 ATOM 267 N ASN 103 39.073 25.709 61.478 1.00 26.22 ATOM 268CA ASN 103 38.513 24.633 62.293 1.00 27.70 ATOM 269 CB ASN 103 39.15424.648 63.691 1.00 28.15 ATOM 270 CG ASN 103 38.674 23.499 64.576 1.0031.04 ATOM 271 OD1 ASN 103 38.244 22.457 64.074 1.00 29.17 ATOM 272 ND2ASN 103 38.761 23.701 65.892 1.00 32.86 ATOM 273 C ASN 103 37.005 24.83462.382 1.00 26.39 ATOM 274 O ASN 103 36.486 25.297 63.395 1.00 28.11ATOM 275 N ILE 104 36.312 24.487 61.304 1.00 27.62 ATOM 276 CA ILE 10434.864 24.640 61.225 1.00 28.58 ATOM 277 CB ILE 104 34.370 24.456 59.7701.00 28.41 ATOM 278 CG2 ILE 104 32.849 24.581 59.710 1.00 29.27 ATOM 279CG1 ILE 104 35.032 25.498 58.861 1.00 28.67 ATOM 280 CD1 ILE 104 34.67425.359 57.387 1.00 27.85 ATOM 281 C ILE 104 34.128 23.655 62.127 1.0030.90 ATOM 282 O ILE 104 34.063 22.460 61.839 1.00 31.19 ATOM 283 N THR105 33.579 24.171 63.222 1.00 32.51 ATOM 284 CA THR 105 32.831 23.36064.177 1.00 33.92 ATOM 285 CB THR 105 33.688 22.982 65.399 1.00 34.56ATOM 286 OG1 THR 105 34.015 24.169 66.133 1.00 35.94 ATOM 287 CG2 THR105 34.972 22.284 64.965 1.00 33.74 ATOM 288 C THR 105 31.649 24.17664.677 1.00 34.62 ATOM 289 O THR 105 31.575 25.384 64.450 1.00 34.35ATOM 290 N THR 106 30.722 23.518 65.360 1.00 34.69 ATOM 291 CA THR 10629.564 24.220 65.889 1.00 35.91 ATOM 292 CB THR 106 28.546 23.229 66.5101.00 36.94 ATOM 293 OG1 THR 106 27.453 23.956 67.085 1.00 40.00 ATOM 294CG2 THR 106 29.205 22.386 67.582 1.00 36.78 ATOM 295 C THR 106 30.04125.219 66.945 1.00 35.21 ATOM 296 O THR 106 29.499 26.318 67.069 1.0034.43 ATOM 297 N GLU 107 31.084 24.840 67.679 1.00 35.12 ATOM 298 CA GLU107 31.638 25.692 68.725 1.00 35.53 ATOM 299 CB GLU 107 32.640 24.90569.576 1.00 38.54 ATOM 300 CG GLU 107 32.084 23.613 70.185 1.00 44.28ATOM 301 CD GLU 107 32.317 22.385 69.310 1.00 47.02 ATOM 302 OE1 GLU 10731.828 22.356 68.161 1.00 48.87 ATOM 303 OE2 GLU 107 32.998 21.44469.775 1.00 50.21 ATOM 304 C GLU 107 32.309 26.957 68.180 1.00 34.45ATOM 305 O GLU 107 32.003 28.066 68.623 1.00 32.19 ATOM 306 N THR 10833.227 26.796 67.229 1.00 33.18 ATOM 307 CA THR 108 33.913 27.949 66.6511.00 32.17 ATOM 308 CB THR 108 35.048 27.527 65.687 1.00 31.68 ATOM 309OG1 THR 108 34.528 26.660 64.673 1.00 31.48 ATOM 310 CG2 THR 108 36.15726.818 66.452 1.00 31.84 ATOM 311 C THR 108 32.925 28.834 65.897 1.0031.26 ATOM 312 O THR 108 33.107 30.045 65.815 1.00 30.78 ATOM 313 N SER109 31.878 28.228 65.347 1.00 31.59 ATOM 314 CA SER 109 30.865 28.98964.623 1.00 32.27 ATOM 315 CB SER 109 29.888 28.054 63.905 1.00 32.03ATOM 316 OG SER 109 30.511 27.388 62.819 1.00 33.62 ATOM 317 C SER 10930.094 29.863 65.602 1.00 33.27 ATOM 318 O SER 109 29.871 31.046 65.3521.00 31.52 ATOM 319 N LYS 110 29.695 29.268 66.722 1.00 34.58 ATOM 320CA LYS 110 28.943 29.985 67.741 1.00 36.62 ATOM 321 CB LYS 110 28.57029.031 68.880 1.00 39.13 ATOM 322 CG LYS 110 27.494 29.561 69.819 1.0043.25 ATOM 323 CD LYS 110 27.052 28.487 70.807 1.00 46.60 ATOM 324 CELYS 110 25.859 28.943 71.639 1.00 48.32 ATOM 325 NZ LYS 110 25.36927.861 72.547 1.00 49.35 ATOM 326 C LYS 110 29.755 31.162 68.279 1.0035.77 ATOM 327 O LYS 110 29.234 32.264 68.449 1.00 36.40 ATOM 328 N ILE111 31.037 30.927 68.535 1.00 34.36 ATOM 329 CA ILE 111 31.909 31.97469.054 1.00 33.18 ATOM 330 CB ILE 111 33.296 31.410 69.408 1.00 33.61ATOM 331 CG2 ILE 111 34.226 32.537 69.837 1.00 33.24 ATOM 332 CG1 ILE111 33.154 30.364 70.517 1.00 34.16 ATOM 333 CD1 ILE 111 34.458 29.69670.907 1.00 33.43 ATOM 334 C ILE 111 32.073 33.107 68.044 1.00 32.41ATOM 335 O ILE 111 32.075 34.284 68.410 1.00 32.05 ATOM 336 N LEU 11232.212 32.749 66.772 1.00 30.05 ATOM 337 CA LEU 112 32.364 33.752 65.7311.00 28.87 ATOM 338 CB LEU 112 32.591 33.084 64.371 1.00 28.19 ATOM 339CG LEU 112 32.709 34.015 63.157 1.00 28.67 ATOM 340 CD1 LEU 112 33.77835.063 63.405 1.00 28.05 ATOM 341 CD2 LEU 112 33.035 33.198 61.918 1.0027.39 ATOM 342 C LEU 112 31.127 34.645 65.672 1.00 28.87 ATOM 343 O LEU112 31.243 35.867 65.612 1.00 27.96 ATOM 344 N LEU 113 29.942 34.04065.700 1.00 28.83 ATOM 345 CA LEU 113 28.710 34.821 65.641 1.00 29.55ATOM 346 CB LEU 113 27.488 33.897 65.581 1.00 28.66 ATOM 347 CG LEU 11327.358 33.047 64.313 1.00 27.25 ATOM 348 CD1 LEU 113 26.146 32.14464.423 1.00 28.60 ATOM 349 CD2 LEU 113 27.238 33.955 63.090 1.00 29.42ATOM 350 C LEU 113 28.595 35.772 66.827 1.00 30.99 ATOM 351 O LEU 11328.035 36.861 66.703 1.00 30.68 ATOM 352 N GLN 114 29.134 35.364 67.9731.00 32.59 ATOM 353 CA GLN 114 29.096 36.205 69.164 1.00 34.05 ATOM 354CB GLN 114 29.461 35.393 70.414 1.00 35.86 ATOM 355 CG GLN 114 28.39734.363 70.797 1.00 41.83 ATOM 356 CD GLN 114 28.802 33.483 71.970 1.0044.71 ATOM 357 OE1 GLN 114 29.028 33.966 73.080 1.00 47.69 ATOM 358 NE2GLN 114 28.892 32.180 71.726 1.00 47.51 ATOM 359 C GLN 114 30.056 37.37568.992 1.00 33.41 ATOM 360 O GLN 114 29.746 38.500 69.380 1.00 33.15ATOM 361 N LYS 115 31.222 37.114 68.409 1.00 33.19 ATOM 362 CA LYS 11532.194 38.177 68.185 1.00 33.34 ATOM 363 CB LYS 115 33.527 37.604 67.6951.00 35.03 ATOM 364 CG LYS 115 34.397 37.022 68.802 1.00 39.16 ATOM 365CD LYS 115 34.872 38.111 69.757 1.00 41.08 ATOM 366 CE LYS 115 35.68237.534 70.912 1.00 43.92 ATOM 367 NZ LYS 115 36.142 38.597 71.855 1.0043.32 ATOM 368 C LYS 115 31.655 39.180 67.172 1.00 32.53 ATOM 369 O LYS115 32.033 40.351 67.192 1.00 30.99 ATOM 370 N ASN 116 30.779 38.71766.283 1.00 33.42 ATOM 371 CA ASN 116 30.180 39.597 65.279 1.00 34.57ATOM 372 CB ASN 116 29.219 38.820 64.368 1.00 36.23 ATOM 373 CG ASN 11629.938 37.996 63.314 1.00 37.73 ATOM 374 OD1 ASN 116 30.671 38.53062.479 1.00 37.42 ATOM 375 ND2 ASN 116 29.719 36.685 63.340 1.00 41.84ATOM 376 C ASN 116 29.404 40.694 66.001 1.00 34.49 ATOM 377 O ASN 11629.531 41.874 65.683 1.00 33.34 ATOM 378 N MET 117 28.597 40.286 66.9751.00 34.71 ATOM 379 CA MET 117 27.794 41.217 67.757 1.00 36.39 ATOM 380CB MET 117 26.943 40.448 68.772 1.00 39.17 ATOM 381 CG MET 117 25.51840.138 68.319 1.00 43.08 ATOM 382 SD MET 117 25.294 40.020 66.531 1.0049.27 ATOM 383 CE MET 117 23.829 41.035 66.302 1.00 47.42 ATOM 384 C MET117 28.670 42.228 68.488 1.00 35.39 ATOM 385 O MET 117 28.320 43.40268.590 1.00 34.85 ATOM 386 N GLN 118 29.814 41.772 68.989 1.00 34.91ATOM 387 CA GLN 118 30.722 42.648 69.719 1.00 35.11 ATOM 388 CB GLN 11831.818 41.826 70.405 1.00 38.55 ATOM 389 CG GLN 118 31.278 40.731 71.3191.00 44.24 ATOM 390 CD GLN 118 32.340 40.138 72.229 1.00 47.30 ATOM 391OE1 GLN 118 33.397 39.702 71.771 1.00 49.53 ATOM 392 NE2 GLN 118 32.06040.115 73.528 1.00 47.80 ATOM 393 C GLN 118 31.352 43.714 68.831 1.0032.85 ATOM 394 O GLN 118 31.371 44.895 69.188 1.00 31.35 ATOM 395 N ILE119 31.869 43.308 67.676 1.00 29.57 ATOM 396 CA ILE 119 32.492 44.26966.776 1.00 28.83 ATOM 397 CB ILE 119 33.274 43.563 65.644 1.00 29.00ATOM 398 CG2 ILE 119 32.319 42.794 64.742 1.00 29.58 ATOM 399 CG1 ILE119 34.063 44.599 64.844 1.00 31.09 ATOM 400 CD1 ILE 119 35.045 43.99263.864 1.00 33.97 ATOM 401 C ILE 119 31.435 45.195 66.179 1.00 26.91ATOM 402 O ILE 119 31.709 46.358 65.872 1.00 25.48 ATOM 403 N ALA 12030.220 44.683 66.024 1.00 25.38 ATOM 404 CA ALA 120 29.135 45.492 65.4821.00 26.14 ATOM 405 CB ALA 120 27.918 44.623 65.202 1.00 24.25 ATOM 406C ALA 120 28.790 46.568 66.509 1.00 25.83 ATOM 407 O ALA 120 28.56647.727 66.165 1.00 25.53 ATOM 408 N ASN 121 28.755 46.178 67.778 1.0025.13 ATOM 409 CA ASN 121 28.443 47.131 68.834 1.00 25.64 ATOM 410 CBASN 121 28.407 46.426 70.191 1.00 28.05 ATOM 411 CG ASN 121 27.94547.341 71.304 1.00 33.48 ATOM 412 OD1 ASN 121 28.666 48.256 71.704 1.0037.03 ATOM 413 ND2 ASN 121 26.732 47.107 71.797 1.00 35.02 ATOM 414 CASN 121 29.474 48.256 68.843 1.00 23.48 ATOM 415 O ASN 121 29.131 49.42169.052 1.00 24.86 ATOM 416 N HIS 122 30.735 47.910 68.603 1.00 21.49ATOM 417 CA HIS 122 31.799 48.908 68.565 1.00 21.72 ATOM 418 CB HIS 12233.171 48.227 68.499 1.00 21.96 ATOM 419 CG HIS 122 34.297 49.165 68.1901.00 23.78 ATOM 420 CD2 HIS 122 35.094 49.902 69.002 1.00 22.69 ATOM 421ND1 HIS 122 34.694 49.456 66.901 1.00 25.06 ATOM 422 CE1 HIS 122 35.68450.330 66.934 1.00 24.61 ATOM 423 NE2 HIS 122 35.946 50.618 68.197 1.0022.29 ATOM 424 C HIS 122 31.624 49.822 67.354 1.00 22.77 ATOM 425 O HIS122 31.801 51.041 67.445 1.00 21.87 ATOM 426 N THR 123 31.278 49.22466.218 1.00 20.58 ATOM 427 CA THR 123 31.083 49.979 64.987 1.00 21.80ATOM 428 CB THR 123 30.823 49.034 63.795 1.00 22.75 ATOM 429 OG1 THR 12331.945 48.155 63.632 1.00 22.95 ATOM 430 CG2 THR 123 30.618 49.83262.509 1.00 23.24 ATOM 431 C THR 123 29.905 50.940 65.128 1.00 21.91ATOM 432 O THR 123 29.972 52.085 64.692 1.00 21.95 ATOM 433 N LEU 12428.829 50.468 65.747 1.00 23.43 ATOM 434 CA LEU 124 27.643 51.291 65.9451.00 24.99 ATOM 435 CB LEU 124 26.538 50.458 66.590 1.00 27.24 ATOM 436CG LEU 124 25.215 51.170 66.870 1.00 29.20 ATOM 437 CD1 LEU 124 24.57551.621 65.556 1.00 31.28 ATOM 438 CD2 LEU 124 24.294 50.228 67.622 1.0030.06 ATOM 439 C LEU 124 27.953 52.501 66.830 1.00 25.57 ATOM 440 O LEU124 27.559 53.628 66.526 1.00 23.70 ATOM 441 N LYS 125 28.664 52.25667.924 1.00 24.93 ATOM 442 CA LYS 125 29.018 53.316 68.855 1.00 26.17ATOM 443 CB LYS 125 29.818 52.747 70.026 1.00 27.56 ATOM 444 CG LYS 12530.174 53.788 71.072 1.00 32.44 ATOM 445 CD LYS 125 31.157 53.249 72.0931.00 34.92 ATOM 446 CE LYS 125 31.464 54.302 73.144 1.00 38.23 ATOM 447NZ LYS 125 31.907 55.587 72.522 1.00 40.02 ATOM 448 C LYS 125 29.83054.422 68.192 1.00 25.74 ATOM 449 O LYS 125 29.455 55.593 68.244 1.0025.50 ATOM 450 N TYR 126 30.948 54.053 67.575 1.00 23.64 ATOM 451 CA TYR126 31.793 55.044 66.930 1.00 23.63 ATOM 452 CB TYR 126 33.193 54.47766.688 1.00 23.98 ATOM 453 CG TYR 126 34.005 54.436 67.961 1.00 24.33ATOM 454 CD1 TYR 126 33.877 53.380 68.865 1.00 24.10 ATOM 455 CE1 TYR126 34.539 53.401 70.094 1.00 24.70 ATOM 456 CD2 TYR 126 34.822 55.50968.314 1.00 25.19 ATOM 457 CE2 TYR 126 35.484 55.540 69.534 1.00 25.45ATOM 458 CZ TYR 126 35.337 54.489 70.420 1.00 24.76 ATOM 459 OH TYR 12635.971 54.545 71.640 1.00 26.84 ATOM 460 C TYR 126 31.199 55.594 65.6441.00 23.81 ATOM 461 O TYR 126 31.426 56.756 65.303 1.00 24.01 ATOM 462 NGLY 127 30.426 54.764 64.945 1.00 23.08 ATOM 463 CA GLY 127 29.79155.198 63.713 1.00 22.50 ATOM 464 C GLY 127 28.741 56.255 63.994 1.0023.32 ATOM 465 O GLY 127 28.616 57.237 63.259 1.00 21.48 ATOM 466 N THR128 27.981 56.050 65.066 1.00 24.15 ATOM 467 CA THR 128 26.945 56.99665.468 1.00 25.03 ATOM 468 CB THR 128 26.166 56.474 66.687 1.00 24.73ATOM 469 OG1 THR 128 25.558 55.221 66.357 1.00 25.50 ATOM 470 CG2 THR128 25.088 57.468 67.103 1.00 23.72 ATOM 471 C THR 128 27.601 58.33265.821 1.00 25.94 ATOM 472 O THR 128 27.138 59.390 65.397 1.00 26.44ATOM 473 N GLN 129 28.680 58.275 66.597 1.00 27.23 ATOM 474 CA GLN 12929.408 59.481 66.980 1.00 28.25 ATOM 475 CB GLN 129 30.587 59.138 67.9011.00 32.26 ATOM 476 CG GLN 129 30.285 59.178 69.396 1.00 38.49 ATOM 477CD GLN 129 31.487 58.779 70.249 1.00 42.52 ATOM 478 OE1 GLN 129 31.78657.594 70.412 1.00 44.86 ATOM 479 NE2 GLN 129 32.187 59.772 70.787 1.0045.22 ATOM 480 C GLN 129 29.943 60.182 65.737 1.00 27.53 ATOM 481 O GLN129 29.824 61.399 65.601 1.00 26.41 ATOM 482 N ALA 130 30.531 59.40564.831 1.00 25.80 ATOM 483 CA ALA 130 31.104 59.944 63.600 1.00 24.69ATOM 484 CB ALA 130 31.699 58.810 62.766 1.00 25.45 ATOM 485 C ALA 13030.100 60.729 62.757 1.00 25.28 ATOM 486 O ALA 130 30.448 61.739 62.1411.00 24.63 ATOM 487 N ARG 131 28.860 60.256 62.723 1.00 24.09 ATOM 488CA ARG 131 27.819 60.908 61.945 1.00 26.32 ATOM 489 CB ARG 131 26.60059.994 61.836 1.00 25.28 ATOM 490 CG ARG 131 26.859 58.750 61.015 1.0026.20 ATOM 491 CD ARG 131 25.613 57.904 60.897 1.00 26.32 ATOM 492 NEARG 131 25.805 56.792 59.972 1.00 25.16 ATOM 493 CZ ARG 131 24.85355.925 59.648 1.00 26.49 ATOM 494 NH1 ARG 131 23.640 56.041 60.180 1.0025.08 ATOM 495 NH2 ARG 131 25.108 54.953 58.780 1.00 27.31 ATOM 496 CARG 131 27.398 62.254 62.519 1.00 27.69 ATOM 497 O ARG 131 26.722 63.03361.848 1.00 27.22 ATOM 498 N LYS 132 27.792 62.524 63.758 1.00 28.78ATOM 499 CA LYS 132 27.444 63.785 64.397 1.00 31.07 ATOM 500 CB LYS 13227.480 63.629 65.920 1.00 32.98 ATOM 501 CG LYS 132 26.404 62.682 66.4371.00 37.31 ATOM 502 CD LYS 132 26.517 62.422 67.931 1.00 40.01 ATOM 503CE LYS 132 25.419 61.469 68.386 1.00 42.18 ATOM 504 NZ LYS 132 25.55161.088 69.821 1.00 44.23 ATOM 505 C LYS 132 28.371 64.906 63.946 1.0030.99 ATOM 506 O LYS 132 28.104 66.082 64.194 1.00 30.45 ATOM 507 N PHE133 29.461 64.543 63.278 1.00 31.38 ATOM 508 CA PHE 133 30.401 65.54262.776 1.00 32.92 ATOM 509 CB PHE 133 31.825 64.980 62.665 1.00 32.55ATOM 510 CG PHE 133 32.531 64.825 63.977 1.00 32.74 ATOM 511 CD1 PHE 13332.357 63.682 64.746 1.00 33.65 ATOM 512 CD2 PHE 133 33.376 65.82864.444 1.00 34.44 ATOM 513 CE1 PHE 133 33.017 63.535 65.965 1.00 35.01ATOM 514 CE2 PHE 133 34.041 65.695 65.664 1.00 34.23 ATOM 515 CZ PHE 13333.861 64.546 66.425 1.00 35.80 ATOM 516 C PHE 133 29.970 65.978 61.3901.00 33.66 ATOM 517 O PHE 133 29.487 65.165 60.601 1.00 33.46 ATOM 518 NASP 134 30.136 67.262 61.095 1.00 34.13 ATOM 519 CA ASP 134 29.80467.769 59.772 1.00 34.82 ATOM 520 CB ASP 134 29.286 69.209 59.836 1.0035.44 ATOM 521 CG ASP 134 28.831 69.724 58.477 1.00 35.56 ATOM 522 OD1ASP 134 29.439 69.336 57.459 1.00 36.13 ATOM 523 OD2 ASP 134 27.87370.522 58.425 1.00 36.65 ATOM 524 C ASP 134 31.121 67.737 59.014 1.0034.27 ATOM 525 O ASP 134 31.909 68.677 59.089 1.00 34.87 ATOM 526 N VAL135 31.361 66.644 58.298 1.00 35.15 ATOM 527 CA VAL 135 32.595 66.47857.540 1.00 35.95 ATOM 528 CB VAL 135 32.530 65.218 56.657 1.00 36.58ATOM 529 CG1 VAL 135 33.794 65.095 55.833 1.00 37.87 ATOM 530 CG2 VAL135 32.355 63.988 57.530 1.00 36.85 ATOM 531 C VAL 135 32.915 67.68256.660 1.00 36.83 ATOM 532 O VAL 135 34.084 67.983 56.415 1.00 36.31ATOM 533 N ASN 136 31.880 68.371 56.189 1.00 37.34 ATOM 534 CA ASN 13632.077 69.540 55.340 1.00 39.98 ATOM 535 CB ASN 136 30.729 70.105 54.8731.00 39.64 ATOM 536 CG ASN 136 29.961 69.138 53.996 1.00 40.40 ATOM 537OD1 ASN 136 30.488 68.633 53.004 1.00 39.43 ATOM 538 ND2 ASN 136 28.70368.879 54.354 1.00 39.64 ATOM 539 C ASN 136 32.851 70.639 56.061 1.0041.21 ATOM 540 O ASN 136 33.593 71.396 55.437 1.00 42.44 ATOM 541 N GLN137 32.684 70.716 57.377 1.00 42.26 ATOM 542 CA GLN 137 33.354 71.74158.173 1.00 43.46 ATOM 543 CB GLN 137 32.486 72.104 59.381 1.00 44.53ATOM 544 CG GLN 137 31.077 72.557 59.023 1.00 47.29 ATOM 545 CD GLN 13731.064 73.786 58.130 1.00 49.81 ATOM 546 OE1 GLN 137 31.620 74.83058.480 1.00 51.43 ATOM 547 NE2 GLN 137 30.424 73.668 56.971 1.00 50.55ATOM 548 C GLN 137 34.755 71.355 58.648 1.00 43.13 ATOM 549 O GLN 13735.518 72.209 59.101 1.00 42.91 ATOM 550 N LEU 138 35.096 70.074 58.5491.00 43.61 ATOM 551 CA LEU 138 36.411 69.608 58.983 1.00 43.43 ATOM 552CB LEU 138 36.432 68.078 59.043 1.00 43.64 ATOM 553 CG LEU 138 36.35867.475 60.451 1.00 44.21 ATOM 554 CD1 LEU 138 35.308 68.189 61.286 1.0044.64 ATOM 555 CD2 LEU 138 36.049 65.994 60.349 1.00 44.83 ATOM 556 CLEU 138 37.530 70.124 58.087 1.00 43.49 ATOM 557 O LEU 138 37.443 70.05556.862 1.00 43.96 ATOM 558 N GLN 139 38.585 70.635 58.716 1.00 43.92ATOM 559 CA GLN 139 39.729 71.199 58.005 1.00 44.02 ATOM 560 CB GLN 13940.392 72.275 58.867 1.00 46.53 ATOM 561 CG GLN 139 40.683 73.572 58.1371.00 49.82 ATOM 562 CD GLN 139 39.418 74.318 57.762 1.00 52.02 ATOM 563OE1 GLN 139 38.581 73.813 57.012 1.00 53.40 ATOM 564 NE2 GLN 139 39.26975.530 58.288 1.00 53.64 ATOM 565 C GLN 139 40.778 70.167 57.603 1.0043.28 ATOM 566 O GLN 139 41.149 70.075 56.434 1.00 44.53 ATOM 567 N ASN140 41.268 69.403 58.575 1.00 41.60 ATOM 568 CA ASN 140 42.280 68.38558.307 1.00 39.70 ATOM 569 CB ASN 140 42.721 67.719 59.614 1.00 38.65ATOM 570 CG ASN 140 43.904 66.782 59.425 1.00 38.74 ATOM 571 OD1 ASN 14043.860 65.877 58.587 1.00 39.03 ATOM 572 ND2 ASN 140 44.959 67.00760.208 1.00 38.01 ATOM 573 C ASN 140 41.715 67.336 57.353 1.00 39.03ATOM 574 O ASN 140 40.752 66.640 57.682 1.00 37.85 ATOM 575 N THR 14142.319 67.222 56.175 1.00 38.84 ATOM 576 CA THR 141 41.862 66.265 55.1751.00 39.36 ATOM 577 CB THR 141 42.689 66.377 53.878 1.00 40.12 ATOM 578OG1 THR 141 44.072 66.148 54.168 1.00 42.67 ATOM 579 CG2 THR 141 42.52767.761 53.263 1.00 40.55 ATOM 580 C THR 141 41.910 64.820 55.673 1.0038.70 ATOM 581 O THR 141 40.965 64.060 55.469 1.00 39.63 ATOM 582 N THR142 43.003 64.442 56.327 1.00 37.88 ATOM 583 CA THR 142 43.141 63.08256.843 1.00 36.04 ATOM 584 CB THR 142 44.516 62.870 57.509 1.00 36.83ATOM 585 OG1 THR 142 45.547 63.012 56.524 1.00 36.96 ATOM 586 CG2 THR142 44.605 61.481 58.126 1.00 37.59 ATOM 587 C THR 142 42.045 62.77057.857 1.00 35.01 ATOM 588 O THR 142 41.465 61.686 57.836 1.00 34.20ATOM 589 N ILE 143 41.770 63.719 58.747 1.00 33.02 ATOM 590 CA ILE 14340.728 63.538 59.754 1.00 32.35 ATOM 591 CB ILE 143 40.706 64.721 60.7541.00 33.52 ATOM 592 CG2 ILE 143 39.488 64.620 61.664 1.00 31.47 ATOM 593CG1 ILE 143 42.000 64.736 61.573 1.00 33.85 ATOM 594 CD1 ILE 143 42.19263.512 62.442 1.00 36.23 ATOM 595 C ILE 143 39.379 63.467 59.048 1.0031.17 ATOM 596 O ILE 143 38.503 62.679 59.413 1.00 29.34 ATOM 597 N LYS144 39.231 64.306 58.028 1.00 30.98 ATOM 598 CA LYS 144 38.016 64.38657.228 1.00 30.73 ATOM 599 CB LYS 144 38.208 65.462 56.153 1.00 33.49ATOM 600 CG LYS 144 36.993 65.776 55.306 1.00 37.03 ATOM 601 CD LYS 14437.360 66.779 54.219 1.00 40.12 ATOM 602 CE LYS 144 36.174 67.118 53.3251.00 42.45 ATOM 603 NZ LYS 144 35.112 67.865 54.051 1.00 43.36 ATOM 604C LYS 144 37.712 63.034 56.574 1.00 28.35 ATOM 605 O LYS 144 36.59062.526 56.645 1.00 27.74 ATOM 606 N ARG 145 38.734 62.459 55.951 1.0026.86 ATOM 607 CA ARG 145 38.631 61.179 55.254 1.00 24.41 ATOM 608 CBARG 145 39.943 60.913 54.512 1.00 24.91 ATOM 609 CG ARG 145 39.93459.733 53.549 1.00 23.83 ATOM 610 CD ARG 145 41.194 59.763 52.692 1.0024.48 ATOM 611 NE ARG 145 41.334 58.608 51.806 1.00 23.26 ATOM 612 CZARG 145 40.576 58.376 50.738 1.00 25.83 ATOM 613 NH1 ARG 145 39.60659.221 50.410 1.00 23.61 ATOM 614 NH2 ARG 145 40.796 57.300 49.988 1.0023.06 ATOM 615 C ARG 145 38.302 60.009 56.187 1.00 24.55 ATOM 616 O ARG145 37.457 59.168 55.871 1.00 22.27 ATOM 617 N ILE 146 38.971 59.94957.333 1.00 23.82 ATOM 618 CA ILE 146 38.720 58.876 58.288 1.00 24.41ATOM 619 CB ILE 146 39.720 58.935 59.468 1.00 25.21 ATOM 620 CG2 ILE 14639.251 58.033 60.600 1.00 22.70 ATOM 621 CG1 ILE 146 41.113 58.51958.979 1.00 25.19 ATOM 622 CD1 ILE 146 42.202 58.625 60.028 1.00 26.27ATOM 623 C ILE 146 37.296 58.932 58.838 1.00 24.39 ATOM 624 O ILE 14636.591 57.922 58.858 1.00 24.78 ATOM 625 N ILE 147 36.874 60.116 59.2741.00 23.99 ATOM 626 CA ILE 147 35.539 60.283 59.832 1.00 24.23 ATOM 627CB ILE 147 35.337 61.724 60.381 1.00 24.80 ATOM 628 CG2 ILE 147 33.87161.960 60.733 1.00 25.96 ATOM 629 CG1 ILE 147 36.219 61.924 61.622 1.0025.41 ATOM 630 CD1 ILE 147 36.029 63.261 62.324 1.00 25.15 ATOM 631 CILE 147 34.441 59.947 58.822 1.00 23.88 ATOM 632 O ILE 147 33.459 59.29359.168 1.00 22.19 ATOM 633 N ALA 148 34.603 60.392 57.579 1.00 25.35ATOM 634 CA ALA 148 33.610 60.099 56.549 1.00 26.35 ATOM 635 CB ALA 14834.041 60.704 55.206 1.00 26.72 ATOM 636 C ALA 148 33.470 58.584 56.4241.00 26.20 ATOM 637 O ALA 148 32.366 58.055 56.296 1.00 26.64 ATOM 638 NLYS 149 34.604 57.892 56.476 1.00 26.33 ATOM 639 CA LYS 149 34.63256.439 56.372 1.00 25.57 ATOM 640 CB LYS 149 36.080 55.970 56.205 1.0028.20 ATOM 641 CG LYS 149 36.244 54.497 55.885 1.00 32.16 ATOM 642 CDLYS 149 37.640 54.228 55.333 1.00 36.26 ATOM 643 CE LYS 149 37.81552.773 54.930 1.00 37.26 ATOM 644 NZ LYS 149 37.763 51.868 56.105 1.0039.38 ATOM 645 C LYS 149 33.989 55.754 57.581 1.00 24.69 ATOM 646 O LYS149 33.302 54.739 57.435 1.00 24.36 ATOM 647 N VAL 150 34.205 56.30758.772 1.00 22.37 ATOM 648 CA VAL 150 33.632 55.727 59.981 1.00 22.59ATOM 649 CB VAL 150 34.270 56.341 61.254 1.00 23.63 ATOM 650 CG1 VAL 15033.651 55.723 62.502 1.00 20.79 ATOM 651 CG2 VAL 150 35.776 56.09961.243 1.00 22.23 ATOM 652 C VAL 150 32.111 55.899 60.035 1.00 21.68ATOM 653 O VAL 150 31.426 55.151 60.730 1.00 21.12 ATOM 654 N GLN 15131.581 56.871 59.294 1.00 20.83 ATOM 655 CA GLN 151 30.133 57.097 59.2671.00 21.36 ATOM 656 CB GLN 151 29.804 58.423 58.566 1.00 21.83 ATOM 657CG GLN 151 30.424 59.658 59.216 1.00 22.21 ATOM 658 CD GLN 151 30.02560.949 58.514 1.00 26.18 ATOM 659 OE1 GLN 151 29.786 60.960 57.306 1.0026.64 ATOM 660 NE2 GLN 151 29.969 62.046 59.266 1.00 23.87 ATOM 661 CGLN 151 29.405 55.948 58.555 1.00 21.63 ATOM 662 O GLN 151 28.178 55.83158.637 1.00 21.51 ATOM 663 N ASP 152 30.162 55.111 57.848 1.00 19.66ATOM 664 CA ASP 152 29.596 53.958 57.141 1.00 21.29 ATOM 665 CB ASP 15230.413 53.657 55.875 1.00 19.46 ATOM 666 CG ASP 152 29.783 52.574 55.0041.00 21.81 ATOM 667 OD1 ASP 152 29.034 51.724 55.528 1.00 21.84 ATOM 668OD2 ASP 152 30.056 52.563 53.784 1.00 22.86 ATOM 669 C ASP 152 29.69052.781 58.109 1.00 20.99 ATOM 670 O ASP 152 30.772 52.240 58.323 1.0020.95 ATOM 671 N LEU 153 28.558 52.386 58.688 1.00 22.58 ATOM 672 CA LEU153 28.535 51.292 59.661 1.00 22.39 ATOM 673 CB LEU 153 27.330 51.43360.593 1.00 22.04 ATOM 674 CG LEU 153 26.824 52.837 60.927 1.00 25.61ATOM 675 CD1 LEU 153 25.697 52.735 61.951 1.00 25.99 ATOM 676 CD2 LEU153 27.956 53.680 61.460 1.00 22.76 ATOM 677 C LEU 153 28.460 49.91959.013 1.00 22.78 ATOM 678 O LEU 153 28.512 48.902 59.704 1.00 21.91ATOM 679 N GLU 154 28.341 49.894 57.691 1.00 22.03 ATOM 680 CA GLU 15428.202 48.644 56.965 1.00 23.75 ATOM 681 CB GLU 154 29.540 47.902 56.8941.00 26.94 ATOM 682 CG GLU 154 30.179 48.049 55.508 1.00 34.66 ATOM 683CD GLU 154 31.604 48.553 55.547 1.00 38.29 ATOM 684 OE1 GLU 154 32.50547.776 55.938 1.00 41.36 ATOM 685 OE2 GLU 154 31.825 49.729 55.185 1.0042.09 ATOM 686 C GLU 154 27.103 47.792 57.603 1.00 21.61 ATOM 687 O GLU154 26.055 48.324 57.952 1.00 22.87 ATOM 688 N ARG 155 27.323 46.49357.773 1.00 20.09 ATOM 689 CA ARG 155 26.275 45.646 58.340 1.00 21.46ATOM 690 CB ARG 155 26.742 44.192 58.430 1.00 20.77 ATOM 691 CG ARG 15527.718 43.918 59.551 1.00 19.96 ATOM 692 CD ARG 155 28.186 42.480 59.5091.00 23.32 ATOM 693 NE ARG 155 28.950 42.205 58.299 1.00 25.43 ATOM 694CZ ARG 155 29.456 41.017 57.994 1.00 29.86 ATOM 695 NH1 ARG 155 29.27439.987 58.814 1.00 28.71 ATOM 696 NH2 ARG 155 30.152 40.858 56.873 1.0031.49 ATOM 697 C ARG 155 25.784 46.105 59.712 1.00 21.73 ATOM 698 O ARG155 24.638 45.846 60.084 1.00 21.61 ATOM 699 N ALA 156 26.645 46.78760.461 1.00 21.87 ATOM 700 CA ALA 156 26.270 47.264 61.789 1.00 24.11ATOM 701 CB ALA 156 27.478 47.878 62.490 1.00 24.00 ATOM 702 C ALA 15625.117 48.270 61.749 1.00 24.29 ATOM 703 O ALA 156 24.566 48.620 62.7881.00 24.68 ATOM 704 N ALA 157 24.748 48.735 60.557 1.00 22.56 ATOM 705CA ALA 157 23.642 49.684 60.447 1.00 22.76 ATOM 706 CB ALA 157 23.72150.438 59.125 1.00 21.66 ATOM 707 C ALA 157 22.297 48.966 60.554 1.0022.55 ATOM 708 O ALA 157 21.258 49.598 60.749 1.00 23.01 ATOM 709 N LEU158 22.322 47.642 60.429 1.00 22.24 ATOM 710 CA LEU 158 21.103 46.83460.490 1.00 21.40 ATOM 711 CB LEU 158 21.365 45.441 59.912 1.00 19.45ATOM 712 CG LEU 158 21.629 45.249 58.418 1.00 16.15 ATOM 713 CD1 LEU 15822.085 43.821 58.168 1.00 18.41 ATOM 714 CD2 LEU 158 20.357 45.55457.632 1.00 14.90 ATOM 715 C LEU 158 20.542 46.655 61.900 1.00 22.60ATOM 716 O LEU 158 21.296 46.550 62.861 1.00 21.61 ATOM 717 N PRO 15919.202 46.616 62.033 1.00 23.33 ATOM 718 CD PRO 159 18.180 46.863 60.9991.00 22.87 ATOM 719 CA PRO 159 18.582 46.430 63.348 1.00 24.44 ATOM 720CB PRO 159 17.096 46.342 63.017 1.00 23.93 ATOM 721 CG PRO 159 16.97047.241 61.824 1.00 24.99 ATOM 722 C PRO 159 19.122 45.111 63.897 1.0025.67 ATOM 723 O PRO 159 19.384 44.182 63.128 1.00 24.90 ATOM 724 N ALA160 19.289 45.035 65.213 1.00 25.35 ATOM 725 CA ALA 160 19.818 43.84165.866 1.00 26.14 ATOM 726 CB ALA 160 19.536 43.909 67.366 1.00 26.95ATOM 727 C ALA 160 19.296 42.516 65.303 1.00 26.55 ATOM 728 O ALA 16020.071 41.584 65.078 1.00 23.79 ATOM 729 N GLN 161 17.989 42.431 65.0771.00 26.32 ATOM 730 CA GLN 161 17.397 41.201 64.563 1.00 29.37 ATOM 731CB GLN 161 15.871 41.313 64.542 1.00 31.38 ATOM 732 CG GLN 161 15.16740.022 64.158 1.00 37.44 ATOM 733 CD GLN 161 13.656 40.124 64.267 1.0041.02 ATOM 734 OE1 GLN 161 13.114 40.363 65.349 1.00 43.87 ATOM 735 NE2GLN 161 12.967 39.947 63.144 1.00 43.01 ATOM 736 C GLN 161 17.909 40.84463.169 1.00 28.25 ATOM 737 O GLN 161 18.313 39.705 62.922 1.00 27.07ATOM 738 N GLU 162 17.884 41.815 62.262 1.00 27.58 ATOM 739 CA GLU 16218.353 41.595 60.898 1.00 28.12 ATOM 740 CB GLU 162 18.056 42.812 60.0141.00 30.05 ATOM 741 CG GLU 162 16.648 42.872 59.439 1.00 36.16 ATOM 742CD GLU 162 15.596 43.218 60.474 1.00 40.46 ATOM 743 OE1 GLU 162 15.34942.396 61.383 1.00 43.71 ATOM 744 OE2 GLU 162 15.015 44.320 60.376 1.0042.20 ATOM 745 C GLU 162 19.852 41.319 60.875 1.00 25.64 ATOM 746 O GLU162 20.338 40.564 60.036 1.00 24.67 ATOM 747 N LEU 163 20.583 41.93361.798 1.00 23.77 ATOM 748 CA LEU 163 22.027 41.741 61.856 1.00 23.77ATOM 749 CB LEU 163 22.658 42.686 62.886 1.00 23.27 ATOM 750 CG LEU 16324.167 42.535 63.139 1.00 22.82 ATOM 751 CD1 LEU 163 24.947 42.72561.843 1.00 24.01 ATOM 752 CD2 LEU 163 24.614 43.548 64.179 1.00 23.32ATOM 753 C LEU 163 22.382 40.299 62.192 1.00 24.03 ATOM 754 O LEU 16323.248 39.700 61.546 1.00 23.44 ATOM 755 N GLU 164 21.717 39.728 63.1921.00 23.75 ATOM 756 CA GLU 164 22.031 38.356 63.562 1.00 25.00 ATOM 757CB GLU 164 21.362 37.974 64.893 1.00 28.77 ATOM 758 CG GLU 164 19.95037.445 64.807 1.00 35.39 ATOM 759 CD GLU 164 19.405 37.035 66.171 1.0040.22 ATOM 760 OE1 GLU 164 18.302 36.450 66.224 1.00 41.83 ATOM 761 OE2GLU 164 20.080 37.303 67.193 1.00 41.78 ATOM 762 C GLU 164 21.628 37.40162.445 1.00 23.01 ATOM 763 O GLU 164 22.319 36.414 62.185 1.00 22.51ATOM 764 N GLU 165 20.524 37.703 61.768 1.00 22.62 ATOM 765 CA GLU 16520.073 36.857 60.670 1.00 24.34 ATOM 766 CB GLU 165 18.669 37.265 60.2091.00 24.26 ATOM 767 CG GLU 165 18.195 36.512 58.973 1.00 26.97 ATOM 768CD GLU 165 16.781 36.876 58.560 1.00 28.34 ATOM 769 OE1 GLU 165 16.32937.996 58.886 1.00 28.72 ATOM 770 OE2 GLU 165 16.127 36.045 57.893 1.0028.15 ATOM 771 C GLU 165 21.065 36.968 59.509 1.00 24.93 ATOM 772 O GLU165 21.395 35.967 58.865 1.00 24.77 ATOM 773 N TYR 166 21.552 38.18159.260 1.00 23.07 ATOM 774 CA TYR 166 22.514 38.402 58.188 1.00 23.12ATOM 775 CB TYR 166 22.764 39.903 57.993 1.00 21.91 ATOM 776 CG TYR 16623.736 40.235 56.875 1.00 21.83 ATOM 777 CD1 TYR 166 23.502 39.80755.568 1.00 22.95 ATOM 778 CE1 TYR 166 24.390 40.119 54.532 1.00 22.34ATOM 779 CD2 TYR 166 24.886 40.985 57.125 1.00 21.46 ATOM 780 CE2 TYR166 25.780 41.301 56.102 1.00 22.52 ATOM 781 CZ TYR 166 25.526 40.86554.808 1.00 23.28 ATOM 782 OH TYR 166 26.403 41.176 53.795 1.00 23.78ATOM 783 C TYR 166 23.831 37.687 58.503 1.00 23.03 ATOM 784 O TYR 16624.412 37.040 57.633 1.00 23.00 ATOM 785 N ASN 167 24.302 37.794 59.7431.00 22.34 ATOM 786 CA ASN 167 25.551 37.129 60.112 1.00 22.66 ATOM 787CB ASN 167 25.979 37.493 61.539 1.00 23.67 ATOM 788 CG ASN 167 26.49938.915 61.649 1.00 24.93 ATOM 789 OD1 ASN 167 27.226 39.393 60.777 1.0026.06 ATOM 790 ND2 ASN 167 26.140 39.594 62.731 1.00 25.88 ATOM 791 CASN 167 25.430 35.616 59.994 1.00 22.26 ATOM 792 O ASN 167 26.363 34.95059.552 1.00 21.60 ATOM 793 N LYS 168 24.280 35.073 60.382 1.00 20.98ATOM 794 CA LYS 168 24.079 33.632 60.307 1.00 21.98 ATOM 795 CB LYS 16822.809 33.214 61.055 1.00 23.33 ATOM 796 CG LYS 168 22.528 31.729 60.9361.00 27.37 ATOM 797 CD LYS 168 21.405 31.270 61.844 1.00 32.52 ATOM 798CE LYS 168 21.082 29.808 61.567 1.00 35.29 ATOM 799 NZ LYS 168 22.32028.969 61.554 1.00 35.98 ATOM 800 C LYS 168 24.006 33.159 58.860 1.0020.98 ATOM 801 O LYS 168 24.509 32.085 58.525 1.00 20.06 ATOM 802 N ILE169 23.374 33.959 58.007 1.00 19.85 ATOM 803 CA ILE 169 23.260 33.61556.595 1.00 21.24 ATOM 804 CB ILE 169 22.368 34.631 55.846 1.00 21.43ATOM 805 CG2 ILE 169 22.611 34.554 54.338 1.00 23.74 ATOM 806 CG1 ILE169 20.900 34.340 56.159 1.00 24.06 ATOM 807 CD1 ILE 169 19.930 35.30255.515 1.00 24.63 ATOM 808 C ILE 169 24.643 33.554 55.944 1.00 19.54ATOM 809 O ILE 169 24.936 32.632 55.188 1.00 21.81 ATOM 810 N LEU 17025.491 34.530 56.244 1.00 19.05 ATOM 811 CA LEU 170 26.837 34.562 55.6871.00 19.74 ATOM 812 CB LEU 170 27.565 35.834 56.131 1.00 19.37 ATOM 813CG LEU 170 27.041 37.157 55.559 1.00 21.50 ATOM 814 CD1 LEU 170 27.81038.328 56.170 1.00 20.18 ATOM 815 CD2 LEU 170 27.188 37.151 54.044 1.0019.99 ATOM 816 C LEU 170 27.620 33.332 56.140 1.00 21.61 ATOM 817 O LEU170 28.300 32.682 55.344 1.00 21.28 ATOM 818 N LEU 171 27.511 33.00957.423 1.00 21.65 ATOM 819 CA LEU 171 28.217 31.862 57.969 1.00 23.32ATOM 820 CB LEU 171 28.042 31.811 59.490 1.00 25.33 ATOM 821 CG LEU 17128.968 30.869 60.262 1.00 28.92 ATOM 822 CD1 LEU 171 30.414 31.24159.990 1.00 30.99 ATOM 823 CD2 LEU 171 28.681 30.977 61.756 1.00 32.45ATOM 824 C LEU 171 27.714 30.569 57.337 1.00 22.19 ATOM 825 O LEU 17128.511 29.705 56.975 1.00 22.62 ATOM 826 N ASP 172 26.396 30.439 57.2021.00 20.90 ATOM 827 CA ASP 172 25.817 29.237 56.615 1.00 21.82 ATOM 828CB ASP 172 24.283 29.261 56.698 1.00 22.55 ATOM 829 CG ASP 172 23.76629.076 58.121 1.00 24.93 ATOM 830 OD1 ASP 172 24.489 28.493 58.952 1.0024.24 ATOM 831 OD2 ASP 172 22.625 29.502 58.404 1.00 26.64 ATOM 832 CASP 172 26.244 29.060 55.161 1.00 22.04 ATOM 833 O ASP 172 26.501 27.94054.720 1.00 21.02 ATOM 834 N MET 173 26.315 30.156 54.411 1.00 20.30ATOM 835 CA MET 173 26.731 30.057 53.014 1.00 20.02 ATOM 836 CB MET 17326.524 31.389 52.277 1.00 16.36 ATOM 837 CG MET 173 25.055 31.743 52.0471.00 14.73 ATOM 838 SD MET 173 24.812 32.982 50.748 1.00 18.57 ATOM 839CE MET 173 25.587 34.426 51.501 1.00 15.06 ATOM 840 C MET 173 28.19529.639 52.925 1.00 19.90 ATOM 841 O MET 173 28.560 28.773 52.129 1.0018.15 ATOM 842 N GLU 174 29.033 30.251 53.751 1.00 21.27 ATOM 843 CA GLU174 30.452 29.931 53.745 1.00 24.34 ATOM 844 CB GLU 174 31.209 30.83054.719 1.00 26.33 ATOM 845 CG GLU 174 32.700 30.567 54.706 1.00 31.24ATOM 846 CD GLU 174 33.296 30.741 53.321 1.00 34.04 ATOM 847 OE1 GLU 17433.424 31.900 52.874 1.00 33.83 ATOM 848 OE2 GLU 174 33.624 29.71652.678 1.00 34.64 ATOM 849 C GLU 174 30.686 28.477 54.122 1.00 23.73ATOM 850 O GLU 174 31.454 27.768 53.464 1.00 23.77 ATOM 851 N THR 17530.024 28.037 55.187 1.00 22.79 ATOM 852 CA THR 175 30.166 26.664 55.6501.00 23.63 ATOM 853 CB THR 175 29.363 26.425 56.941 1.00 23.79 ATOM 854OG1 THR 175 29.850 27.294 57.971 1.00 23.95 ATOM 855 CG2 THR 175 29.50224.973 57.391 1.00 23.49 ATOM 856 C THR 175 29.693 25.671 54.593 1.0022.90 ATOM 857 O THR 175 30.391 24.701 54.279 1.00 24.74 ATOM 858 N THR176 28.507 25.917 54.050 1.00 19.50 ATOM 859 CA THR 176 27.937 25.05253.025 1.00 21.93 ATOM 860 CB THR 176 26.605 25.616 52.494 1.00 21.32ATOM 861 OG1 THR 176 25.646 25.661 53.559 1.00 22.38 ATOM 862 CG2 THR176 26.068 24.740 51.358 1.00 20.84 ATOM 863 C THR 176 28.884 24.87051.842 1.00 21.08 ATOM 864 O THR 176 29.060 23.761 51.342 1.00 22.40ATOM 865 N TYR 177 29.492 25.963 51.395 1.00 20.72 ATOM 866 CA TYR 17730.406 25.906 50.260 1.00 19.26 ATOM 867 CB TYR 177 30.784 27.327 49.8161.00 18.41 ATOM 868 CG TYR 177 31.707 27.374 48.610 1.00 18.79 ATOM 869CD1 TYR 177 31.196 27.356 47.311 1.00 16.82 ATOM 870 CE1 TYR 177 32.04427.376 46.197 1.00 16.82 ATOM 871 CD2 TYR 177 33.094 27.410 48.770 1.0017.18 ATOM 872 CE2 TYR 177 33.954 27.424 47.662 1.00 17.14 ATOM 873 CZTYR 177 33.418 27.406 46.382 1.00 18.38 ATOM 874 OH TYR 177 34.25627.403 45.289 1.00 18.18 ATOM 875 C TYR 177 31.682 25.126 50.581 1.0019.83 ATOM 876 O TYR 177 32.089 24.244 49.826 1.00 19.73 ATOM 877 N SER178 32.298 25.448 51.712 1.00 19.67 ATOM 878 CA SER 178 33.555 24.82852.117 1.00 22.76 ATOM 879 CB SER 178 34.208 25.678 53.211 1.00 23.75ATOM 880 OG SER 178 34.560 26.953 52.702 1.00 28.52 ATOM 881 C SER 17833.543 23.363 52.556 1.00 22.80 ATOM 882 O SER 178 34.606 22.752 52.6721.00 22.47 ATOM 883 N VAL 179 32.368 22.796 52.803 1.00 22.17 ATOM 884CA VAL 179 32.309 21.401 53.219 1.00 23.76 ATOM 885 CB VAL 179 31.67621.255 54.631 1.00 24.20 ATOM 886 CG1 VAL 179 32.400 22.160 55.617 1.0023.61 ATOM 887 CG2 VAL 179 30.189 21.584 54.588 1.00 23.11 ATOM 888 CVAL 179 31.527 20.541 52.231 1.00 23.17 ATOM 889 O VAL 179 31.277 19.36652.482 1.00 24.77 ATOM 890 N ALA 180 31.153 21.122 51.098 1.00 22.77ATOM 891 CA ALA 180 30.395 20.384 50.093 1.00 21.75 ATOM 892 CB ALA 18029.810 21.352 49.064 1.00 19.82 ATOM 893 C ALA 180 31.247 19.329 49.3911.00 21.47 ATOM 894 O ALA 180 32.429 19.549 49.121 1.00 20.99 ATOM 895 NTHR 181 30.644 18.179 49.106 1.00 21.38 ATOM 896 CA THR 181 31.35417.111 48.411 1.00 22.06 ATOM 897 CB THR 181 31.768 15.957 49.371 1.0023.05 ATOM 898 OG1 THR 181 30.598 15.325 49.901 1.00 25.28 ATOM 899 CG2THR 181 32.615 16.487 50.520 1.00 22.65 ATOM 900 C THR 181 30.491 16.52747.298 1.00 22.17 ATOM 901 O THR 181 29.266 16.673 47.294 1.00 22.75ATOM 902 N VAL 182 31.145 15.881 46.343 1.00 22.72 ATOM 903 CA VAL 18230.459 15.244 45.228 1.00 24.25 ATOM 904 CB VAL 182 30.941 15.813 43.8841.00 23.11 ATOM 905 CG1 VAL 182 30.204 15.133 42.738 1.00 23.43 ATOM 906CG2 VAL 182 30.707 17.324 43.852 1.00 22.55 ATOM 907 C VAL 182 30.81913.767 45.329 1.00 26.05 ATOM 908 O VAL 182 31.990 13.404 45.239 1.0026.03 ATOM 909 N CYS 183 29.813 12.920 45.522 1.00 30.03 ATOM 910 CA CYS183 30.051 11.489 45.689 1.00 34.00 ATOM 911 C CYS 183 29.670 10.59644.514 1.00 36.77 ATOM 912 O CYS 183 28.800 10.927 43.711 1.00 37.04ATOM 913 CB CYS 183 29.301 10.976 46.916 1.00 33.01 ATOM 914 SG CYS 18329.491 11.922 48.460 1.00 34.26 ATOM 915 N HIS 184 30.333 9.443 44.4501.00 40.51 ATOM 916 CA HIS 184 30.085 8.433 43.427 1.00 43.09 ATOM 917CB HIS 184 31.392 7.748 43.028 1.00 43.26 ATOM 918 CG HIS 184 32.2408.552 42.097 1.00 44.35 ATOM 919 CD2 HIS 184 33.423 9.183 42.287 1.0044.78 ATOM 920 ND1 HIS 184 31.902 8.761 40.777 1.00 45.33 ATOM 921 CE1HIS 184 32.842 9.483 40.194 1.00 45.93 ATOM 922 NE2 HIS 184 33.777 9.75241.088 1.00 46.19 ATOM 923 C HIS 184 29.141 7.394 44.027 1.00 45.42 ATOM924 O HIS 184 28.935 7.360 45.243 1.00 45.31 ATOM 925 N PRO 185 28.5546.531 43.181 1.00 47.60 ATOM 926 CD PRO 185 28.637 6.523 41.709 1.0048.72 ATOM 927 CA PRO 185 27.632 5.493 43.654 1.00 48.59 ATOM 928 CB PRO185 27.370 4.674 42.394 1.00 48.70 ATOM 929 CG PRO 185 27.411 5.72141.320 1.00 48.86 ATOM 930 C PRO 185 28.231 4.651 44.780 1.00 49.38 ATOM931 O PRO 185 27.577 4.403 45.795 1.00 49.51 ATOM 932 N ASN 186 29.4784.220 44.597 1.00 49.61 ATOM 933 CA ASN 186 30.154 3.407 45.602 1.0050.29 ATOM 934 CB ASN 186 31.594 3.082 45.168 1.00 49.31 ATOM 935 CG ASN186 32.299 4.260 44.507 1.00 47.77 ATOM 936 OD1 ASN 186 32.262 5.38445.012 1.00 47.20 ATOM 937 ND2 ASN 186 32.955 3.993 43.377 1.00 45.72ATOM 938 C ASN 186 30.164 4.072 46.974 1.00 50.98 ATOM 939 O ASN 18629.525 3.592 47.913 1.00 53.09 ATOM 940 N GLY 187 30.885 5.180 47.0861.00 50.22 ATOM 941 CA GLY 187 30.964 5.881 48.353 1.00 47.28 ATOM 942 CGLY 187 32.148 6.822 48.369 1.00 45.22 ATOM 943 O GLY 187 32.458 7.43249.392 1.00 46.04 ATOM 944 N SER 188 32.824 6.927 47.232 1.00 42.88 ATOM945 CA SER 188 33.965 7.821 47.122 1.00 41.34 ATOM 946 CB SER 188 34.8557.415 45.948 1.00 41.68 ATOM 947 OG SER 188 35.413 6.130 46.160 1.0045.75 ATOM 948 C SER 188 33.431 9.230 46.904 1.00 38.80 ATOM 949 O SER188 32.807 9.517 45.884 1.00 37.31 ATOM 950 N CYS 189 33.655 10.09647.883 1.00 36.07 ATOM 951 CA CYS 189 33.202 11.472 47.793 1.00 33.90ATOM 952 C CYS 189 34.416 12.358 47.579 1.00 32.06 ATOM 953 O CYS 18935.459 12.159 48.202 1.00 33.88 ATOM 954 CB CYS 189 32.479 11.883 49.0701.00 34.32 ATOM 955 SG CYS 189 30.963 10.949 49.464 1.00 35.61 ATOM 956N LEU 190 34.280 13.331 46.689 1.00 28.75 ATOM 957 CA LEU 190 35.37714.237 46.387 1.00 26.04 ATOM 958 CB LEU 190 35.644 14.252 44.875 1.0026.05 ATOM 959 CG LEU 190 36.265 13.013 44.216 1.00 27.11 ATOM 960 CD1LEU 190 35.318 11.828 44.314 1.00 28.50 ATOM 961 CD2 LEU 190 36.56913.323 42.753 1.00 27.77 ATOM 962 C LEU 190 35.107 15.659 46.866 1.0024.84 ATOM 963 O LEU 190 33.988 16.159 46.765 1.00 23.97 ATOM 964 N GLN191 36.138 16.297 47.405 1.00 24.09 ATOM 965 CA GLN 191 36.028 17.67747.857 1.00 25.37 ATOM 966 CB GLN 191 36.881 17.902 49.109 1.00 27.00ATOM 967 CG GLN 191 36.405 17.122 50.329 1.00 31.92 ATOM 968 CD GLN 19137.279 17.348 51.546 1.00 34.94 ATOM 969 OE1 GLN 191 38.476 17.06151.527 1.00 38.38 ATOM 970 NE2 GLN 191 36.684 17.862 52.614 1.00 37.18ATOM 971 C GLN 191 36.550 18.534 46.704 1.00 23.81 ATOM 972 O GLN 19137.239 18.024 45.818 1.00 21.41 ATOM 973 N LEU 192 36.222 19.824 46.7051.00 23.17 ATOM 974 CA LEU 192 36.680 20.709 45.639 1.00 22.33 ATOM 975CB LEU 192 36.151 22.131 45.856 1.00 21.16 ATOM 976 CG LEU 192 36.58623.161 44.808 1.00 19.56 ATOM 977 CD1 LEU 192 36.115 22.726 43.425 1.0019.50 ATOM 978 CD2 LEU 192 36.015 24.527 45.166 1.00 21.09 ATOM 979 CLEU 192 38.206 20.719 45.582 1.00 23.46 ATOM 980 O LEU 192 38.801 20.49444.533 1.00 23.60 ATOM 981 N GLU 193 38.844 20.973 46.716 1.00 25.17ATOM 982 CA GLU 193 40.297 20.989 46.751 1.00 27.25 ATOM 983 CB GLU 19340.796 22.297 47.367 1.00 31.24 ATOM 984 CG GLU 193 40.244 23.527 46.6621.00 37.45 ATOM 985 CD GLU 193 41.081 24.769 46.892 1.00 43.41 ATOM 986OE1 GLU 193 41.256 25.170 48.060 1.00 46.60 ATOM 987 OE2 GLU 193 41.56425.348 45.896 1.00 48.13 ATOM 988 C GLU 193 40.789 19.794 47.558 1.0027.24 ATOM 989 O GLU 193 40.398 19.614 48.710 1.00 28.55 ATOM 990 N PRO194 41.663 18.964 46.965 1.00 26.18 ATOM 991 CD PRO 194 42.458 17.98747.737 1.00 26.80 ATOM 992 CA PRO 194 42.200 19.094 45.607 1.00 24.97ATOM 993 CB PRO 194 43.662 18.750 45.806 1.00 26.63 ATOM 994 CG PRO 19443.547 17.564 46.737 1.00 25.86 ATOM 995 C PRO 194 41.558 18.143 44.5951.00 23.91 ATOM 996 O PRO 194 41.868 18.203 43.404 1.00 22.16 ATOM 997 NASP 195 40.672 17.273 45.072 1.00 22.30 ATOM 998 CA ASP 195 40.03716.269 44.225 1.00 21.76 ATOM 999 CB ASP 195 39.029 15.452 45.036 1.0022.60 ATOM 1000 CG ASP 195 39.608 14.946 46.341 1.00 26.35 ATOM 1001 OD1ASP 195 40.763 14.474 46.339 1.00 26.43 ATOM 1002 OD2 ASP 195 38.90215.018 47.369 1.00 29.80 ATOM 1003 C ASP 195 39.365 16.754 42.945 1.0021.71 ATOM 1004 O ASP 195 39.793 16.392 41.850 1.00 23.10 ATOM 1005 NLEU 196 38.308 17.551 43.068 1.00 19.29 ATOM 1006 CA LEU 196 37.60418.027 41.875 1.00 19.93 ATOM 1007 CB LEU 196 36.316 18.753 42.273 1.0019.22 ATOM 1008 CG LEU 196 35.288 17.859 42.971 1.00 21.05 ATOM 1009 CD1LEU 196 34.177 18.719 43.553 1.00 21.19 ATOM 1010 CD2 LEU 196 34.72616.834 41.978 1.00 18.71 ATOM 1011 C LEU 196 38.473 18.933 41.020 1.0018.92 ATOM 1012 O LEU 196 38.405 18.887 39.794 1.00 19.13 ATOM 1013 NTHR 197 39.287 19.757 41.673 1.00 19.32 ATOM 1014 CA THR 197 40.17920.667 40.968 1.00 20.23 ATOM 1015 CB THR 197 40.994 21.530 41.962 1.0021.09 ATOM 1016 OG1 THR 197 40.098 22.333 42.739 1.00 23.68 ATOM 1017CG2 THR 197 41.962 22.444 41.212 1.00 23.82 ATOM 1018 C THR 197 41.13819.855 40.103 1.00 20.96 ATOM 1019 O THR 197 41.408 20.203 38.950 1.0018.55 ATOM 1020 N ASN 198 41.649 18.762 40.660 1.00 20.33 ATOM 1021 CAASN 198 42.566 17.916 39.910 1.00 21.82 ATOM 1022 CB ASN 198 43.14416.820 40.800 1.00 24.76 ATOM 1023 CG ASN 198 44.158 15.971 40.068 1.0029.65 ATOM 1024 OD1 ASN 198 45.283 16.409 39.812 1.00 31.73 ATOM 1025ND2 ASN 198 43.759 14.757 39.701 1.00 31.98 ATOM 1026 C ASN 198 41.87617.272 38.706 1.00 19.19 ATOM 1027 O ASN 198 42.457 17.200 37.624 1.0021.70 ATOM 1028 N VAL 199 40.645 16.800 38.893 1.00 18.96 ATOM 1029 CAVAL 199 39.907 16.180 37.795 1.00 18.37 ATOM 1030 CB VAL 199 38.51615.666 38.257 1.00 19.57 ATOM 1031 CG1 VAL 199 37.680 15.275 37.048 1.0018.46 ATOM 1032 CG2 VAL 199 38.682 14.451 39.187 1.00 20.39 ATOM 1033 CVAL 199 39.715 17.182 36.650 1.00 18.73 ATOM 1034 O VAL 199 39.96516.869 35.485 1.00 15.90 ATOM 1035 N MET 200 39.279 18.392 36.988 1.0018.95 ATOM 1036 CA MET 200 39.063 19.423 35.980 1.00 17.76 ATOM 1037 CBMET 200 38.475 20.680 36.630 1.00 18.24 ATOM 1038 CG MET 200 37.08420.494 37.227 1.00 16.87 ATOM 1039 SD MET 200 35.914 19.807 36.056 1.0020.02 ATOM 1040 CE MET 200 35.798 21.162 34.832 1.00 21.44 ATOM 1041 CMET 200 40.353 19.794 35.244 1.00 16.67 ATOM 1042 O MET 200 40.32820.125 34.060 1.00 17.29 ATOM 1043 N ALA 201 41.478 19.724 35.944 1.0015.31 ATOM 1044 CA ALA 201 42.764 20.088 35.356 1.00 16.45 ATOM 1045 CBALA 201 43.708 20.570 36.458 1.00 14.53 ATOM 1046 C ALA 201 43.47319.014 34.530 1.00 17.34 ATOM 1047 O ALA 201 44.191 19.336 33.580 1.0018.65 ATOM 1048 N THR 202 43.263 17.750 34.875 1.00 14.75 ATOM 1049 CATHR 202 43.963 16.665 34.199 1.00 15.77 ATOM 1050 CB THR 202 44.71715.818 35.230 1.00 16.12 ATOM 1051 OG1 THR 202 43.773 15.222 36.124 1.0017.60 ATOM 1052 CG2 THR 202 45.669 16.694 36.042 1.00 16.30 ATOM 1053 CTHR 202 43.151 15.721 33.322 1.00 17.01 ATOM 1054 O THR 202 43.68015.157 32.364 1.00 17.58 ATOM 1055 N SER 203 41.876 15.531 33.634 1.0016.36 ATOM 1056 CA SER 203 41.070 14.635 32.816 1.00 16.62 ATOM 1057 CBSER 203 39.717 14.379 33.471 1.00 17.45 ATOM 1058 OG SER 203 38.88313.637 32.592 1.00 17.94 ATOM 1059 C SER 203 40.841 15.190 31.411 1.0017.76 ATOM 1060 O SER 203 40.627 16.390 31.231 1.00 16.09 ATOM 1061 NARG 204 40.894 14.305 30.420 1.00 17.37 ATOM 1062 CA ARG 204 40.65614.675 29.029 1.00 18.83 ATOM 1063 CB ARG 204 41.899 14.394 28.175 1.0021.32 ATOM 1064 CG ARG 204 42.806 15.601 27.910 1.00 25.72 ATOM 1065 CDARG 204 42.784 16.603 29.041 1.00 24.96 ATOM 1066 NE ARG 204 44.00917.391 29.117 1.00 25.28 ATOM 1067 CZ ARG 204 44.224 18.329 30.035 1.0025.48 ATOM 1068 NH1 ARG 204 45.366 18.998 30.055 1.00 27.49 ATOM 1069NH2 ARG 204 43.287 18.610 30.928 1.00 26.72 ATOM 1070 C ARG 204 39.47313.859 28.510 1.00 18.41 ATOM 1071 O ARG 204 39.333 13.648 27.306 1.0018.06 ATOM 1072 N LYS 205 38.629 13.394 29.427 1.00 19.07 ATOM 1073 CALYS 205 37.449 12.614 29.058 1.00 19.70 ATOM 1074 CB LYS 205 37.39611.320 29.876 1.00 20.49 ATOM 1075 CG LYS 205 38.655 10.464 29.712 1.0025.63 ATOM 1076 CD LYS 205 38.499 9.071 30.304 1.00 27.27 ATOM 1077 CELYS 205 37.450 8.267 29.552 1.00 32.01 ATOM 1078 NZ LYS 205 37.428 6.84730.001 1.00 36.31 ATOM 1079 C LYS 205 36.181 13.441 29.276 1.00 18.76ATOM 1080 O LYS 205 35.836 13.786 30.412 1.00 16.76 ATOM 1081 N TYR 20635.499 13.750 28.175 1.00 17.94 ATOM 1082 CA TYR 206 34.280 14.56428.187 1.00 18.82 ATOM 1083 CB TYR 206 33.561 14.456 26.834 1.00 17.41ATOM 1084 CG TYR 206 32.581 15.582 26.551 1.00 17.19 ATOM 1085 CD1 TYR206 32.960 16.682 25.782 1.00 17.56 ATOM 1086 CE1 TYR 206 32.068 17.71825.509 1.00 17.54 ATOM 1087 CD2 TYR 206 31.276 15.546 27.049 1.00 18.96ATOM 1088 CE2 TYR 206 30.373 16.581 26.787 1.00 19.27 ATOM 1089 CZ TYR206 30.778 17.666 26.015 1.00 20.83 ATOM 1090 OH TYR 206 29.908 18.71125.768 1.00 21.81 ATOM 1091 C TYR 206 33.298 14.209 29.303 1.00 18.43ATOM 1092 O TYR 206 32.820 15.092 30.016 1.00 18.33 ATOM 1093 N GLU 20732.996 12.922 29.454 1.00 17.90 ATOM 1094 CA GLU 207 32.049 12.49230.479 1.00 18.16 ATOM 1095 CB GLU 207 31.598 11.046 30.224 1.00 20.18ATOM 1096 CG GLU 207 30.791 10.830 28.943 1.00 20.70 ATOM 1097 CD GLU207 29.494 11.633 28.895 1.00 23.77 ATOM 1098 OE1 GLU 207 28.760 11.66129.907 1.00 22.24 ATOM 1099 OE2 GLU 207 29.202 12.226 27.833 1.00 24.84ATOM 1100 C GLU 207 32.548 12.619 31.917 1.00 17.41 ATOM 1101 O GLU 20731.752 12.866 32.821 1.00 16.71 ATOM 1102 N ASP 208 33.848 12.443 32.1451.00 16.59 ATOM 1103 CA ASP 208 34.373 12.560 33.506 1.00 17.48 ATOM1104 CB ASP 208 35.774 11.944 33.617 1.00 19.01 ATOM 1105 CG ASP 20835.779 10.440 33.362 1.00 24.16 ATOM 1106 OD1 ASP 208 34.689 9.83033.331 1.00 26.06 ATOM 1107 OD2 ASP 208 36.875 9.865 33.201 1.00 23.40ATOM 1108 C ASP 208 34.416 14.033 33.906 1.00 16.55 ATOM 1109 O ASP 20834.133 14.389 35.052 1.00 13.04 ATOM 1110 N LEU 209 34.769 14.885 32.9511.00 15.38 ATOM 1111 CA LEU 209 34.822 16.319 33.200 1.00 16.48 ATOM1112 CB LEU 209 35.386 17.048 31.974 1.00 14.57 ATOM 1113 CG LEU 20936.893 16.869 31.731 1.00 14.85 ATOM 1114 CD1 LEU 209 37.298 17.51230.412 1.00 14.52 ATOM 1115 CD2 LEU 209 37.668 17.501 32.880 1.00 14.67ATOM 1116 C LEU 209 33.404 16.803 33.499 1.00 16.80 ATOM 1117 O LEU 20933.192 17.636 34.385 1.00 17.09 ATOM 1118 N LEU 210 32.434 16.258 32.7681.00 15.84 ATOM 1119 CA LEU 210 31.037 16.631 32.955 1.00 15.80 ATOM1120 CB LEU 210 30.160 15.971 31.881 1.00 18.19 ATOM 1121 CG LEU 21028.670 16.336 31.924 1.00 18.57 ATOM 1122 CD1 LEU 210 28.524 17.85031.917 1.00 23.32 ATOM 1123 CD2 LEU 210 27.942 15.731 30.735 1.00 22.22ATOM 1124 C LEU 210 30.530 16.250 34.342 1.00 16.05 ATOM 1125 O LEU 21029.840 17.037 34.998 1.00 16.25 ATOM 1126 N TRP 211 30.869 15.042 34.7841.00 15.85 ATOM 1127 CA TRP 211 30.452 14.556 36.099 1.00 16.79 ATOM1128 CB TRP 211 31.033 13.159 36.362 1.00 19.10 ATOM 1129 CG TRP 21130.687 12.625 37.721 1.00 22.86 ATOM 1130 CD2 TRP 211 31.472 12.74638.916 1.00 24.67 ATOM 1131 CE2 TRP 211 30.727 12.167 39.967 1.00 26.17ATOM 1132 CE3 TRP 211 32.731 13.290 39.199 1.00 25.03 ATOM 1133 CD1 TRP211 29.531 11.991 38.086 1.00 25.13 ATOM 1134 NE1 TRP 211 29.549 11.71439.436 1.00 25.08 ATOM 1135 CZ2 TRP 211 31.202 12.119 41.284 1.00 27.62ATOM 1136 CZ3 TRP 211 33.203 13.241 40.509 1.00 26.84 ATOM 1137 CH2 TRP211 32.439 12.659 41.533 1.00 27.01 ATOM 1138 C TRP 211 30.914 15.50537.208 1.00 15.76 ATOM 1139 O TRP 211 30.139 15.871 38.091 1.00 15.00ATOM 1140 N ALA 212 32.181 15.899 37.158 1.00 16.39 ATOM 1141 CA ALA 21232.739 16.796 38.162 1.00 15.16 ATOM 1142 CB ALA 212 34.256 16.86338.010 1.00 14.42 ATOM 1143 C ALA 212 32.142 18.200 38.063 1.00 15.48ATOM 1144 O ALA 212 31.839 18.826 39.080 1.00 16.14 ATOM 1145 N TRP 21331.982 18.684 36.835 1.00 15.80 ATOM 1146 CA TRP 213 31.436 20.01936.581 1.00 16.29 ATOM 1147 CB TRP 213 31.506 20.331 35.082 1.00 15.34ATOM 1148 CG TRP 213 31.110 21.741 34.725 1.00 15.79 ATOM 1149 CD2 TRP213 29.792 22.209 34.413 1.00 15.16 ATOM 1150 CE2 TRP 213 29.885 23.60134.179 1.00 16.51 ATOM 1151 CE3 TRP 213 28.538 21.588 34.312 1.00 16.54ATOM 1152 CD1 TRP 213 31.929 22.837 34.666 1.00 16.30 ATOM 1153 NE1 TRP213 31.199 23.958 34.338 1.00 15.53 ATOM 1154 CZ2 TRP 213 28.771 24.38233.849 1.00 14.24 ATOM 1155 CZ3 TRP 213 27.432 22.366 33.985 1.00 16.40ATOM 1156 CH2 TRP 213 27.558 23.748 33.756 1.00 15.28 ATOM 1157 C TRP213 29.985 20.138 37.057 1.00 15.56 ATOM 1158 O TRP 213 29.634 21.07037.779 1.00 13.86 ATOM 1159 N GLU 214 29.149 19.192 36.639 1.00 15.67ATOM 1160 CA GLU 214 27.741 19.178 37.019 1.00 15.17 ATOM 1161 CB GLU214 26.982 18.139 36.187 1.00 17.45 ATOM 1162 CG GLU 214 25.473 18.10136.444 1.00 19.85 ATOM 1163 CD GLU 214 24.785 19.410 36.087 1.00 23.48ATOM 1164 OE1 GLU 214 25.012 19.911 34.968 1.00 25.84 ATOM 1165 OE2 GLU214 24.012 19.938 36.918 1.00 26.74 ATOM 1166 C GLU 214 27.576 18.85738.499 1.00 16.13 ATOM 1167 O GLU 214 26.791 19.497 39.206 1.00 15.22ATOM 1168 N GLY 215 28.321 17.858 38.962 1.00 17.03 ATOM 1169 CA GLY 21528.244 17.452 40.352 1.00 17.32 ATOM 1170 C GLY 215 28.530 18.576 41.3281.00 18.14 ATOM 1171 O GLY 215 27.812 18.750 42.312 1.00 18.29 ATOM 1172N TRP 216 29.584 19.340 41.067 1.00 17.32 ATOM 1173 CA TRP 216 29.94020.440 41.952 1.00 16.83 ATOM 1174 CB TRP 216 31.209 21.145 41.459 1.0015.21 ATOM 1175 CG TRP 216 31.605 22.288 42.345 1.00 16.54 ATOM 1176 CD2TRP 216 31.879 22.226 43.751 1.00 17.16 ATOM 1177 CE2 TRP 216 32.14123.544 44.185 1.00 16.95 ATOM 1178 CE3 TRP 216 31.924 21.182 44.689 1.0017.45 ATOM 1179 CD1 TRP 216 31.716 23.603 41.991 1.00 14.98 ATOM 1180NE1 TRP 216 32.036 24.364 43.092 1.00 17.71 ATOM 1181 CZ2 TRP 216 32.44423.849 45.518 1.00 16.83 ATOM 1182 CZ3 TRP 216 32.225 21.487 46.016 1.0017.47 ATOM 1183 CH2 TRP 216 32.480 22.811 46.415 1.00 18.90 ATOM 1184 CTRP 216 28.796 21.441 42.028 1.00 15.17 ATOM 1185 O TRP 216 28.42221.900 43.105 1.00 17.84 ATOM 1186 N ARG 217 28.234 21.779 40.878 1.0015.34 ATOM 1187 CA ARG 217 27.136 22.724 40.854 1.00 16.45 ATOM 1188 CBARG 217 26.868 23.142 39.407 1.00 13.86 ATOM 1189 CG ARG 217 27.98124.074 38.923 1.00 16.46 ATOM 1190 CD ARG 217 28.079 24.265 37.416 1.0015.80 ATOM 1191 NE ARG 217 29.144 25.230 37.139 1.00 15.22 ATOM 1192 CZARG 217 30.444 24.974 37.269 1.00 15.55 ATOM 1193 NH1 ARG 217 31.33325.920 37.009 1.00 16.82 ATOM 1194 NH2 ARG 217 30.860 23.766 37.632 1.0015.71 ATOM 1195 C ARG 217 25.903 22.145 41.547 1.00 17.65 ATOM 1196 OARG 217 25.202 22.858 42.263 1.00 17.39 ATOM 1197 N ASP 218 25.66120.848 41.374 1.00 18.73 ATOM 1198 CA ASP 218 24.513 20.215 42.021 1.0020.64 ATOM 1199 CB ASP 218 24.388 18.745 41.612 1.00 22.06 ATOM 1200 CGASP 218 24.011 18.570 40.161 1.00 24.98 ATOM 1201 OD1 ASP 218 23.55519.550 39.537 1.00 24.48 ATOM 1202 OD2 ASP 218 24.158 17.437 39.648 1.0026.98 ATOM 1203 C ASP 218 24.610 20.272 43.545 1.00 19.56 ATOM 1204 OASP 218 23.619 20.520 44.227 1.00 19.81 ATOM 1205 N LYS 219 25.80720.043 44.077 1.00 20.45 ATOM 1206 CA LYS 219 26.003 20.031 45.525 1.0021.29 ATOM 1207 CB LYS 219 27.121 19.051 45.890 1.00 21.65 ATOM 1208 CGLYS 219 26.895 17.629 45.373 1.00 25.13 ATOM 1209 CD LYS 219 25.54317.058 45.813 1.00 28.05 ATOM 1210 CE LYS 219 25.447 16.918 47.328 1.0029.00 ATOM 1211 NZ LYS 219 26.538 16.060 47.868 1.00 30.61 ATOM 1212 CLYS 219 26.279 21.378 46.183 1.00 21.42 ATOM 1213 O LYS 219 25.71921.678 47.236 1.00 24.45 ATOM 1214 N ALA 220 27.143 22.188 45.579 1.0021.30 ATOM 1215 CA ALA 220 27.468 23.492 46.153 1.00 20.70 ATOM 1216 CBALA 220 28.902 23.878 45.799 1.00 20.00 ATOM 1217 C ALA 220 26.50424.578 45.685 1.00 19.99 ATOM 1218 O ALA 220 25.902 25.276 46.501 1.0021.16 ATOM 1219 N GLY 221 26.358 24.711 44.370 1.00 18.26 ATOM 1220 CAGLY 221 25.476 25.722 43.819 1.00 18.25 ATOM 1221 C GLY 221 24.02825.653 44.275 1.00 19.99 ATOM 1222 O GLY 221 23.496 26.628 44.808 1.0019.79 ATOM 1223 N ARG 222 23.378 24.512 44.067 1.00 17.04 ATOM 1224 CAARG 222 21.982 24.377 44.467 1.00 19.12 ATOM 1225 CB ARG 222 21.44322.989 44.091 1.00 17.89 ATOM 1226 CG ARG 222 21.397 22.730 42.592 1.0019.59 ATOM 1227 CD ARG 222 20.767 21.367 42.283 1.00 24.35 ATOM 1228 NEARG 222 20.643 21.152 40.845 1.00 30.28 ATOM 1229 CZ ARG 222 20.35319.984 40.276 1.00 33.18 ATOM 1230 NH1 ARG 222 20.150 18.901 41.021 1.0031.51 ATOM 1231 NH2 ARG 222 20.281 19.896 38.954 1.00 33.98 ATOM 1232 CARG 222 21.800 24.611 45.965 1.00 18.43 ATOM 1233 O ARG 222 20.80325.193 46.385 1.00 19.58 ATOM 1234 N ALA 223 22.771 24.171 46.757 1.0016.28 ATOM 1235 CA ALA 223 22.715 24.317 48.210 1.00 19.92 ATOM 1236 CBALA 223 23.824 23.483 48.859 1.00 19.14 ATOM 1237 C ALA 223 22.81525.767 48.681 1.00 19.46 ATOM 1238 O ALA 223 22.435 26.089 49.806 1.0022.30 ATOM 1239 N ILE 224 23.329 26.646 47.833 1.00 18.66 ATOM 1240 CAILE 224 23.457 28.045 48.222 1.00 17.34 ATOM 1241 CB ILE 224 24.67928.705 47.522 1.00 16.89 ATOM 1242 CG2 ILE 224 24.729 30.202 47.819 1.0015.15 ATOM 1243 CG1 ILE 224 25.966 28.023 47.993 1.00 14.94 ATOM 1244CD1 ILE 224 26.218 28.141 49.488 1.00 15.97 ATOM 1245 C ILE 224 22.18728.830 47.897 1.00 17.43 ATOM 1246 O ILE 224 21.883 29.825 48.550 1.0018.29 ATOM 1247 N LEU 225 21.435 28.360 46.907 1.00 16.61 ATOM 1248 CALEU 225 20.217 29.044 46.480 1.00 18.87 ATOM 1249 CB LEU 225 19.51128.233 45.386 1.00 17.28 ATOM 1250 CG LEU 225 28.251 28.880 44.803 1.0017.62 ATOM 1251 CD1 LEU 225 18.591 30.250 44.247 1.00 15.98 ATOM 1252CD2 LEU 225 17.664 27.993 43.712 1.00 17.36 ATOM 1253 C LEU 225 19.20829.387 47.582 1.00 20.30 ATOM 1254 O LEU 225 18.573 30.440 47.529 1.0021.05 ATOM 1255 N GLN 226 19.054 28.522 48.582 1.00 20.59 ATOM 1256 CAGLN 226 18.086 28.812 49.635 1.00 20.98 ATOM 1257 CB GLN 226 17.88727.602 50.554 1.00 22.39 ATOM 1258 CG GLN 226 19.098 27.206 51.373 1.0022.59 ATOM 1259 CD GLN 226 18.743 26.255 52.506 1.00 28.86 ATOM 1260 OE1GLN 226 19.401 25.236 52.708 1.00 29.99 ATOM 1261 NE2 GLN 226 17.70226.594 53.259 1.00 30.07 ATOM 1262 C GLN 226 18.460 30.027 50.476 1.0020.99 ATOM 1263 O GLN 226 17.594 30.624 51.113 1.00 20.68 ATOM 1264 NPHE 227 19.738 30.402 50.472 1.00 17.78 ATOM 1265 CA PHE 227 20.18831.548 51.261 1.00 18.81 ATOM 1266 CE PHE 227 21.555 31.278 51.901 1.0018.57 ATOM 1267 CG PHE 227 21.626 30.016 52.709 1.00 20.93 ATOM 1268 CD1PHE 227 22.241 28.881 52.191 1.00 19.23 ATOM 1269 CD2 PHE 227 21.10629.970 53.998 1.00 19.89 ATOM 1270 CE1 PHE 227 22.340 27.720 52.945 1.0020.37 ATOM 1271 CE2 PHE 227 21.198 28.812 54.763 1.00 20.86 ATOM 1272 CZPHE 227 21.818 27.683 54.236 1.00 21.52 ATOM 1273 C PHE 227 20.32032.875 50.515 1.00 18.52 ATOM 1274 O PHE 227 20.150 33.936 51.116 1.0018.03 ATOM 1275 N TYR 228 20.631 32.824 49.220 1.00 17.84 ATOM 1276 CATYR 228 20.870 34.046 48.458 1.00 15.89 ATOM 1277 CB TYR 228 21.26733.716 47.013 1.00 14.37 ATOM 1278 CG TYR 228 22.396 34.599 46.526 1.0013.39 ATOM 1279 CD1 TYR 228 23.678 34.485 47.068 1.00 11.77 ATOM 1280CE1 TYR 228 24.720 35.322 46.653 1.00 12.65 ATOM 1281 CD2 TYR 228 22.17835.573 45.555 1.00 14.08 ATOM 1282 CE2 TYR 228 23.207 36.420 45.134 1.0013.53 ATOM 1283 CZ TYR 228 24.472 36.289 45.685 1.00 24.24 ATOM 1284 OHTYR 228 25.484 37.127 45.274 1.00 15.11 ATOM 1285 C TYR 228 19.81735.146 48.437 1.00 16.77 ATOM 1286 O TYR 228 20.143 36.313 48.645 1.0016.17 ATOM 1287 N PRO 229 18.546 34.805 48.173 1.00 16.14 ATOM 1288 CDPRO 229 17.939 33.525 47.766 1.00 16.20 ATOM 1289 CA PRO 229 17.55635.887 48.156 1.00 16.22 ATOM 1290 CB PRO 229 16.240 35.150 47.888 1.0016.46 ATOM 1291 CG PRO 229 16.688 33.982 47.027 1.00 16.36 ATOM 1292 CPRO 229 17.525 36.702 49.451 1.00 16.67 ATOM 1293 O PRO 229 17.39537.924 49.414 1.00 18.90 ATOM 1294 N LYS 230 17.655 36.030 50.590 1.0017.12 ATOM 1295 CA LYS 230 17.629 36.717 51.881 1.00 18.28 ATOM 1296 CBLYS 230 17.459 35.711 53.019 1.00 20.03 ATOM 1297 CG LYS 230 16.96836.337 54.314 1.00 24.93 ATOM 1298 CD LYS 230 15.626 37.010 54.076 1.0029.71 ATOM 1299 CE LYS 230 14.991 37.481 55.356 1.00 33.08 ATOM 1300 NZLYS 230 13.687 38.138 55.078 1.00 33.19 ATOM 1301 C LYS 230 18.90937.525 52.090 1.00 17.96 ATOM 1302 O LYS 230 18.886 38.617 52.662 1.0015.33 ATOM 1303 N TYR 231 20.022 36.971 51.627 1.00 16.71 ATOM 1304 CATYR 231 21.314 37.638 51.715 1.00 16.94 ATOM 1305 CB TYR 231 22.38336.730 51.107 1.00 14.95 ATOM 1306 CG TYR 231 23.567 37.445 50.490 1.0013.63 ATOM 1307 CD1 TYR 231 24.576 37.988 51.286 1.00 13.32 ATOM 1308CE1 TYR 231 25.693 38.608 50.715 1.00 14.67 ATOM 1309 CD2 TYR 231 23.69437.543 49.101 1.00 14.54 ATOM 1310 CE2 TYR 231 24.802 38.162 48.518 1.0013.31 ATOM 1311 CZ TYR 231 25.797 38.688 49.329 1.00 12.39 ATOM 1312 OHTYR 231 26.899 39.279 48.764 1.00 13.70 ATOM 1313 C TYR 231 21.25138.961 50.949 1.00 14.98 ATOM 1314 O TYR 231 21.702 39.997 51.434 1.0014.92 ATOM 1315 N VAL 232 20.695 38.910 49.742 1.00 16.25 ATOM 1316 CAVAL 232 20.568 40.091 48.888 1.00 15.73 ATOM 1317 CB VAL 232 19.97839.693 47.511 1.00 16.32 ATOM 1318 CG1 VAL 232 19.518 40.922 46.744 1.0014.95 ATOM 1319 CG2 VAL 232 21.041 38.931 46.706 1.00 14.49 ATOM 1320 CVAL 232 19.705 41.168 49.546 1.00 17.00 ATOM 1321 O VAL 232 20.04442.359 49.532 1.00 14.95 ATOM 1322 N GLU 233 18.596 40.742 50.136 1.0016.77 ATOM 1323 CA GLU 233 17.695 41.670 50.802 1.00 18.55 ATOM 1324 CBGLU 233 16.459 40.919 51.315 1.00 20.59 ATOM 1325 CG GLU 233 15.55441.728 52.234 1.00 27.30 ATOM 1326 CD GLU 233 14.310 40.956 52.658 1.0032.53 ATOM 1327 OE1 GLU 233 14.424 39.751 52.977 1.00 32.64 ATOM 1328OE2 GLU 233 13.217 41.561 52.679 1.00 38.43 ATOM 1329 C GLU 233 18.41342.355 51.959 1.00 17.80 ATOM 1330 O GLU 233 18.380 43.576 52.081 1.0017.11 ATOM 1331 N LEU 234 19.084 41.566 52.791 1.00 17.72 ATOM 1332 CALEU 234 19.782 42.107 53.951 1.00 17.47 ATOM 1333 CB LEU 234 20.16140.971 54.906 1.00 17.40 ATOM 1334 CG LEU 234 18.941 40.262 55.503 1.0022.59 ATOM 1335 CD1 LEU 234 19.386 39.093 56.366 1.00 22.34 ATOM 1336CD2 LEU 234 18.119 41.256 56.319 1.00 22.15 ATOM 1337 C LEU 234 21.00642.963 53.638 1.00 17.17 ATOM 1338 O LEU 234 21.205 43.995 54.273 1.0016.30 ATOM 1339 N ILE 235 21.823 42.560 52.666 1.00 14.58 ATOM 1340 CAILE 235 23.000 43.363 52.355 1.00 14.01 ATOM 1341 CB ILE 235 24.02342.592 51.472 1.00 13.57 ATOM 1342 CG2 ILE 235 23.462 42.349 50.074 1.0012.52 ATOM 1343 CG1 ILE 235 25.331 43.389 51.395 1.00 11.74 ATOM 1344CD1 ILE 235 26.469 42.632 50.735 1.00 11.93 ATOM 1345 C ILE 235 22.56344.661 51.679 1.00 14.36 ATOM 1346 O ILE 235 23.193 45.705 51.857 1.0013.51 ATOM 1347 N ASN 236 21.474 44.600 50.916 1.00 14.39 ATOM 1348 CAASN 236 20.951 45.798 50.261 1.00 15.23 ATOM 1349 CB ASN 236 19.83745.448 49.264 1.00 15.19 ATOM 1350 CG ASN 236 20.365 45.201 47.862 1.0015.72 ATOM 1351 OD1 ASN 236 21.519 45.501 47.560 1.00 15.27 ATOM 1352ND2 ASN 236 19.512 44.667 46.992 1.00 18.17 ATOM 1353 C ASN 236 20.39446.751 51.322 1.00 15.66 ATOM 1354 O ASN 236 20.570 47.964 51.231 1.0016.15 ATOM 1355 N GLN 237 19.721 46.190 52.322 1.00 17.57 ATOM 1356 CAGLN 237 19.146 46.989 53.404 1.00 18.43 ATOM 1357 CB GLN 237 18.39146.090 54.391 1.00 19.68 ATOM 1358 CG GLN 237 17.537 46.858 55.391 1.0022.74 ATOM 1359 CD GLN 237 16.845 45.947 56.397 1.00 25.62 ATOM 1360 OE1GLN 237 16.460 44.821 56.073 1.00 25.13 ATOM 1361 NE2 GLN 237 16.66746.441 57.620 1.00 25.08 ATOM 1362 C GLN 237 20.261 47.727 54.139 1.0017.44 ATOM 1363 O GLN 237 20.158 48.924 54.402 1.00 17.22 ATOM 1364 NALA 238 21.323 47.003 54.478 1.00 15.64 ATOM 1365 CA ALA 238 22.46047.604 55.162 1.00 16.63 ATOM 1366 CB ALA 238 23.530 46.549 55.436 1.0014.09 ATOM 1367 C ALA 238 23.038 48.727 54.303 1.00 16.39 ATOM 1368 OALA 238 23.385 49.790 54.813 1.00 18.77 ATOM 1369 N ALA 239 23.14248.484 52.998 1.00 15.79 ATOM 1370 CA ALA 239 23.672 49.482 52.076 1.0016.70 ATOM 1371 CB ALA 239 23.725 48.921 50.650 1.00 14.56 ATOM 1372 CALA 239 22.827 50.758 52.102 1.00 17.22 ATOM 1373 O ALA 239 23.36951.866 52.172 1.00 14.26 ATOM 1374 N ARG 240 21.505 50.606 52.043 1.0015.36 ATOM 1375 CA ARG 240 20.622 51.774 52.064 1.00 17.46 ATOM 1376 CBARG 240 19.162 51.376 51.793 1.00 15.33 ATOM 1377 CG ARG 240 18.89350.824 50.388 1.00 17.28 ATOM 1378 CD ARG 240 17.393 50.778 50.080 1.0016.93 ATOM 1379 NE ARG 240 16.638 50.067 51.108 1.00 19.77 ATOM 1380 CZARG 240 16.521 48.744 51.180 1.00 22.01 ATOM 1381 NH1 ARG 240 17.10747.966 50.271 1.00 19.52 ATOM 1382 NH2 ARG 240 15.823 48.197 52.169 1.0018.66 ATOM 1383 C ARG 240 20.701 52.506 53.404 1.00 17.66 ATOM 1384 OARG 240 20.569 53.729 53.460 1.00 16.54 ATOM 1385 N LEU 241 20.91651.759 54.482 1.00 17.65 ATOM 1386 CA LEU 241 21.005 52.374 55.800 1.0019.55 ATOM 1387 CB LEU 241 20.827 51.315 56.898 1.00 19.64 ATOM 1388 CGLEU 241 19.413 50.726 57.017 1.00 19.83 ATOM 1389 CD1 LEU 241 19.41649.573 57.999 1.00 20.06 ATOM 1390 CD2 LEU 241 18.434 51.804 57.470 1.0022.50 ATOM 1391 C LEU 241 22.326 53.117 55.973 1.00 19.27 ATOM 1392 OLEU 241 22.548 53.783 56.986 1.00 20.50 ATOM 1393 N ASN 242 23.20253.001 54.980 1.00 16.73 ATOM 1394 CA ASN 242 24.481 53.693 55.021 1.0016.25 ATOM 1395 CB ASN 242 25.636 52.697 54.897 1.00 15.12 ATOM 1396 CGASN 242 25.891 51.952 56.195 1.00 19.42 ATOM 1397 OD1 ASN 242 26.13952.571 57.234 1.00 19.98 ATOM 1398 ND2 ASN 242 25.825 50.622 56.148 1.0018.09 ATOM 1399 C ASN 242 24.572 54.763 53.934 1.00 17.24 ATOM 1400 OASN 242 25.652 55.290 53.655 1.00 17.37 ATOM 1401 N GLY 243 23.42955.066 53.321 1.00 15.75 ATOM 1402 CA GLY 243 23.373 56.099 52.299 1.0016.87 ATOM 1403 C GLY 243 23.543 55.696 50.844 1.00 15.89 ATOM 1404 OGLY 243 23.626 56.565 49.978 1.00 15.97 ATOM 1405 N TYR 244 23.60854.398 50.565 1.00 16.21 ATOM 1406 CA TYR 244 23.764 53.922 49.189 1.0014.57 ATOM 1407 CB TYR 244 24.761 52.757 49.135 1.00 14.48 ATOM 1408 CGTYR 244 26.167 53.146 49.521 1.00 15.74 ATOM 1409 CD1 TYR 244 26.66552.860 50.787 1.00 14.52 ATOM 1410 CE1 TYR 244 27.951 53.250 51.158 1.0016.68 ATOM 1411 CD2 TYR 244 26.989 53.833 48.627 1.00 16.81 ATOM 1412CE2 TYR 244 28.274 54.231 48.988 1.00 16.81 ATOM 1413 CZ TYR 244 28.74753.935 50.255 1.00 16.66 ATOM 1414 OH TYR 244 30.013 54.329 50.619 1.0020.02 ATOM 1415 C TYR 244 22.423 53.462 48.628 1.00 15.50 ATOM 1416 OTYR 244 21.483 53.254 49.385 1.00 17.45 ATOM 1417 N VAL 245 22.32553.308 47.307 1.00 15.80 ATOM 1418 CA VAL 245 21.069 52.854 46.713 1.0015.94 ATOM 1419 CB VAL 245 20.945 53.283 45.227 1.00 19.25 ATOM 1420 CG1VAL 245 20.843 54.804 45.137 1.00 21.35 ATOM 1421 CG2 VAL 245 22.13352.795 44.436 1.00 19.37 ATOM 1422 C VAL 245 20.926 51.335 46.830 1.0015.52 ATOM 1423 O VAL 245 19.810 50.817 46.890 1.00 16.08 ATOM 1424 NASP 246 22.057 50.630 46.871 1.00 12.67 ATOM 1425 CA ASP 246 22.07749.169 47.017 1.00 12.71 ATOM 1426 CB ASP 246 21.487 48.477 45.776 1.0010.13 ATOM 1427 CG ASP 246 22.273 48.765 44.509 1.00 12.08 ATOM 1428 OD1ASP 246 23.483 48.446 44.453 1.00 15.10 ATOM 1429 OD2 ASP 246 21.67649.312 43.561 1.00 15.37 ATOM 1430 C ASP 246 23.507 48.677 47.273 1.0011.44 ATOM 1431 O ASP 246 24.450 49.463 47.236 1.00 12.92 ATOM 1432 NALA 247 23.666 47.381 47.537 1.00 12.55 ATOM 1433 CA ALA 247 24.98646.813 47.819 1.00 12.99 ATOM 1434 CB ALA 247 24.855 45.318 48.148 1.0012.30 ATOM 1435 C ALA 247 26.016 47.011 46.704 1.00 11.82 ATOM 1436 OALA 247 27.204 47.218 46.975 1.00 12.97 ATOM 1437 N GLY 248 25.57046.935 45.453 1.00 10.87 ATOM 1438 CA GLY 248 26.484 47.116 44.335 1.0010.26 ATOM 1439 C GLY 248 27.077 48.512 44.352 1.00 13.13 ATOM 1440 OGLY 248 28.277 48.708 44.134 1.00 13.09 ATOM 1441 N ASP 249 26.21449.490 44.606 1.00 14.71 ATOM 1442 CA ASP 249 26.615 50.894 44.685 1.0015.46 ATOM 1443 CB ASP 249 25.369 51.744 44.977 1.00 15.97 ATOM 1444 CGASP 249 25.671 53.226 45.132 1.00 17.81 ATOM 1445 OD1 ASP 249 26.50353.765 44.373 1.00 16.36 ATOM 1446 OD2 ASP 249 25.040 53.856 46.005 1.0018.13 ATOM 1447 C ASP 249 27.652 51.008 45.804 1.00 15.19 ATOM 1448 OASP 249 28.718 51.598 45.626 1.00 14.88 ATOM 1449 N SER 250 27.34650.418 46.954 1.00 15.48 ATOM 1450 CA SER 250 28.267 50.448 48.083 1.0015.85 ATOM 1451 CB SER 250 27.669 49.667 49.257 1.00 18.56 ATOM 1452 OGSER 250 28.534 49.703 50.376 1.00 19.16 ATOM 1453 C SER 250 29.65049.877 47.723 1.00 15.52 ATOM 1454 O SER 250 30.680 50.479 48.036 1.0013.65 ATOM 1455 N TRP 251 29.676 48.718 47.065 1.00 14.06 ATOM 1456 CATRP 251 30.945 48.093 46.672 1.00 14.44 ATOM 1457 CB TRP 251 30.70046.698 46.082 1.00 13.11 ATOM 1458 CG TRP 251 30.248 45.674 47.075 1.0014.95 ATOM 1459 CD2 TRP 251 30.022 44.282 46.820 1.00 15.48 ATOM 1460CE2 TRP 251 29.626 43.691 48.041 1.00 17.39 ATOM 1461 CE3 TRP 251 30.11743.477 45.676 1.00 12.92 ATOM 1462 CD1 TRP 251 29.985 45.868 48.405 1.0016.16 ATOM 1463 NE1 TRP 251 29.612 44.680 48.992 1.00 16.30 ATOM 1464CZ2 TRP 251 29.323 42.323 48.151 1.00 16.20 ATOM 1465 CZ3 TRP 251 29.81742.120 45.784 1.00 15.52 ATOM 1466 CH2 TRP 251 29.425 41.558 47.014 1.0015.29 ATOM 1467 C TRP 251 31.735 48.923 45.662 1.00 14.40 ATOM 1468 OTRP 251 32.956 49.057 45.776 1.00 11.76 ATOM 1469 N ARG 252 31.04349.471 44.665 1.00 14.90 ATOM 1470 CA ARG 252 31.714 50.272 43.655 1.0013.31 ATOM 1471 CB ARG 252 30.740 50.668 42.528 1.00 14.60 ATOM 1472 CGARG 252 30.243 49.494 41.672 1.00 14.42 ATOM 1473 CD ARG 252 29.47249.970 40.447 1.00 12.08 ATOM 1474 NE ARG 252 28.233 50.687 40.771 1.0013.50 ATOM 1475 CZ ARG 252 27.063 50.107 41.037 1.00 14.82 ATOM 1476 NH1ARG 252 26.002 50.854 41.319 1.00 13.27 ATOM 1477 NH2 ARG 252 26.94248.783 41.011 1.00 13.16 ATOM 1478 C ARG 252 32.337 51.527 44.267 1.0016.12 ATOM 1479 O ARG 252 33.361 52.004 43.787 1.00 14.85 ATOM 1480 NSER 253 31.730 52.050 45.332 1.00 15.54 ATOM 1481 CA SER 253 32.23953.260 45.977 1.00 16.04 ATOM 1482 CB SER 253 31.309 53.703 47.112 1.0016.20 ATOM 1483 OG SER 253 31.590 52.997 48.309 1.00 20.61 ATOM 1484 CSER 253 33.652 53.086 46.527 1.00 14.43 ATOM 1485 O SER 253 34.33954.069 46.789 1.00 14.48 ATOM 1486 N MET 254 34.085 51.840 46.697 1.0014.27 ATOM 1487 CA MET 254 35.429 51.562 47.209 1.00 16.48 ATOM 1488 CBMET 254 35.657 50.051 47.360 1.00 17.80 ATOM 1489 CG MET 254 34.74049.358 48.359 1.00 21.06 ATOM 1490 SD MET 254 35.187 47.614 48.574 1.0031.02 ATOM 1491 CE MET 254 34.226 46.857 47.338 1.00 27.13 ATOM 1492 CMET 254 36.517 52.121 46.298 1.00 15.51 ATOM 1493 O MET 254 37.66652.265 46.714 1.00 16.06 ATOM 1494 N TYR 255 36.163 52.423 45.053 1.0014.88 ATOM 1495 CA TYR 255 37.135 52.956 44.105 1.00 15.20 ATOM 1496 CBTYR 255 36.904 52.360 42.704 1.00 15.30 ATOM 1497 CG TYR 255 37.20650.880 42.631 1.00 13.36 ATOM 1498 CD1 TYR 255 36.245 49.935 42.986 1.0012.66 ATOM 1499 CE1 TYR 255 36.544 48.568 43.000 1.00 13.69 ATOM 1500CD2 TYR 255 38.479 50.427 42.281 1.00 12.94 ATOM 1501 CE2 TYR 255 38.79249.064 42.293 1.00 14.05 ATOM 1502 CZ TYR 255 37.818 48.143 42.659 1.0013.41 ATOM 1503 OH TYR 255 38.129 46.806 42.721 1.00 13.11 ATOM 1504 CTYR 255 37.126 54.479 44.023 1.00 14.46 ATOM 1505 O TYR 255 38.00055.068 43.393 1.00 14.81 ATOM 1506 N GLU 256 36.139 55.111 44.654 1.0015.24 ATOM 1507 CA GLU 256 36.028 56.574 44.642 1.00 16.61 ATOM 1508 CBGLU 256 37.103 57.195 45.539 1.00 17.37 ATOM 1509 CG GLU 256 37.10956.665 46.966 1.00 22.10 ATOM 1510 CD GLU 256 38.044 57.453 47.878 1.0023.83 ATOM 1511 OE1 GLU 256 39.253 57.535 47.579 1.00 26.54 ATOM 1512OE2 GLU 256 37.565 57.988 48.894 1.00 26.05 ATOM 1513 C GLU 256 36.19157.103 43.222 1.00 15.97 ATOM 1514 O GLU 256 36.852 58.114 42.991 1.0016.36 ATOM 1515 N THR 257 35.575 56.413 42.273 1.00 16.18 ATOM 1516 CATHR 257 35.678 56.786 40.872 1.00 17.13 ATOM 1517 CB THR 257 36.62855.824 40.144 1.00 18.70 ATOM 1518 OG1 THR 257 37.905 55.848 40.796 1.0017.37 ATOM 1519 CG2 THR 257 36.789 56.226 38.679 1.00 17.93 ATOM 1520 CTHR 257 34.309 56.761 40.201 1.00 16.00 ATOM 1521 O THR 257 33.81855.707 39.797 1.00 15.27 ATOM 1522 N PRO 258 33.673 57.936 40.077 1.0015.23 ATOM 1523 CD PRO 258 34.141 59.242 40.584 1.00 15.95 ATOM 1524 CAPRO 258 32.349 58.057 39.456 1.00 15.97 ATOM 1525 CB PRO 258 32.12059.569 39.426 1.00 16.42 ATOM 1526 CG PRO 258 32.851 60.041 40.663 1.0016.92 ATOM 1527 C PRO 258 32.254 57.434 38.064 1.00 15.58 ATOM 1528 OPRO 258 31.208 56.909 37.683 1.00 16.29 ATOM 1529 N SER 259 33.34857.487 37.310 1.00 15.31 ATOM 1530 CA SER 259 33.355 56.939 35.953 1.0015.70 ATOM 1531 CB SER 259 34.330 57.740 35.085 1.00 17.61 ATOM 1532 OGSER 259 35.657 57.612 35.573 1.00 18.28 ATOM 1533 C SER 259 33.72855.452 35.884 1.00 14.57 ATOM 1534 O SER 259 33.917 54.913 34.798 1.0013.39 ATOM 1535 N LEU 260 33.810 54.790 37.036 1.00 13.86 ATOM 1536 CALEU 260 34.200 53.376 37.094 1.00 14.52 ATOM 1537 CB LEU 260 33.93652.806 38.497 1.00 14.33 ATOM 1538 CG LEU 260 34.446 51.379 38.763 1.0017.84 ATOM 1539 CD1 LEU 260 35.965 51.348 38.632 1.00 17.38 ATOM 1540CD2 LEU 260 34.033 50.922 40.161 1.00 17.16 ATOM 1541 C LEU 260 33.57752.437 36.056 1.00 13.87 ATOM 1542 O LEU 260 34.299 51.777 35.311 1.009.84 ATOM 1543 N GLU 261 32.248 52.363 36.003 1.00 13.07 ATOM 1544 CAGLU 261 31.607 51.448 35.061 1.00 14.77 ATOM 1545 CB GLU 261 30.07951.514 35.191 1.00 12.37 ATOM 1546 CG GLU 261 29.591 51.176 36.596 1.0015.59 ATOM 1547 CD GLU 261 28.174 50.633 36.623 1.00 17.28 ATOM 1548 OE1GLU 261 27.524 50.604 35.560 1.00 21.19 ATOM 1549 OE2 GLU 261 27.71450.234 37.712 1.00 18.05 ATOM 1550 C GLU 261 32.030 51.664 33.618 1.0014.11 ATOM 1551 O GLU 261 32.295 50.704 32.895 1.00 14.05 ATOM 1552 NGLN 262 32.108 52.919 33.200 1.00 15.79 ATOM 1553 CA GLN 262 32.52253.232 31.839 1.00 16.53 ATOM 1554 CB GLN 262 32.280 54.712 31.547 1.0021.41 ATOM 1555 CG GLN 262 30.809 55.095 31.459 1.00 27.97 ATOM 1556 CDGLN 262 30.587 56.587 31.641 1.00 32.44 ATOM 1557 OE1 GLN 262 29.65557.162 31.077 1.00 34.42 ATOM 1558 NE2 GLN 262 31.439 57.220 32.447 1.0033.41 ATOM 1559 C GLN 262 34.001 52.901 31.642 1.00 17.20 ATOM 1560 OGLN 262 34.382 52.314 30.625 1.00 15.46 ATOM 1561 N ASP 263 34.83053.280 32.612 1.00 16.67 ATOM 1562 CA ASP 263 36.263 53.011 32.524 1.0015.94 ATOM 1563 CB ASP 263 36.998 53.485 33.781 1.00 19.14 ATOM 1564 CGASP 263 37.032 54.998 33.914 1.00 22.47 ATOM 1565 OD1 ASP 263 37.01655.698 32.878 1.00 21.52 ATOM 1566 OD2 ASP 263 37.097 55.486 35.060 1.0022.10 ATOM 1567 C ASP 263 36.535 51.519 32.346 1.00 16.31 ATOM 1568 OASP 263 37.341 51.121 31.507 1.00 17.06 ATOM 1569 N LEU 264 35.86650.696 33.146 1.00 15.79 ATOM 1570 CA LEU 264 36.056 49.251 33.082 1.0016.11 ATOM 1571 CB LEU 264 35.334 48.585 34.258 1.00 17.87 ATOM 1572 CGLEU 264 35.807 49.044 35.641 1.00 18.11 ATOM 1573 CD1 LEU 264 35.05048.285 36.717 1.00 19.50 ATOM 1574 CD2 LEU 264 37.303 48.819 35.781 1.0019.36 ATOM 1575 C LEU 264 35.567 48.667 31.757 1.00 16.10 ATOM 1576 OLEU 264 36.175 47.746 31.215 1.00 14.50 ATOM 1577 N GLU 265 34.46849.206 31.240 1.00 17.12 ATOM 1578 CA GLU 265 33.911 48.745 29.970 1.0018.85 ATOM 1579 CB GLU 265 32.571 49.440 29.708 1.00 21.26 ATOM 1580 CGGLU 265 31.924 49.123 28.364 1.00 27.69 ATOM 1581 CD GLU 265 31.61747.648 28.189 1.00 34.09 ATOM 1582 OE1 GLU 265 31.001 47.050 29.100 1.0036.70 ATOM 1583 OE2 GLU 265 31.984 47.087 27.134 1.00 37.08 ATOM 1584 CGLU 265 34.890 49.034 28.830 1.00 19.85 ATOM 1585 O GLU 265 35.07748.207 27.935 1.00 19.78 ATOM 1586 N ARG 266 35.515 50.210 28.859 1.0017.74 ATOM 1587 CA ARG 266 36.475 50.567 27.822 1.00 17.75 ATOM 1588 CBARG 266 36.920 52.026 27.970 1.00 20.40 ATOM 1589 CG ARG 266 35.88553.041 27.507 1.00 25.02 ATOM 1590 CD ARG 266 36.506 54.424 27.397 1.0028.27 ATOM 1591 NE ARG 266 36.724 55.042 28.701 1.00 34.44 ATOM 1592 CZARG 266 35.776 55.660 29.401 1.00 36.31 ATOM 1593 NH1 ARG 266 34.54155.747 28.920 1.00 36.59 ATOM 1594 NH2 ARG 266 36.061 56.191 30.582 1.0036.92 ATOM 1595 C ARG 266 37.686 49.645 27.894 1.00 16.78 ATOM 1596 OARG 266 38.203 49.206 26.867 1.00 15.67 ATOM 1597 N LEU 267 38.14049.352 29.108 1.00 15.01 ATOM 1598 CA LEU 267 39.280 48.459 29.289 1.0014.82 ATOM 1599 CB LEU 267 39.646 48.362 30.773 1.00 16.36 ATOM 1600 CGLEU 267 40.160 49.672 31.381 1.00 16.60 ATOM 1601 CD1 LEU 267 40.34449.515 32.884 1.00 16.07 ATOM 1602 CD2 LEU 267 41.486 50.064 30.709 1.0015.87 ATOM 1603 C LEU 267 38.932 47.076 28.743 1.00 17.23 ATOM 1604 OLEU 267 39.737 46.439 28.054 1.00 15.82 ATOM 1605 N PHE 268 37.72346.616 29.046 1.00 15.48 ATOM 1606 CA PHE 268 37.286 45.314 28.569 1.0016.55 ATOM 1607 CB PHE 268 35.879 44.994 29.062 1.00 18.24 ATOM 1608 CGPHE 268 35.345 43.707 28.512 1.00 21.70 ATOM 1609 CD1 PHE 268 35.82642.488 28.981 1.00 22.36 ATOM 1610 CD2 PHE 268 34.425 43.711 27.468 1.0021.62 ATOM 1611 CE1 PHE 268 35.403 41.292 28.415 1.00 24.19 ATOM 1612CE2 PHE 268 33.996 42.517 26.894 1.00 23.63 ATOM 1613 CZ PHE 268 34.48941.306 27.371 1.00 22.93 ATOM 1614 C PHE 268 37.291 45.258 27.043 1.0017.17 ATOM 1615 O PHE 268 37.776 44.295 26.445 1.00 15.21 ATOM 1616 NGLN 269 36.739 46.292 26.416 1.00 16.96 ATOM 1617 CA GLN 269 36.67746.361 24.962 1.00 17.31 ATOM 1618 CB GLN 269 35.905 47.606 24.517 1.0019.68 ATOM 1619 CG GLN 269 34.408 47.569 24.831 1.00 24.90 ATOM 1620 CDGLN 269 33.706 46.381 24.198 1.00 28.78 ATOM 1621 OE1 GLN 269 33.93846.057 23.032 1.00 31.92 ATOM 1622 NE2 GLN 269 32.832 45.732 24.960 1.0030.59 ATOM 1623 C GLN 269 38.048 46.354 24.292 1.00 16.49 ATOM 1624 OGLN 269 38.197 45.811 23.207 1.00 15.38 ATOM 1625 N GLU 270 39.04646.960 24.926 1.00 16.98 ATOM 1626 CA GLU 270 40.386 46.992 24.345 1.0020.14 ATOM 1627 CB GLU 270 41.288 47.941 25.129 1.00 23.65 ATOM 1628 CGGLU 270 40.839 49.382 25.073 1.00 30.06 ATOM 1629 CD GLU 270 41.82150.306 25.743 1.00 35.93 ATOM 1630 OE1 GLU 270 42.956 50.432 25.234 1.0040.83 ATOM 1631 OE2 GLU 270 41.465 50.903 26.779 1.00 39.30 ATOM 1632 CGLU 270 41.032 45.614 24.291 1.00 19.09 ATOM 1633 O GLU 270 41.86145.344 23.420 1.00 17.60 ATOM 1634 N LEU 271 40.652 44.745 25.222 1.0017.35 ATOM 1635 CA LEU 271 41.197 43.393 25.269 1.00 18.44 ATOM 1636 CBLEU 271 41.356 42.961 26.726 1.00 20.14 ATOM 1637 CG LEU 271 42.65543.506 27.322 1.00 24.11 ATOM 1638 CD1 LEU 271 42.449 43.927 28.754 1.0026.75 ATOM 1639 CD2 LEU 271 43.731 42.429 27.210 1.00 25.08 ATOM 1640 CLEU 271 40.366 42.366 24.495 1.00 18.59 ATOM 1641 O LEU 271 40.72241.188 24.434 1.00 17.40 ATOM 1642 N GLN 272 39.270 42.818 23.894 1.0018.72 ATOM 1643 CA GLN 272 38.395 41.941 23.117 1.00 21.08 ATOM 1644 CBGLN 272 37.207 42.734 22.565 1.00 22.80 ATOM 1645 CG GLN 272 35.99342.745 23.461 1.00 24.90 ATOM 1646 CD GLN 272 35.383 41.367 23.607 1.0027.57 ATOM 1647 OE1 GLN 272 35.940 40.495 24.274 1.00 28.36 ATOM 1648NE2 GLN 272 34.235 41.161 22.973 1.00 28.83 ATOM 1649 C GLN 272 39.09841.233 21.960 1.00 21.24 ATOM 1650 O GLN 272 39.024 40.010 22.835 1.0023.38 ATOM 1651 N PRO 273 39.783 41.992 21.091 1.00 21.84 ATOM 1652 CDPRO 273 39.893 43.462 21.019 1.00 22.66 ATOM 1653 CA PRO 273 40.47641.364 19.961 1.00 22.92 ATOM 1654 CB PRO 273 41.237 42.531 19.336 1.0023.77 ATOM 1655 CG PRO 273 40.304 43.685 19.570 1.00 21.85 ATOM 1656 CPRO 273 41.398 40.223 20.381 1.00 22.91 ATOM 1657 O PRO 273 41.43239.162 19.745 1.00 23.26 ATOM 1658 N LEU 274 42.142 40.442 21.457 1.0022.09 ATOM 1659 CA LEU 274 43.062 39.433 21.951 1.00 19.44 ATOM 1660 CBLEU 274 43.971 40.044 23.017 1.00 21.98 ATOM 1661 CG LEU 274 45.17539.249 23.520 1.00 26.32 ATOM 1662 CD1 LEU 274 45.869 38.537 22.366 1.0025.68 ATOM 1663 CD2 LEU 274 46.138 40.216 24.215 1.00 26.73 ATOM 1664 CLEU 274 42.294 38.234 22.511 1.00 18.52 ATOM 1665 O LEU 274 42.60737.087 22.186 1.00 16.12 ATOM 1666 N TYR 275 41.286 38.487 23.345 1.0015.05 ATOM 1667 CA TYR 275 40.520 37.376 23.897 1.00 16.26 ATOM 1668 CBTYR 275 39.462 37.844 24.898 1.00 14.51 ATOM 1669 CG TYR 275 38.65536.674 25.425 1.00 15.81 ATOM 1670 CD1 TYR 275 39.259 35.687 26.205 1.0014.55 ATOM 1671 CE1 TYR 275 38.550 34.567 26.627 1.00 15.08 ATOM 1672CD2 TYR 275 37.313 36.512 25.082 1.00 15.17 ATOM 1673 CE2 TYR 275 36.59235.394 25.499 1.00 14.87 ATOM 1674 CZ TYR 275 37.217 34.427 26.271 1.0013.90 ATOM 1675 OH TYR 275 36.513 33.326 26.697 1.00 13.75 ATOM 1676 CTYR 275 39.816 36.576 22.801 1.00 14.63 ATOM 1677 O TYR 275 39.85235.346 22.803 1.00 13.73 ATOM 1678 N LEU 276 39.174 37.268 21.865 1.0014.03 ATOM 1679 CA LEU 276 38.458 36.567 20.799 1.00 15.37 ATOM 1680 CBLEU 276 37.718 37.563 19.906 1.00 15.87 ATOM 1681 CG LEU 276 36.57038.318 20.588 1.00 18.77 ATOM 1682 CD1 LEU 276 35.991 39.340 19.620 1.0017.96 ATOM 1683 CD2 LEU 276 35.494 37.336 21.039 1.00 19.76 ATOM 1684 CLEU 276 39.381 35.691 19.960 1.00 15.77 ATOM 1685 O LEU 276 38.98634.612 19.513 1.00 15.97 ATOM 1686 N ASN 277 40.609 36.151 19.740 1.0013.92 ATOM 1687 CA ASN 277 41.558 35.367 18.965 1.00 14.44 ATOM 1688 CBASN 277 42.734 36.239 18.528 1.00 14.75 ATOM 1689 CG ASN 277 42.46336.954 17.219 1.00 17.20 ATOM 1690 OD1 ASN 277 42.442 36.330 16.157 1.0016.39 ATOM 1691 ND2 ASN 277 42.239 38.266 17.288 1.00 16.71 ATOM 1692 CASN 277 42.044 34.158 19.760 1.00 14.54 ATOM 1693 O ASN 277 42.27233.090 19.199 1.00 12.53 ATOM 1694 N LEU 278 42.192 34.319 21.071 1.0012.24 ATOM 1695 CA LEU 278 42.635 33.204 21.900 1.00 13.24 ATOM 1696 CBLEU 278 42.986 33.691 23.311 1.00 12.96 ATOM 1697 CG LEU 278 43.37832.597 24.310 1.00 12.38 ATOM 1698 CD1 LEU 278 44.717 31.969 23.898 1.0012.63 ATOM 1699 CD2 LEU 278 43.484 33.201 25.713 1.00 14.10 ATOM 1700 CLEU 278 41.507 32.173 21.972 1.00 12.49 ATOM 1701 O LEU 278 41.74730.969 21.906 1.00 10.75 ATOM 1702 N HIS 279 40.280 32.669 22.111 1.0012.22 ATOM 1703 CA HIS 279 39.080 31.837 22.190 1.00 13.07 ATOM 1704 CBHIS 279 37.847 32.740 22.333 1.00 11.98 ATOM 1705 CG HIS 279 36.53932.007 22.308 1.00 12.16 ATOM 1706 CD2 HIS 279 35.775 31.586 21.273 1.009.43 ATOM 1707 ND1 HIS 279 35.844 31.678 23.454 1.00 14.66 ATOM 1708 CE1HIS 279 34.707 31.091 23.126 1.00 10.50 ATOM 1709 NE2 HIS 279 34.64131.022 21.808 1.00 16.46 ATOM 1710 C HIS 279 38.946 30.972 20.936 1.0013.49 ATOM 1711 O HIS 279 38.766 29.759 21.026 1.00 14.71 ATOM 1712 NALA 280 39.037 31.603 19.769 1.00 11.17 ATOM 1713 CA ALA 280 38.91830.891 18.501 1.00 12.70 ATOM 1714 CB ALA 280 38.966 31.887 17.342 1.0011.01 ATOM 1715 C ALA 280 40.010 29.828 18.328 1.00 13.11 ATOM 1716 OALA 280 39.752 28.728 17.828 1.00 14.49 ATOM 1717 N TYR 281 41.23130.161 18.734 1.00 14.23 ATOM 1718 CA TYR 281 42.349 29.230 18.624 1.0014.13 ATOM 1719 CB TYR 281 43.658 29.942 18.979 1.00 13.18 ATOM 1720 CGTYR 281 44.863 29.030 19.022 1.00 15.59 ATOM 1721 CD1 TYR 281 45.46528.571 17.849 1.00 16.24 ATOM 1722 CE1 TYR 281 46.565 27.709 17.889 1.0016.63 ATOM 1723 CD2 TYR 281 45.390 28.609 20.239 1.00 14.46 ATOM 1724CE2 TYR 281 46.482 27.753 20.291 1.00 19.39 ATOM 1725 CZ TYR 281 47.06527.305 19.114 1.00 18.64 ATOM 1726 OH TYR 281 48.143 26.448 19.182 1.0019.16 ATOM 1727 C TYR 281 42.142 28.025 19.544 1.00 14.20 ATOM 1728 OTYR 281 42.339 26.876 19.140 1.00 12.95 ATOM 1729 N VAL 282 41.74728.291 20.785 1.00 13.42 ATOM 1730 CA VAL 282 41.514 27.217 21.744 1.0013.04 ATOM 1731 CB VAL 282 41.263 27.790 23.156 1.00 12.69 ATOM 1732 CG1VAL 282 40.806 26.681 24.113 1.00 10.82 ATOM 1733 CG2 VAL 282 42.54428.439 23.674 1.00 11.44 ATOM 1734 C VAL 282 40.328 26.351 21.309 1.0013.40 ATOM 1735 O VAL 282 40.356 25.129 21.451 1.00 12.76 ATOM 1736 NARG 283 39.294 26.989 20.770 1.00 12.27 ATOM 1737 CA ARG 283 38.11226.276 20.301 1.00 12.41 ATOM 1738 CB ARG 283 37.073 27.280 19.788 1.0010.58 ATOM 1739 CG ARG 283 35.801 26.655 19.227 1.00 10.97 ATOM 1740 CDARG 283 34.793 27.732 18.829 1.00 11.14 ATOM 1741 NE ARG 283 35.37428.708 17.911 1.00 12.22 ATOM 1742 CZ ARG 283 34.815 29.873 17.593 1.0014.58 ATOM 1743 NH1 ARG 283 33.647 30.225 18.119 1.00 12.82 ATOM 1744NH2 ARG 283 35.431 30.691 16.744 1.00 13.94 ATOM 1745 C ARG 283 38.49725.290 19.189 1.00 15.02 ATOM 1746 O ARG 283 37.973 24.174 19.121 1.0014.50 ATOM 1747 N ARG 284 39.415 25.705 18.320 1.00 15.37 ATOM 1748 CAARG 284 39.865 24.842 17.231 1.00 16.53 ATOM 1749 CB ARG 284 40.79125.619 16.289 1.00 15.14 ATOM 1750 CG ARG 284 41.532 24.771 15.262 1.0017.18 ATOM 1751 CD ARG 284 40.608 24.186 14.201 1.00 17.98 ATOM 1752 NEARG 284 39.899 25.226 13.458 1.00 17.50 ATOM 1753 CZ ARG 284 39.12124.987 12.406 1.00 20.20 ATOM 1754 NH1 ARG 284 38.505 25.989 11.789 1.0017.52 ATOM 1755 NH2 ARG 284 38.967 23.742 11.963 1.00 18.66 ATOM 1756 CARG 284 40.592 23.615 17.793 1.00 17.62 ATOM 1757 O ARG 284 40.36922.490 17.340 1.00 16.82 ATOM 1758 N ALA 285 41.456 23.838 18.782 1.0016.05 ATOM 1759 CA ALA 285 42.213 22.751 19.400 1.00 16.40 ATOM 1760 CBALA 285 43.247 23.312 20.369 1.00 15.81 ATOM 1761 C ALA 285 41.28821.770 20.122 1.00 17.14 ATOM 1762 O ALA 285 41.527 20.560 20.111 1.0015.20 ATOM 1763 N LEU 286 40.237 22.289 20.748 1.00 14.27 ATOM 1764 CALEU 286 39.285 21.428 21.449 1.00 16.86 ATOM 1765 CB LEU 286 38.33122.266 22.301 1.00 15.32 ATOM 1766 CG LEU 286 38.945 22.925 23.542 1.0017.90 ATOM 1767 CD1 LEU 286 37.887 23.785 24.230 1.00 15.75 ATOM 1768CD2 LEU 286 39.470 21.850 24.505 1.00 13.91 ATOM 1769 C LEU 286 38.50220.615 20.422 1.00 17.67 ATOM 1770 O LEU 286 38.172 19.452 20.651 1.0017.19 ATOM 1771 N HIS 287 38.212 21.245 19.286 1.00 16.68 ATOM 1772 CAHIS 287 37.494 20.601 18.196 1.00 18.26 ATOM 1773 CB HIS 287 37.29221.621 17.062 1.00 18.41 ATOM 1774 CG HIS 287 36.648 21.061 15.831 1.0018.72 ATOM 1775 CD2 HIS 287 35.373 21.137 15.380 1.00 17.00 ATOM 1776ND1 HIS 287 37.351 20.359 14.875 1.00 18.34 ATOM 1777 CE1 HIS 287 36.53720.031 13.887 1.00 14.90 ATOM 1778 NE2 HIS 287 35.332 20.492 14.169 1.0016.90 ATOM 1779 C HIS 287 38.361 19.421 17.740 1.00 19.03 ATOM 1780 OHIS 287 37.866 18.327 17.471 1.00 17.36 ATOM 1781 N ARG 288 39.66619.659 17.700 1.00 18.55 ATOM 1782 CA ARG 288 40.649 18.662 17.295 1.0020.61 ATOM 1783 CB ARG 288 42.028 19.320 17.254 1.00 23.74 ATOM 1784 CGARG 288 42.870 19.014 16.032 1.00 30.47 ATOM 1785 CD ARG 288 43.92220.102 15.857 1.00 33.76 ATOM 1786 NE ARG 288 44.686 20.306 17.083 1.0033.81 ATOM 1787 CZ ARG 288 45.113 21.487 17.514 1.00 35.70 ATOM 1788 NH1ARG 288 44.852 22.587 16.817 1.00 35.23 ATOM 1789 NH2 ARG 288 45.80021.569 18.646 1.00 36.87 ATOM 1790 C ARG 288 40.679 17.468 18.253 1.0020.35 ATOM 1791 O ARG 288 40.773 16.314 17.825 1.00 19.01 ATOM 1792 NHIS 289 40.586 17.747 19.550 1.00 19.12 ATOM 1793 CA HIS 289 40.64116.692 20.559 1.00 20.16 ATOM 1794 CB HIS 289 41.247 17.230 21.858 1.0021.21 ATOM 1795 CG HIS 289 41.407 16.184 22.916 1.00 23.81 ATOM 1796 CD2HIS 289 40.632 15.866 23.980 1.00 24.22 ATOM 1797 ND1 HIS 289 42.44015.270 22.909 1.00 26.00 ATOM 1798 CE1 HIS 289 42.292 14.433 23.921 1.0024.08 ATOM 1799 NE2 HIS 289 41.202 14.772 24.585 1.00 27.58 ATOM 1800 CHIS 289 39.327 15.997 20.903 1.00 20.43 ATOM 1801 O HIS 289 39.27614.768 20.978 1.00 20.43 ATOM 1802 N TYR 290 38.270 16.772 21.123 1.0019.15 ATOM 1803 CA TYR 290 36.990 16.194 21.503 1.00 18.20 ATOM 1804 CBTYR 290 36.298 17.098 22.527 1.00 17.79 ATOM 1805 CG TYR 290 37.02517.158 23.859 1.00 17.11 ATOM 1806 CD1 TYR 290 37.840 18.242 24.188 1.0014.34 ATOM 1807 CE1 TYR 290 38.538 18.284 25.403 1.00 15.63 ATOM 1808CD2 TYR 290 36.922 16.111 24.778 1.00 17.43 ATOM 1809 CE2 TYR 290 37.61616.140 25.990 1.00 16.23 ATOM 1810 CZ TYR 290 38.421 17.227 26.296 1.0017.84 ATOM 1811 OH TYR 290 39.117 17.242 27.485 1.00 16.73 ATOM 1812 CTYR 290 36.026 15.842 20.375 1.00 19.53 ATOM 1813 O TYR 290 34.98515.235 20.624 1.00 19.64 ATOM 1814 N GLY 291 36.359 16.224 19.145 1.0019.76 ATOM 1815 CA GLY 291 35.503 15.890 18.017 1.00 19.38 ATOM 1816 CGLY 291 34.552 16.967 17.537 1.00 17.77 ATOM 1817 O GLY 291 34.05817.772 18.317 1.00 16.36 ATOM 1818 N ALA 292 34.279 16.958 16.237 1.0018.00 ATOM 1819 CA ALA 292 33.392 17.939 15.620 1.00 17.85 ATOM 1820 CBALA 292 33.401 17.757 14.094 1.00 18.60 ATOM 1821 C ALA 292 31.96117.871 16.142 1.00 17.75 ATOM 1822 O ALA 292 31.235 18.859 16.095 1.0017.45 ATOM 1823 N GLN 293 31.548 16.705 16.631 1.00 17.76 ATOM 1824 CAGLN 293 30.194 16.544 17.149 1.00 17.65 ATOM 1825 CB GLN 293 29.84515.053 17.276 1.00 19.36 ATOM 1826 CG GLN 293 29.784 14.287 15.947 1.0018.52 ATOM 1827 CD GLN 293 28.512 14.554 15.153 1.00 19.88 ATOM 1828 OE1GLN 293 27.616 15.264 15.606 1.00 19.17 ATOM 1829 NE2 GLN 293 28.42813.973 13.959 1.00 18.08 ATOM 1830 C GLN 293 30.005 17.229 18.503 1.0018.04 ATOM 1831 O GLN 293 28.873 17.405 18.960 1.00 17.48 ATOM 1832 NHIS 294 31.105 17.630 19.137 1.00 16.33 ATOM 1833 CA HIS 294 31.02118.277 20.446 1.00 17.25 ATOM 1834 CB HIS 294 31.784 17.445 21.478 1.0018.66 ATOM 1835 CG HIS 294 31.345 16.014 21.532 1.00 21.25 ATOM 1836 CD2HIS 294 31.954 14.879 21.111 1.00 21.69 ATOM 1837 ND1 HIS 294 30.11415.631 22.021 1.00 22.71 ATOM 1838 CE1 HIS 294 29.982 14.322 21.894 1.0023.73 ATOM 1839 NE2 HIS 294 31.084 13.842 21.344 1.00 24.62 ATOM 1840 CHIS 294 31.519 19.720 20.480 1.00 18.08 ATOM 1841 O HIS 294 31.35620.409 21.488 1.00 19.39 ATOM 1842 N ILE 295 32.122 20.180 19.387 1.0017.59 ATOM 1843 CA ILE 295 32.625 21.552 19.323 1.00 17.39 ATOM 1844 CBILE 295 34.177 21.600 19.335 1.00 18.25 ATOM 1845 CG2 ILE 295 34.65023.050 19.161 1.00 19.44 ATOM 1846 CG1 ILE 295 34.724 20.998 20.634 1.0019.74 ATOM 1847 CD1 ILE 295 34.452 21.827 21.889 1.00 19.50 ATOM 1848 CILE 295 32.150 22.259 18.060 1.00 15.69 ATOM 1849 O ILE 295 32.46721.836 16.948 1.00 16.28 ATOM 1850 N ASN 296 31.381 23.328 18.234 1.0014.98 ATOM 1851 CA ASN 296 30.896 24.112 17.105 1.00 17.48 ATOM 1852 CBASN 296 29.559 24.766 17.450 1.00 18.21 ATOM 1853 CG ASN 296 28.99525.586 16.304 1.00 20.95 ATOM 1854 OD1 ASN 296 29.639 25.764 15.271 1.0018.66 ATOM 1855 ND2 ASN 296 27.786 26.096 16.487 1.00 24.30 ATOM 1856 CASN 296 31.946 25.194 16.840 1.00 17.45 ATOM 1857 O ASN 296 32.13526.091 17.662 1.00 17.17 ATOM 1858 N LEU 297 32.621 25.105 15.697 1.0015.65 ATOM 1859 CA LEU 297 33.670 26.060 15.333 1.00 17.18 ATOM 1860 CBLEU 297 34.357 25.613 14.042 1.00 15.85 ATOM 1861 CG LEU 297 35.20224.338 14.136 1.00 15.74 ATOM 1862 CD1 LEU 297 35.632 23.934 12.741 1.0017.98 ATOM 1863 CD2 LEU 297 36.415 24.565 15.032 1.00 15.34 ATOM 1864 CLEU 297 33.192 27.502 15.182 1.00 17.65 ATOM 1865 O LEU 297 34.00628.418 15.037 1.00 15.95 ATOM 1866 N GLU 298 31.877 27.702 15.214 1.0017.41 ATOM 1867 CA GLU 298 31.311 29.041 15.101 1.00 19.65 ATOM 1868 CBGLU 298 30.460 29.158 13.830 1.00 22.80 ATOM 1869 CG GLU 298 31.16328.684 12.570 1.00 27.54 ATOM 1870 CD GLU 298 30.365 28.977 11.309 1.0031.19 ATOM 1871 OE1 GLU 298 29.148 28.692 11.282 1.00 32.45 ATOM 1872OE2 GLU 298 30.961 29.488 10.342 1.00 32.93 ATOM 1873 C GLU 298 30.44529.366 16.317 1.00 18.22 ATOM 1874 O GLU 298 29.660 30.318 16.294 1.0020.41 ATOM 1875 N GLY 299 30.588 28.581 17.381 1.00 14.98 ATOM 1876 CAGLY 299 29.785 28.818 18.567 1.00 12.99 ATOM 1877 C GLY 299 30.56228.885 19.867 1.00 13.29 ATOM 1878 O GLY 299 31.793 28.909 19.858 1.0013.77 ATOM 1879 N PRO 300 29.864 28.918 21.014 1.00 14.38 ATOM 1880 CDPRO 300 28.397 28.934 21.180 1.00 14.36 ATOM 1881 CA PRO 300 30.53928.982 22.311 1.00 15.04 ATOM 1882 CB PRO 300 29.411 29.353 23.263 1.0015.56 ATOM 1883 CG PRO 300 28.232 28.651 22.661 1.00 16.94 ATOM 1884 CPRO 300 31.217 27.660 22.676 1.00 15.92 ATOM 1885 O PRO 300 30.91426.614 22.100 1.00 14.68 ATOM 1886 N ILE 301 32.131 27.724 23.639 1.0014.52 ATOM 1887 CA ILE 301 32.885 26.560 24.090 1.00 13.49 ATOM 1888 CBILE 301 34.345 26.958 24.416 1.00 14.98 ATOM 1889 CG2 ILE 301 35.10425.763 25.013 1.00 13.64 ATOM 1890 CG1 ILE 301 35.033 27.492 23.158 1.0015.50 ATOM 1891 CD1 ILE 301 36.413 28.053 23.409 1.00 14.09 ATOM 1892 CILE 301 32.275 25.957 25.351 1.00 13.55 ATOM 1893 O ILE 301 31.94626.681 26.288 1.00 9.28 ATOM 1894 N PRO 302 32.097 24.623 25.380 1.0012.22 ATOM 1895 CD PRO 302 32.236 23.667 24.271 1.00 12.83 ATOM 1896 CAPRO 302 31.528 23.966 26.562 1.00 13.66 ATOM 1897 CB PRO 302 31.60822.487 26.200 1.00 12.81 ATOM 1898 CG PRO 302 31.360 22.510 24.733 1.0013.21 ATOM 1899 C PRO 302 32.387 24.325 27.777 1.00 12.95 ATOM 1900 OPRO 302 33.606 24.133 27.772 1.00 10.63 ATOM 1901 N ALA 303 31.73124.835 28.814 1.00 13.88 ATOM 1902 CA ALA 303 32.386 25.304 30.033 1.0013.20 ATOM 1903 CB ALA 303 31.348 25.984 30.917 1.00 12.25 ATOM 1904 CALA 303 33.197 24.326 30.876 1.00 14.39 ATOM 1905 O ALA 303 33.89724.752 31.798 1.00 14.70 ATOM 1906 N HIS 304 33.125 23.032 30.583 1.0013.10 ATOM 1907 CA HIS 304 33.861 22.065 31.391 1.00 15.86 ATOM 1908 CBHIS 304 32.972 20.847 31.673 1.00 14.23 ATOM 1909 CG HIS 304 32.62220.057 30.448 1.00 16.26 ATOM 1910 CD2 HIS 304 32.663 18.725 30.202 1.0014.69 ATOM 1911 ND1 HIS 304 32.138 20.644 29.297 1.00 16.27 ATOM 1912CE1 HIS 304 31.896 19.708 28.396 1.00 16.80 ATOM 1913 NE2 HIS 304 32.20518.534 28.920 1.00 16.57 ATOM 1914 C HIS 304 35.175 21.596 30.772 1.0015.34 ATOM 1915 O HIS 304 35.876 20.776 31.362 1.00 13.95 ATOM 1916 NLEU 305 35.519 22.136 29.605 1.00 14.97 ATOM 1917 CA LEU 305 36.72521.716 28.891 1.00 14.04 ATOM 1918 CB LEU 305 36.383 21.531 27.405 1.0012.83 ATOM 1919 CG LEU 305 35.144 20.690 27.076 1.00 12.75 ATOM 1920 CD1LEU 305 34.877 20.727 25.564 1.00 9.86 ATOM 1921 CD2 LEU 305 35.36719.260 27.559 1.00 10.56 ATOM 1922 C LEU 305 37.947 22.624 28.991 1.0015.10 ATOM 1923 O LEU 305 38.921 22.424 28.262 1.00 16.46 ATOM 1924 NLEU 306 37.925 23.602 29.889 1.00 14.31 ATOM 1925 CA LEU 306 39.04724.527 29.972 1.00 15.42 ATOM 1926 CB LEU 306 38.524 25.972 30.053 1.0013.51 ATOM 1927 CG LEU 306 37.764 26.550 28.848 1.00 14.73 ATOM 1928 CD1LEU 306 38.592 26.362 27.577 1.00 14.30 ATOM 1929 CD2 LEU 306 36.41025.870 28.694 1.00 15.38 ATOM 1930 C LEU 306 40.080 24.275 31.070 1.0015.84 ATOM 1931 O LEU 306 40.937 25.124 31.313 1.00 15.82 ATOM 1932 NGLY 307 39.997 23.120 31.728 1.00 16.01 ATOM 1933 CA GLY 307 40.96722.766 32.758 1.00 15.85 ATOM 1934 C GLY 307 40.780 23.392 34.126 1.0016.19 ATOM 1935 O GLY 307 41.595 23.195 35.035 1.00 14.81 ATOM 1936 NASN 308 39.692 24.137 34.275 1.00 15.62 ATOM 1937 CA ASN 308 39.38124.815 35.522 1.00 15.37 ATOM 1938 CB ASN 308 39.878 26.265 35.430 1.0014.32 ATOM 1939 CG ASN 308 39.391 27.132 36.570 1.00 15.28 ATOM 1940 OD1ASN 308 38.277 27.654 36.530 1.00 15.45 ATOM 1941 ND2 ASN 308 40.22627.292 37.598 1.00 13.64 ATOM 1942 C ASN 308 37.869 24.734 35.769 1.0014.00 ATOM 1943 O ASN 308 37.072 24.858 34.842 1.00 12.08 ATOM 1944 NMET 309 37.486 24.519 37.023 1.00 13.86 ATOM 1945 CA MET 309 36.07724.368 37.390 1.00 14.00 ATOM 1946 CB MET 309 35.951 24.234 38.916 1.0014.12 ATOM 1947 CG MET 309 34.527 24.008 39.414 1.00 15.15 ATOM 1948 SDMET 309 33.787 22.492 38.767 1.00 16.63 ATOM 1949 CE MET 309 34.42821.288 39.947 1.00 16.22 ATOM 1950 C MET 309 35.155 25.478 36.884 1.0014.78 ATOM 1951 O MET 309 33.996 25.220 36.548 1.00 13.18 ATOM 1952 NTRP 310 35.671 26.703 36.812 1.00 11.51 ATOM 1953 CA TRP 310 34.87227.843 36.366 1.00 14.25 ATOM 1954 CB TRP 310 34.970 28.968 37.403 1.0012.20 ATOM 1955 CG TRP 310 34.625 28.480 38.772 1.00 12.52 ATOM 1956 CD2TRP 310 35.538 27.959 39.745 1.00 12.82 ATOM 1957 CE2 TRP 310 34.76427.461 40.817 1.00 13.24 ATOM 1958 CE3 TRP 310 36.937 27.855 39.810 1.0013.78 ATOM 1959 CD1 TRP 310 33.373 28.295 39.283 1.00 11.84 ATOM 1960NE1 TRP 310 33.447 27.681 40.509 1.00 12.66 ATOM 1961 CZ2 TRP 310 35.34026.866 41.948 1.00 12.55 ATOM 1962 CZ3 TRP 310 37.513 27.260 40.934 1.0013.31 ATOM 1963 CH2 TRP 310 36.708 26.773 41.990 1.00 12.52 ATOM 1964 CTRP 310 35.309 28.360 35.001 1.00 13.97 ATOM 1965 O TRP 310 34.77229.348 34.508 1.00 12.98 ATOM 1966 N ALA 311 36.269 27.670 34.388 1.0014.15 ATOM 1967 CA ALA 311 36.799 28.086 33.096 1.00 13.77 ATOM 1968 CBALA 311 35.719 27.964 32.021 1.00 14.05 ATOM 1969 C ALA 311 37.29729.534 33.179 1.00 13.58 ATOM 1970 O ALA 311 37.249 30.263 32.189 1.0013.90 ATOM 1971 N GLN 312 37.761 29.952 34.358 1.00 13.19 ATOM 1972 CAGLN 312 38.247 31.325 34.541 1.00 13.69 ATOM 1973 CB GLN 312 38.08831.770 36.000 1.00 12.28 ATOM 1974 CG GLN 312 38.917 30.995 36.999 1.0014.52 ATOM 1975 CD GLN 312 38.542 31.318 38.433 1.00 17.57 ATOM 1976 OE1GLN 312 37.382 31.187 38.828 1.00 15.61 ATOM 1977 NE2 GLN 312 39.52231.739 39.220 1.00 19.96 ATOM 1978 C GLN 312 39.700 31.485 34.102 1.0013.47 ATOM 1979 O GLN 312 40.137 32.587 33.771 1.00 11.19 ATOM 1980 NTHR 313 40.442 30.382 34.124 1.00 12.33 ATOM 1981 CA THR 313 41.83530.354 33.687 1.00 13.83 ATOM 1982 CB THR 313 42.826 30.403 34.875 1.0016.20 ATOM 1983 OG1 THR 313 42.468 29.425 35.858 1.00 16.40 ATOM 1984CG2 THR 313 42.819 31.789 35.511 1.00 17.20 ATOM 1985 C THR 313 41.96429.040 32.918 1.00 16.52 ATOM 1986 O THR 313 41.415 28.021 33.335 1.0014.73 ATOM 1987 N TRP 314 42.675 29.065 31.795 1.00 14.06 ATOM 1988 CATRP 314 42.788 27.881 30.948 1.00 15.86 ATOM 1989 CB TRP 314 42.31828.216 29.529 1.00 15.32 ATOM 1990 CG TRP 314 40.991 28.934 29.408 1.0013.99 ATOM 1991 CD2 TRP 314 40.457 29.529 28.219 1.00 13.70 ATOM 1992CE2 TRP 314 39.164 30.012 28.534 1.00 14.95 ATOM 1993 CE3 TRP 314 40.94329.698 26.915 1.00 12.93 ATOM 1994 CD1 TRP 314 40.032 29.079 30.372 1.0014.30 ATOM 1995 NE1 TRP 314 38.929 29.725 29.854 1.00 13.72 ATOM 1996CZ2 TRP 314 38.355 30.650 27.592 1.00 13.70 ATOM 1997 CZ3 TRP 314 40.13730.332 25.979 1.00 16.03 ATOM 1998 CH2 TRP 314 38.853 30.800 26.325 1.0016.16 ATOM 1999 C TRP 314 44.171 27.255 30.816 1.00 17.18 ATOM 2000 OTRP 314 44.363 26.402 29.950 1.00 16.26 ATOM 2001 N SER 315 45.12527.655 31.648 1.00 16.81 ATOM 2002 CA SER 315 46.482 27.131 31.514 1.0018.73 ATOM 2003 CB SER 315 47.429 27.840 32.493 1.00 19.48 ATOM 2004 OGSER 315 47.078 27.573 33.834 1.00 23.23 ATOM 2005 C SER 315 46.62825.618 31.658 1.00 17.43 ATOM 2006 O SER 315 47.599 25.043 31.165 1.0016.20 ATOM 2007 N ASN 316 45.669 24.967 32.309 1.00 16.52 ATOM 2008 CAASN 316 45.758 23.526 32.487 1.00 16.72 ATOM 2009 CB ASN 316 44.82723.068 33.617 1.00 16.47 ATOM 2010 CG ASN 316 45.342 23.494 34.991 1.0018.32 ATOM 2011 OD1 ASN 316 46.504 23.262 35.323 1.00 19.09 ATOM 2012ND2 ASN 316 44.484 24.116 35.788 1.00 15.86 ATOM 2013 C ASN 316 45.54022.700 31.219 1.00 17.50 ATOM 2014 O ASN 316 45.834 21.508 31.210 1.0017.87 ATOM 2015 N ILE 317 45.028 23.311 30.150 1.00 17.39 ATOM 2016 CAILE 317 44.869 22.568 28.901 1.00 17.13 ATOM 2017 CB ILE 317 43.47922.759 28.246 1.00 16.82 ATOM 2018 CG2 ILE 317 42.394 22.220 29.170 1.0016.53 ATOM 2019 CG1 ILE 317 43.242 24.230 27.902 1.00 17.65 ATOM 2020CD1 ILE 317 42.036 24.444 27.019 1.00 18.86 ATOM 2021 C ILE 317 45.94723.014 27.915 1.00 18.07 ATOM 2022 O ILE 317 45.793 22.892 26.697 1.0016.69 ATOM 2023 N TYR 318 47.047 23.536 28.454 1.00 18.93 ATOM 2024 CATYR 318 48.155 23.983 27.618 1.00 20.39 ATOM 2025 CB TYR 318 49.33724.421 28.479 1.00 21.07 ATOM 2026 CG TYP 318 50.567 24.757 27.667 1.0023.88 ATOM 2027 CD1 TYR 318 50.635 25.931 26.917 1.00 22.79 ATOM 2028CE1 TYR 318 51.749 26.225 26.138 1.00 25.90 ATOM 2029 CD2 TYR 318 51.65223.879 27.618 1.00 25.81 ATOM 2030 CE2 TYR 318 52.774 24.163 26.841 1.0026.76 ATOM 2031 CZ TYR 318 52.815 25.335 26.105 1.00 27.14 ATOM 2032 OHTYR 318 53.919 25.616 25.338 1.00 27.90 ATOM 2033 C TYR 318 48.60922.861 26.682 1.00 20.54 ATOM 2034 O TYR 318 48.933 23.108 25.525 1.0019.56 ATOM 2035 N ASP 319 48.624 21.634 27.194 1.00 21.68 ATOM 2036 CAASP 319 49.041 20.468 26.415 1.00 24.93 ATOM 2037 CB ASP 319 48.94219.205 27.273 1.00 27.75 ATOM 2038 CG ASP 319 47.532 18.947 27.770 1.0033.89 ATOM 2039 OD1 ASP 319 46.943 19.866 28.377 1.00 37.33 ATOM 2040OD2 ASP 319 47.009 17.829 27.560 1.00 36.71 ATOM 2041 C ASP 319 48.21420.275 25.144 1.00 24.42 ATOM 2042 O ASP 319 48.721 19.790 24.133 1.0024.30 ATOM 2043 N LEU 320 46.940 20.648 25.200 1.00 22.05 ATOM 2044 CALEU 320 46.057 20.502 24.048 1.00 21.65 ATOM 2045 CB LEU 320 44.59420.431 24.503 1.00 21.37 ATOM 2046 CG LEU 320 44.138 19.298 25.429 1.0020.50 ATOM 2047 CD1 LEU 320 42.647 19.458 25.712 1.00 20.57 ATOM 2048CD2 LEU 320 44.414 17.946 24.780 1.00 20.05 ATOM 2049 C LEU 320 46.19021.626 23.023 1.00 20.30 ATOM 2050 O LEU 320 45.750 21.476 21.884 1.0020.89 ATOM 2051 N VAL 321 46.803 22.743 23.411 1.00 18.20 ATOM 2052 CAVAL 321 46.911 23.878 22.497 1.00 17.14 ATOM 2053 CB VAL 321 46.01425.051 22.986 1.00 15.95 ATOM 2054 CG1 VAL 321 44.637 24.529 23.358 1.0016.89 ATOM 2055 CG2 VAL 321 46.648 25.737 24.182 1.00 13.25 ATOM 2056 CVAL 321 48.319 24.420 22.267 1.00 18.07 ATOM 2057 O VAL 321 48.47725.496 21.697 1.00 19.68 ATOM 2058 N VAL 322 49.342 23.689 22.699 1.0020.47 ATOM 2059 CA VAL 322 50.715 24.154 22.516 1.00 23.25 ATOM 2060 CBVAL 322 51.735 23.050 22.893 1.00 25.43 ATOM 2061 CG1 VAL 322 51.48721.801 22.069 1.00 27.69 ATOM 2062 CG2 VAL 322 53.156 23.561 22.680 1.0027.11 ATOM 2063 C VAL 322 50.975 24.620 21.077 1.00 22.80 ATOM 2064 OVAL 322 50.758 23.875 20.123 1.00 23.34 ATOM 2065 N PRO 323 51.43225.874 20.904 1.00 23.14 ATOM 2066 CD PRO 323 51.589 26.917 21.934 1.0021.86 ATOM 2067 CA PRO 323 51.712 26.414 19.566 1.00 24.47 ATOM 2068 CBPRO 323 52.152 27.848 19.855 1.00 23.04 ATOM 2069 CG PRO 323 51.42228.181 21.134 1.00 22.71 ATOM 2070 C PRO 323 52.790 25.620 18.821 1.0026.42 ATOM 2071 O PRO 323 52.615 25.255 17.658 1.00 26.23 ATOM 2072 NPHE 324 53.905 25.359 19.494 1.00 27.57 ATOM 2073 CA PHE 324 54.99624.606 18.885 1.00 28.92 ATOM 2074 CB PHE 324 56.232 25.494 18.707 1.0029.24 ATOM 2075 CG PHE 324 56.003 26.667 17.801 1.00 28.40 ATOM 2076 CD1PHE 324 55.591 27.890 18.314 1.00 28.05 ATOM 2077 CD2 PHE 324 56.15926.538 16.426 1.00 30.34 ATOM 2078 CE1 PHE 324 55.333 28.964 17.473 1.0028.58 ATOM 2079 CE2 PHE 324 55.903 27.605 15.575 1.00 28.99 ATOM 2080 CZPHE 324 55.490 28.823 16.099 1.00 29.77 ATOM 2081 C PHE 324 55.33923.400 19.738 1.00 29.62 ATOM 2082 O PHE 324 56.221 23.460 20.596 1.0027.80 ATOM 2083 N PRO 325 54.633 22.280 19.514 1.00 31.43 ATOM 2084 CDPRO 325 53.589 22.095 18.491 1.00 32.36 ATOM 2085 CA PRO 325 54.85521.042 20.263 1.00 34.46 ATOM 2086 CB PRO 325 53.756 20.118 19.737 1.0033.87 ATOM 2087 CG PRO 325 53.560 20.595 18.336 1.00 33.40 ATOM 2088 CPRO 325 56.257 20.463 20.083 1.00 36.18 ATOM 2089 O PRO 325 56.67719.593 20.849 1.00 37.18 ATOM 2090 N SER 326 56.980 20.947 19.077 1.0037.49 ATOM 2091 CA SER 326 58.337 20.473 18.832 1.00 41.11 ATOM 2092 CBSER 326 58.858 20.989 17.490 1.00 42.68 ATOM 2093 OG SER 326 58.21820.326 16.416 1.00 46.06 ATOM 2094 C SER 326 59.259 20.936 19.949 1.0041.74 ATOM 2095 O SER 326 60.210 20.246 20.300 1.00 42.06 ATOM 2096 NALA 327 58.974 22.113 20.498 1.00 42.81 ATOM 2097 CA ALA 327 59.76722.663 21.591 1.00 44.30 ATOM 2098 CB ALA 327 59.778 24.183 21.516 1.0044.00 ATOM 2099 C ALA 327 59.138 22.200 22.903 1.00 45.75 ATOM 2100 OALA 327 58.246 22.857 23.440 1.00 45.98 ATOM 2101 N PRO 328 59.60121.059 23.439 1.00 46.83 ATOM 2102 CD PRO 328 60.768 20.265 23.013 1.0047.01 ATOM 2103 CA PRO 328 59.051 20.539 24.692 1.00 48.00 ATOM 2104 CBPRO 328 59.746 19.189 24.834 1.00 48.21 ATOM 2105 CG PRO 328 61.10019.469 24.262 1.00 48.04 ATOM 2106 C PRO 328 59.297 21.448 25.890 1.0048.18 ATOM 2107 O PRO 328 60.282 22.187 25.940 1.00 46.83 ATOM 2108 NALA 329 58.381 21.388 26.849 1.00 49.04 ATOM 2109 CA ALA 329 58.48422.185 28.063 1.00 50.15 ATOM 2110 CB ALA 329 57.284 23.123 28.183 1.0050.22 ATOM 2111 C ALA 329 58.521 21.222 29.240 1.00 49.64 ATOM 2112 OALA 329 57.741 20.270 29.293 1.00 49.91 ATOM 2113 N MET 330 59.43221.462 30.177 1.00 49.53 ATOM 2114 CA MET 330 59.547 20.599 31.340 1.0049.53 ATOM 2115 CB MET 330 60.673 21.070 32.257 1.00 51.15 ATOM 2116 CGMET 330 62.029 20.527 31.884 1.00 53.03 ATOM 2117 SD MET 330 63.17120.647 33.253 1.00 57.37 ATOM 2118 CE MET 330 62.679 19.231 34.226 1.0055.84 ATOM 2119 C MET 330 58.262 20.525 32.144 1.00 48.79 ATOM 2120 OMET 330 57.481 21.475 32.183 1.00 49.29 ATOM 2121 N ASP 331 58.04819.381 32.781 1.00 47.29 ATOM 2122 CA ASP 331 56.874 19.182 33.615 1.0045.73 ATOM 2123 CB ASP 331 56.656 17.689 33.862 1.00 47.61 ATOM 2124 CGASP 331 55.342 17.400 34.557 1.00 48.84 ATOM 2125 OD1 ASP 331 54.96218.178 35.459 1.00 49.28 ATOM 2126 OD2 ASP 331 54.698 16.388 34.211 1.0049.53 ATOM 2127 C ASP 331 57.190 19.889 34.932 1.00 43.86 ATOM 2128 OASP 331 57.723 19.279 35.860 1.00 42.31 ATOM 2129 N THR 332 56.87221.178 34.999 1.00 41.74 ATOM 2130 CA THR 332 57.140 21.978 36.191 1.0040.58 ATOM 2131 CB THR 332 56.484 23.371 36.090 1.00 41.27 ATOM 2132 OG1THR 332 56.908 24.016 34.881 1.00 42.14 ATOM 2133 CG2 THR 332 56.89624.236 37.275 1.00 42.66 ATOM 2134 C THR 332 56.669 21.307 37.476 1.0039.17 ATOM 2135 O THR 332 57.411 21.245 38.457 1.00 37.70 ATOM 2136 NTHR 333 55.437 20.807 37.472 1.00 37.74 ATOM 2137 CA THR 333 54.89020.144 38.648 1.00 36.86 ATOM 2138 CB THR 333 53.427 19.719 38.418 1.0037.40 ATOM 2139 OG1 THR 333 52.628 20.882 38.169 1.00 36.62 ATOM 2140CG2 THR 333 52.886 18.984 39.635 1.00 37.24 ATOM 2141 C THR 333 55.72218.914 38.981 1.00 36.88 ATOM 2142 O THR 333 56.088 18.692 40.137 1.0036.19 ATOM 2143 N ALA 334 56.023 18.116 37.960 1.00 36.39 ATOM 2144 CAALA 334 56.826 16.917 38.153 1.00 35.82 ATOM 2145 CB ALA 334 57.01716.187 36.828 1.00 36.09 ATOM 2146 C ALA 334 58.176 17.327 38.725 1.0035.55 ATOM 2147 O ALA 334 58.707 16.666 39.618 1.00 36.24 ATOM 2148 NALA 335 58.723 18.424 38.209 1.00 34.21 ATOM 2149 CA ALA 335 60.00918.923 38.675 1.00 33.61 ATOM 2150 CB ALA 335 60.436 20.128 37.846 1.0033.15 ATOM 2151 C ALA 335 59.901 19.304 40.146 1.00 33.27 ATOM 2152 OALA 335 60.704 18.866 40.965 1.00 31.41 ATOM 2153 N MET 336 58.89420.107 40.482 1.00 34.57 ATOM 2154 CA MET 336 58.688 20.531 41.866 1.0034.78 ATOM 2155 CB MET 336 57.427 21.394 41.975 1.00 32.50 ATOM 2156 CGMET 336 57.541 22.735 41.264 1.00 29.70 ATOM 2157 SD MET 336 56.07423.759 41.452 1.00 28.38 ATOM 2158 CE MET 336 56.194 24.182 43.188 1.0022.94 ATOM 2159 C MET 336 58.578 19.323 42.795 1.00 35.93 ATOM 2160 OMET 336 59.274 19.241 43.810 1.00 35.89 ATOM 2161 N LEU 337 57.70618.384 42.440 1.00 37.76 ATOM 2162 CA LEU 337 57.524 17.178 43.239 1.0040.14 ATOM 2163 CB LEU 337 56.380 16.334 42.666 1.00 40.76 ATOM 2164 CGLEU 337 54.971 16.932 42.725 1.00 41.59 ATOM 2165 CD1 LEU 337 54.02416.102 41.871 1.00 41.83 ATOM 2166 CD2 LEU 337 54.491 16.982 44.171 1.0041.58 ATOM 2167 C LEU 337 58.817 16.365 43.241 1.00 41.26 ATOM 2168 OLEU 337 59.253 15.871 44.283 1.00 41.87 ATOM 2169 N ALA 338 59.43016.242 42.067 1.00 41.93 ATOM 2170 CA ALA 338 60.671 15.490 41.913 1.0042.20 ATOM 2171 CB ALA 338 61.200 15.641 40.495 1.00 43.26 ATOM 2172 CALA 338 61.736 15.922 42.909 1.00 42.52 ATOM 2173 O ALA 338 62.38615.081 43.530 1.00 42.44 ATOM 2174 N GLN 339 61.926 17.230 43.062 1.0042.25 ATOM 2175 CA GLN 339 62.928 17.713 44.001 1.00 41.65 ATOM 2176 CBGLN 339 63.734 18.859 43.394 1.00 42.74 ATOM 2177 CG GLN 339 63.02619.643 42.327 1.00 44.14 ATOM 2178 CD GLN 339 63.993 20.157 41.285 1.0045.56 ATOM 2179 OE1 GLN 339 64.984 20.807 41.613 1.00 47.00 ATOM 2180NE2 GLN 339 63.715 19.862 40.019 1.00 45.62 ATOM 2181 C GLN 339 62.35718.113 45.350 1.00 40.44 ATOM 2182 O GLN 339 62.847 19.031 46.004 1.0041.27 ATOM 2183 N GLY 340 61.312 17.399 45.752 1.00 39.31 ATOM 2184 CAGLY 340 60.678 17.619 47.038 1.00 38.16 ATOM 2185 C GLY 340 60.25719.015 47.451 1.00 35.80 ATOM 2186 O GLY 340 60.453 19.396 48.603 1.0035.38 ATOM 2187 N TRP 341 59.690 19.788 46.533 1.00 34.88 ATOM 2188 CATRP 341 59.229 21.119 46.900 1.00 33.70 ATOM 2189 CB TRP 341 58.80521.916 45.663 1.00 32.35 ATOM 2190 CG TRP 341 59.926 22.667 45.025 1.0032.45 ATOM 2191 CD2 TRP 341 59.992 24.080 44.792 1.00 33.12 ATOM 2192CE2 TRP 341 61.228 24.341 44.163 1.00 33.53 ATOM 2193 CE3 TRP 341 59.12525.151 45.053 1.00 33.17 ATOM 2194 CD1 TRP 341 61.089 22.146 44.544 1.0033.26 ATOM 2195 NE1 TRP 341 61.877 23.143 44.024 1.00 33.74 ATOM 2196CZ2 TRP 341 61.624 25.632 43.788 1.00 33.86 ATOM 2197 CZ3 TRP 341 59.51726.435 44.681 1.00 33.83 ATOM 2198 CH2 TRP 341 60.758 26.663 44.054 1.0033.79 ATOM 2199 C TRP 341 58.035 20.916 47.822 1.00 32.71 ATOM 2200 OTRP 341 57.268 19.968 47.650 1.00 32.15 ATOM 2201 N THR 342 57.89221.790 48.812 1.00 31.61 ATOM 2202 CA THR 342 56.782 21.697 49.754 1.0030.86 ATOM 2203 CB THR 342 57.271 21.368 51.176 1.00 31.36 ATOM 2204 OG1THR 342 58.015 22.481 51.687 1.00 30.07 ATOM 2205 CG2 THR 342 58.15820.128 51.170 1.00 32.63 ATOM 2206 C THR 342 56.072 23.042 49.825 1.0029.61 ATOM 2207 O THR 342 56.577 24.044 49.324 1.00 28.37 ATOM 2208 NPRO 343 54.882 23.078 50.442 1.00 29.45 ATOM 2209 CD PRO 343 54.02421.946 50.843 1.00 27.29 ATOM 2210 CA PRO 343 54.160 24.347 50.552 1.0028.24 ATOM 2211 CB PRO 343 52.937 23.969 51.378 1.00 27.42 ATOM 2212 CGPRO 343 52.646 22.579 50.887 1.00 27.57 ATOM 2213 C PRO 343 55.03625.393 51.247 1.00 28.41 ATOM 2214 O PRO 343 55.105 26.543 50.816 1.0028.24 ATOM 2215 N ARG 344 55.721 24.982 52.311 1.00 29.01 ATOM 2216 CAARG 344 56.588 25.896 53.052 1.00 30.23 ATOM 2217 CB ARG 344 57.20725.183 54.260 1.00 32.72 ATOM 2218 CG ARG 344 57.690 26.117 55.376 1.0038.15 ATOM 2219 CD ARG 344 58.192 25.317 56.580 1.00 41.91 ATOM 2220 NEARG 344 58.217 26.096 57.821 1.00 46.21 ATOM 2221 CZ ARG 344 59.09527.056 58.100 1.00 46.40 ATOM 2222 NH1 ARG 344 59.026 27.700 59.258 1.0046.37 ATOM 2223 NH2 ARG 344 60.046 27.368 57.232 1.00 48.36 ATOM 2224 CARG 344 57.689 26.436 52.140 1.00 29.35 ATOM 2225 O ARG 344 58.01627.620 52.183 1.00 28.16 ATOM 2226 N ARG 345 58.248 25.565 51.304 1.0028.94 ATOM 2227 CA ARG 345 59.302 25.968 50.378 1.00 28.91 ATOM 2228 CBARG 345 59.793 24.764 49.567 1.00 32.39 ATOM 2229 CG ARG 345 61.30424.601 49.543 1.00 38.26 ATOM 2230 CD ARG 345 62.016 25.852 49.048 1.0041.91 ATOM 2231 NE ARG 345 62.441 25.769 47.650 1.00 47.14 ATOM 2232 CZARG 345 63.250 24.830 47.163 1.00 48.30 ATOM 2233 NH1 ARG 345 63.72423.877 47.955 1.00 50.47 ATOM 2234 NH2 ARG 345 63.609 24.858 45.888 1.0048.82 ATOM 2235 C ARG 345 58.771 27.020 49.414 1.00 26.66 ATOM 2236 OARG 345 59.443 28.008 49.117 1.00 25.29 ATOM 2237 N MET 346 57.55826.783 48.925 1.00 24.67 ATOM 2238 CA MET 346 56.909 27.680 47.981 1.0023.82 ATOM 2239 CB MET 346 55.538 27.115 47.593 1.00 22.88 ATOM 2240 CGMET 346 55.631 25.817 46.789 1.00 22.60 ATOM 2241 SD MET 346 54.09924.884 46.702 1.00 23.12 ATOM 2242 CE MET 346 53.193 25.800 45.456 1.0022.77 ATOM 2243 C MET 346 56.776 29.087 48.548 1.00 22.51 ATOM 2244 OMET 346 57.111 30.061 47.877 1.00 22.36 ATOM 2245 N PHE 347 56.29929.198 49.783 1.00 22.71 ATOM 2246 CA PHE 347 56.154 30.512 50.397 1.0023.33 ATOM 2247 CB PHE 347 55.272 30.431 51.650 1.00 21.23 ATOM 2248 CGPHE 347 53.810 30.232 51.344 1.00 20.37 ATOM 2249 CD1 PHE 347 53.28028.957 51.191 1.00 20.90 ATOM 2250 CD2 PHE 347 52.974 31.328 51.156 1.0020.68 ATOM 2251 CE1 PHE 347 51.937 28.775 50.855 1.00 22.83 ATOM 2252CE2 PHE 347 51.633 31.158 50.820 1.00 19.46 ATOM 2253 CZ PHE 347 51.11329.879 50.668 1.00 20.69 ATOM 2254 C PHE 347 57.521 31.109 50.731 1.0024.58 ATOM 2255 O PHE 347 57.698 32.329 50.701 1.00 23.58 ATOM 2256 NLYS 348 58.489 30.248 51.039 1.00 25.53 ATOM 2257 CA LYS 348 59.83830.708 51.349 1.00 25.95 ATOM 2258 CB LYS 348 60.726 29.531 51.772 1.0029.39 ATOM 2259 CG LYS 348 60.529 29.067 53.209 1.00 32.76 ATOM 2260 CDLYS 348 61.020 30.117 54.201 1.00 37.96 ATOM 2261 CE LYS 348 60.99529.590 55.633 1.00 38.41 ATOM 2262 NZ LYS 348 61.587 30.556 56.606 1.0038.93 ATOM 2263 C LYS 348 60.428 31.383 50.115 1.00 25.86 ATOM 2264 OLYS 348 61.081 32.418 50.223 1.00 26.39 ATOM 2265 N GLU 349 60.19730.796 48.941 1.00 25.73 ATOM 2266 CA GLU 349 60.701 31.375 47.696 1.0025.00 ATOM 2267 CB GLU 349 60.425 30.445 46.510 1.00 27.57 ATOM 2268 CGGLU 349 61.252 29.163 46.476 1.00 32.10 ATOM 2269 CD GLU 349 62.75429.418 46.536 1.00 34.82 ATOM 2270 OE1 GLU 349 63.207 30.487 46.066 1.0035.04 ATOM 2271 OE2 GLU 349 63.484 28.538 47.041 1.00 36.16 ATOM 2272 CGLU 349 60.031 32.727 47.446 1.00 24.44 ATOM 2273 O GLU 349 60.67933.684 47.018 1.00 23.97 ATOM 2274 N ALA 350 58.727 32.797 47.702 1.0023.38 ATOM 2275 CA ALA 350 57.985 34.043 47.522 1.00 22.42 ATOM 2276 CBALA 350 56.511 33.829 47.857 1.00 22.54 ATOM 2277 C ALA 350 58.57935.104 48.444 1.00 21.24 ATOM 2278 O ALA 350 58.844 36.233 48.027 1.0021.74 ATOM 2279 N ASP 351 58.787 34.732 49.702 1.00 20.72 ATOM 2280 CAASP 351 59.353 35.652 50.682 1.00 21.66 ATOM 2281 CB ASP 351 59.49934.949 52.037 1.00 23.19 ATOM 2282 CG ASP 351 59.901 35.900 53.150 1.0026.89 ATOM 2283 OD1 ASP 351 59.198 36.914 53.364 1.00 26.58 ATOM 2284OD2 ASP 351 60.921 35.633 53.818 1.00 26.96 ATOM 2285 C ASP 351 60.70836.163 50.198 1.00 22.19 ATOM 2286 O ASP 351 61.051 37.330 50.392 1.0022.86 ATOM 2287 N ASP 352 61.472 35.289 49.548 1.00 23.64 ATOM 2288 CAASP 352 62.787 35.667 49.041 1.00 23.82 ATOM 2289 CB ASP 352 63.55334.430 48.548 1.00 23.91 ATOM 2290 CG ASP 352 64.921 34.780 47.988 1.0026.32 ATOM 2291 OD1 ASP 352 65.096 34.724 46.753 1.00 25.02 ATOM 2292OD2 ASP 352 65.821 35.124 48.786 1.00 28.34 ATOM 2293 C ASP 352 62.68036.688 47.916 1.00 23.50 ATOM 2294 O ASP 352 63.486 37.612 47.836 1.0022.72 ATOM 2295 N PHE 353 61.681 36.534 47.051 1.00 23.52 ATOM 2296 CAPHE 353 61.522 37.475 45.953 1.00 22.24 ATOM 2297 CB PHE 353 60.39737.045 45.001 1.00 21.06 ATOM 2298 CG PHE 353 60.542 37.609 43.607 1.0019.58 ATOM 2299 CD1 PHE 353 60.744 36.767 42.516 1.00 21.35 ATOM 2300CD2 PHE 353 60.528 38.984 43.392 1.00 19.63 ATOM 2301 CE1 PHE 353 60.93537.288 41.230 1.00 19.63 ATOM 2302 CE2 PHE 353 60.718 39.513 42.115 1.0019.63 ATOM 2303 CZ PHE 353 60.923 38.660 41.029 1.00 29.46 ATOM 2304 CPHE 353 61.237 38.870 46.504 1.00 20.90 ATOM 2305 O PHE 353 61.83739.849 46.059 1.00 22.16 ATOM 2306 N PHE 354 60.329 38.968 47.471 1.0020.76 ATOM 2307 CA PHE 354 60.019 40.269 48.057 1.00 20.13 ATOM 2308 CBPHE 354 58.915 40.143 49.115 1.00 20.30 ATOM 2309 CG PHE 354 57.52640.045 48.535 1.00 18.25 ATOM 2310 CD1 PHE 354 56.932 38.805 48.306 1.0017.88 ATOM 2311 CD2 PHE 354 56.826 41.200 48.187 1.00 19.40 ATOM 2312CE1 PHE 354 55.662 38.713 47.738 1.00 17.04 ATOM 2313 CE2 PHE 354 55.54841.123 47.612 1.00 18.88 ATOM 2314 CZ PHE 354 54.968 39.875 47.388 1.0019.24 ATOM 2315 C PHE 354 61.258 40.935 48.671 1.00 21.10 ATOM 2316 OPHE 354 61.517 42.120 48.427 1.00 19.45 ATOM 2317 N THR 355 62.02840.184 49.456 1.00 22.06 ATOM 2318 CA THR 355 63.224 40.748 50.081 1.0024.14 ATOM 2319 CB THR 355 63.849 39.787 51.126 1.00 24.56 ATOM 2320 OG1THR 355 64.083 38.505 50.533 1.00 26.60 ATOM 2321 CG2 THR 355 62.92639.633 52.326 1.00 25.22 ATOM 2322 C THR 355 64.289 41.118 49.055 1.0023.51 ATOM 2323 O THR 355 65.042 42.070 49.257 1.00 25.42 ATOM 2324 NSER 356 64.342 40.386 47.948 1.00 23.09 ATOM 2325 CA SER 356 65.33240.676 46.913 1.00 22.30 ATOM 2326 CB SER 356 65.256 39.642 45.784 1.0023.31 ATOM 2327 OG SER 356 64.163 39.901 44.915 1.00 25.00 ATOM 2328 CSER 356 65.088 42.068 46.345 1.00 22.33 ATOM 2329 O SER 356 66.00542.707 45.824 1.00 22.15 ATOM 2330 N LEU 357 63.846 42.535 46.452 1.0020.54 ATOM 2331 CA LEU 357 63.477 43.855 45.951 1.00 21.18 ATOM 2332 CBLEU 357 62.007 43.874 45.515 1.00 20.21 ATOM 2333 CG LEU 357 61.56742.939 44.386 1.00 22.18 ATOM 2334 CD1 LEU 357 60.089 43.169 44.092 1.0020.93 ATOM 2335 CD2 LEU 357 62.391 43.197 43.140 1.00 19.15 ATOM 2336 CLEU 357 63.687 44.929 47.015 1.00 21.10 ATOM 2337 O LEU 357 63.44846.113 46.769 1.00 21.69 ATOM 2338 N GLY 358 64.133 44.513 48.193 1.0020.78 ATOM 2339 CA GLY 358 64.340 45.465 49.269 1.00 22.52 ATOM 2340 CGLY 358 63.086 45.581 50.120 1.00 23.30 ATOM 2341 O GLY 358 63.05346.339 51.091 1.00 23.76 ATOM 2342 N LEU 359 62.051 44.826 49.754 1.0020.72 ATOM 2343 CA LEU 359 60.792 44.844 50.487 1.00 21.07 ATOM 2344 CBLEU 359 59.667 44.293 49.604 1.00 17.66 ATOM 2345 CG LEU 359 59.41745.174 48.371 1.00 19.03 ATOM 2346 CD1 LEU 359 58.362 44.551 47.459 1.0016.52 ATOM 2347 CD2 LEU 359 58.977 46.563 48.829 1.00 16.74 ATOM 2348 CLEU 359 60.909 44.062 51.797 1.00 21.60 ATOM 2349 O LEU 359 61.93243.424 52.058 1.00 21.13 ATOM 2350 N LEU 360 59.863 44.112 52.616 1.0021.11 ATOM 2351 CA LEU 360 59.869 43.451 53.921 1.00 22.96 ATOM 2352 CBLEU 360 58.815 44.093 54.830 1.00 23.88 ATOM 2353 CG LEU 360 58.98245.575 55.274 1.00 27.26 ATOM 2354 CD1 LEU 360 57.692 46.100 55.788 1.0027.98 ATOM 2355 CD2 LEU 360 60.162 45.756 56.131 1.00 25.65 ATOM 2356 CLEU 360 59.654 41.942 53.937 1.00 23.76 ATOM 2357 O LEU 360 58.87041.401 53.163 1.00 24.22 ATOM 2358 N PRO 361 60.355 41.241 54.840 1.0025.33 ATOM 2359 CD PRO 361 61.465 41.730 55.683 1.00 26.75 ATOM 2360 CAPRO 361 60.217 39.791 54.953 1.00 25.45 ATOM 2361 CB PRO 361 61.56239.373 55.529 1.00 27.39 ATOM 2362 CG PRO 361 61.851 40.492 56.480 1.0027.59 ATOM 2363 C PRO 361 59.071 39.538 55.926 1.00 25.74 ATOM 2364 OPRO 361 58.773 40.394 56.759 1.00 26.40 ATOM 2365 N VAL 362 58.41238.390 55.827 1.00 25.30 ATOM 2366 CA VAL 362 57.323 38.115 56.757 1.0025.65 ATOM 2367 CB VAL 362 56.462 36.916 56.303 1.00 24.53 ATOM 2368 CG1VAL 362 55.770 37.249 54.980 1.00 23.68 ATOM 2369 CG2 VAL 362 57.32735.674 56.167 1.00 23.66 ATOM 2370 C VAL 362 57.926 37.820 58.127 1.0027.19 ATOM 2371 O VAL 362 59.013 37.247 58.221 1.00 27.05 ATOM 2372 NPRO 363 57.235 38.226 59.207 1.00 26.80 ATOM 2373 CD PRO 363 56.02239.063 59.229 1.00 26.99 ATOM 2374 CA PRO 363 57.726 37.995 60.570 1.0027.57 ATOM 2375 CB PRO 363 56.685 38.706 61.441 1.00 26.11 ATOM 2376 CGPRO 363 56.169 39.793 60.545 1.00 27.52 ATOM 2377 C PRO 363 57.82636.513 60.911 1.00 27.67 ATOM 2378 O PRO 363 57.114 35.684 60.340 1.0027.28 ATOM 2379 N PRO 364 58.722 36.160 61.847 1.00 28.91 ATOM 2380 CDPRO 364 59.688 37.033 62.542 1.00 30.07 ATOM 2381 CA PRO 364 58.88834.761 62.252 1.00 27.66 ATOM 2382 CB PRO 364 59.844 34.864 63.437 1.0030.48 ATOM 2383 CG PRO 364 60.707 36.037 63.061 1.00 31.62 ATOM 2384 CPRO 364 57.537 34.165 62.650 1.00 27.12 ATOM 2385 O PRO 364 57.24533.003 62.369 1.00 25.49 ATOM 2386 N GLU 365 56.715 34.985 63.297 1.0028.48 ATOM 2387 CA GLU 365 55.387 34.578 63.755 1.00 29.40 ATOM 2388 CBGLU 365 54.705 35.769 64.439 1.00 31.16 ATOM 2389 CG GLU 365 53.28735.524 64.907 1.00 34.46 ATOM 2390 CD GLU 365 52.757 36.659 65.770 1.0037.66 ATOM 2391 OE1 GLU 365 53.118 37.831 65.518 1.00 38.25 ATOM 2392OE2 GLU 365 51.967 36.381 66.696 1.00 38.79 ATOM 2393 C GLU 365 54.51134.039 62.617 1.00 29.17 ATOM 2394 O GLU 365 53.653 33.178 62.832 1.0029.47 ATOM 2395 N PHE 366 54.736 34.549 61.409 1.00 28.47 ATOM 2396 CAPHE 366 53.990 34.128 60.222 1.00 26.31 ATOM 2397 CB PHE 366 54.48734.904 58.997 1.00 25.09 ATOM 2398 CG PHE 366 53.986 34.361 57.680 1.0023.73 ATOM 2399 CD1 PHE 366 52.829 34.865 57.096 1.00 22.77 ATOM 2400CD2 PHE 366 54.681 33.348 57.023 1.00 24.15 ATOM 2401 CE1 PHE 366 52.36834.371 55.873 1.00 21.92 ATOM 2402 CE2 PHE 366 54.228 32.845 55.799 1.0022.88 ATOM 2403 CZ PHE 366 53.071 33.358 55.225 1.00 22.34 ATOM 2404 CPHE 366 54.162 32.632 59.965 1.00 25.92 ATOM 2405 O PHE 366 53.19031.899 59.774 1.00 24.62 ATOM 2406 N TRP 367 55.414 32.189 59.948 1.0026.49 ATOM 2407 CA TRP 367 55.724 30.788 59.699 1.00 28.05 ATOM 2408 CBTRP 367 57.242 30.605 59.640 1.00 27.25 ATOM 2409 CG TRP 367 57.86931.421 58.559 1.00 26.72 ATOM 2410 CD2 TRP 367 57.708 31.235 57.148 1.0024.28 ATOM 2411 CE2 TRP 367 58.450 32.249 56.508 1.00 24.53 ATOM 2412CE3 TRP 367 57.007 30.308 56.363 1.00 25.77 ATOM 2413 CD1 TRP 367 58.67832.507 58.713 1.00 26.27 ATOM 2414 NE1 TRP 367 59.032 33.011 57.486 1.0024.78 ATOM 2415 CZ2 TRP 367 58.515 32.367 55.115 1.00 25.59 ATOM 2416CZ3 TRP 367 57.070 30.423 54.975 1.00 25.39 ATOM 2417 CH2 TRP 367 57.82031.446 54.368 1.00 26.81 ATOM 2418 C TRP 367 55.128 29.845 60.737 1.0028.77 ATOM 2419 O TRP 367 54.818 28.693 60.436 1.00 29.68 ATOM 2420 NASN 368 54.948 30.341 61.955 1.00 29.29 ATOM 2421 CA ASN 368 54.40729.517 63.023 1.00 30.04 ATOM 2422 CB ASN 368 54.955 29.999 64.369 1.0033.90 ATOM 2423 CG ASN 368 54.405 29.197 65.545 1.00 37.17 ATOM 2424 OD1ASN 368 53.214 29.307 65.846 1.00 41.44 ATOM 2425 ND2 ASN 368 55.23328.397 66.223 1.00 37.16 ATOM 2426 C ASN 368 52.882 29.448 63.097 1.0030.01 ATOM 2427 O ASN 368 52.323 28.404 63.431 1.00 27.10 ATOM 2428 NLYS 369 52.206 30.547 62.780 1.00 28.47 ATOM 2429 CA LYS 369 50.75330.567 62.870 1.00 29.06 ATOM 2430 CB LYS 369 50.308 31.882 63.513 1.0030.23 ATOM 2431 CG LYS 369 50.848 32.067 64.931 1.00 32.99 ATOM 2432 CDLYS 369 50.314 33.335 65.573 1.00 38.01 ATOM 2433 CE LYS 369 50.83133.502 66.996 1.00 40.47 ATOM 2434 NZ LYS 369 50.244 34.711 67.648 1.0043.23 ATOM 2435 C LYS 369 49.964 30.320 61.584 1.00 28.08 ATOM 2436 OLYS 369 48.788 29.961 61.645 1.00 29.11 ATOM 2437 N SER 370 50.59430.498 60.426 1.00 27.36 ATOM 2438 CA SER 370 49.904 30.288 59.151 1.0026.35 ATOM 2439 CB SER 370 50.774 30.764 57.977 1.00 24.78 ATOM 2440 OGSER 370 50.954 32.171 57.991 1.00 22.65 ATOM 2441 C SER 370 49.52428.830 58.908 1.00 27.44 ATOM 2442 O SER 370 50.158 27.911 59.430 1.0027.46 ATOM 2443 N MET 371 48.475 28.628 58.117 1.00 27.03 ATOM 2444 CAMET 371 48.029 27.288 57.749 1.00 27.37 ATOM 2445 CB MET 371 46.52427.117 57.973 1.00 25.87 ATOM 2446 CG MET 371 46.028 25.700 57.695 1.0023.55 ATOM 2447 SD MET 371 44.257 25.591 57.365 1.00 24.62 ATOM 2448 CEMET 371 44.241 25.865 55.602 1.00 23.28 ATOM 2449 C MET 371 48.33627.186 56.259 1.00 28.01 ATOM 2450 O MET 371 47.493 27.511 55.419 1.0027.83 ATOM 2451 N LEU 372 49.547 26.742 55.935 1.00 28.67 ATOM 2452 CALEU 372 49.976 26.636 54.544 1.00 27.98 ATOM 2453 CB LEU 372 51.48826.849 54.463 1.00 26.09 ATOM 2454 CG LEU 372 52.000 28.142 55.109 1.0026.99 ATOM 2455 CD1 LEU 372 53.516 28.186 55.014 1.00 25.50 ATOM 2456CD2 LEU 372 51.382 29.362 54.421 1.00 25.38 ATOM 2457 C LEU 372 49.59725.325 53.861 1.00 29.45 ATOM 2458 O LEU 372 49.835 25.154 52.664 1.0029.43 ATOM 2459 N GLU 373 49.002 24.407 54.618 1.00 30.71 ATOM 2460 CAGLU 373 48.589 23.115 54.074 1.00 33.88 ATOM 2461 CB GLU 373 49.57622.012 54.460 1.00 36.25 ATOM 2462 CG GLU 373 51.022 22.277 54.127 1.0043.43 ATOM 2463 CD GLU 373 51.929 21.197 54.686 1.00 46.04 ATOM 2464 OE1GLU 373 51.953 21.025 55.924 1.00 49.71 ATOM 2465 OE2 GLU 373 52.60920.515 53.892 1.00 48.87 ATOM 2466 C GLU 373 47.230 22.718 54.622 1.0033.50 ATOM 2467 O GLU 373 46.854 23.115 55.726 1.00 32.75 ATOM 2468 NLYS 374 46.506 21.917 53.851 1.00 33.65 ATOM 2469 CA LYS 374 45.20021.429 54.271 1.00 35.26 ATOM 2470 CB LYS 374 44.523 20.687 53.121 1.0035.25 ATOM 2471 CG LYS 374 43.155 20.120 53.456 1.00 35.45 ATOM 2472 CDLYS 374 42.518 19.531 52.208 1.00 35.40 ATOM 2473 CE LYS 374 41.13218.994 52.483 1.00 36.09 ATOM 2474 NZ LYS 374 40.514 18.496 51.224 1.0036.76 ATOM 2475 C LYS 374 45.432 20.474 55.435 1.00 36.99 ATOM 2476 OLYS 374 46.171 19.496 55.307 1.00 37.40 ATOM 2477 N PRO 375 44.81320.747 56.591 1.00 38.18 ATOM 2478 CD PRO 375 44.031 21.941 56.951 1.0038.24 ATOM 2479 CA PRO 375 44.992 19.873 57.753 1.00 40.05 ATOM 2480 CBPRO 375 44.133 20.545 58.822 1.00 39.71 ATOM 2481 CG PRO 375 44.20921.993 58.451 1.00 39.38 ATOM 2482 C PRO 375 44.570 18.427 57.509 1.0041.45 ATOM 2483 O PRO 375 43.595 18.159 56.808 1.00 40.45 ATOM 2484 NTHR 376 45.330 17.502 58.084 1.00 43.87 ATOM 2485 CA THR 376 45.04216.077 57.989 1.00 46.82 ATOM 2486 CB THR 376 46.331 15.268 57.766 1.0047.11 ATOM 2487 OG1 THR 376 47.272 15.569 58.804 1.00 48.76 ATOM 2488CG2 THR 376 46.946 15.622 56.425 1.00 46.74 ATOM 2489 C THR 376 44.45015.750 59.355 1.00 48.06 ATOM 2490 O THR 376 44.102 14.612 59.664 1.0049.50 ATOM 2491 N ASP 377 44.345 16.808 60.151 1.00 49.79 ATOM 2492 CAASP 377 43.821 16.801 61.510 1.00 50.68 ATOM 2493 CB ASP 377 43.72218.252 61.991 1.00 51.52 ATOM 2494 CG ASP 377 44.084 18.416 63.445 1.0053.90 ATOM 2495 OD1 ASP 377 43.505 17.705 64.293 1.00 56.14 ATOM 2496OD2 ASP 377 44.950 19.267 63.737 1.00 54.87 ATOM 2497 C ASP 377 42.43916.162 61.607 1.00 50.48 ATOM 2498 O ASP 377 41.919 15.965 62.705 1.0050.57 ATOM 2499 N GLY 378 41.845 15.831 60.465 1.00 50.81 ATOM 2500 CAGLY 378 40.504 15.280 60.486 1.00 50.66 ATOM 2501 C GLY 378 39.63516.487 60.795 1.00 50.28 ATOM 2502 O GLY 378 38.488 16.379 61.230 1.0051.71 ATOM 2503 N ARG 379 40.231 17.653 60.560 1.00 48.17 ATOM 2504 CAARG 379 39.613 18.954 60.788 1.00 45.10 ATOM 2505 CB ARG 379 40.68819.934 61.261 1.00 45.50 ATOM 2506 CG ARG 379 40.269 20.913 62.332 1.0044.65 ATOM 2507 CD ARG 379 41.270 22.052 62.408 1.00 44.87 ATOM 2508 NEARG 379 42.651 21.577 62.397 1.00 44.55 ATOM 2509 CZ ARG 379 43.70522.356 62.170 1.00 44.28 ATOM 2510 NH1 ARG 379 43.540 23.651 61.933 1.0042.73 ATOM 2511 NH2 ARG 379 44.927 21.841 62.174 1.00 44.56 ATOM 2512 CARG 379 39.013 19.464 59.477 1.00 41.98 ATOM 2513 O ARG 379 39.52219.167 58.398 1.00 42.26 ATOM 2514 N GLU 380 37.932 20.227 59.573 1.0038.86 ATOM 2515 CA GLU 380 37.286 20.788 58.390 1.00 35.74 ATOM 2516 CBGLU 380 35.767 20.654 58.508 1.00 37.72 ATOM 2517 CG GLU 380 35.00820.940 57.225 1.00 41.39 ATOM 2518 CD GLU 380 34.671 19.679 56.439 1.0044.40 ATOM 2519 OE1 GLU 380 33.991 18.792 57.003 1.00 45.17 ATOM 2520OE2 GLU 380 35.075 19.577 55.260 1.00 43.36 ATOM 2521 C GLU 380 37.68122.266 58.330 1.00 31.68 ATOM 2522 O GLU 380 37.643 22.958 59.346 1.0028.60 ATOM 2523 N VAL 381 38.066 22.749 57.150 1.00 29.12 ATOM 2524 CAVAL 381 38.480 24.145 57.013 1.00 25.82 ATOM 2525 CB VAL 381 40.02224.281 57.096 1.00 26.30 ATOM 2526 CG1 VAL 381 40.546 23.600 58.347 1.0026.29 ATOM 2527 CG2 VAL 381 40.669 23.673 55.855 1.00 26.07 ATOM 2528 CVAL 381 38.041 24.806 55.708 1.00 25.16 ATOM 2529 O VAL 381 37.52824.150 54.799 1.00 24.70 ATOM 2530 N VAL 382 38.238 26.120 55.637 1.0022.13 ATOM 2531 CA VAL 382 37.929 26.879 54.433 1.00 22.57 ATOM 2532 CBVAL 382 37.533 28.341 54.764 1.00 23.19 ATOM 2533 CG1 VAL 382 37.28929.122 53.479 1.00 22.36 ATOM 2534 CG2 VAL 382 36.279 28.355 55.636 1.0021.95 ATOM 2535 C VAL 382 39.254 26.864 53.679 1.00 22.05 ATOM 2536 OVAL 382 40.199 27.551 54.056 1.00 22.15 ATOM 2537 N CYS 383 39.33126.059 52.626 1.00 22.87 ATOM 2538 CA CYS 383 40.561 25.937 51.857 1.0022.31 ATOM 2539 C CYS 383 40.946 27.106 50.957 1.00 22.33 ATOM 2540 OCYS 383 42.134 27.335 50.723 1.00 22.41 ATOM 2541 CB CYS 383 40.52124.664 51.018 1.00 23.58 ATOM 2542 SG CYS 383 41.168 23.197 51.879 1.0025.88 ATOM 2543 N HIS 384 39.958 27.841 50.456 1.00 21.14 ATOM 2544 CAHIS 384 40.231 28.961 49.558 1.00 19.98 ATOM 2545 CB HIS 384 38.95429.761 49.286 1.00 17.69 ATOM 2546 CG HIS 384 39.075 30.695 48.123 1.0016.80 ATOM 2547 CD2 HIS 384 39.392 32.009 48.067 1.00 16.85 ATOM 2548ND1 HIS 384 38.954 30.273 46.816 1.00 17.45 ATOM 2549 CE1 HIS 384 39.19631.287 46.004 1.00 17.61 ATOM 2550 NE2 HIS 384 39.466 32.352 46.737 1.0020.78 ATOM 2551 C HIS 384 41.309 29.884 50.124 1.00 19.92 ATOM 2552 OHIS 384 41.173 30.412 51.226 1.00 19.94 ATOM 2553 N ALA 385 42.37630.080 49.355 1.00 19.69 ATOM 2554 CA ALA 385 43.497 30.917 49.779 1.0018.75 ATOM 2555 CB ALA 385 44.529 31.007 48.657 1.00 16.28 ATOM 2556 CALA 385 43.110 32.322 50.228 1.00 17.94 ATOM 2557 O ALA 385 42.29832.990 49.589 1.00 16.36 ATOM 2558 N SER 386 43.708 32.769 51.328 1.0019.03 ATOM 2559 CA SER 386 43.450 34.110 51.847 1.00 19.74 ATOM 2560 CBSER 386 42.098 34.163 52.581 1.00 20.01 ATOM 2561 OG SER 386 42.04133.244 53.656 1.00 24.98 ATOM 2562 C SER 386 44.576 34.584 52.767 1.0019.49 ATOM 2563 O SER 386 45.305 33.775 53.355 1.00 20.16 ATOM 2564 NALA 387 44.721 35.903 52.860 1.00 19.32 ATOM 2565 CA ALA 387 45.74436.541 53.682 1.00 18.05 ATOM 2566 CB ALA 387 46.571 37.502 52.840 1.0018.53 ATOM 2567 C ALA 387 45.048 37.292 54.804 1.00 19.41 ATOM 2568 OALA 387 44.006 37.922 54.594 1.00 18.50 ATOM 2569 N TRP 388 45.64137.243 55.988 1.00 18.57 ATOM 2570 CA TRP 388 45.043 37.862 57.157 1.0020.63 ATOM 2571 CB TRP 388 44.672 36.764 58.158 1.00 20.94 ATOM 2572 CGTRP 388 43.693 35.759 57.626 1.00 20.63 ATOM 2573 CD2 TRP 388 42.42335.424 58.195 1.00 20.38 ATOM 2574 CE2 TRP 388 41.847 34.427 57.374 1.0020.45 ATOM 2575 CE3 TRP 388 41.715 35.872 59.321 1.00 20.78 ATOM 2576CD1 TRP 388 43.834 34.974 56.513 1.00 21.13 ATOM 2577 NE1 TRP 388 42.72834.171 56.356 1.00 19.97 ATOM 2578 CZ2 TRP 388 40.591 33.867 57.645 1.0021.53 ATOM 2579 CZ3 TRP 388 40.464 35.315 59.590 1.00 22.62 ATOM 2580CH2 TRP 388 39.917 34.323 58.754 1.00 22.52 ATOM 2581 C TRP 388 45.87338.923 57.877 1.00 21.09 ATOM 2582 O TRP 388 47.062 38.734 58.148 1.0020.91 ATOM 2583 N ASP 389 45.222 40.040 58.183 1.00 20.21 ATOM 2584 CAASP 389 45.845 41.127 58.922 1.00 20.18 ATOM 2585 CB ASP 389 45.57742.472 58.241 1.00 18.75 ATOM 2586 CG ASP 389 46.327 43.615 58.900 1.0019.53 ATOM 2587 OD1 ASP 389 46.749 43.451 60.065 1.00 19.53 ATOM 2588OD2 ASP 389 46.492 44.676 58.261 1.00 18.57 ATOM 2589 C ASP 389 45.14041.091 60.283 1.00 21.39 ATOM 2590 O ASP 389 43.913 41.234 60.350 1.0019.21 ATOM 2591 N PHE 390 45.894 40.875 61.358 1.00 21.15 ATOM 2592 CAPHE 390 45.286 40.819 62.687 1.00 23.78 ATOM 2593 CB PHE 390 45.95939.741 63.546 1.00 22.15 ATOM 2594 CG PHE 390 45.567 38.341 63.165 1.0023.26 ATOM 2595 CD1 PHE 390 46.029 37.771 61.983 1.00 21.17 ATOM 2596CD2 PHE 390 44.707 37.604 63.974 1.00 23.14 ATOM 2597 CE1 PHE 390 45.64036.490 61.608 1.00 22.67 ATOM 2598 CE2 PHE 390 44.310 36.321 63.610 1.0025.19 ATOM 2599 CZ PHE 390 44.780 35.761 62.420 1.00 24.11 ATOM 2600 CPHE 390 45.289 42.159 63.414 1.00 24.86 ATOM 2601 O PHE 390 45.07942.226 64.627 1.00 26.08 ATOM 2602 N TYR 391 45.529 43.218 62.649 1.0026.25 ATOM 2603 CA TYR 391 45.535 44.597 63.133 1.00 29.34 ATOM 2604 CBTYR 391 44.097 45.083 63.329 1.00 32.35 ATOM 2605 CG TYR 391 43.17444.734 62.188 1.00 36.14 ATOM 2606 CD1 TYR 391 42.490 43.521 62.172 1.0038.33 ATOM 2607 CE1 TYR 391 41.645 43.185 61.126 1.00 41.84 ATOM 2608CD2 TYR 391 42.992 45.609 61.118 1.00 39.05 ATOM 2609 CE2 TYR 391 42.14845.281 60.059 1.00 42.44 ATOM 2610 CZ TYR 391 41.477 44.068 60.074 1.0042.85 ATOM 2611 OH TYR 391 40.630 43.737 59.042 1.00 48.25 ATOM 2612 CTYR 391 46.334 44.960 64.382 1.00 29.54 ATOM 2613 O TYR 391 45.89745.802 65.166 1.00 30.88 ATOM 2614 N ASN 392 47.492 44.342 64.583 1.0028.09 ATOM 2615 CA ASN 392 48.317 44.697 65.732 1.00 26.46 ATOM 2616 CBASN 392 48.375 43.554 66.762 1.00 25.72 ATOM 2617 CG ASN 392 49.06942.311 66.238 1.00 24.13 ATOM 2618 OD1 ASN 392 49.450 42.234 65.074 1.0019.92 ATOM 2619 ND2 ASN 392 49.232 41.324 67.110 1.00 24.99 ATOM 2620 CASN 392 49.703 45.042 65.208 1.00 26.86 ATOM 2621 O ASN 392 50.63045.301 65.974 1.00 26.07 ATOM 2622 N GLY 393 49.820 45.051 63.880 1.0026.09 ATOM 2623 CA GLY 393 51.075 45.371 63.225 1.00 24.15 ATOM 2624 CGLY 393 52.155 44.325 63.404 1.00 24.36 ATOM 2625 O GLY 393 53.31344.560 63.061 1.00 25.32 ATOM 2626 N LYS 394 51.784 43.159 63.916 1.0023.94 ATOM 2627 CA LYS 394 52.763 42.107 64.147 1.00 26.37 ATOM 2628 CBLYS 394 53.069 42.017 65.645 1.00 29.65 ATOM 2629 CG LYS 394 54.52242.251 65.990 1.00 35.63 ATOM 2630 CD LYS 394 54.954 43.660 65.631 1.0038.94 ATOM 2631 CE LYS 394 54.438 44.665 66.640 1.00 42.85 ATOM 2632 NZLYS 394 55.031 44.415 67.988 1.00 44.66 ATOM 2633 C LYS 394 52.33640.732 63.647 1.00 25.74 ATOM 2634 O LYS 394 53.145 39.984 63.097 1.0026.30 ATOM 2635 N ASP 395 51.062 40.413 63.839 1.00 24.66 ATOM 2636 CAASP 395 50.514 39.117 63.461 1.00 24.69 ATOM 2637 CB ASP 395 49.52938.674 64.549 1.00 22.82 ATOM 2638 CG ASP 395 49.088 37.237 64.402 1.0024.52 ATOM 2639 OD1 ASP 395 49.389 36.602 63.368 1.00 24.94 ATOM 2640OD2 ASP 395 48.424 36.738 65.333 1.00 27.00 ATOM 2641 C ASP 395 49.83039.102 62.086 1.00 25.11 ATOM 2642 O ASP 395 48.725 39.631 61.919 1.0023.47 ATOM 2643 N PHE 396 50.498 38.498 61.106 1.00 24.32 ATOM 2644 CAPHE 396 49.955 38.383 59.750 1.00 23.41 ATOM 2645 CB PHE 396 50.78339.188 58.743 1.00 23.60 ATOM 2646 CG PHE 396 51.136 40.571 59.203 1.0024.38 ATOM 2647 CD1 PHE 396 52.341 40.813 59.858 1.00 25.69 ATOM 2648CD2 PHE 396 50.274 41.641 58.965 1.00 25.33 ATOM 2649 CE1 PHE 396 52.68742.104 60.267 1.00 23.83 ATOM 2650 CE2 PHE 396 50.611 42.934 59.371 1.0023.41 ATOM 2651 CZ PHE 396 51.821 43.164 60.023 1.00 23.93 ATOM 2652 CPHE 396 50.027 36.910 59.379 1.00 23.79 ATOM 2653 O PHE 396 51.02336.246 59.670 1.00 24.61 ATOM 2654 N ARG 397 48.984 36.394 58.736 1.0023.34 ATOM 2655 CA ARG 397 48.973 34.984 58.371 1.00 21.97 ATOM 2656 CBARG 397 48.245 34.166 59.443 1.00 22.90 ATOM 2657 CG ARG 397 48.55534.552 60.881 1.00 23.65 ATOM 2658 CD ARG 397 47.710 33.717 61.832 1.0024.02 ATOM 2659 NE ARG 397 47.685 34.268 63.183 1.00 24.58 ATOM 2660 CZARG 397 46.977 33.755 64.184 1.00 25.68 ATOM 2661 NH1 ARG 397 46.23532.672 63.988 1.00 24.67 ATOM 2662 NH2 ARG 397 46.998 34.333 65.377 1.0025.68 ATOM 2663 C ARG 397 48.312 34.679 57.035 1.00 22.32 ATOM 2664 OARG 397 47.522 35.468 56.507 1.00 20.61 ATOM 2665 N ILE 398 48.63633.504 56.505 1.00 22.29 ATOM 2666 CA ILE 398 48.057 33.029 55.260 1.0020.95 ATOM 2667 CB ILE 398 49.137 32.891 54.154 1.00 20.55 ATOM 2668 CG2ILE 398 48.629 32.009 53.016 1.00 21.09 ATOM 2669 CG1 ILE 398 49.50234.282 53.625 1.00 18.02 ATOM 2670 CD1 ILE 398 50.575 34.283 52.548 1.0017.26 ATOM 2671 C ILE 398 47.400 31.679 55.544 1.00 21.59 ATOM 2672 OILE 398 47.938 30.862 56.300 1.00 21.62 ATOM 2673 N LYS 399 46.21431.478 54.971 1.00 20.68 ATOM 2674 CA LYS 399 45.453 30.239 55.115 1.0019.59 ATOM 2675 CB LYS 399 44.115 30.495 55.818 1.00 19.25 ATOM 2676 CGLYS 399 43.236 29.248 55.912 1.00 20.50 ATOM 2677 CD LYS 399 41.79629.585 56.296 1.00 20.84 ATOM 2678 CE LYS 399 41.143 30.517 55.274 1.0019.03 ATOM 2679 NZ LYS 399 41.207 29.974 53.882 1.00 17.95 ATOM 2680 CLYS 399 45.188 29.723 53.704 1.00 20.32 ATOM 2681 O LYS 399 44.37930.291 52.966 1.00 17.80 ATOM 2682 N GLN 400 45.857 28.638 53.335 1.0019.73 ATOM 2683 CA GLN 400 45.716 28.092 51.993 1.00 19.81 ATOM 2684 CBGLN 400 46.701 28.819 51.074 1.00 20.96 ATOM 2685 CG GLN 400 46.65228.439 49.606 1.00 22.65 ATOM 2686 CD GLN 400 47.679 29.200 48.788 1.0023.34 ATOM 2687 OE1 GLN 400 47.979 30.360 49.073 1.00 23.98 ATOM 2688NE2 GLN 400 48.213 28.556 47.757 1.00 25.85 ATOM 2689 C GLN 400 46.01326.601 51.986 1.00 20.97 ATOM 2690 O GLN 400 47.011 26.173 52.559 1.0019.21 ATOM 2691 N CYS 401 45.148 25.810 51.356 1.00 22.51 ATOM 2692 CACYS 401 45.389 24.372 51.268 1.00 24.18 ATOM 2693 C CYS 401 46.24124.204 50.017 1.00 24.54 ATOM 2694 O CYS 401 45.795 23.703 48.982 1.0024.83 ATOM 2695 CB CYS 401 44.077 23.602 51.144 1.00 24.18 ATOM 2696 SGCYS 401 42.962 23.853 52.560 1.00 26.68 ATOM 2697 N THR 402 47.48124.653 50.145 1.00 23.39 ATOM 2698 CA THR 402 48.455 24.649 49.072 1.0023.83 ATOM 2699 CB THR 402 49.761 25.296 49.553 1.00 24.60 ATOM 2700 OG1THR 402 49.458 26.532 50.214 1.00 24.98 ATOM 2701 CG2 THR 402 50.69425.564 48.377 1.00 24.72 ATOM 2702 C THR 402 48.789 23.295 48.468 1.0023.55 ATOM 2703 O THR 402 49.037 22.323 49.178 1.00 22.36 ATOM 2704 NTHR 403 48.790 23.250 47.142 1.00 24.22 ATOM 2705 CA THR 403 49.14222.044 46.407 1.00 25.66 ATOM 2706 CB THR 403 48.096 21.716 45.323 1.0026.94 ATOM 2707 OG1 THR 403 46.879 21.298 45.953 1.00 31.08 ATOM 2708CG2 THR 403 48.589 20.597 44.421 1.00 30.68 ATOM 2709 C THR 403 50.48222.350 45.752 1.00 24.67 ATOM 2710 O THR 403 50.747 23.494 45.377 1.0024.35 ATOM 2711 N VAL 404 51.329 21.337 45.618 1.00 25.92 ATOM 2712 CAVAL 404 52.644 21.533 45.021 1.00 25.04 ATOM 2713 CB VAL 404 53.64820.485 45.549 1.00 25.96 ATOM 2714 CG1 VAL 404 55.024 20.725 44.949 1.0024.79 ATOM 2715 CG2 VAL 404 53.716 20.557 47.068 1.00 24.67 ATOM 2716 CVAL 404 52.632 21.494 43.493 1.00 25.52 ATOM 2717 O VAL 404 52.73720.429 42.881 1.00 26.04 ATOM 2718 N ASN 405 52.491 22.671 42.893 1.0024.32 ATOM 2719 CA ASN 405 52.490 22.835 41.440 1.00 24.14 ATOM 2720 CBASN 405 51.176 22.345 40.818 1.00 24.83 ATOM 2721 CG ASN 405 49.95422.969 41.456 1.00 27.35 ATOM 2722 OD1 ASN 405 49.858 24.187 41.591 1.0029.21 ATOM 2723 ND2 ASN 405 49.004 22.132 41.842 1.00 28.69 ATOM 2724 CASN 405 52.702 24.311 41.133 1.00 24.79 ATOM 2725 O ASN 405 52.66725.150 42.041 1.00 22.13 ATOM 2726 N LEU 406 52.922 24.629 39.862 1.0022.38 ATOM 2727 CA LEU 406 53.167 26.005 39.459 1.00 24.32 ATOM 2728 CBLEU 406 53.582 26.056 37.986 1.00 24.24 ATOM 2729 CG LEU 406 53.91227.439 37.417 1.00 26.51 ATOM 2730 CD1 LEU 406 54.969 28.127 38.280 1.0025.09 ATOM 2731 CD2 LEU 406 54.403 27.288 35.980 1.00 27.04 ATOM 2732 CLEU 406 51.978 26.931 39.691 1.00 24.77 ATOM 2733 O LEU 406 52.15228.082 40.082 1.00 24.88 ATOM 2734 N GLU 407 50.773 26.428 39.452 1.0024.97 ATOM 2735 CA GLU 407 49.571 27.231 39.635 1.00 27.47 ATOM 2736 CBGLU 407 48.334 26.392 39.285 1.00 29.90 ATOM 2737 CG GLU 407 47.01127.143 39.341 1.00 33.59 ATOM 2738 CD GLU 407 45.921 26.457 38.527 1.0036.42 ATOM 2739 OE1 GLU 407 45.788 25.218 38.627 1.00 36.53 ATOM 2740OE2 GLU 407 45.193 27.159 37.791 1.00 37.68 ATOM 2741 C GLU 407 49.48227.767 41.066 1.00 26.40 ATOM 2742 O GLU 407 49.209 28.948 41.278 1.0027.12 ATOM 2743 N ASP 408 49.729 26.901 42.043 1.00 25.56 ATOM 2744 CAASP 408 49.683 27.303 43.448 1.00 26.24 ATOM 2745 CB ASP 408 49.56726.070 44.345 1.00 28.50 ATOM 2746 CG ASP 408 48.160 25.857 44.850 1.0032.70 ATOM 2747 OD1 ASP 408 47.216 26.002 44.047 1.00 38.19 ATOM 2748OD2 ASP 408 47.992 25.541 46.046 1.00 36.12 ATOM 2749 C ASP 408 50.89528.132 43.866 1.00 25.11 ATOM 2750 O ASP 408 50.853 28.837 44.873 1.0023.90 ATOM 2751 N LEU 409 51.980 28.039 43.103 1.00 22.82 ATOM 2752 CALEU 409 53.170 28.819 43.416 1.00 22.42 ATOM 2753 CB LEU 409 54.34928.401 42.532 1.00 23.11 ATOM 2754 CG LEU 409 55.660 29.142 42.815 1.0023.64 ATOM 2755 CD1 LEU 409 56.084 28.889 44.253 1.00 23.67 ATOM 2756CD2 LEU 409 56.739 28.674 41.855 1.00 23.00 ATOM 2757 C LEU 409 52.81130.274 43.140 1.00 21.63 ATOM 2758 O LEU 409 53.165 31.175 43.906 1.0019.27 ATOM 2759 N VAL 410 52.100 30.491 42.037 1.00 19.69 ATOM 2760 CAVAL 410 51.664 31.829 41.666 1.00 20.55 ATOM 2761 CB VAL 410 50.97731.834 40.282 1.00 21.61 ATOM 2762 CG1 VAL 410 50.409 33.215 39.983 1.0020.73 ATOM 2763 CG2 VAL 410 51.981 31.433 39.209 1.00 24.65 ATOM 2764 CVAL 410 50.678 32.332 42.717 1.00 19.32 ATOM 2765 O VAL 410 50.74733.485 43.138 1.00 20.39 ATOM 2766 N VAL 411 49.766 31.465 43.150 1.0019.65 ATOM 2767 CA VAL 411 48.790 31.858 44.163 1.00 20.22 ATOM 2768 CBVAL 411 47.767 30.730 44.439 1.00 20.61 ATOM 2769 CG1 VAL 411 46.82431.137 45.578 1.00 19.72 ATOM 2770 CG2 VAL 411 46.957 30.447 43.174 1.0018.85 ATOM 2771 C VAL 411 49.497 32.226 45.466 1.00 21.47 ATOM 2772 OVAL 411 49.085 33.150 46.171 1.00 20.05 ATOM 2773 N ALA 412 50.57231.510 45.776 1.00 20.65 ATOM 2774 CA ALA 412 51.332 31.781 46.989 1.0020.54 ATOM 2775 CB ALA 412 52.448 30.755 47.145 1.00 20.33 ATOM 2776 CALA 412 51.912 33.196 46.935 1.00 20.50 ATOM 2777 O ALA 412 51.90233.915 47.934 1.00 20.25 ATOM 2778 N HIS 413 52.422 33.591 45.769 1.0019.01 ATOM 2779 CA HIS 413 52.979 34.931 45.605 1.00 18.24 ATOM 2780 CBHIS 413 53.653 35.084 44.236 1.00 18.06 ATOM 2781 CG HIS 413 55.00634.452 44.161 1.00 17.97 ATOM 2782 CD2 HIS 413 56.243 35.001 44.109 1.0017.44 ATOM 2783 ND1 HIS 413 55.193 33.087 44.199 1.00 18.68 ATOM 2784CE1 HIS 413 56.488 32.822 44.176 1.00 17.45 ATOM 2785 NE2 HIS 413 57.14633.965 44.123 1.00 17.19 ATOM 2786 C HIS 413 51.861 35.950 45.736 1.0016.58 ATOM 2787 O HIS 413 52.041 37.005 46.339 1.00 15.66 ATOM 2788 NHIS 414 50.708 35.623 45.158 1.00 16.88 ATOM 2789 CA HIS 414 49.53436.492 45.212 1.00 16.63 ATOM 2790 CB HIS 414 48.320 35.785 44.596 1.0017.03 ATOM 2791 CG HIS 414 47.034 36.539 44.760 1.00 17.66 ATOM 2792 CD2HIS 414 46.091 36.491 45.732 1.00 16.85 ATOM 2793 ND1 HIS 414 46.61237.497 43.863 1.00 17.56 ATOM 2794 CE1 HIS 414 45.463 38.005 44.275 1.0017.61 ATOM 2795 NE2 HIS 414 45.125 37.411 45.406 1.00 17.08 ATOM 2796 CHIS 414 49.218 36.835 46.662 1.00 16.06 ATOM 2797 O HIS 414 49.07038.006 47.017 1.00 17.09 ATOM 2798 N GLU 415 49.118 35.799 47.493 1.0015.07 ATOM 2799 CA GLU 415 48.807 35.964 48.910 1.00 16.06 ATOM 2800 CBGLU 415 48.527 34.600 49.553 1.00 16.75 ATOM 2801 CG GLU 415 47.32733.845 48.972 1.00 16.11 ATOM 2802 CD GLU 415 46.013 34.599 49.145 1.0016.59 ATOM 2803 OE1 GLU 415 45.878 35.334 50.142 1.00 17.28 ATOM 2804OE2 GLU 415 45.109 34.444 48.292 1.00 15.42 ATOM 2805 C GLU 415 49.92036.679 49.676 1.00 17.92 ATOM 2806 O GLU 415 49.642 37.486 50.570 1.0018.35 ATOM 2807 N MET 416 51.174 36.383 49.338 1.00 16.54 ATOM 2808 CAMET 416 52.295 37.034 50.008 1.00 17.95 ATOM 2809 CB MET 416 53.61936.392 49.583 1.00 17.54 ATOM 2810 CG MET 416 53.855 35.041 50.243 1.0019.19 ATOM 2811 SD MET 416 54.175 35.197 52.034 1.00 21.75 ATOM 2812 CEMET 416 55.966 35.333 52.015 1.00 20.55 ATOM 2813 C MET 416 52.28038.522 49.670 1.00 18.12 ATOM 2814 O MET 416 52.789 39.356 50.427 1.0015.13 ATOM 2815 N GLY 417 51.680 38.840 48.526 1.00 17.95 ATOM 2816 CAGLY 417 51.561 40.222 48.109 1.00 15.72 ATOM 2817 C GLY 417 50.62140.942 49.066 1.00 15.92 ATOM 2818 O GLY 417 50.856 42.094 49.413 1.0014.01 ATOM 2819 N HIS 418 49.551 40.268 49.487 1.00 16.50 ATOM 2820 CAHIS 418 48.603 40.861 50.434 1.00 17.17 ATOM 2821 CB HIS 418 47.41539.931 50.697 1.00 15.51 ATOM 2822 CG HIS 418 46.421 39.866 49.578 1.0017.03 ATOM 2823 CD2 HIS 418 45.843 38.807 48.963 1.00 15.43 ATOM 2824ND1 HIS 418 45.848 40.991 49.022 1.00 19.32 ATOM 2825 CE1 HIS 418 44.95840.626 48.115 1.00 17.79 ATOM 2826 NE2 HIS 418 44.935 39.306 48.060 1.0017.55 ATOM 2827 C HIS 418 49.320 41.110 51.758 1.00 17.69 ATOM 2828 OHIS 418 49.163 42.167 52.370 1.00 16.65 ATOM 2829 N ILE 419 50.10040.126 52.199 1.00 16.39 ATOM 2830 CA ILE 419 50.848 40.239 53.450 1.0018.31 ATOM 2831 CB ILE 419 51.640 38.941 53.745 1.00 17.86 ATOM 2832 CG2ILE 419 52.498 39.115 54.995 1.00 17.98 ATOM 2833 CG1 ILE 419 50.66837.767 53.910 1.00 17.08 ATOM 2834 CD1 ILE 419 49.723 37.907 55.078 1.0016.70 ATOM 2835 C ILE 419 51.821 41.417 53.410 1.00 17.09 ATOM 2836 OILE 419 51.988 42.127 54.403 1.00 18.17 ATOM 2837 N GLN 420 52.45741.628 52.260 1.00 17.68 ATOM 2838 CA GLN 420 53.404 42.728 52.115 1.0016.85 ATOM 2839 CB GLN 420 54.093 42.677 50.746 1.00 17.05 ATOM 2840 CGGLN 420 55.148 43.766 50.562 1.00 17.55 ATOM 2841 CD GLN 420 56.38043.547 51.428 1.00 18.80 ATOM 2842 OE1 GLN 420 57.049 44.501 51.824 1.0017.97 ATOM 2843 NE2 GLN 420 56.694 42.286 51.710 1.00 18.82 ATOM 2844 CGLN 420 52.671 44.054 52.274 1.00 17.71 ATOM 2845 O GLN 420 53.17144.985 52.909 1.00 17.12 ATOM 2846 N TYR 421 51.479 44.138 51.695 1.0018.42 ATOM 2847 CA TYR 421 50.688 45.356 51.792 1.00 18.42 ATOM 2848 CBTYR 421 49.418 45.217 50.943 1.00 16.41 ATOM 2849 CG TYR 421 49.11346.419 50.075 1.00 15.65 ATOM 2850 CD1 TYR 421 48.661 46.257 48.764 1.0014.49 ATOM 2851 CE1 TYR 421 48.335 47.352 47.973 1.00 14.23 ATOM 2852CD2 TYR 421 49.237 47.717 50.570 1.00 16.14 ATOM 2853 CE2 TYR 421 48.91348.825 49.783 1.00 15.24 ATOM 2854 CZ TYR 421 48.459 48.633 48.486 1.0016.86 ATOM 2855 OH TYR 421 48.108 49.718 47.703 1.00 14.61 ATOM 2856 CTYR 421 50.344 45.619 53.266 1.00 19.47 ATOM 2857 O TYR 421 50.47346.746 53.744 1.00 19.23 ATOM 2858 N PHE 422 49.928 44.577 53.986 1.0019.13 ATOM 2859 CA PHE 422 49.591 44.716 55.407 1.00 20.97 ATOM 2860 CBPHE 422 49.260 43.353 56.029 1.00 19.61 ATOM 2861 CG PHE 422 48.02942.690 55.463 1.00 19.85 ATOM 2862 CD1 PHE 422 47.863 41.309 55.574 1.0020.06 ATOM 2863 CD2 PHE 422 47.038 43.434 54.829 1.00 18.91 ATOM 2864CE1 PHE 422 46.731 40.675 55.058 1.00 19.40 ATOM 2865 CE2 PHE 422 45.89842.807 54.312 1.00 18.30 ATOM 2866 CZ PHE 422 45.748 41.425 54.427 1.0018.76 ATOM 2867 C PHE 422 50.771 45.314 56.170 1.00 21.67 ATOM 2868 OPHE 422 50.619 46.274 56.923 1.00 21.52 ATOM 2869 N MET 423 51.95044.737 55.964 1.00 21.08 ATOM 2870 CA MET 423 53.153 45.196 56.644 1.0021.47 ATOM 2871 CB MET 423 54.316 44.237 56.373 1.00 21.55 ATOM 2872 CGMET 423 54.057 42.811 56.820 1.00 23.09 ATOM 2873 SD MET 423 55.57241.828 56.883 1.00 26.45 ATOM 2874 CE MET 423 55.812 41.441 55.121 1.0020.52 ATOM 2875 C MET 423 53.560 46.610 56.257 1.00 22.13 ATOM 2876 OMET 423 54.024 47.375 57.104 1.00 21.14 ATOM 2877 N GLN 424 53.38146.957 54.985 1.00 21.08 ATOM 2878 CA GLN 424 53.747 48.281 54.499 1.0021.09 ATOM 2879 CB GLN 424 53.668 48.326 52.967 1.00 21.81 ATOM 2880 CGGLN 424 54.783 47.570 52.238 1.00 20.30 ATOM 2881 CD GLN 424 56.14548.214 52.419 1.00 21.34 ATOM 2882 OE1 GLN 424 56.248 49.415 52.677 1.0021.87 ATOM 2883 NE2 GLN 424 57.200 47.422 52.262 1.00 20.74 ATOM 2884 CGLN 424 52.921 49.431 55.082 1.00 22.17 ATOM 2885 O GLN 424 53.46050.514 55.319 1.00 21.22 ATOM 2886 N TYR 425 51.624 49.219 55.308 1.0021.31 ATOM 2887 CA TYR 425 50.791 50.293 55.861 1.00 20.51 ATOM 2888 CBTYR 425 49.551 50.538 54.975 1.00 18.49 ATOM 2889 CG TYR 425 48.60349.360 54.753 1.00 18.46 ATOM 2890 CD1 TYR 425 48.144 48.581 55.820 1.0016.90 ATOM 2891 CE1 TYR 425 47.193 47.564 55.624 1.00 16.58 ATOM 2892CD2 TYR 425 48.091 49.089 53.478 1.00 16.81 ATOM 2893 CE2 TYR 425 47.13948.083 53.272 1.00 16.87 ATOM 2894 CZ TYR 425 46.694 47.324 54.349 1.0018.42 ATOM 2895 OH TYR 425 45.744 46.342 54.150 1.00 17.95 ATOM 2896 CTYR 425 50.354 50.082 57.310 1.00 21.09 ATOM 2897 O TYR 425 49.44750.758 57.795 1.00 21.46 ATOM 2898 N LYS 426 51.018 49.162 58.003 1.0021.85 ATOM 2899 CA LYS 426 50.678 48.840 59.391 1.00 24.15 ATOM 2900 CBLYS 426 51.593 47.727 59.912 1.00 23.65 ATOM 2901 CG LYS 426 53.04848.138 60.077 1.00 27.12 ATOM 2902 CD LYS 426 53.883 46.986 60.636 1.0029.68 ATOM 2903 CE LYS 426 55.337 47.396 60.853 1.00 32.06 ATOM 2904 NZLYS 426 55.457 48.484 61.862 1.00 35.07 ATOM 2905 C LYS 426 50.70850.007 60.383 1.00 24.45 ATOM 2906 O LYS 426 50.117 49.914 61.460 1.0024.16 ATOM 2907 N ASP 427 51.385 51.098 60.033 1.00 25.44 ATOM 2908 CAASP 427 51.473 52.238 60.941 1.00 27.31 ATOM 2909 CB ASP 427 52.88852.816 60.921 1.00 29.17 ATOM 2910 CG ASP 427 53.919 51.824 61.410 1.0032.66 ATOM 2911 OD1 ASP 427 53.697 51.226 62.484 1.00 34.11 ATOM 2912OD2 ASP 427 54.948 51.644 60.727 1.00 35.93 ATOM 2913 C ASP 427 50.46653.354 60.686 1.00 27.40 ATOM 2914 O ASP 427 50.487 54.382 61.362 1.0027.53 ATOM 2915 N LEU 428 49.586 53.163 59.711 1.00 26.71 ATOM 2916 CALEU 428 48.581 54.175 59.417 1.00 25.14 ATOM 2917 CB LEU 428 48.15954.110 57.946 1.00 25.72 ATOM 2918 CG LEU 428 49.169 54.334 56.819 1.0024.48 ATOM 2919 CD1 LEU 428 48.466 54.097 55.487 1.00 23.73 ATOM 2920CD2 LEU 428 49.731 55.743 56.878 1.00 24.31 ATOM 2921 C LEU 428 47.35653.897 60.271 1.00 23.90 ATOM 2922 O LEU 428 47.199 52.798 60.801 1.0023.96 ATOM 2923 N PRO 429 46.477 54.897 60.433 1.00 23.83 ATOM 2924 CDPRO 429 46.585 56.303 60.003 1.00 22.86 ATOM 2925 CA PRO 429 45.26754.676 61.232 1.00 24.74 ATOM 2926 CB PRO 429 44.497 55.977 61.046 1.0022.89 ATOM 2927 CG PRO 429 45.593 56.993 60.911 1.00 23.44 ATOM 2928 CPRO 429 44.555 53.484 60.584 1.00 25.64 ATOM 2929 O PRO 429 44.52953.380 59.356 1.00 25.40 ATOM 2930 N VAL 430 43.986 52.590 61.390 1.0026.24 ATOM 2931 CA VAL 430 43.320 51.404 60.854 1.00 26.47 ATOM 2932 CBVAL 430 42.621 50.590 61.972 1.00 29.13 ATOM 2933 CG1 VAL 430 43.66050.035 62.933 1.00 28.70 ATOM 2934 CG2 VAL 430 41.620 51.467 62.708 1.0030.53 ATOM 2935 C VAL 430 42.307 51.672 59.743 1.00 25.82 ATOM 2936 OVAL 430 42.148 50.856 58.837 1.00 24.60 ATOM 2937 N ALA 431 41.62952.812 59.802 1.00 24.76 ATOM 2938 CA ALA 431 40.639 53.143 58.786 1.0024.41 ATOM 2939 CB ALA 431 39.898 54.419 59.171 1.00 26.53 ATOM 2940 CALA 431 41.286 53.313 57.419 1.00 23.48 ATOM 2941 O ALA 431 40.62353.198 56.391 1.00 23.10 ATOM 2942 N LEU 432 42.587 53.583 57.407 1.0023.44 ATOM 2943 CA LEU 432 43.297 53.785 56.153 1.00 22.88 ATOM 2944 CBLEU 432 44.143 55.059 56.236 1.00 23.01 ATOM 2945 CG LEU 432 43.36556.321 56.628 1.00 22.58 ATOM 2946 CD1 LEU 432 44.321 57.500 56.716 1.0021.61 ATOM 2947 CD2 LEU 432 42.267 56.597 55.606 1.00 24.25 ATOM 2948 CLEU 432 44.178 52.595 55.787 1.00 23.45 ATOM 2949 O LEU 432 44.97452.666 54.844 1.00 23.80 ATOM 2950 N ARG 433 44.030 51.501 56.529 1.0022.08 ATOM 2951 CA ARG 433 44.815 50.303 56.260 1.00 22.75 ATOM 2952 CBARG 433 45.026 49.497 57.546 1.00 23.50 ATOM 2953 CG ARG 433 45.84950.225 58.607 1.00 26.73 ATOM 2954 CD ARG 433 46.193 49.307 59.779 1.0029.04 ATOM 2955 NE ARG 433 46.793 50.044 60.888 1.00 32.42 ATOM 2956 CZARG 433 47.191 49.492 62.031 1.00 33.50 ATOM 2957 NH1 ARG 433 47.06148.187 62.229 1.00 33.63 ATOM 2958 NH2 ARG 433 47.710 50.252 62.986 1.0035.11 ATOM 2959 C ARG 433 44.162 49.424 55.188 1.00 21.02 ATOM 2960 OARG 433 43.635 48.347 55.474 1.00 19.37 ATOM 2961 N GLU 434 44.18849.914 53.954 1.00 20.40 ATOM 2962 CA GLU 434 43.644 49.196 52.803 1.0021.33 ATOM 2963 CB GLU 434 42.172 49.560 52.567 1.00 24.12 ATOM 2964 CGGLU 434 41.226 49.009 53.624 1.00 34.46 ATOM 2965 CD GLU 434 40.54250.099 54.420 1.00 38.95 ATOM 2966 OE1 GLU 434 41.253 50.975 54.958 1.0042.61 ATOM 2967 OE2 GLU 434 39.295 50.078 54.515 1.00 42.67 ATOM 2968 CGLU 434 44.476 49.606 51.604 1.00 18.30 ATOM 2969 O GLU 434 45.30350.507 51.713 1.00 16.88 ATOM 2970 N GLY 435 44.271 48.945 50.466 1.0019.36 ATOM 2971 CA GLY 435 45.031 49.296 49.276 1.00 18.55 ATOM 2972 CGLY 435 44.491 50.578 48.679 1.00 18.67 ATOM 2973 O GLY 435 43.40051.005 49.055 1.00 17.09 ATOM 2974 N ALA 436 45.246 51.204 47.775 1.0019.08 ATOM 2975 CA ALA 436 44.799 52.442 47.123 1.00 17.26 ATOM 2976 CBALA 436 45.667 52.731 45.906 1.00 17.85 ATOM 2977 C ALA 436 43.33652.215 46.722 1.00 16.59 ATOM 2978 O ALA 436 42.493 53.097 46.842 1.0016.06 ATOM 2979 N ASN 437 43.066 51.020 46.212 1.00 16.87 ATOM 2980 CAASN 437 41.712 50.570 45.889 1.00 16.03 ATOM 2981 CB ASN 437 41.18551.088 44.526 1.00 14.52 ATOM 2982 CG ASN 437 41.872 50.474 43.324 1.0014.43 ATOM 2983 OD1 ASN 437 42.105 49.269 43.261 1.00 15.44 ATOM 2984ND2 ASN 437 42.162 51.311 42.335 1.00 13.55 ATOM 2985 C ASN 437 41.86549.054 45.948 1.00 16.39 ATOM 2986 O ASN 437 42.988 48.551 45.956 1.0015.77 ATOM 2987 N PRO 438 40.756 48.306 46.030 1.00 15.87 ATOM 2988 CDPRO 438 39.350 48.730 46.157 1.00 14.94 ATOM 2989 CA PRO 438 40.86946.846 46.105 1.00 13.68 ATOM 2990 CB PRO 438 39.413 46.391 46.059 1.0014.60 ATOM 2991 CG PRO 438 38.712 47.508 46.793 1.00 16.23 ATOM 2992 CPRO 438 41.737 46.185 45.039 1.00 14.27 ATOM 2993 O PRO 438 42.37945.170 45.306 1.00 14.30 ATOM 2994 N GLY 439 41.760 46.760 43.840 1.0013.68 ATOM 2995 CA GLY 439 42.563 46.201 42.766 1.00 13.77 ATOM 2996 CGLY 439 44.051 46.182 43.070 1.00 14.65 ATOM 2997 O GLY 439 44.74145.203 42.776 1.00 12.71 ATOM 2998 N PHE 440 44.553 47.269 43.649 1.0014.29 ATOM 2999 CA PHE 440 45.968 47.364 44.006 1.00 14.09 ATOM 3000 CBPHE 440 46.262 48.708 44.691 1.00 14.69 ATOM 3001 CG PHE 440 46.46749.856 43.736 1.00 17.06 ATOM 3002 CD1 PHE 440 45.474 50.226 42.836 1.0016.87 ATOM 3003 CD2 PHE 440 47.658 50.580 43.753 1.00 16.76 ATOM 3004CE1 PHE 440 45.663 51.307 41.962 1.00 16.34 ATOM 3005 CE2 PHE 440 47.85651.655 42.890 1.00 16.34 ATOM 3006 CZ PHE 440 46.857 52.019 41.993 1.0016.50 ATOM 3007 C PHE 440 46.369 46.235 44.954 1.00 13.76 ATOM 3008 OPHE 440 47.432 45.629 44.807 1.00 12.46 ATOM 3009 N HIS 441 45.52145.962 45.940 1.00 14.94 ATOM 3010 CA HIS 441 45.813 44.911 46.910 1.0015.78 ATOM 3011 CB HIS 441 44.703 44.833 47.964 1.00 17.07 ATOM 3012 CGHIS 441 45.209 44.750 49.374 1.00 15.66 ATOM 3013 CD2 HIS 441 44.96045.526 50.456 1.00 15.15 ATOM 3014 ND1 HIS 441 46.073 43.763 49.802 1.0016.88 ATOM 3015 CE1 HIS 441 46.332 43.935 51.087 1.00 14.94 ATOM 3016NE2 HIS 441 45.669 44.998 51.508 1.00 15.07 ATOM 3017 C HIS 441 45.95843.555 46.220 1.00 16.92 ATOM 3018 O HIS 441 46.813 42.747 46.592 1.0015.31 ATOM 3019 N GLU 442 45.122 43.311 45.214 1.00 16.74 ATOM 3020 CAGLU 442 45.162 42.049 44.482 1.00 15.92 ATOM 3021 CB GLU 442 43.86141.851 43.701 1.00 15.02 ATOM 3022 CG GLU 442 42.590 41.822 44.542 1.0011.10 ATOM 3023 CD GLU 442 42.635 40.757 45.617 1.00 11.15 ATOM 3024 OE1GLU 442 43.250 39.697 45.371 1.00 14.00 ATOM 3025 OE2 GLU 442 42.05540.975 46.699 1.00 11.81 ATOM 3026 C GLU 442 46.329 41.955 43.497 1.0017.24 ATOM 3027 O GLU 442 46.778 40.859 43.162 1.00 16.84 ATOM 3028 NALA 443 46.826 43.100 43.039 1.00 15.95 ATOM 3029 CA ALA 443 47.89443.114 42.041 1.00 17.36 ATOM 3030 CB ALA 443 47.799 44.404 41.221 1.0015.87 ATOM 3031 C ALA 443 49.343 42.907 42.491 1.00 16.95 ATOM 3032 OALA 443 50.135 42.328 41.750 1.00 17.94 ATOM 3033 N ILE 444 49.69243.374 43.686 1.00 16.73 ATOM 3034 CA ILE 444 51.070 43.264 44.176 1.0015.92 ATOM 3035 CB ILE 444 51.166 43.630 45.671 1.00 15.04 ATOM 3036 CG2ILE 444 52.631 43.664 46.095 1.00 16.89 ATOM 3037 CG1 ILE 444 50.50244.990 45.927 1.00 14.90 ATOM 3038 CD1 ILE 444 51.112 46.139 45.153 1.0015.89 ATOM 3039 C ILE 444 51.744 41.902 43.980 1.00 16.43 ATOM 3040 OILE 444 52.792 41.807 43.332 1.00 15.13 ATOM 3041 N GLY 445 51.15540.858 44.554 1.00 15.53 ATOM 3042 CA GLY 445 51.724 39.528 44.427 1.0016.88 ATOM 3043 C GLY 445 51.844 39.072 42.985 1.00 18.50 ATOM 3044 OGLY 445 52.866 38.512 42.581 1.00 17.19 ATOM 3045 N ASP 446 50.79639.317 42.205 1.00 16.96 ATOM 3046 CA ASP 446 50.775 38.935 40.795 1.0017.24 ATOM 3047 CB ASP 446 49.438 39.334 40.157 1.00 15.35 ATOM 3048 CGASP 446 48.291 38.426 40.579 1.00 17.38 ATOM 3049 OD1 ASP 446 48.29837.936 41.728 1.00 14.96 ATOM 3050 OD2 ASP 446 47.370 38.212 39.761 1.0016.72 ATOM 3051 C ASP 446 51.919 39.572 40.016 1.00 18.31 ATOM 3052 OASP 446 52.503 38.939 39.132 1.00 16.77 ATOM 3053 N VAL 447 52.23440.829 40.328 1.00 18.18 ATOM 3054 CA VAL 447 53.314 41.508 39.629 1.0018.02 ATOM 3055 CB VAL 447 53.542 42.935 40.158 1.00 17.59 ATOM 3056 CG1VAL 447 54.795 43.520 39.514 1.00 20.25 ATOM 3057 CG2 VAL 447 52.33043.816 39.831 1.00 15.79 ATOM 3058 C VAL 447 54.611 40.716 39.765 1.0018.36 ATOM 3059 O VAL 447 55.293 40.471 38.773 1.00 17.66 ATOM 3060 NLEU 448 54.948 40.312 40.986 1.00 18.09 ATOM 3061 CA LEU 448 56.16739.543 41.194 1.00 18.49 ATOM 3062 CB LEU 448 56.464 39.378 42.691 1.0017.75 ATOM 3063 CG LEU 448 57.233 40.500 43.405 1.00 18.33 ATOM 3064 CD1LEU 448 56.458 41.811 43.359 1.00 17.13 ATOM 3065 CD2 LEU 448 57.48740.082 44.848 1.00 18.72 ATOM 3066 C LEU 448 56.053 38.170 40.529 1.0019.50 ATOM 3067 O LEU 448 57.011 37.682 39.930 1.00 20.72 ATOM 3068 NALA 449 54.879 37.551 40.627 1.00 18.48 ATOM 3069 CA ALA 449 54.67136.240 40.028 1.00 18.81 ATOM 3070 CB ALA 449 53.260 35.731 40.337 1.0018.00 ATOM 3071 C ALA 449 54.905 36.272 38.518 1.00 17.58 ATOM 3072 OALA 449 55.285 35.261 37.925 1.00 17.76 ATOM 3073 N LEU 450 54.67737.424 37.890 1.00 16.49 ATOM 3074 CA LEU 450 54.898 37.536 36.449 1.0016.51 ATOM 3075 CB LEU 450 54.516 38.933 35.935 1.00 15.69 ATOM 3076 CGLEU 450 53.027 39.294 35.797 1.00 14.12 ATOM 3077 CD1 LEU 450 52.88740.749 35.374 1.00 12.95 ATOM 3078 CD2 LEU 450 52.356 38.385 34.770 1.0015.02 ATOM 3079 C LEU 450 56.376 37.262 36.150 1.00 18.30 ATOM 3080 OLEU 450 56.702 36.552 35.196 1.00 17.45 ATOM 3081 N SER 451 57.26637.824 36.966 1.00 18.19 ATOM 3082 CA SER 451 58.701 37.617 36.777 1.0018.99 ATOM 3083 CB SER 451 59.507 38.572 37.663 1.00 16.95 ATOM 3084 OGSER 451 59.480 39.890 37.141 1.00 17.53 ATOM 3085 C SER 451 59.09236.178 37.092 1.00 19.71 ATOM 3086 O SER 451 59.896 35.575 36.383 1.0020.72 ATOM 3087 N VAL 452 58.520 35.635 38.160 1.00 21.54 ATOM 3088 CAVAL 452 58.798 34.263 38.574 1.00 22.76 ATOM 3089 CB VAL 452 57.99733.893 39.843 1.00 22.77 ATOM 3090 CG1 VAL 452 58.217 32.428 40.195 1.0025.58 ATOM 3091 CG2 VAL 452 58.419 34.781 40.997 1.00 25.93 ATOM 3092 CVAL 452 58.435 33.259 37.482 1.00 24.01 ATOM 3093 O VAL 452 59.11232.243 37.307 1.00 23.13 ATOM 3094 N SER 453 57.358 33.552 36.757 1.0022.60 ATOM 3095 CA SER 453 56.870 32.678 35.693 1.00 23.40 ATOM 3096 CBSER 453 55.434 33.067 35.317 1.00 21.89 ATOM 3097 OG SER 453 54.54632.810 36.393 1.00 20.22 ATOM 3098 C SER 453 57.715 32.622 34.424 1.0022.87 ATOM 3099 O SER 453 57.563 31.697 33.631 1.00 22.16 ATOM 3100 NTHR 454 58.592 33.602 34.219 1.00 23.18 ATOM 3101 CA THR 454 59.42033.601 33.016 1.00 24.33 ATOM 3102 CB THR 454 60.373 34.817 32.972 1.0023.24 ATOM 3103 OG1 THR 454 61.199 34.827 34.143 1.00 24.32 ATOM 3104CG2 THR 454 59.576 36.115 32.894 1.00 24.49 ATOM 3105 C THR 454 60.24032.313 32.940 1.00 25.55 ATOM 3106 O THR 454 60.749 31.827 33.949 1.0025.28 ATOM 3107 N PRO 455 60.368 31.738 31.734 1.00 25.92 ATOM 3108 CDPRO 455 59.860 32.211 30.433 1.00 26.48 ATOM 3109 CA PRO 455 61.13430.499 31.574 1.00 27.37 ATOM 3110 CB PRO 455 61.238 30.351 30.058 1.0027.14 ATOM 3111 CG PRO 455 59.949 30.959 29.578 1.00 25.75 ATOM 3112 CPRO 455 62.499 30.573 32.245 1.00 27.20 ATOM 3113 O PRO 455 62.90929.646 32.946 1.00 26.66 ATOM 3114 N LYS 456 63.193 31.688 32.045 1.0028.50 ATOM 3115 CA LYS 456 64.513 31.851 32.626 1.00 29.18 ATOM 3116 CBLYS 456 65.150 33.161 32.164 1.00 31.89 ATOM 3117 CG LYS 456 66.66933.142 32.280 1.00 36.40 ATOM 3118 CD LYS 456 67.296 34.487 31.959 1.0039.36 ATOM 3119 CE LYS 456 68.815 34.374 31.932 1.00 40.98 ATOM 3120 NZLYS 456 69.335 33.657 33.129 1.00 43.02 ATOM 3121 C LYS 456 64.50131.795 34.151 1.00 29.42 ATOM 3122 O LYS 456 65.366 31.151 34.753 1.0028.75 ATOM 3123 N HIS 457 63.534 32.458 34.785 1.00 24.85 ATOM 3124 CAHIS 457 63.486 32.427 36.242 1.00 23.20 ATOM 3125 CB HIS 457 62.43933.397 36.791 1.00 23.95 ATOM 3126 CG HIS 457 62.503 33.558 38.278 1.0023.17 ATOM 3127 CD2 HIS 457 61.930 32.846 39.277 1.00 23.50 ATOM 3128ND1 HIS 457 63.300 34.501 38.892 1.00 24.07 ATOM 3129 CE1 HIS 457 63.21834.360 40.203 1.00 25.29 ATOM 3130 NE2 HIS 457 62.393 33.361 40.463 1.0025.90 ATOM 3131 C HIS 457 63.167 31.019 36.738 1.00 23.20 ATOM 3132 OHIS 457 63.768 30.541 37.701 1.00 21.36 ATOM 3133 N LEU 458 62.20830.362 36.089 1.00 24.06 ATOM 3134 CA LEU 458 61.835 29.010 36.481 1.0025.22 ATOM 3135 CB LEU 458 60.694 28.486 35.600 1.00 25.32 ATOM 3136 CGLEU 458 59.302 29.096 35.812 1.00 24.79 ATOM 3137 CD1 LEU 458 58.31428.482 34.827 1.00 24.94 ATOM 3138 CD2 LEU 458 58.848 28.852 37.249 1.0024.07 ATOM 3139 C LEU 458 63.058 28.105 36.350 1.00 26.11 ATOM 3140 OLEU 458 63.265 27.204 37.157 1.00 24.93 ATOM 3141 N HIS 459 63.87528.356 35.334 1.00 28.43 ATOM 3142 CA HIS 459 65.070 27.548 35.140 1.0031.28 ATOM 3143 CB HIS 459 65.731 27.872 33.799 1.00 33.71 ATOM 3144 CGHIS 459 66.959 27.060 33.521 1.00 39.54 ATOM 3145 CD2 HIS 459 67.15225.977 32.730 1.00 40.92 ATOM 3146 ND1 HIS 459 68.174 27.316 34.120 1.0042.70 ATOM 3147 CE1 HIS 459 69.062 26.427 33.711 1.00 42.68 ATOM 3148NE2 HIS 459 68.467 25.603 32.867 1.00 43.45 ATOM 3149 C HIS 459 66.05327.782 36.283 1.00 30.04 ATOM 3150 O HIS 459 66.755 26.861 36.699 1.0029.57 ATOM 3151 N SER 460 66.087 29.008 36.803 1.00 28.70 ATOM 3152 CASER 460 66.997 29.335 37.897 1.00 27.62 ATOM 3153 CB SER 460 67.03430.850 38.142 1.00 27.69 ATOM 3154 OG SER 460 65.945 31.283 38.942 1.0027.73 ATOM 3155 C SER 460 66.579 28.613 39.174 1.00 27.55 ATOM 3156 OSER 460 67.380 28.446 40.091 1.00 26.24 ATOM 3157 N LEU 461 65.32128.186 39.228 1.00 26.91 ATOM 3158 CA LEU 461 64.808 27.463 40.388 1.0029.43 ATOM 3159 CB LEU 461 63.337 27.813 40.641 1.00 27.64 ATOM 3160 CGLEU 461 63.027 29.239 41.101 1.00 28.24 ATOM 3161 CD1 LEU 461 61.52329.462 41.111 1.00 28.05 ATOM 3162 CD2 LEU 461 63.611 29.461 42.488 1.0027.97 ATOM 3163 C LEU 461 64.931 25.971 40.119 1.00 30.51 ATOM 3164 OLEU 461 64.528 25.142 40.938 1.00 31.19 ATOM 3165 N ASN 462 65.49125.649 38.957 1.00 32.47 ATOM 3166 CA ASN 462 65.684 24.272 38.523 1.0034.80 ATOM 3167 CB ASN 462 66.447 23.484 39.594 1.00 35.75 ATOM 3168 CGASN 462 67.114 22.241 39.036 1.00 38.55 ATOM 3169 OD1 ASN 462 67.73222.283 37.973 1.00 38.16 ATOM 3170 ND2 ASN 462 67.006 21.132 39.758 1.0039.43 ATOM 3171 C ASN 462 64.337 23.607 38.222 1.00 36.15 ATOM 3172 OASN 462 64.154 22.414 38.466 1.00 35.72 ATOM 3173 N LEU 463 63.40224.391 37.689 1.00 36.82 ATOM 3174 CA LEU 463 62.074 23.886 37.345 1.0039.43 ATOM 3175 CB LEU 463 60.987 24.713 38.038 1.00 37.66 ATOM 3176 CGLEU 463 60.997 24.667 39.569 1.00 37.31 ATOM 3177 CD1 LEU 463 59.83625.492 40.111 1.00 36.51 ATOM 3178 CD2 LEU 463 60.898 23.227 40.046 1.0036.47 ATOM 3179 C LEU 463 61.851 23.900 35.839 1.00 41.12 ATOM 3180 OLEU 463 60.771 23.568 35.355 1.00 42.26 ATOM 3181 N LEU 464 62.88024.307 35.105 1.00 43.53 ATOM 3182 CA LEU 464 62.832 24.341 33.647 1.0046.78 ATOM 3183 CB LEU 464 62.358 25.707 33.131 1.00 47.15 ATOM 3184 CGLEU 464 60.846 25.963 33.126 1.00 47.86 ATOM 3185 CD1 LEU 464 60.55327.253 32.374 1.00 48.43 ATOM 3186 CD2 LEU 464 60.122 24.801 32.457 1.0048.04 ATOM 3187 C LEU 464 64.217 24.032 33.097 1.00 47.91 ATOM 3188 OLEU 464 65.208 24.081 33.830 1.00 48.74 ATOM 3189 N SER 465 64.28223.702 31.812 1.00 49.72 ATOM 3190 CA SER 465 65.552 23.375 31.173 1.0051.10 ATOM 3191 CB SER 465 65.619 21.873 30.887 1.00 51.49 ATOM 3192 OGSER 465 64.505 21.452 30.117 1.00 52.92 ATOM 3193 C SER 465 65.74524.157 29.879 1.00 51.56 ATOM 3194 O SER 465 66.428 25.182 29.860 1.0052.18 ATOM 3195 N GLY 470 64.653 32.326 21.785 1.00 48.10 ATOM 3196 CAGLY 470 63.950 31.478 20.839 1.00 48.51 ATOM 3197 C GLY 470 62.52231.928 20.591 1.00 47.84 ATOM 3198 O GLY 470 61.718 31.998 21.520 1.0048.31 ATOM 3199 N ALA 471 62.202 32.229 19.336 1.00 46.54 ATOM 3200 CAALA 471 60.864 32.681 18.976 1.00 45.12 ATOM 3201 CB ALA 471 60.79932.979 17.485 1.00 46.24 ATOM 3202 C ALA 471 59.799 31.654 19.351 1.0044.20 ATOM 3203 O ALA 471 58.843 31.976 20.056 1.00 44.05 ATOM 3204 NGLU 472 59.965 30.420 18.883 1.00 41.85 ATOM 3205 CA GLU 472 59.00229.367 19.178 1.00 40.72 ATOM 3206 CB GLU 472 59.411 28.062 18.492 1.0040.77 ATOM 3207 CG GLU 472 59.039 28.041 17.019 1.00 43.32 ATOM 3208 CDGLU 472 59.363 26.728 16.336 1.00 44.64 ATOM 3209 OE1 GLU 472 59.31925.675 17.008 1.00 44.66 ATOM 3210 OE2 GLU 472 59.641 26.753 15.117 1.0046.17 ATOM 3211 C GLU 472 58.810 29.146 20.672 1.00 39.99 ATOM 3212 OGLU 472 57.724 28.762 21.111 1.00 37.39 ATOM 3213 N HIS 473 59.85929.380 21.454 1.00 39.00 ATOM 3214 CA HIS 473 59.746 29.226 22.896 1.0038.09 ATOM 3215 CB HIS 473 61.121 29.080 23.551 1.00 40.74 ATOM 3216 CGHIS 473 61.664 27.684 23.510 1.00 43.40 ATOM 3217 CD2 HIS 473 61.47526.632 24.341 1.00 44.06 ATOM 3218 ND1 HIS 473 62.501 27.236 22.510 1.0045.60 ATOM 3219 CE1 HIS 473 62.805 25.969 22.729 1.00 45.16 ATOM 3220NE2 HIS 473 62.195 25.578 23.833 1.00 45.60 ATOM 3221 C HIS 473 59.03230.449 23.453 1.00 36.31 ATOM 3222 O HIS 473 58.367 30.368 24.482 1.0036.98 ATOM 3223 N ASP 474 59.172 31.581 22.766 1.00 34.37 ATOM 3224 CAASP 474 58.516 32.810 23.187 1.00 34.17 ATOM 3225 CB ASP 474 59.00034.009 22.365 1.00 38.03 ATOM 3226 CG ASP 474 60.243 34.647 22.937 1.0041.09 ATOM 3227 OD1 ASP 474 60.257 34.930 24.154 1.00 42.53 ATOM 3228OD2 ASP 474 61.202 34.878 22.169 1.00 43.99 ATOM 3229 C ASP 474 57.00732.692 23.021 1.00 32.16 ATOM 3230 O ASP 474 56.248 33.095 23.903 1.0030.43 ATOM 3231 N ILE 475 56.580 32.153 21.880 1.00 28.89 ATOM 3232 CAILE 475 55.159 31.996 21.595 1.00 25.76 ATOM 3233 CB ILE 475 54.92231.577 20.122 1.00 26.10 ATOM 3234 CG2 ILE 475 53.425 31.456 19.838 1.0022.06 ATOM 3235 CG1 ILE 475 55.544 32.613 19.183 1.00 23.79 ATOM 3236CD1 ILE 475 54.998 34.015 19.363 1.00 25.45 ATOM 3237 C ILE 475 54.53930.962 22.526 1.00 24.56 ATOM 3238 O ILE 475 53.422 31.150 23.009 1.0023.51 ATOM 3239 N ASN 476 55.258 29.869 22.775 1.00 22.07 ATOM 3240 CAASN 476 54.749 28.843 23.673 1.00 22.59 ATOM 3241 CB ASN 476 55.71827.658 23.777 1.00 22.82 ATOM 3242 CG ASN 476 55.557 26.656 22.640 1.0023.84 ATOM 3243 OD1 ASN 476 54.640 26.756 21.822 1.00 23.67 ATOM 3244ND2 ASN 476 56.451 25.674 22.595 1.00 22.00 ATOM 3245 C ASN 476 54.56429.465 25.057 1.00 22.14 ATOM 3246 O ASN 476 53.554 29.231 25.721 1.0020.32 ATOM 3247 N PHE 477 55.544 30.258 25.487 1.00 19.74 ATOM 3248 CAPHE 477 55.473 30.907 26.795 1.00 20.07 ATOM 3249 CB PHE 477 56.77931.630 27.118 1.00 19.28 ATOM 3250 CG PHE 477 56.697 32.491 28.348 1.0019.26 ATOM 3251 CD1 PHE 477 56.387 31.930 29.582 1.00 19.77 ATOM 3252CD2 PHE 477 56.908 33.861 28.270 1.00 18.99 ATOM 3253 CE1 PHE 477 56.28832.721 30.723 1.00 20.49 ATOM 3254 CE2 PHE 477 56.811 34.664 29.404 1.0021.68 ATOM 3255 CZ PHE 477 56.501 34.091 30.634 1.00 20.79 ATOM 3256 CPHE 477 54.327 31.910 26.879 1.00 18.41 ATOM 3257 O PHE 477 53.55831.907 27.840 1.00 17.57 ATOM 3258 N LEU 478 54.230 32.782 25.882 1.0016.70 ATOM 3259 CA LEU 478 53.171 33.778 25.858 1.00 17.73 ATOM 3260 CBLEU 478 53.315 34.692 24.634 1.00 18.54 ATOM 3261 CG LEU 478 54.44135.733 24.725 1.00 18.88 ATOM 3262 CD1 LEU 478 54.594 36.453 23.399 1.0020.51 ATOM 3263 CD2 LEU 478 54.133 36.732 25.835 1.00 21.13 ATOM 3264 CLEU 478 51.808 33.094 25.857 1.00 17.77 ATOM 3265 O LEU 478 50.85933.602 26.454 1.00 16.81 ATOM 3266 N MET 479 51.710 31.943 25.192 1.0016.85 ATOM 3267 CA MET 479 50.447 31.207 25.155 1.00 16.42 ATOM 3268 CBMET 479 50.523 30.020 24.187 1.00 16.54 ATOM 3269 CG MET 479 49.26529.145 24.170 1.00 15.90 ATOM 3270 SD MET 479 47.741 30.068 23.800 1.0020.51 ATOM 3271 CE MET 479 47.978 30.453 22.101 1.00 14.74 ATOM 3272 CMET 479 50.112 30.697 26.552 1.00 18.16 ATOM 3273 O MET 479 48.96530.772 26.987 1.00 16.49 ATOM 3274 N LYS 480 51.108 30.169 27.257 1.0017.20 ATOM 3275 CA LYS 480 50.852 29.673 28.600 1.00 19.57 ATOM 3276 CBLYS 480 52.117 29.038 29.191 1.00 22.36 ATOM 3277 CG LYS 480 51.83728.140 30.387 1.00 27.80 ATOM 3278 CD LYS 480 53.012 27.221 30.741 1.0033.74 ATOM 3279 CE LYS 480 54.250 28.002 31.184 1.00 37.33 ATOM 3280 NZLYS 480 55.332 27.126 31.746 1.00 39.64 ATOM 3281 C LYS 480 50.36830.835 29.478 1.00 17.85 ATOM 3282 O LYS 480 49.420 30.689 30.247 1.0018.61 ATOM 3283 N MET 481 51.006 31.992 29.343 1.00 15.91 ATOM 3284 CAMET 481 50.619 33.165 30.123 1.00 16.21 ATOM 3285 CB MET 481 51.62734.302 29.925 1.00 15.78 ATOM 3286 CG MET 481 53.019 34.045 30.504 1.0017.36 ATOM 3287 SD MET 481 53.024 33.719 32.288 1.00 23.53 ATOM 3288 CEMET 481 52.210 35.205 32.913 1.00 14.65 ATOM 3289 C MET 481 49.22433.662 29.740 1.00 14.73 ATOM 3290 O MET 481 48.430 34.029 30.605 1.0015.28 ATOM 3291 N ALA 482 48.930 33.672 28.444 1.00 12.83 ATOM 3292 CAALA 482 47.635 34.144 27.966 1.00 14.42 ATOM 3293 CB ALA 482 47.64034.229 26.440 1.00 12.60 ATOM 3294 C ALA 482 46.485 33.254 28.432 1.0013.98 ATOM 3295 O ALA 482 45.404 33.737 28.742 1.00 12.54 ATOM 3296 NLEU 483 46.721 31.950 28.469 1.00 12.96 ATOM 3297 CA LEU 483 45.68731.019 28.889 1.00 15.49 ATOM 3298 CB LEU 483 46.221 29.581 28.845 1.0013.86 ATOM 3299 CG LEU 483 46.433 29.004 27.438 1.00 12.19 ATOM 3300 CD1LEU 483 47.119 27.645 27.522 1.00 12.00 ATOM 3301 CD2 LEU 483 45.09928.868 26.744 1.00 11.05 ATOM 3302 C LEU 483 45.172 31.377 30.286 1.0015.60 ATOM 3303 O LEU 483 44.029 31.076 30.633 1.00 13.79 ATOM 3304 NASP 484 46.011 32.026 31.088 1.00 17.99 ATOM 3305 CA ASP 484 45.57932.432 32.421 1.00 19.85 ATOM 3306 CB ASP 484 46.675 32.186 33.457 1.0023.35 ATOM 3307 CG ASP 484 46.697 30.752 33.950 1.00 31.47 ATOM 3308 OD1ASP 484 45.708 30.017 33.703 1.00 32.89 ATOM 3309 OD2 ASP 484 47.69230.358 34.590 1.00 35.68 ATOM 3310 C ASP 484 45.159 33.900 32.469 1.0019.15 ATOM 3311 O ASP 484 44.016 34.205 32.801 1.00 19.40 ATOM 3312 NLYS 485 46.074 34.797 32.106 1.00 15.90 ATOM 3313 CA LYS 485 45.80936.233 32.153 1.00 15.26 ATOM 3314 CB LYS 485 47.115 37.013 31.937 1.0016.44 ATOM 3315 CG LYS 485 48.221 36.683 32.935 1.00 17.03 ATOM 3316 CDLYS 485 47.780 36.925 34.376 1.00 16.07 ATOM 3317 CE LYS 485 48.91436.634 35.355 1.00 16.43 ATOM 3318 NZ LYS 485 48.526 36.873 36.774 1.0015.12 ATOM 3319 C LYS 485 44.743 36.792 31.207 1.00 15.09 ATOM 3320 OLYS 485 43.963 37.655 31.608 1.00 14.86 ATOM 3321 N ILE 486 44.72036.338 29.954 1.00 12.89 ATOM 3322 CA ILE 486 43.738 36.845 28.997 1.0012.96 ATOM 3323 CB ILE 486 44.206 36.634 27.534 1.00 12.31 ATOM 3324 CG2ILE 486 43.111 37.083 26.564 1.00 11.47 ATOM 3325 CG1 ILE 486 45.49237.431 27.269 1.00 14.69 ATOM 3326 CD1 ILE 486 45.378 38.921 27.561 1.0014.14 ATOM 3327 C ILE 486 42.370 36.185 29.177 1.00 13.40 ATOM 3328 OILE 486 41.339 36.856 29.155 1.00 13.09 ATOM 3329 N ALA 487 42.36334.868 29.343 1.00 13.68 ATOM 3330 CA ALA 487 41.108 34.143 29.523 1.0013.77 ATOM 3331 CB ALA 487 41.381 32.640 29.672 1.00 13.45 ATOM 3332 CALA 487 40.356 34.655 30.746 1.00 12.99 ATOM 3333 O ALA 487 39.13034.653 30.773 1.00 14.04 ATOM 3334 N PHE 488 41.095 35.111 31.750 1.0011.52 ATOM 3335 CA PHE 488 40.488 35.595 32.984 1.00 12.47 ATOM 3336 CBPHE 488 41.548 35.663 34.079 1.00 10.72 ATOM 3337 CG PHE 488 41.00235.979 35.445 1.00 13.51 ATOM 3338 CD1 PHE 488 40.295 35.019 36.172 1.0011.90 ATOM 3339 CD2 PHE 488 41.245 37.216 36.031 1.00 12.70 ATOM 3340CE1 PHE 488 39.850 35.286 37.467 1.00 12.84 ATOM 3341 CE2 PHE 488 40.80337.492 37.324 1.00 12.47 ATOM 3342 CZ PHE 488 40.106 36.524 38.043 1.0011.48 ATOM 3343 C PHE 488 39.806 36.957 32.858 1.00 12.87 ATOM 3344 OPHE 488 38.944 37.290 33.669 1.00 14.49 ATOM 3345 N ILE 489 40.19037.738 31.851 1.00 13.59 ATOM 3346 CA ILE 489 39.616 39.064 31.661 1.0012.89 ATOM 3347 CB ILE 489 40.200 39.758 30.404 1.00 14.05 ATOM 3348 CG2ILE 489 39.399 41.024 30.076 1.00 11.51 ATOM 3349 CG1 ILE 489 41.67740.100 30.636 1.00 15.42 ATOM 3350 CD1 ILE 489 41.931 41.022 31.840 1.0016.62 ATOM 3351 C ILE 489 38.083 39.080 31.581 1.00 14.01 ATOM 3352 OILE 489 37.433 39.771 32.361 1.00 13.07 ATOM 3353 N PRO 490 37.48638.340 30.630 1.00 11.60 ATOM 3354 CD PRO 490 38.036 37.616 29.470 1.0012.38 ATOM 3355 CA PRO 490 36.022 38.377 30.580 1.00 12.27 ATOM 3356 CBPRO 490 35.694 37.643 29.276 1.00 12.12 ATOM 3357 CG PRO 490 36.87636.749 29.062 1.00 14.13 ATOM 3358 C PRO 490 35.339 37.767 31.802 1.0011.71 ATOM 3359 O PRO 490 34.267 38.218 32.202 1.00 11.51 ATOM 3360 NPHE 491 35.950 36.747 32.401 1.00 10.88 ATOM 3361 CA PHE 491 35.34636.126 33.581 1.00 10.74 ATOM 3362 CB PHE 491 36.113 34.871 34.017 1.009.32 ATOM 3363 CG PHE 491 35.556 34.230 35.269 1.00 9.41 ATOM 3364 CD1PHE 491 34.443 33.396 35.206 1.00 10.06 ATOM 3365 CD2 PHE 491 36.12134.492 36.511 1.00 9.76 ATOM 3366 CE1 PHE 491 33.901 32.834 36.365 1.0012.14 ATOM 3367 CE2 PHE 491 35.589 33.937 37.679 1.00 11.37 ATOM 3368 CZPHE 491 34.476 33.104 37.606 1.00 11.49 ATOM 3369 C PHE 491 35.33737.110 34.745 1.00 10.49 ATOM 3370 O PHE 491 34.308 37.310 35.390 1.0011.46 ATOM 3371 N SER 492 36.482 37.732 35.005 1.00 10.88 ATOM 3372 CASER 492 36.584 38.673 36.117 1.00 12.32 ATOM 3373 CB SER 492 38.03139.125 36.308 1.00 11.29 ATOM 3374 OG SER 492 38.510 39.836 35.181 1.0011.99 ATOM 3375 C SER 492 35.679 39.888 35.940 1.00 13.79 ATOM 3376 OSER 492 35.297 40.533 36.919 1.00 15.69 ATOM 3377 N TYR 493 35.34040.190 34.693 1.00 12.01 ATOM 3378 CA TYR 493 34.468 41.320 34.374 1.0012.81 ATOM 3379 CB TYR 493 34.633 41.700 32.897 1.00 14.65 ATOM 3380 CGTYR 493 33.937 42.983 32.493 1.00 16.68 ATOM 3381 CD1 TYR 493 34.36244.214 32.989 1.00 18.71 ATOM 3382 CE1 TYR 493 33.724 45.398 32.624 1.0020.68 ATOM 3383 CD2 TYR 493 32.852 42.966 31.617 1.00 17.79 ATOM 3384CE2 TYR 493 32.207 44.147 31.245 1.00 20.59 ATOM 3385 CZ TYR 493 32.64945.357 31.753 1.00 19.58 ATOM 3386 OH TYR 493 32.014 46.526 31.400 1.0018.46 ATOM 3387 C TYR 493 33.010 40.948 34.621 1.00 13.40 ATOM 3388 OTYR 493 32.227 41.727 35.162 1.00 13.85 ATOM 3389 N LEU 494 32.66639.733 34.217 1.00 12.33 ATOM 3390 CA LEU 494 31.313 39.197 34.311 1.0013.77 ATOM 3391 CB LEU 494 31.293 37.864 33.551 1.00 16.44 ATOM 3392 CGLEU 494 30.246 36.756 33.614 1.00 23.07 ATOM 3393 CD1 LEU 494 30.66535.692 32.600 1.00 23.72 ATOM 3394 CD2 LEU 494 30.142 36.150 34.994 1.0018.70 ATOM 3395 C LEU 494 30.713 39.016 35.704 1.00 11.84 ATOM 3396 OLEU 494 29.542 39.330 35.925 1.00 13.02 ATOM 3397 N VAL 495 31.50538.516 36.643 1.00 10.62 ATOM 3398 CA VAL 495 30.990 38.236 37.979 1.0011.98 ATOM 3399 CB VAL 495 32.112 37.768 38.922 1.00 11.36 ATOM 3400 CG1VAL 495 31.552 37.498 40.309 1.00 9.21 ATOM 3401 CG2 VAL 495 32.75136.504 38.362 1.00 13.56 ATOM 3402 C VAL 495 30.207 39.360 38.642 1.0012.05 ATOM 3403 O VAL 495 29.064 39.150 39.050 1.00 8.92 ATOM 3404 N ASP496 30.802 40.543 38.760 1.00 11.08 ATOM 3405 CA ASP 496 30.086 41.64139.391 1.00 11.99 ATOM 3406 CB ASP 496 31.056 42.624 40.061 1.00 11.20ATOM 3407 CG ASP 496 31.579 42.096 41.400 1.00 12.07 ATOM 3408 OD1 ASP496 31.048 41.069 41.881 1.00 13.72 ATOM 3409 OD2 ASP 496 32.507 42.69541.980 1.00 10.70 ATOM 3410 C ASP 496 29.120 42.358 38.453 1.00 13.14ATOM 3411 O ASP 496 28.297 43.151 38.906 1.00 12.97 ATOM 3412 N GLN 49729.207 42.096 37.151 1.00 12.75 ATOM 3413 CA GLN 497 28.234 42.71136.255 1.00 12.19 ATOM 3414 CB GLN 497 28.561 42.447 34.781 1.00 14.86ATOM 3415 CG GLN 497 29.789 43.181 34.232 1.00 15.25 ATOM 3416 CD GLN497 29.717 44.698 34.383 1.00 19.00 ATOM 3417 OE1 GLN 497 28.641 45.29034.356 1.00 17.62 ATOM 3418 NE2 GLN 497 30.875 45.330 34.526 1.00 19.82ATOM 3419 C GLN 497 26.926 42.008 36.633 1.00 14.20 ATOM 3420 O GLN 49725.857 42.615 36.640 1.00 12.70 ATOM 3421 N TRP 498 27.033 40.720 36.9641.00 12.15 ATOM 3422 CA TRP 498 25.876 39.927 37.371 1.00 13.21 ATOM3423 CB TRP 498 26.230 38.435 37.414 1.00 12.05 ATOM 3424 CG TRP 49825.081 37.551 37.820 1.00 12.38 ATOM 3425 CD2 TRP 498 24.828 37.02539.124 1.00 11.96 ATOM 3426 CE2 TRP 498 23.647 36.251 39.043 1.00 14.37ATOM 3427 CE3 TRP 498 25.487 37.129 40.357 1.00 12.53 ATOM 3428 CD1 TRP498 24.068 37.091 37.018 1.00 13.82 ATOM 3429 NE1 TRP 498 23.204 36.30937.747 1.00 13.23 ATOM 3430 CZ2 TRP 498 23.111 35.584 40.150 1.00 12.76ATOM 3431 CZ3 TRP 498 24.953 36.463 41.458 1.00 14.42 ATOM 3432 CH2 TRP498 23.777 35.702 41.345 1.00 12.98 ATOM 3433 C TRP 498 25.388 40.36338.757 1.00 12.74 ATOM 3434 O TRP 498 24.202 40.609 38.945 1.00 12.76ATOM 3435 N ARG 499 26.297 40.458 39.726 1.00 14.02 ATOM 3436 CA ARG 49925.907 40.862 41.080 1.00 14.05 ATOM 3437 CB ARG 499 27.069 40.69342.066 1.00 13.99 ATOM 3438 CG ARG 499 27.111 39.317 42.732 1.00 15.24ATOM 3439 CD ARG 499 28.018 39.283 43.967 1.00 14.11 ATOM 3440 NE ARG499 29.427 39.442 43.618 1.00 12.25 ATOM 3441 CZ ARG 499 30.435 38.95944.333 1.00 14.41 ATOM 3442 NH1 ARG 499 30.195 38.280 45.453 1.00 13.25ATOM 3443 NH2 ARG 499 31.686 39.137 43.917 1.00 12.95 ATOM 3444 C ARG499 25.362 42.289 41.177 1.00 15.06 ATOM 3445 O ARG 499 24.423 42.53941.936 1.00 13.96 ATOM 3446 N TRP 500 25.942 43.223 40.427 1.00 12.32ATOM 3447 CA TRP 500 25.454 44.600 40.469 1.00 14.74 ATOM 3448 CB TRP500 26.277 45.529 39.561 1.00 11.23 ATOM 3449 CG TRP 500 27.692 45.75339.989 1.00 12.02 ATOM 3450 CD2 TRP 500 28.757 46.277 39.181 1.00 11.01ATOM 3451 CE2 TRP 500 29.916 46.302 39.984 1.00 10.87 ATOM 3452 CE3 TRP500 28.841 46.728 37.855 1.00 13.39 ATOM 3453 CD1 TRP 500 28.233 45.49541.214 1.00 10.03 ATOM 3454 NE1 TRP 500 29.567 45.819 41.218 1.00 10.74ATOM 3455 CZ2 TRP 500 31.153 46.759 39.508 1.00 8.74 ATOM 3456 CZ3 TRP500 30.073 47.186 37.378 1.00 11.68 ATOM 3457 CH2 TRP 500 31.210 47.19538.205 1.00 11.27 ATOM 3458 C TRP 500 23.997 44.651 40.015 1.00 15.43ATOM 3459 O TRP 500 23.213 45.457 40.513 1.00 14.95 ATOM 3460 N ARG 50123.643 43.799 39.056 1.00 15.05 ATOM 3461 CA ARG 501 22.275 43.76938.551 1.00 15.13 ATOM 3462 CB ARG 501 22.249 43.170 37.142 1.00 17.81ATOM 3463 CG ARG 501 22.833 44.107 36.088 1.00 22.48 ATOM 3464 CD ARG501 22.988 43.403 34.751 1.00 29.90 ATOM 3465 NE ARG 501 21.713 42.90134.245 1.00 35.03 ATOM 3466 CZ ARG 501 21.596 41.864 33.422 1.00 37.06ATOM 3467 NH1 ARG 501 22.678 41.213 33.012 1.00 37.13 ATOM 3468 NH2 ARG501 20.397 41.481 33.004 1.00 36.72 ATOM 3469 C ARG 501 21.346 43.00639.493 1.00 15.12 ATOM 3470 O ARG 501 20.129 43.222 39.497 1.00 13.20ATOM 3471 N VAL 502 21.917 42.102 40.284 1.00 13.23 ATOM 3472 CA VAL 50221.126 41.367 41.262 1.00 14.21 ATOM 3473 CB VAL 502 21.910 40.17541.854 1.00 10.98 ATOM 3474 CG1 VAL 502 21.207 39.660 43.102 1.00 11.32ATOM 3475 CG2 VAL 502 22.003 39.052 40.816 1.00 14.99 ATOM 3476 C VAL502 20.820 42.369 42.373 1.00 14.19 ATOM 3477 O VAL 502 19.678 42.51342.813 1.00 14.12 ATOM 3478 N PHE 503 21.862 43.072 42.802 1.00 14.50ATOM 3479 CA PHE 503 21.749 44.070 43.856 1.00 15.39 ATOM 3480 CB PHE503 23.139 44.614 44.197 1.00 14.83 ATOM 3481 CG PHE 503 23.999 43.64744.971 1.00 14.46 ATOM 3482 CD1 PHE 503 25.383 43.722 44.901 1.00 14.93ATOM 3483 CD2 PHE 503 23.422 42.677 45.793 1.00 16.22 ATOM 3484 CE1 PHE503 26.186 42.848 45.640 1.00 14.36 ATOM 3485 CE2 PHE 503 24.218 41.79746.537 1.00 12.05 ATOM 3486 CZ PHE 503 25.598 41.886 46.459 1.00 15.10ATOM 3487 C PHE 503 20.802 45.221 43.509 1.00 15.02 ATOM 3488 O PHE 50320.022 45.650 44.359 1.00 14.79 ATOM 3489 N ASP 504 20.853 45.722 42.2741.00 14.97 ATOM 3490 CA ASP 504 19.963 46.820 41.916 1.00 15.11 ATOM3491 CB ASP 504 20.575 47.716 40.819 1.00 15.57 ATOM 3492 CG ASP 50420.520 47.100 39.426 1.00 16.33 ATOM 3493 OD1 ASP 504 19.860 46.05739.220 1.00 17.34 ATOM 3494 OD2 ASP 504 21.144 47.689 38.522 1.00 17.52ATOM 3495 C ASP 504 18.565 46.356 41.516 1.00 16.58 ATOM 3496 O ASP 50417.756 47.153 41.044 1.00 17.20 ATOM 3497 N GLY 505 18.287 45.067 41.7081.00 16.74 ATOM 3498 CA GLY 505 16.971 44.527 41.400 1.00 17.30 ATOM3499 C GLY 505 16.636 44.167 39.961 1.00 17.93 ATOM 3500 O GLY 50515.520 43.732 39.693 1.00 18.99 ATOM 3501 N SER 506 17.578 44.341 39.0391.00 17.16 ATOM 3502 CA SER 506 17.350 44.013 37.630 1.00 18.82 ATOM3503 CB SER 506 18.514 44.514 36.771 1.00 19.99 ATOM 3504 OG SER 50618.605 45.920 36.805 1.00 25.35 ATOM 3505 C SER 506 17.185 42.509 37.4011.00 18.71 ATOM 3506 O SER 506 16.500 42.089 36.470 1.00 19.68 ATOM 3507N ILE 507 17.837 41.709 38.241 1.00 17.20 ATOM 3508 CA ILE 507 17.76740.253 38.147 1.00 17.19 ATOM 3509 CB ILE 507 19.184 39.630 38.004 1.0016.86 ATOM 3510 CG2 ILE 507 19.076 38.112 37.912 1.00 15.71 ATOM 3511CG1 ILE 507 19.890 40.193 36.767 1.00 17.34 ATOM 3512 CD1 ILE 507 21.35739.746 36.640 1.00 15.06 ATOM 3513 C ILE 507 17.123 39.695 39.420 1.0017.07 ATOM 3514 O ILE 507 17.689 39.807 40.509 1.00 16.98 ATOM 3515 NTHR 508 15.940 39.105 39.281 1.00 17.01 ATOM 3516 CA THR 508 15.22738.531 40.421 1.00 18.33 ATOM 3517 CB THR 508 13.710 38.551 40.196 1.0018.44 ATOM 3518 OG1 THR 508 13.365 37.586 39.191 1.00 20.70 ATOM 3519CG2 THR 508 13.263 39.931 39.734 1.00 20.95 ATOM 3520 C THR 508 15.67137.088 40.581 1.00 18.12 ATOM 3521 O THR 508 16.318 36.540 39.689 1.0017.12 ATOM 3522 N LYS 509 15.312 36.469 41.703 1.00 20.57 ATOM 3523 CALYS 509 15.702 35.087 41.961 1.00 23.09 ATOM 3524 CB LYS 509 15.24034.637 43.352 1.00 24.96 ATOM 3525 CG LYS 509 13.763 34.281 43.465 1.0029.41 ATOM 3526 CD LYS 509 13.455 33.746 44.859 1.00 32.03 ATOM 3527 CELYS 509 12.017 33.278 44.988 1.00 33.33 ATOM 3528 NZ LYS 509 11.72432.824 46.378 1.00 34.91 ATOM 3529 C LYS 509 15.142 34.148 40.909 1.0024.36 ATOM 3530 O LYS 509 15.601 33.018 40.769 1.00 25.76 ATOM 3531 NGLU 510 14.146 34.619 40.169 1.00 25.33 ATOM 3532 CA GLU 510 13.53433.819 39.116 1.00 26.94 ATOM 3533 CB GLU 510 12.240 34.481 38.649 1.0031.14 ATOM 3534 CG GLU 510 11.420 35.078 39.776 1.00 39.75 ATOM 3535 CDGLU 510 10.187 34.265 40.094 1.00 42.36 ATOM 3536 OE1 GLU 510 9.31234.169 39.212 1.00 46.25 ATOM 3537 OE2 GLU 510 10.094 33.725 41.217 1.0045.33 ATOM 3538 C GLU 510 14.489 33.726 37.927 1.00 26.01 ATOM 3539 OGLU 510 14.458 32.758 37.163 1.00 25.45 ATOM 3540 N ASN 511 15.34334.736 37.780 1.00 22.90 ATOM 3541 CA ASN 511 16.271 34.785 36.657 1.0021.40 ATOM 3542 CB ASN 511 15.973 36.028 35.811 1.00 23.82 ATOM 3543 CGASN 511 14.538 36.057 35.315 1.00 29.85 ATOM 3544 OD1 ASN 511 14.08635.126 34.646 1.00 30.15 ATOM 3545 ND2 ASN 511 13.811 37.122 35.647 1.0028.53 ATOM 3546 C ASN 511 17.759 34.747 37.000 1.00 18.64 ATOM 3547 OASN 511 18.593 34.993 36.131 1.00 16.50 ATOM 3548 N TYR 512 18.08934.441 38.251 1.00 15.85 ATOM 3549 CA TYR 512 19.487 34.360 38.681 1.0015.32 ATOM 3550 CB TYR 512 19.604 33.604 40.007 1.00 14.72 ATOM 3551 CGTYR 512 19.244 34.359 41.266 1.00 14.45 ATOM 3552 CD1 TYR 512 19.00833.667 42.450 1.00 14.67 ATOM 3553 CE1 TYR 512 18.736 34.335 43.637 1.0016.30 ATOM 3554 CD2 TYR 512 19.194 35.753 41.295 1.00 14.34 ATOM 3555CE2 TYR 512 18.920 36.435 42.484 1.00 17.16 ATOM 3556 CZ TYR 512 18.69535.714 43.648 1.00 18.10 ATOM 3557 OH TYR 512 18.451 36.361 44.837 1.0021.96 ATOM 3558 C TYR 512 20.378 33.613 37.688 1.00 16.40 ATOM 3559 OTYR 512 21.318 34.171 37.108 1.00 13.43 ATOM 3560 N ASN 513 20.07732.328 37.521 1.00 15.11 ATOM 3561 CA ASN 513 20.877 31.461 36.673 1.0014.44 ATOM 3562 CB ASN 513 20.478 29.999 36.894 1.00 14.83 ATOM 3563 CGASN 513 21.677 29.073 36.872 1.00 13.79 ATOM 3564 OD1 ASN 513 22.62029.261 37.634 1.00 15.96 ATOM 3565 ND2 ASN 513 21.652 28.078 35.993 1.0013.24 ATOM 3566 C ASN 513 20.840 31.778 35.198 1.00 14.91 ATOM 3567 OASN 513 21.865 31.701 34.517 1.00 12.27 ATOM 3568 N GLN 514 19.66432.133 34.697 1.00 13.28 ATOM 3569 CA GLN 514 19.539 32.441 33.285 1.0016.41 ATOM 3570 CB GLN 514 18.062 32.642 32.924 1.00 18.43 ATOM 3571 CGGLN 514 17.219 31.363 33.087 1.00 25.86 ATOM 3572 CD GLN 514 16.62831.163 34.492 1.00 27.97 ATOM 3573 OE1 GLN 514 17.184 31.606 35.501 1.0022.77 ATOM 3574 NE2 GLN 514 15.493 30.468 34.551 1.00 32.36 ATOM 3575 CGLN 514 20.378 33.660 32.900 1.00 16.35 ATOM 3576 O GLN 514 21.00433.682 31.830 1.00 14.47 ATOM 3577 N GLU 515 20.406 34.668 33.769 1.0014.45 ATOM 3578 CA GLU 515 21.188 35.872 33.486 1.00 15.60 ATOM 3579 CBGLU 515 20.762 37.023 34.398 1.00 17.63 ATOM 3580 CG GLU 515 19.36137.553 34.107 1.00 23.50 ATOM 3581 CD GLU 515 19.200 37.998 32.663 1.0029.39 ATOM 3582 OE1 GLU 515 20.051 38.776 32.177 1.00 29.30 ATOM 3583OE2 GLU 515 18.220 37.570 32.016 1.00 31.22 ATOM 3584 C GLU 515 22.68035.591 33.656 1.00 13.08 ATOM 3585 O GLU 515 23.512 36.209 32.992 1.0014.72 ATOM 3586 N TRP 516 23.018 34.671 34.555 1.00 11.64 ATOM 3587 CATRP 516 24.423 34.303 34.752 1.00 12.26 ATOM 3588 CB TRP 516 24.55933.298 35.901 1.00 10.60 ATOM 3589 CG TRP 516 25.924 32.648 36.038 1.0013.26 ATOM 3590 CD2 TRP 516 27.086 33.201 36.671 1.00 13.09 ATOM 3591CE2 TRP 516 28.110 32.228 36.593 1.00 14.57 ATOM 3592 CE3 TRP 516 27.36234.423 37.300 1.00 14.40 ATOM 3593 CD1 TRP 516 26.281 31.402 35.612 1.0015.30 ATOM 3594 NE1 TRP 516 27.593 31.140 35.943 1.00 14.97 ATOM 3595CZ2 TRP 516 29.392 32.438 37.119 1.00 14.78 ATOM 3596 CZ3 TRP 516 28.64034.632 37.827 1.00 15.38 ATOM 3597 CH2 TRP 516 29.636 33.642 37.731 1.0016.29 ATOM 3598 C TRP 516 24.945 33.701 33.450 1.00 12.53 ATOM 3599 OTRP 516 26.014 34.081 32.967 1.00 15.24 ATOM 3600 N TRP 517 24.18632.778 32.864 1.00 11.64 ATOM 3601 CA TRP 517 24.631 32.169 31.618 1.0012.88 ATOM 3602 CB TRP 517 23.892 30.850 31.371 1.00 11.74 ATOM 3603 CGTRP 517 24.494 29.780 32.238 1.00 11.07 ATOM 3604 CD2 TRP 517 25.76829.150 32.047 1.00 10.34 ATOM 3605 CE2 TRP 517 26.014 28.349 33.182 1.0011.07 ATOM 3606 CE3 TRP 517 26.730 29.193 31.028 1.00 13.21 ATOM 3607CD1 TRP 517 24.028 29.338 33.442 1.00 10.52 ATOM 3608 NE1 TRP 517 24.93728.480 34.019 1.00 12.71 ATOM 3609 CZ2 TRP 517 27.185 27.596 33.328 1.0011.38 ATOM 3610 CZ3 TRP 517 27.899 28.441 31.174 1.00 13.92 ATOM 3611CH2 TRP 517 28.112 27.657 32.315 1.00 11.19 ATOM 3612 C TRP 517 24.57133.092 30.402 1.00 13.68 ATOM 3613 O TRP 517 25.360 32.937 29.473 1.0013.23 ATOM 3614 N SER 518 23.662 34.063 30.403 1.00 13.61 ATOM 3615 CASER 518 23.606 35.001 29.289 1.00 13.77 ATOM 3616 CB SER 518 22.40635.938 29.429 1.00 16.27 ATOM 3617 OG SER 518 21.198 35.215 29.273 1.0025.55 ATOM 3618 C SER 518 24.908 35.812 29.306 1.00 13.80 ATOM 3619 OSER 518 25.438 36.174 28.261 1.00 11.73 ATOM 3620 N LEU 519 25.42036.085 30.503 1.00 12.48 ATOM 3621 CA LEU 519 26.664 36.835 30.642 1.0013.86 ATOM 3622 CB LEU 519 26.792 37.386 32.065 1.00 13.18 ATOM 3623 CGLEU 519 25.820 38.521 32.408 1.00 17.32 ATOM 3624 CD1 LEU 519 25.99638.936 33.869 1.00 15.81 ATOM 3625 CD2 LEU 519 26.082 39.706 31.497 1.0018.32 ATOM 3626 C LEU 519 27.854 35.936 30.315 1.00 14.53 ATOM 3627 OLEU 519 28.833 36.374 29.701 1.00 13.21 ATOM 3628 N ARG 520 27.76334.680 30.740 1.00 12.53 ATOM 3629 CA ARG 520 28.811 33.698 30.483 1.0014.43 ATOM 3630 CB ARG 520 28.415 32.342 31.080 1.00 12.24 ATOM 3631 CGARG 520 28.505 32.295 32.602 1.00 10.71 ATOM 3632 CD ARG 520 29.93332.016 33.047 1.00 11.25 ATOM 3633 NE ARG 520 30.126 30.601 33.360 1.0011.37 ATOM 3634 CZ ARG 520 31.309 30.021 33.547 1.00 14.25 ATOM 3635 NH1ARG 520 31.364 28.728 33.843 1.00 11.46 ATOM 3636 NH2 ARG 520 32.43530.722 33.418 1.00 8.82 ATOM 3637 C ARG 520 29.018 33.581 28.975 1.0015.32 ATOM 3638 O ARG 520 30.154 33.479 28.499 1.00 14.29 ATOM 3639 NLEU 521 27.914 33.602 28.232 1.00 14.48 ATOM 3640 CA LEU 521 27.96433.534 26.775 1.00 15.03 ATOM 3641 CB LEU 521 26.570 33.237 26.197 1.0014.34 ATOM 3642 CG LEU 521 26.464 33.320 24.663 1.00 17.99 ATOM 3643 CD1LEU 521 27.277 32.193 24.036 1.00 14.70 ATOM 3644 CD2 LEU 521 25.00333.225 24.221 1.00 19.69 ATOM 3645 C LEU 521 28.463 34.862 26.195 1.0015.14 ATOM 3646 O LEU 521 29.426 34.901 25.433 1.00 16.02 ATOM 3647 NLYS 522 27.800 35.952 26.564 1.00 15.84 ATOM 3648 CA LYS 522 28.15637.273 26.053 1.00 16.80 ATOM 3649 CB LYS 522 27.257 38.340 26.691 1.0020.30 ATOM 3650 CG LYS 522 27.614 39.767 26.290 1.00 25.17 ATOM 3651 CDLYS 522 26.641 40.777 26.885 1.00 25.79 ATOM 3652 CE LYS 522 27.03542.197 26.505 1.00 27.00 ATOM 3653 NZ LYS 522 26.061 43.202 27.014 1.0029.07 ATOM 3654 C LYS 522 29.618 37.664 26.245 1.00 15.29 ATOM 3655 OLYS 522 30.254 38.159 25.322 1.00 15.94 ATOM 3656 N TYR 523 30.15937.446 27.437 1.00 14.11 ATOM 3657 CA TYR 523 31.545 37.823 27.689 1.0014.39 ATOM 3658 CB TYR 523 31.672 38.370 29.115 1.00 16.01 ATOM 3659 CGTYR 523 30.969 39.699 29.274 1.00 19.66 ATOM 3660 CD1 TYR 523 29.84239.833 30.085 1.00 22.54 ATOM 3661 CE1 TYR 523 29.159 41.054 30.173 1.0024.34 ATOM 3662 CD2 TYR 523 31.400 40.816 28.560 1.00 21.80 ATOM 3663CE2 TYR 523 30.730 42.029 28.641 1.00 24.56 ATOM 3664 CZ TYR 523 29.61142.142 29.444 1.00 24.26 ATOM 3665 OH TYR 523 28.946 43.346 29.493 1.0030.82 ATOM 3666 C TYR 523 32.605 36.752 27.437 1.00 14.99 ATOM 3667 OTYR 523 33.610 37.023 26.781 1.00 12.52 ATOM 3668 N GLN 524 32.38935.537 27.935 1.00 13.32 ATOM 3669 CA GLN 524 33.382 34.470 27.751 1.0012.95 ATOM 3670 CB GLN 524 33.425 33.566 28.980 1.00 11.02 ATOM 3671 CGGLN 524 33.970 34.205 30.230 1.00 12.37 ATOM 3672 CD GLN 524 34.03333.207 31.356 1.00 10.81 ATOM 3673 OE1 GLN 524 33.043 32.974 32.049 1.0012.38 ATOM 3674 NE2 GLN 524 35.191 32.577 31.520 1.00 10.48 ATOM 3675 CGLN 524 33.162 33.584 26.534 1.00 11.74 ATOM 3676 O GLN 524 34.05932.845 26.137 1.00 12.11 ATOM 3677 N GLY 525 31.973 33.637 25.949 1.0012.72 ATOM 3678 CA GLY 525 31.709 32.785 24.804 1.00 13.19 ATOM 3679 CGLY 525 31.674 31.328 25.237 1.00 13.82 ATOM 3680 O GLY 525 32.18030.444 24.540 1.00 12.99 ATOM 3681 N LEU 526 31.087 31.074 26.403 1.0012.01 ATOM 3682 CA LEU 526 30.975 29.710 26.913 1.00 11.37 ATOM 3683 CBLEU 526 31.581 29.598 28.317 1.00 11.79 ATOM 3684 CG LEU 526 33.05229.983 28.498 1.00 11.39 ATOM 3685 CD1 LEU 526 33.439 29.852 29.978 1.0012.76 ATOM 3686 CD2 LEU 526 33.926 29.084 27.625 1.00 9.67 ATOM 3687 CLEU 526 29.515 29.289 26.989 1.00 14.13 ATOM 3688 O LEU 526 28.61730.134 27.059 1.00 14.75 ATOM 3689 N CYS 527 29.284 27.978 26.963 1.0013.45 ATOM 3690 CA CYS 527 27.939 27.429 27.078 1.00 15.05 ATOM 3691 CBCYS 527 27.424 26.919 25.722 1.00 15.05 ATOM 3692 SG CYS 527 28.47425.702 24.876 1.00 19.74 ATOM 3693 C CYS 527 27.978 26.287 28.091 1.0015.94 ATOM 3694 O CYS 527 29.019 25.653 28.289 1.00 15.05 ATOM 3695 NPRO 528 26.854 26.034 28.773 1.00 15.16 ATOM 3696 CD PRO 528 25.58726.794 28.757 1.00 16.64 ATOM 3697 CA PRO 528 26.816 24.952 29.761 1.0015.93 ATOM 3698 CB PRO 528 25.579 25.291 30.588 1.00 15.52 ATOM 3699 CGPRO 528 24.653 25.904 29.560 1.00 17.39 ATOM 3700 C PRO 528 26.70623.606 29.040 1.00 16.28 ATOM 3701 O PRO 528 25.832 23.426 28.195 1.0016.69 ATOM 3702 N PRO 529 27.602 22.650 29.359 1.00 15.89 ATOM 3703 CDPRO 529 28.620 22.713 30.423 1.00 17.16 ATOM 3704 CA PRO 529 27.59521.325 28.728 1.00 16.53 ATOM 3705 CB PRO 529 28.813 20.646 29.347 1.0016.86 ATOM 3706 CG PRO 529 28.864 21.250 30.719 1.00 17.60 ATOM 3707 CPRO 529 26.299 20.564 28.979 1.00 16.93 ATOM 3708 O PRO 529 25.92919.675 28.214 1.00 19.21 ATOM 3709 N VAL 530 25.620 20.919 30.064 1.0015.31 ATOM 3710 CA VAL 530 24.345 20.309 30.421 1.00 18.95 ATOM 3711 CBVAL 530 24.447 19.514 31.747 1.00 18.21 ATOM 3712 CG1 VAL 530 23.05719.197 32.277 1.00 20.68 ATOM 3713 CG2 VAL 530 25.221 18.216 31.516 1.0020.27 ATOM 3714 C VAL 530 23.331 21.439 30.591 1.00 18.93 ATOM 3715 OVAL 530 23.586 22.402 31.320 1.00 17.96 ATOM 3716 N PRO 531 22.17921.351 29.908 1.00 19.85 ATOM 3717 CD PRO 531 21.701 20.311 28.982 1.0021.08 ATOM 3718 CA PRO 531 21.186 22.422 30.055 1.00 20.04 ATOM 3719 CBPRO 531 20.019 21.940 29.186 1.00 23.88 ATOM 3720 CG PRO 531 20.20720.436 29.134 1.00 24.49 ATOM 3721 C PRO 531 20.806 22.624 31.519 1.0020.47 ATOM 3722 O PRO 531 20.590 21.660 32.258 1.00 19.22 ATOM 3723 NARG 532 20.748 23.880 31.946 1.00 17.94 ATOM 3724 CA ARG 532 20.40824.173 33.331 1.00 19.58 ATOM 3725 CB ARG 532 20.850 25.597 33.698 1.0017.12 ATOM 3726 CG ARG 532 22.203 26.006 33.109 1.00 17.15 ATOM 3727 CDARG 532 23.261 24.916 33.259 1.00 14.33 ATOM 3728 NE ARG 532 23.62524.670 34.650 1.00 16.72 ATOM 3729 CZ ARG 532 23.756 23.457 35.175 1.0018.54 ATOM 3730 NH1 ARG 532 23.548 22.382 34.418 1.00 18.00 ATOM 3731NH2 ARG 532 24.100 23.316 36.447 1.00 16.39 ATOM 3732 C ARG 532 18.90324.018 33.538 1.00 20.97 ATOM 3733 O ARG 532 18.125 24.148 32.593 1.0021.91 ATOM 3734 N THR 533 18.502 23.735 34.773 1.00 21.56 ATOM 3735 CATHR 533 17.089 23.560 35.099 1.00 23.91 ATOM 3736 CB THR 533 16.74322.075 35.337 1.00 24.39 ATOM 3737 OG1 THR 533 17.593 21.542 36.363 1.0026.32 ATOM 3738 CG2 THR 533 16.930 21.273 34.054 1.00 26.00 ATOM 3739 CTHR 533 16.734 24.342 36.354 1.00 24.49 ATOM 3740 O THR 533 17.62224.792 37.088 1.00 22.75 ATOM 3741 N GLN 534 15.436 24.494 36.601 1.0025.56 ATOM 3742 CA GLN 534 14.963 25.227 37.769 1.00 27.46 ATOM 3743 CBGLN 534 13.429 25.173 37.845 1.00 29.98 ATOM 3744 CG GLN 534 12.83426.077 38.917 1.00 34.85 ATOM 3745 CD GLN 534 12.498 25.332 40.196 1.0038.40 ATOM 3746 OE1 GLN 534 13.144 24.341 40.542 1.00 39.55 ATOM 3747NE2 GLN 534 11.487 25.815 40.914 1.00 40.66 ATOM 3748 C GLN 534 15.58924.628 39.023 1.00 26.85 ATOM 3749 O GLN 534 15.630 23.410 39.195 1.0028.91 ATOM 3750 N GLY 535 16.088 25.486 39.900 1.00 26.04 ATOM 3751 CAGLY 535 16.722 24.988 41.103 1.00 22.99 ATOM 3752 C GLY 535 18.23025.145 41.032 1.00 20.56 ATOM 3753 O GLY 535 18.893 25.172 42.062 1.0021.12 ATOM 3754 N ASP 536 18.783 25.236 39.824 1.00 19.34 ATOM 3755 CAASP 536 20.229 25.412 39.690 1.00 18.42 ATOM 3756 CB ASP 536 20.71025.126 38.262 1.00 18.23 ATOM 3757 CG ASP 536 20.693 23.647 37.917 1.0017.73 ATOM 3758 OD1 ASP 536 20.885 22.814 38.829 1.00 16.38 ATOM 3759OD2 ASP 536 20.509 23.326 36.726 1.00 18.51 ATOM 3760 C ASP 536 20.61726.845 40.039 1.00 17.25 ATOM 3761 O ASP 536 19.893 27.786 39.722 1.0017.90 ATOM 3762 N PHE 537 21.761 26.996 40.694 1.00 15.41 ATOM 3763 CAPHE 537 22.285 28.309 41.069 1.00 15.10 ATOM 3764 CB PHE 537 21.91428.654 42.511 1.00 13.69 ATOM 3765 CG PHE 537 22.344 30.031 42.934 1.0014.67 ATOM 3766 CD1 PHE 537 21.970 31.150 42.190 1.00 14.51 ATOM 3767CD2 PHE 537 23.127 30.211 44.073 1.00 14.42 ATOM 3768 CE1 PHE 537 22.37232.434 42.576 1.00 16.76 ATOM 3769 CE2 PHE 537 23.535 31.490 44.469 1.0016.13 ATOM 3770 CZ PHE 537 23.155 32.602 43.717 1.00 16.55 ATOM 3771 CPHE 537 23.798 28.188 40.929 1.00 14.34 ATOM 3772 O PHE 537 24.53428.107 41.910 1.00 11.59 ATOM 3773 N ASP 538 24.246 28.160 39.683 1.0013.08 ATOM 3774 CA ASP 538 25.656 28.013 39.380 1.00 12.91 ATOM 3775 CBASP 538 25.812 27.915 37.858 1.00 14.42 ATOM 3776 CG ASP 538 24.98426.761 37.275 1.00 13.98 ATOM 3777 OD1 ASP 538 24.869 25.725 37.959 1.0015.77 ATOM 3778 OD2 ASP 538 24.456 26.875 36.148 1.00 16.17 ATOM 3779 CASP 538 26.546 29.093 40.005 1.00 13.57 ATOM 3780 O ASP 538 27.68028.814 40.391 1.00 14.25 ATOM 3781 N PRO 539 26.049 30.336 40.125 1.0012.45 ATOM 3782 CD PRO 539 24.833 30.944 39.554 1.00 12.63 ATOM 3783 CAPRO 539 26.903 31.362 40.738 1.00 14.07 ATOM 3784 CB PRO 539 25.99832.596 40.760 1.00 13.43 ATOM 3785 CG PRO 539 25.203 32.428 39.495 1.0014.83 ATOM 3786 C PRO 539 27.318 30.945 42.149 1.00 14.32 ATOM 3787 OPRO 539 28.405 31.290 42.620 1.00 15.96 ATOM 3788 N GLY 540 26.44330.201 42.818 1.00 13.56 ATOM 3789 CA GLY 540 26.726 29.759 44.173 1.0013.06 ATOM 3790 C GLY 540 27.880 28.779 44.262 1.00 14.35 ATOM 3791 OGLY 540 28.410 28.530 45.350 1.00 14.78 ATOM 3792 N ALA 541 28.27828.233 43.116 1.00 13.27 ATOM 3793 CA ALA 541 29.374 27.268 43.057 1.0013.82 ATOM 3794 CB ALA 541 29.142 26.282 41.908 1.00 13.95 ATOM 3795 CALA 541 30.736 27.948 42.899 1.00 14.23 ATOM 3796 O ALA 541 31.75527.277 42.723 1.00 14.48 ATOM 3797 N LYS 542 30.744 29.278 42.950 1.0013.31 ATOM 3798 CA LYS 542 31.981 30.051 42.845 1.00 13.43 ATOM 3799 CBLYS 542 31.854 31.131 41.758 1.00 11.46 ATOM 3800 CG LYS 542 33.08032.052 41.629 1.00 11.83 ATOM 3801 CD LYS 542 34.363 31.258 41.356 1.0011.07 ATOM 3802 CE LYS 542 35.594 32.152 41.434 1.00 13.88 ATOM 3803 NZLYS 542 36.866 31.380 41.387 1.00 13.39 ATOM 3804 C LYS 542 32.19530.690 44.215 1.00 14.23 ATOM 3805 O LYS 542 31.363 31.472 44.678 1.0013.83 ATOM 3806 N PHE 543 33.309 30.346 44.857 1.00 14.52 ATOM 3807 CAPHE 543 33.640 30.842 46.197 1.00 15.65 ATOM 3808 CB PHE 543 35.15630.803 46.422 1.00 16.34 ATOM 3809 CG PHE 543 35.581 31.353 47.760 1.0016.35 ATOM 3810 CD1 PHE 543 35.489 30.574 48.909 1.00 18.40 ATOM 3811CD2 PHE 543 36.047 32.661 47.875 1.00 19.53 ATOM 3812 CE1 PHE 543 35.85831.090 50.161 1.00 18.32 ATOM 3813 CE2 PHE 543 36.418 33.188 49.120 1.0018.19 ATOM 3814 CZ PHE 543 36.323 32.399 50.263 1.00 18.52 ATOM 3815 CPHE 543 33.159 32.242 46.577 1.00 16.50 ATOM 3816 O PHE 543 32.41132.411 47.540 1.00 17.35 ATOM 3817 N HIS 544 33.603 33.242 45.822 1.0013.72 ATOM 3818 CA HIS 544 33.284 34.635 46.119 1.00 14.78 ATOM 3819 CBHIS 544 34.006 35.543 45.116 1.00 13.88 ATOM 3820 CG HIS 544 35.48435.298 45.050 1.00 13.02 ATOM 3821 CD2 HIS 544 36.536 36.070 45.408 1.0010.61 ATOM 3822 ND1 HIS 544 36.017 34.106 44.606 1.00 14.71 ATOM 3823CE1 HIS 544 37.335 34.155 44.693 1.00 13.70 ATOM 3824 NE2 HIS 544 37.67835.335 45.176 1.00 13.80 ATOM 3825 C HIS 544 31.808 35.016 46.213 1.0014.84 ATOM 3826 O HIS 544 31.470 36.034 46.826 1.00 14.80 ATOM 3827 NILE 545 30.930 34.212 45.622 1.00 14.32 ATOM 3828 CA ILE 545 29.50434.511 45.670 1.00 13.72 ATOM 3829 CB ILE 545 28.733 33.701 44.598 1.0014.44 ATOM 3830 CG2 ILE 545 27.234 33.908 44.749 1.00 12.67 ATOM 3831CG1 ILE 545 29.190 34.138 43.199 1.00 16.16 ATOM 3832 CD1 ILE 545 29.03235.621 42.922 1.00 16.96 ATOM 3833 C ILE 545 28.954 34.249 47.079 1.0014.60 ATOM 3834 O ILE 545 28.518 35.182 47.757 1.00 13.03 ATOM 3835 NPRO 546 28.976 32.986 47.549 1.00 15.66 ATOM 3836 CD PRO 546 29.35531.713 46.909 1.00 13.25 ATOM 3837 CA PRO 546 28.457 32.750 48.903 1.0015.17 ATOM 3838 CB PRO 546 28.453 31.222 49.014 1.00 16.53 ATOM 3839 CGPRO 546 29.579 30.812 48.111 1.00 17.51 ATOM 3840 C PRO 546 29.30533.419 49.990 1.00 16.68 ATOM 3841 O PRO 546 28.799 33.732 51.074 1.0015.08 ATOM 3842 N SER 547 30.589 33.641 49.701 1.00 13.81 ATOM 3843 CASER 547 31.488 34.284 50.659 1.00 15.60 ATOM 3844 CB SER 547 32.94733.918 50.362 1.00 18.79 ATOM 3845 OG SER 547 33.183 32.536 50.565 1.0022.02 ATOM 3846 C SER 547 31.342 35.803 50.646 1.00 13.58 ATOM 3847 OSER 547 31.965 36.499 51.443 1.00 13.34 ATOM 3848 N SER 548 30.52936.312 49.727 1.00 13.46 ATOM 3849 CA SER 548 30.288 37.751 49.617 1.0013.96 ATOM 3850 CB SER 548 29.427 38.231 50.791 1.00 14.80 ATOM 3851 OGSER 548 28.929 39.544 50.566 1.00 14.76 ATOM 3852 C SER 548 31.57138.587 49.542 1.00 15.62 ATOM 3853 O SER 548 31.743 39.553 50.288 1.0015.61 ATOM 3854 N VAL 549 32.464 38.201 48.637 1.00 14.22 ATOM 3855 CAVAL 549 33.718 38.914 48.413 1.00 14.31 ATOM 3856 CB VAL 549 34.93637.957 48.426 1.00 14.24 ATOM 3857 CG1 VAL 549 36.200 38.716 48.029 1.0015.66 ATOM 3858 CG2 VAL 549 35.105 37.337 49.813 1.00 15.47 ATOM 3859 CVAL 549 33.611 39.538 47.023 1.00 13.23 ATOM 3860 O VAL 549 33.44838.826 46.034 1.00 14.20 ATOM 3861 N PRO 550 33.680 40.877 46.931 1.0013.00 ATOM 3862 CD PRO 550 33.789 41.840 48.040 1.00 12.51 ATOM 3863 CAPRO 550 33.588 41.572 45.637 1.00 13.72 ATOM 3864 CB PRO 550 33.87043.026 46.007 1.00 12.92 ATOM 3865 CG PRO 550 33.282 43.120 47.399 1.0013.93 ATOM 3866 C PRO 550 34.597 41.006 44.640 1.00 13.40 ATOM 3867 OPRO 550 35.694 40.602 45.027 1.00 12.68 ATOM 3868 N TYR 551 34.23840.996 43.357 1.00 12.51 ATOM 3869 CA TYR 551 35.111 40.419 42.337 1.0011.74 ATOM 3870 CB TYR 551 34.343 39.339 41.565 1.00 12.26 ATOM 3871 CGTYR 551 35.216 38.181 41.146 1.00 11.10 ATOM 3872 CD1 TYR 551 35.58937.201 42.069 1.00 12.21 ATOM 3873 CE1 TYR 551 36.445 36.163 41.716 1.0011.38 ATOM 3874 CD2 TYR 551 35.717 38.092 39.849 1.00 10.70 ATOM 3875CE2 TYR 551 36.578 37.052 39.479 1.00 11.88 ATOM 3876 CZ TYR 551 36.93636.095 40.422 1.00 12.73 ATOM 3877 OH TYR 551 37.789 35.078 40.077 1.0012.21 ATOM 3878 C TYR 551 35.758 41.362 41.316 1.00 12.92 ATOM 3879 OTYR 551 36.772 41.009 40.713 1.00 12.28 ATOM 3880 N ILE 552 35.18242.543 41.106 1.00 10.57 ATOM 3881 CA ILE 552 35.729 43.474 40.123 1.0010.70 ATOM 3882 CB ILE 552 34.866 44.760 40.042 1.00 10.46 ATOM 3883 CG2ILE 552 35.175 45.681 41.219 1.00 10.81 ATOM 3884 CG1 ILE 552 35.11145.464 38.706 1.00 11.02 ATOM 3885 CD1 ILE 552 34.654 44.656 37.494 1.0011.29 ATOM 3886 C ILE 552 37.195 43.826 40.404 1.00 11.68 ATOM 3887 OILE 552 37.940 44.198 39.499 1.00 12.19 ATOM 3888 N ARG 553 37.60743.692 41.660 1.00 11.17 ATOM 3889 CA ARG 553 38.989 43.952 42.055 1.0010.89 ATOM 3890 CB ARG 553 39.156 43.668 43.549 1.00 11.30 ATOM 3891 CGARG 553 38.686 42.265 43.958 1.00 13.00 ATOM 3892 CD ARG 553 38.70442.074 45.474 1.00 13.72 ATOM 3893 NE ARG 553 37.886 43.088 46.134 1.0010.87 ATOM 3894 CZ ARG 553 37.634 43.123 47.439 1.00 13.84 ATOM 3895 NH1ARG 553 38.132 42.196 48.247 1.00 11.15 ATOM 3896 NH2 ARG 553 36.88944.100 47.941 1.00 13.85 ATOM 3897 C ARG 553 39.971 43.071 41.260 1.0012.16 ATOM 3898 O ARG 553 41.105 43.478 40.990 1.00 11.49 ATOM 3899 NTYR 554 39.539 41.871 40.881 1.00 10.69 ATOM 3900 CA TYR 554 40.40840.965 40.130 1.00 12.89 ATOM 3901 CB TYR 554 39.882 39.525 40.215 1.0010.20 ATOM 3902 CG TYR 554 39.814 39.009 41.640 1.00 12.03 ATOM 3903 CD1TYR 554 38.586 38.818 42.274 1.00 14.17 ATOM 3904 CE1 TYR 554 38.51538.381 43.599 1.00 13.54 ATOM 3905 CD2 TYR 554 40.978 38.750 42.367 1.0012.66 ATOM 3906 CE2 TYR 554 40.920 38.317 43.695 1.00 13.05 ATOM 3907 CZTYR 554 39.683 38.133 44.302 1.00 13.70 ATOM 3908 OH TYR 554 39.60337.697 45.610 1.00 13.05 ATOM 3909 C TYR 554 40.558 41.394 38.672 1.0012.72 ATOM 3910 O TYR 554 41.599 41.152 38.051 1.00 12.24 ATOM 3911 NPHE 555 39.515 42.016 38.128 1.00 10.68 ATOM 3912 CA PHE 555 39.55042.509 36.750 1.00 11.93 ATOM 3913 CB PHE 555 38.154 42.980 36.317 1.0011.21 ATOM 3914 CG PHE 555 38.125 43.646 34.968 1.00 14.00 ATOM 3915 CD1PHE 555 38.050 42.892 33.801 1.00 14.57 ATOM 3916 CD2 PHE 555 38.19345.031 34.867 1.00 15.09 ATOM 3917 CE1 PHE 555 38.043 43.510 32.549 1.0016.67 ATOM 3918 CE2 PHE 555 38.189 45.660 33.619 1.00 17.16 ATOM 3919 CZPHE 555 38.113 44.899 32.458 1.00 17.19 ATOM 3920 C PHE 555 40.52743.689 36.735 1.00 13.11 ATOM 3921 O PHE 555 41.400 43.779 35.872 1.0013.19 ATOM 3922 N VAL 556 40.366 44.592 37.698 1.00 10.88 ATOM 3923 CAVAL 556 41.239 45.753 37.809 1.00 11.92 ATOM 3924 CB VAL 556 40.83046.642 39.004 1.00 11.44 ATOM 3925 CG1 VAL 556 41.847 47.767 39.202 1.0013.68 ATOM 3926 CG2 VAL 556 39.433 47.226 38.757 1.00 12.64 ATOM 3927 CVAL 556 42.683 45.276 37.989 1.00 12.43 ATOM 3928 O VAL 556 43.59045.746 37.308 1.00 12.45 ATOM 3929 N SER 557 42.882 44.325 38.895 1.0012.83 ATOM 3930 CA SER 557 44.211 43.781 39.156 1.00 13.38 ATOM 3931 CBSER 557 44.124 42.658 40.195 1.00 14.45 ATOM 3932 OG SER 557 45.36641.981 40.321 1.00 15.47 ATOM 3933 C SER 557 44.915 43.252 37.908 1.0014.80 ATOM 3934 O SER 557 46.080 43.567 37.659 1.00 13.56 ATOM 3935 NPHE 558 44.220 42.438 37.123 1.00 13.85 ATOM 3936 CA PHE 558 44.84341.878 35.936 1.00 16.13 ATOM 3937 CB PHE 558 43.930 40.813 35.311 1.0014.35 ATOM 3938 CG PHE 558 44.109 39.446 35.921 1.00 12.86 ATOM 3939 CD1PHE 558 44.081 39.279 37.304 1.00 14.64 ATOM 3940 CD2 PHE 558 44.35238.336 35.116 1.00 12.97 ATOM 3941 CE1 PHE 558 44.301 38.021 37.881 1.0014.77 ATOM 3942 CE2 PHE 558 44.570 37.081 35.674 1.00 14.28 ATOM 3943 CZPHE 558 44.546 36.921 37.061 1.00 14.43 ATOM 3944 C PHE 558 45.26542.937 34.923 1.00 17.21 ATOM 3945 O PHE 558 46.248 42.757 34.210 1.0018.29 ATOM 3946 N ILE 559 44.545 44.052 34.875 1.00 17.72 ATOM 3947 CAILE 559 44.907 45.124 33.956 1.00 17.85 ATOM 3948 CB ILE 559 43.75446.148 33.780 1.00 19.20 ATOM 3949 CG2 ILE 559 44.260 47.363 33.011 1.0019.44 ATOM 3950 CG1 ILE 559 42.564 45.502 33.064 1.00 21.05 ATOM 3951CD1 ILE 559 42.807 45.211 31.605 1.00 22.66 ATOM 3952 C ILE 559 46.12045.891 34.491 1.00 16.91 ATOM 3953 O ILE 559 47.155 45.991 33.826 1.0018.09 ATOM 3954 N ILE 560 45.991 46.417 35.704 1.00 15.99 ATOM 3955 CAILE 560 47.056 47.221 36.294 1.00 14.87 ATOM 3956 CB ILE 560 46.56047.971 37.563 1.00 15.25 ATOM 3957 CG2 ILE 560 45.253 48.708 37.249 1.0013.63 ATOM 3958 CG1 ILE 560 46.366 46.996 38.725 1.00 14.28 ATOM 3959CD1 ILE 560 45.970 47.678 40.039 1.00 14.84 ATOM 3960 C ILE 560 48.33746.467 36.639 1.00 16.49 ATOM 3961 O ILE 560 49.415 47.060 36.666 1.0014.18 ATOM 3962 N GLN 561 48.245 45.167 36.900 1.00 15.61 ATOM 3963 CAGLN 561 49.461 44.443 37.233 1.00 16.41 ATOM 3964 CB GLN 561 49.15243.001 37.663 1.00 15.73 ATOM 3965 CG GLN 561 48.557 42.090 36.604 1.0014.21 ATOM 3966 CD GLN 561 48.239 40.715 37.171 1.00 17.73 ATOM 3967 OE1GLN 561 48.834 39.715 36.771 1.00 16.09 ATOM 3968 NE2 GLN 561 47.30040.664 38.121 1.00 14.54 ATOM 3969 C GLN 561 50.450 44.476 36.064 1.0016.86 ATOM 3970 O GLN 561 51.664 44.434 36.273 1.00 16.40 ATOM 3971 NPHE 562 49.939 44.565 34.836 1.00 15.77 ATOM 3972 CA PHE 562 50.82444.631 33.684 1.00 16.79 ATOM 3973 CB PHE 562 50.096 44.217 32.399 1.0015.11 ATOM 3974 CG PHE 562 49.994 42.729 32.236 1.00 16.63 ATOM 3975 CD1PHE 562 48.911 42.029 32.757 1.00 14.63 ATOM 3976 CD2 PHE 562 51.03742.012 31.648 1.00 18.81 ATOM 3977 CE1 PHE 562 48.865 40.637 32.705 1.0018.62 ATOM 3978 CE2 PHE 562 51.006 40.615 31.589 1.00 18.29 ATOM 3979 CZPHE 562 49.915 39.927 32.121 1.00 17.80 ATOM 3980 C PHE 562 51.38546.042 33.579 1.00 17.19 ATOM 3981 O PHE 562 52.517 46.238 33.143 1.0015.79 ATOM 3982 N GLN 563 50.592 47.022 33.998 1.00 16.85 ATOM 3983 CAGLN 563 51.043 48.407 34.001 1.00 18.71 ATOM 3984 CB GLN 563 49.90949.347 34.418 1.00 18.72 ATOM 3985 CG GLN 563 48.890 49.651 33.335 1.0016.23 ATOM 3986 CD GLN 563 47.819 50.607 33.825 1.00 18.40 ATOM 3987 OE1GLN 563 46.777 50.188 34.326 1.00 16.56 ATOM 3988 NE2 GLN 563 48.08451.908 33.700 1.00 15.19 ATOM 3989 C GLN 563 52.184 48.528 35.011 1.0018.91 ATOM 3990 O GLN 563 53.159 49.237 34.773 1.00 21.62 ATOM 3991 NPHE 564 52.048 47.846 36.148 1.00 17.60 ATOM 3992 CA PHE 564 53.08247.879 37.179 1.00 17.70 ATOM 3993 CB PHE 564 52.576 47.237 38.479 1.0016.56 ATOM 3994 CG PHE 564 51.412 47.961 39.114 1.00 16.88 ATOM 3995 CD1PHE 564 51.009 49.216 38.655 1.00 17.26 ATOM 3996 CD2 PHE 564 50.73247.393 40.193 1.00 17.51 ATOM 3997 CE1 PHE 564 49.948 49.896 39.262 1.0017.30 ATOM 3998 CE2 PHE 564 49.668 48.065 40.811 1.00 16.87 ATOM 3999 CZPHE 564 49.275 49.316 40.346 1.00 17.82 ATOM 4000 C PHE 564 54.32047.132 36.682 1.00 18.19 ATOM 4001 O PHE 564 55.448 47.583 36.866 1.0016.35 ATOM 4002 N HIS 565 54.103 45.980 36.058 1.00 18.26 ATOM 4003 CAHIS 565 55.201 45.191 35.523 1.00 17.93 ATOM 4004 CB HIS 565 54.65243.948 34.813 1.00 16.92 ATOM 4005 CG HIS 565 55.712 43.026 34.290 1.0019.54 ATOM 4006 CD2 HIS 565 55.963 42.577 33.036 1.00 18.23 ATOM 4007ND1 HIS 565 56.645 42.424 35.106 1.00 19.14 ATOM 4008 CE1 HIS 565 57.42341.641 34.379 1.00 19.86 ATOM 4009 NE2 HIS 565 57.030 41.716 33.120 1.0018.37 ATOM 4010 C HIS 565 56.001 46.053 34.536 1.00 19.62 ATOM 4011 OHIS 565 57.224 46.140 34.623 1.00 19.79 ATOM 4012 N GLU 566 55.29946.692 33.605 1.00 19.55 ATOM 4013 CA GLU 566 55.938 47.546 32.607 1.0021.41 ATOM 4014 CB GLU 566 54.874 48.175 31.702 1.00 21.29 ATOM 4015 CGGLU 566 55.420 49.067 30.595 1.00 22.84 ATOM 4016 CD GLU 566 54.32049.736 29.798 1.00 23.16 ATOM 4017 OE1 GLU 566 53.587 50.571 30.370 1.0025.71 ATOM 4018 OE2 GLU 566 54.180 49.423 28.599 1.00 24.72 ATOM 4019 CGLU 566 56.781 48.645 33.259 1.00 22.27 ATOM 4020 O GLU 566 57.95448.823 32.920 1.00 22.02 ATOM 4021 N ALA 567 56.185 49.375 34.199 1.0022.14 ATOM 4022 CA ALA 567 56.884 50.457 34.887 1.00 22.62 ATOM 4023 CBALA 567 55.918 51.206 35.794 1.00 21.46 ATOM 4024 C ALA 567 58.08149.966 35.698 1.00 23.23 ATOM 4025 O ALA 567 59.165 50.544 35.633 1.0021.96 ATOM 4026 N LEU 568 57.884 48.898 36.463 1.00 23.52 ATOM 4027 CALEU 568 58.953 48.353 37.287 1.00 24.49 ATOM 4028 CB LEU 568 58.42747.204 38.149 1.00 23.80 ATOM 4029 CG LEU 568 57.319 47.563 39.146 1.0025.68 ATOM 4030 CD1 LEU 568 56.974 46.337 39.976 1.00 24.01 ATOM 4031CD2 LEU 568 57.770 48.705 40.047 1.00 24.11 ATOM 4032 C LEU 568 60.12947.874 36.444 1.00 26.12 ATOM 4033 O LEU 568 61.287 48.041 36.835 1.0025.53 ATOM 4034 N CYS 569 59.829 47.277 35.293 1.00 26.09 ATOM 4035 CACYS 569 60.866 46.785 34.394 1.00 26.84 ATOM 4036 C CYS 569 61.66247.954 33.833 1.00 29.17 ATOM 4037 O CYS 569 62.888 47.891 33.735 1.0029.21 ATOM 4038 CB CYS 569 60.245 45.983 33.251 1.00 24.41 ATOM 4039 SGCYS 569 59.479 44.440 33.829 1.00 23.54 ATOM 4040 N GLN 570 60.95849.018 33.461 1.00 30.60 ATOM 4041 CA GLN 570 61.609 50.205 32.929 1.0033.85 ATOM 4042 CB GLN 570 60.560 51.241 32.508 1.00 36.01 ATOM 4043 CGGLN 570 61.123 52.471 31.797 1.00 40.86 ATOM 4044 CD GLN 570 61.63453.535 32.755 1.00 44.93 ATOM 4045 OE1 GLN 570 62.251 54.518 32.338 1.0047.36 ATOM 4046 NE2 GLN 570 61.370 53.349 34.044 1.00 46.77 ATOM 4047 CGLN 570 62.518 50.774 34.018 1.00 34.13 ATOM 4048 O GLN 570 63.65151.168 33.750 1.00 35.84 ATOM 4049 N ALA 571 62.023 50.793 35.252 1.0033.88 ATOM 4050 CA ALA 571 62.798 51.308 36.376 1.00 33.88 ATOM 4051 CBALA 571 61.922 51.397 37.616 1.00 33.43 ATOM 4052 C ALA 571 64.00850.421 36.655 1.00 34.68 ATOM 4053 O ALA 571 65.025 50.891 37.168 1.0033.79 ATOM 4054 N ALA 572 63.894 49.140 36.314 1.00 34.10 ATOM 4055 CAALA 572 64.979 48.187 36.529 1.00 34.04 ATOM 4056 CB ALA 572 64.41446.781 36.698 1.00 31.78 ATOM 4057 C ALA 572 65.987 48.209 35.381 1.0034.28 ATOM 4058 O ALA 572 66.963 47.456 35.387 1.00 33.48 ATOM 4059 NGLY 573 65.740 49.067 34.396 1.00 35.90 ATOM 4060 CA GLY 573 66.63949.173 33.261 1.00 36.02 ATOM 4061 C GLY 573 66.486 48.083 32.214 1.0036.88 ATOM 4062 O GLY 573 67.380 47.876 31.391 1.00 36.25 ATOM 4063 NHIS 574 65.357 47.381 32.232 1.00 36.48 ATOM 4064 CA HIS 574 65.12446.320 31.262 1.00 34.33 ATOM 4065 CB HIS 574 63.916 45.472 31.661 1.0035.35 ATOM 4066 CG HIS 574 63.584 44.400 30.670 1.00 36.05 ATOM 4067 CD2HIS 574 62.614 44.325 29.727 1.00 36.62 ATOM 4068 ND1 HIS 574 64.32743.245 30.547 1.00 36.78 ATOM 4069 CE1 HIS 574 63.829 42.506 29.571 1.0036.45 ATOM 4070 NE2 HIS 574 62.790 43.138 29.057 1.00 35.54 ATOM 4071 CHIS 574 64.874 46.906 29.881 1.00 33.60 ATOM 4072 O HIS 574 64.23747.946 29.743 1.00 33.03 ATOM 4073 N THR 575 65.380 46.227 28.859 1.0032.54 ATOM 4074 CA THR 575 65.192 46.671 27.488 1.00 33.83 ATOM 4075 CBTHR 575 66.501 47.234 26.889 1.00 34.38 ATOM 4076 OG1 THR 575 67.43546.166 26.684 1.00 35.54 ATOM 4077 CG2 THR 575 67.115 48.261 27.831 1.0035.04 ATOM 4078 C THR 575 64.751 45.462 26.676 1.00 33.06 ATOM 4079 OTHR 575 65.060 44.322 27.030 1.00 33.26 ATOM 4080 N GLY 576 64.02345.711 25.594 1.00 32.96 ATOM 4081 CA GLY 576 63.554 44.618 24.764 1.0032.46 ATOM 4082 C GLY 576 62.144 44.192 25.125 1.00 32.04 ATOM 4083 OGLY 576 61.479 44.862 25.915 1.00 32.23 ATOM 4084 N PRO 577 61.66343.068 24.571 1.00 31.90 ATOM 4085 CD PRO 577 62.410 42.136 23.709 1.0030.59 ATOM 4086 CA PRO 577 60.314 42.558 24.841 1.00 29.53 ATOM 4087 CBPRO 577 60.351 41.158 24.235 1.00 30.83 ATOM 4088 CG PRO 577 61.29741.321 23.087 1.00 32.27 ATOM 4089 C PRO 577 59.972 42.538 26.329 1.0028.72 ATOM 4090 O PRO 577 60.709 41.981 27.143 1.00 28.66 ATOM 4091 NLEU 578 58.842 43.146 26.672 1.00 27.32 ATOM 4092 CA LEU 578 58.39343.211 28.055 1.00 25.47 ATOM 4093 CB LEU 578 57.073 43.990 28.135 1.0024.84 ATOM 4094 CG LEU 578 56.462 44.208 29.523 1.00 23.79 ATOM 4095 CD1LEU 578 57.435 44.990 30.395 1.00 23.05 ATOM 4096 CD2 LEU 578 55.14144.962 29.390 1.00 24.13 ATOM 4097 C LEU 578 58.224 41.831 28.695 1.0024.37 ATOM 4098 O LEU 578 58.540 41.646 29.874 1.00 25.18 ATOM 4099 NHIS 579 57.743 40.855 27.927 1.00 22.93 ATOM 4100 CA HIS 579 57.53339.521 28.482 1.00 22.45 ATOM 4101 CB HIS 579 56.736 38.635 27.511 1.0022.24 ATOM 4102 CG HIS 579 57.512 38.181 26.313 1.00 22.10 ATOM 4103 CD2HIS 579 58.201 37.038 26.080 1.00 23.76 ATOM 4104 ND1 HIS 579 57.62738.938 25.166 1.00 24.64 ATOM 4105 CE1 HIS 579 58.350 38.279 24.277 1.0025.23 ATOM 4106 NE2 HIS 579 58.711 37.123 24.807 1.00 25.73 ATOM 4107 CHIS 579 58.810 38.796 28.900 1.00 23.53 ATOM 4108 O HIS 579 58.74437.743 29.535 1.00 24.05 ATOM 4109 N LYS 580 59.968 39.348 28.547 1.0023.73 ATOM 4110 CA LYS 580 61.244 38.734 28.919 1.00 26.19 ATOM 4111 CBLYS 580 62.272 38.902 27.794 1.00 27.71 ATOM 4112 CG LYS 580 61.99338.075 26.553 1.00 31.25 ATOM 4113 CD LYS 580 63.043 38.351 25.481 1.0034.78 ATOM 4114 CE LYS 580 62.733 37.611 24.191 1.00 37.22 ATOM 4115 NZLYS 580 63.671 37.995 23.096 1.00 40.53 ATOM 4116 C LYS 580 61.81139.340 30.206 1.00 26.16 ATOM 4117 O LYS 580 62.850 38.903 30.706 1.0023.22 ATOM 4118 N CYS 581 61.124 40.344 30.739 1.00 24.41 ATOM 4119 CACYS 581 61.569 41.006 31.959 1.00 23.52 ATOM 4120 C CYS 581 61.40740.186 33.240 1.00 24.04 ATOM 4121 O CYS 581 60.418 39.469 33.419 1.0021.53 ATOM 4122 CB CYS 581 60.838 42.342 32.119 1.00 23.29 ATOM 4123 SGCYS 581 61.004 43.098 33.770 1.00 24.70 ATOM 4124 N ASP 582 62.40040.306 34.121 1.00 21.19 ATOM 4125 CA ASP 582 62.419 39.637 35.421 1.0022.50 ATOM 4126 CB ASP 582 63.317 38.394 35.392 1.00 22.61 ATOM 4127 CGASP 582 63.390 37.685 36.742 1.00 23.83 ATOM 4128 OD1 ASP 582 62.90638.239 37.758 1.00 24.26 ATOM 4129 OD2 ASP 582 63.947 36.567 36.793 1.0023.11 ATOM 4130 C ASP 582 63.010 40.680 36.360 1.00 24.44 ATOM 4131 OASP 582 64.211 40.968 36.302 1.00 24.08 ATOM 4132 N ILE 583 62.16541.253 37.213 1.00 22.22 ATOM 4133 CA ILE 583 62.601 42.294 38.138 1.0021.09 ATOM 4134 CB ILE 583 61.413 43.184 38.568 1.00 19.80 ATOM 4135 CG2ILE 583 60.751 43.796 37.340 1.00 18.47 ATOM 4136 CG1 ILE 583 60.40842.355 39.369 1.00 19.27 ATOM 4137 CD1 ILE 583 59.301 43.181 40.010 1.0021.03 ATOM 4138 C ILE 583 63.279 41.779 39.401 1.00 21.02 ATOM 4139 OILE 583 63.533 42.552 40.325 1.00 21.75 ATOM 4140 N TYR 584 63.57540.484 39.445 1.00 21.19 ATOM 4141 CA TYR 584 64.220 39.906 40.620 1.0022.52 ATOM 4142 CB TYR 584 64.660 38.466 40.346 1.00 23.63 ATOM 4143 CGTYR 584 65.245 37.787 41.565 1.00 25.38 ATOM 4144 CD1 TYR 584 64.42037.304 42.576 1.00 24.65 ATOM 4145 CE1 TYR 584 64.951 36.724 43.725 1.0026.30 ATOM 4146 CD2 TYR 584 66.625 37.672 41.731 1.00 25.96 ATOM 4147CE2 TYR 584 67.167 37.095 42.878 1.00 27.41 ATOM 4148 CZ TYR 584 66.32536.624 43.869 1.00 27.35 ATOM 4149 OH TYR 584 66.852 36.048 45.003 1.0029.28 ATOM 4150 C TYR 584 65.434 40.721 41.068 1.00 22.10 ATOM 4151 OTYR 584 66.273 41.102 40.252 1.00 19.45 ATOM 4152 N GLN 585 65.50140.980 42.373 1.00 24.34 ATOM 4153 CA GLN 585 66.581 41.736 43.014 1.0025.79 ATOM 4154 CB GLN 585 67.937 41.063 42.740 1.00 27.46 ATOM 4155 CGGLN 585 69.106 41.754 43.433 1.00 30.44 ATOM 4156 CD GLN 585 70.38340.939 43.418 1.00 32.54 ATOM 4157 OE1 GLN 585 71.474 41.474 43.621 1.0033.54 ATOM 4158 NE2 GLN 585 70.253 39.636 43.194 1.00 31.30 ATOM 4159 CGLN 585 66.666 43.231 42.687 1.00 25.96 ATOM 4160 O GLN 585 67.58543.919 43.139 1.00 27.28 ATOM 4161 N SER 586 65.707 43.747 41.924 1.0024.70 ATOM 4162 CA SER 586 65.716 45.165 41.577 1.00 25.28 ATOM 4163 CBSER 586 64.829 45.436 40.365 1.00 24.97 ATOM 4164 OG SER 586 64.66746.834 40.178 1.00 25.13 ATOM 4165 C SER 586 65.247 46.047 42.728 1.0026.57 ATOM 4166 O SER 586 64.072 46.026 43.103 1.00 26.45 ATOM 4167 NLYS 587 66.167 46.832 43.277 1.00 25.12 ATOM 4168 CA LYS 587 65.84347.724 44.378 1.00 26.77 ATOM 4169 CB LYS 587 67.126 48.207 45.067 1.0026.74 ATOM 4170 CG LYS 587 67.944 47.087 45.702 1.00 27.54 ATOM 4171 CDLYS 587 67.119 46.297 46.712 1.00 27.45 ATOM 4172 CE LYS 587 67.92545.161 47.332 1.00 26.21 ATOM 4173 NZ LYS 587 68.401 44.190 46.311 1.0025.90 ATOM 4174 C LYS 587 65.022 48.918 43.897 1.00 25.59 ATOM 4175 OLYS 587 64.201 49.448 44.642 1.00 26.97 ATOM 4176 N GLU 588 65.24549.344 42.657 1.00 24.23 ATOM 4177 CA GLU 588 64.496 50.467 42.104 1.0025.34 ATOM 4178 CB GLU 588 65.025 50.849 40.718 1.00 29.07 ATOM 4179 CGGLU 588 66.440 51.417 40.693 1.00 34.67 ATOM 4180 CD GLU 588 67.49650.393 41.060 1.00 38.21 ATOM 4181 OE1 GLU 588 67.482 49.283 40.480 1.0038.94 ATOM 4182 OE2 GLU 588 68.348 50.704 41.921 1.00 41.97 ATOM 4183 CGLU 588 63.021 50.071 41.987 1.00 25.42 ATOM 4184 O GLU 588 62.12550.880 42.238 1.00 22.32 ATOM 4185 N ALA 589 62.783 48.822 41.596 1.0024.18 ATOM 4186 CA ALA 589 61.426 48.306 41.452 1.00 24.57 ATOM 4187 CBALA 589 61.455 46.903 40.851 1.00 24.39 ATOM 4188 C ALA 589 60.76148.271 42.822 1.00 24.55 ATOM 4189 O ALA 589 59.665 48.801 43.009 1.0024.25 ATOM 4190 N GLY 590 61.439 47.646 43.778 1.00 23.98 ATOM 4191 CAGLY 590 60.902 47.551 45.121 1.00 26.42 ATOM 4192 C GLY 590 60.58248.897 45.746 1.00 27.69 ATOM 4193 O GLY 590 59.577 49.039 46.442 1.0028.18 ATOM 4194 N GLN 591 61.429 49.890 45.500 1.00 27.79 ATOM 4195 CAGLN 591 61.214 51.214 46.066 1.00 29.11 ATOM 4196 CB GLN 591 62.37652.143 45.715 1.00 31.76 ATOM 4197 CG GLN 591 62.271 53.502 46.384 1.0036.94 ATOM 4198 CD GLN 591 62.181 53.386 47.896 1.00 41.21 ATOM 4199 OE1GLN 591 63.116 52.925 48.554 1.00 44.17 ATOM 4200 NE2 GLN 591 61.04853.795 48.454 1.00 43.27 ATOM 4201 C GLN 591 59.904 51.843 45.600 1.0028.84 ATOM 4202 O GLN 591 59.228 52.522 46.371 1.00 26.01 ATOM 4203 NARG 592 59.547 51.625 44.340 1.00 28.52 ATOM 4204 CA ARG 592 58.30752.191 43.823 1.00 29.49 ATOM 4205 CB ARG 592 58.258 52.089 42.298 1.0030.74 ATOM 4206 CG ARG 592 59.232 53.022 41.610 1.00 33.59 ATOM 4207 CDARG 592 58.864 53.215 40.162 1.00 34.84 ATOM 4208 NE ARG 592 59.81754.071 39.469 1.00 36.89 ATOM 4209 CZ ARG 592 59.720 54.401 38.187 1.0039.66 ATOM 4210 NH1 ARG 592 58.706 53.948 37.460 1.00 40.17 ATOM 4211NH2 ARG 592 60.641 55.173 37.628 1.00 40.49 ATOM 4212 C ARG 592 57.08651.515 44.428 1.00 28.08 ATOM 4213 O ARG 592 56.103 52.177 44.758 1.0030.13 ATOM 4214 N LEU 593 57.144 50.197 44.576 1.00 25.72 ATOM 4215 CALEU 593 56.028 49.468 45.162 1.00 24.31 ATOM 4216 CB LEU 593 56.25747.960 45.061 1.00 23.41 ATOM 4217 CG LEU 593 56.003 47.293 43.710 1.0024.09 ATOM 4218 CD1 LEU 593 56.340 45.814 43.814 1.00 22.31 ATOM 4219CD2 LEU 593 54.541 47.482 43.309 1.00 24.13 ATOM 4220 C LEU 593 55.85649.851 46.630 1.00 24.61 ATOM 4221 O LEU 593 54.734 50.014 47.113 1.0022.28 ATOM 4222 N ALA 594 56.979 49.994 47.327 1.00 22.88 ATOM 4223 CAALA 594 56.975 50.342 48.743 1.00 24.40 ATOM 4224 CB ALA 594 58.40050.304 49.299 1.00 23.81 ATOM 4225 C ALA 594 56.350 51.704 49.016 1.0023.79 ATOM 4226 O ALA 594 55.480 51.824 49.878 1.00 24.99 ATOM 4227 NTHR 595 56.784 52.729 48.288 1.00 23.07 ATOM 4228 CA THR 595 56.24454.065 48.506 1.00 26.20 ATOM 4229 CB THR 595 56.956 55.126 47.627 1.0028.03 ATOM 4230 OG1 THR 595 56.705 54.861 46.242 1.00 35.56 ATOM 4231CG2 THR 595 58.457 55.094 47.873 1.00 28.43 ATOM 4232 C THR 595 54.74554.092 48.218 1.00 25.47 ATOM 4233 O THR 595 53.983 54.780 48.901 1.0024.49 ATOM 4234 N ALA 596 54.326 53.331 47.211 1.00 23.19 ATOM 4235 CAALA 596 52.918 53.265 46.846 1.00 22.32 ATOM 4236 CB ALA 596 52.75652.563 45.496 1.00 22.20 ATOM 4237 C ALA 596 52.123 52.530 47.919 1.0020.86 ATOM 4238 O ALA 596 51.067 52.993 48.347 1.00 21.03 ATOM 4239 NMET 597 52.631 51.385 48.362 1.00 20.23 ATOM 4240 CA MET 597 51.93050.608 49.376 1.00 20.17 ATOM 4241 CB MET 597 52.610 49.249 49.581 1.0018.97 ATOM 4242 CG MET 597 52.435 48.280 48.412 1.00 18.62 ATOM 4243 SDMET 597 53.001 46.611 48.797 1.00 20.81 ATOM 4244 CE MET 597 54.71446.755 48.344 1.00 18.21 ATOM 4245 C MET 597 51.824 51.338 50.710 1.0021.22 ATOM 4246 O MET 597 50.834 51.194 51.426 1.00 19.46 ATOM 4247 NLYS 598 52.839 52.128 51.039 1.00 22.34 ATOM 4248 CA LYS 598 52.84552.863 52.298 1.00 23.65 ATOM 4249 CB LYS 598 54.194 53.565 52.492 1.0023.93 ATOM 4250 CG LYS 598 55.328 52.609 52.830 1.00 28.85 ATOM 4251 CDLYS 598 56.610 53.354 53.162 1.00 31.84 ATOM 4252 CE LYS 598 57.62552.428 53.822 1.00 35.46 ATOM 4253 NZ LYS 598 58.006 51.266 52.967 1.0038.87 ATOM 4254 C LYS 598 51.706 53.875 52.417 1.00 22.67 ATOM 4255 OLYS 598 51.337 54.267 53.522 1.00 23.02 ATOM 4256 N LEU 599 51.15454.299 51.284 1.00 20.77 ATOM 4257 CA LEU 599 50.050 55.257 51.290 1.0020.03 ATOM 4258 CB LEU 599 49.807 55.812 49.883 1.00 21.69 ATOM 4259 CGLEU 599 50.838 56.754 49.260 1.00 22.59 ATOM 4260 CD1 LEU 599 50.42057.074 47.835 1.00 22.70 ATOM 4261 CD2 LEU 599 50.947 58.026 50.085 1.0022.77 ATOM 4262 C LEU 599 48.757 54.614 51.784 1.00 20.21 ATOM 4263 OLEU 599 47.834 55.306 52.219 1.00 19.40 ATOM 4264 N GLY 600 48.69053.290 51.717 1.00 20.15 ATOM 4265 CA GLY 600 47.478 52.611 52.134 1.0020.16 ATOM 4266 C GLY 600 46.297 53.228 51.402 1.00 20.63 ATOM 4267 OGLY 600 46.347 53.438 50.185 1.00 20.76 ATOM 4268 N PHE 601 45.24553.544 52.150 1.00 20.86 ATOM 4269 CA PHE 601 44.031 54.143 51.593 1.0021.23 ATOM 4270 CB PHE 601 42.807 53.406 52.161 1.00 20.65 ATOM 4271 CGPHE 601 41.509 53.733 51.470 1.00 24.23 ATOM 4272 CD1 PHE 601 41.34053.471 50.115 1.00 25.84 ATOM 4273 CD2 PHE 601 40.449 54.283 52.183 1.0024.34 ATOM 4274 CE1 PHE 601 40.130 53.751 49.479 1.00 28.01 ATOM 4275CE2 PHE 601 39.233 54.568 51.557 1.00 27.29 ATOM 4276 CZ PHE 601 39.07554.300 50.202 1.00 26.47 ATOM 4277 C PHE 601 43.972 55.632 51.961 1.0020.30 ATOM 4278 O PHE 601 42.899 56.230 51.999 1.00 21.85 ATOM 4279 NSER 602 45.133 56.231 52.209 1.00 21.00 ATOM 4280 CA SER 602 45.20857.641 52.609 1.00 22.21 ATOM 4281 CB SER 602 46.560 57.918 53.270 1.0022.60 ATOM 4282 OG SER 602 47.619 57.789 52.338 1.00 20.98 ATOM 4283 CSER 602 44.982 58.679 51.506 1.00 23.68 ATOM 4284 O SER 602 44.63659.827 51.795 1.00 23.46 ATOM 4285 N ARG 603 45.177 58.285 50.252 1.0022.88 ATOM 4286 CA ARG 603 45.005 59.207 49.130 1.00 25.54 ATOM 4287 CBARG 603 46.380 59.662 48.620 1.00 27.34 ATOM 4288 CG ARG 603 47.24760.373 49.654 1.00 31.36 ATOM 4289 CD ARG 603 46.692 61.748 49.980 1.0035.45 ATOM 4290 NE ARG 603 46.606 62.585 48.784 1.00 40.01 ATOM 4291 CZARG 603 46.063 63.799 48.754 1.00 42.24 ATOM 4292 NH1 ARG 603 45.55264.329 49.857 1.00 44.20 ATOM 4293 NH2 ARG 603 46.029 64.483 47.618 1.0041.85 ATOM 4294 C ARG 603 44.243 58.549 47.981 1.00 23.92 ATOM 4295 OARG 603 44.199 57.330 47.884 1.00 24.89 ATOM 4296 N PRO 604 43.62359.353 47.101 1.00 24.43 ATOM 4297 CD PRO 604 43.538 60.825 47.105 1.0024.47 ATOM 4298 CA PRO 604 42.881 58.785 45.967 1.00 23.43 ATOM 4299 CBPRO 604 42.495 60.021 45.161 1.00 24.04 ATOM 4300 CG PRO 604 42.32761.076 46.235 1.00 24.67 ATOM 4301 C PRO 604 43.856 57.874 45.217 1.0022.52 ATOM 4302 O PRO 604 45.017 58.241 45.026 1.00 19.66 ATOM 4303 NTRP 605 43.397 56.702 44.784 1.00 21.06 ATOM 4304 CA TRP 605 44.29555.761 44.115 1.00 19.74 ATOM 4305 CB TRP 605 43.547 54.478 43.719 1.0017.20 ATOM 4306 CG TRP 605 42.556 54.624 42.617 1.00 16.80 ATOM 4307 CD2TRP 605 42.839 54.662 41.218 1.00 13.73 ATOM 4308 CE2 TRP 605 41.60454.771 40.545 1.00 13.99 ATOM 4309 CE3 TRP 605 44.019 54.611 40.465 1.0014.13 ATOM 4310 CD1 TRP 605 41.198 54.716 42.736 1.00 16.73 ATOM 4311NE1 TRP 605 40.619 54.802 41.496 1.00 15.70 ATOM 4312 CZ2 TRP 605 41.51454.835 39.153 1.00 12.90 ATOM 4313 CZ3 TRP 605 43.929 54.674 39.083 1.0015.39 ATOM 4314 CH2 TRP 605 42.684 54.783 38.442 1.00 15.57 ATOM 4315 CTRP 605 45.110 56.278 42.928 1.00 18.46 ATOM 4316 O TRP 605 46.20355.777 42.671 1.00 19.34 ATOM 4317 N PRO 606 44.599 57.271 42.179 1.0019.18 ATOM 4318 CD PRO 606 43.257 57.880 42.148 1.00 18.96 ATOM 4319 CAPRO 606 45.409 57.748 41.052 1.00 20.80 ATOM 4320 CB PRO 606 44.58358.910 40.507 1.00 20.75 ATOM 4321 CG PRO 606 43.184 58.426 40.733 1.0020.74 ATOM 4322 C PRO 606 46.813 58.182 41.485 1.00 21.70 ATOM 4323 OPRO 606 47.751 58.138 40.697 1.00 20.53 ATOM 4324 N GLU 607 46.95158.596 42.742 1.00 22.05 ATOM 4325 CA GLU 607 48.250 59.020 43.250 1.0023.78 ATOM 4326 CB GLU 607 48.102 59.712 44.606 1.00 24.14 ATOM 4327 CGGLU 607 47.576 61.128 44.482 1.00 30.40 ATOM 4328 CD GLU 607 47.54261.858 45.811 1.00 32.85 ATOM 4329 OE1 GLU 607 48.566 61.837 46.530 1.0033.25 ATOM 4330 OE2 GLU 607 46.493 62.457 46.127 1.00 34.78 ATOM 4331 CGLU 607 49.197 57.838 43.367 1.00 23.11 ATOM 4332 O GLU 607 50.37057.949 43.017 1.00 22.68 ATOM 4333 N ALA 608 48.691 56.711 43.861 1.0020.59 ATOM 4334 CA ALA 608 49.514 55.513 43.984 1.00 21.79 ATOM 4335 CBALA 608 48.766 54.431 44.770 1.00 19.65 ATOM 4336 C ALA 608 49.85455.014 42.575 1.00 20.36 ATOM 4337 O ALA 608 50.941 54.484 42.341 1.0020.96 ATOM 4338 N MET 609 48.922 55.191 41.641 1.00 19.66 ATOM 4339 CAMET 609 49.139 54.772 40.257 1.00 19.69 ATOM 4340 CB MET 609 47.87354.978 39.425 1.00 19.14 ATOM 4341 CG MET 609 48.052 54.689 37.933 1.0017.12 ATOM 4342 SD MET 609 48.510 52.964 37.574 1.00 19.73 ATOM 4343 CEMET 609 46.861 52.188 37.611 1.00 15.34 ATOM 4344 C MET 609 50.26655.601 39.658 1.00 21.29 ATOM 4345 O MET 609 51.131 55.080 38.956 1.0021.89 ATOM 4346 N GLN 610 50.244 56.899 39.945 1.00 22.60 ATOM 4347 CAGLN 610 51.254 57.820 39.444 1.00 24.68 ATOM 4348 CB GLN 610 50.88059.253 39.810 1.00 28.02 ATOM 4349 CG GLN 610 51.680 60.294 39.059 1.0032.26 ATOM 4350 CD GLN 610 50.791 61.215 38.261 1.00 34.82 ATOM 4351 OE1GLN 610 50.166 62.126 38.805 1.00 37.92 ATOM 4352 NE2 GLN 610 50.70960.969 36.962 1.00 39.74 ATOM 4353 C GLN 610 52.628 57.493 40.018 1.0025.43 ATOM 4354 O GLN 610 53.626 57.492 39.297 1.00 26.39 ATOM 4355 NLEU 611 52.677 57.221 41.318 1.00 25.09 ATOM 4356 CA LEU 611 53.93656.889 41.976 1.00 26.89 ATOM 4357 CB LEU 611 53.704 56.624 43.466 1.0028.27 ATOM 4358 CG LEU 611 53.394 57.852 44.319 1.00 30.25 ATOM 4359 CD1LEU 611 53.105 57.417 45.742 1.00 30.76 ATOM 4360 CD2 LEU 611 54.57758.818 44.279 1.00 30.95 ATOM 4361 C LEU 611 54.624 55.677 41.357 1.0025.11 ATOM 4362 O LEU 611 55.850 55.622 41.271 1.00 25.06 ATOM 4363 NILE 612 53.834 54.703 40.928 1.00 23.32 ATOM 4364 CA ILE 612 54.39453.497 40.339 1.00 22.85 ATOM 4365 CB ILE 612 53.449 52.286 40.530 1.0023.45 ATOM 4366 CG2 ILE 612 54.042 51.054 39.856 1.00 24.69 ATOM 4367CG1 ILE 612 53.216 52.018 42.017 1.00 24.83 ATOM 4368 CD1 ILE 612 52.07851.033 42.285 1.00 23.21 ATOM 4369 C ILE 612 54.678 53.607 38.844 1.0022.85 ATOM 4370 O ILE 612 55.739 53.187 38.380 1.00 23.82 ATOM 4371 NTHR 613 53.736 54.179 38.099 1.00 22.01 ATOM 4372 CA THR 613 53.84654.262 36.642 1.00 22.05 ATOM 4373 CB THR 613 52.552 53.740 35.993 1.0020.57 ATOM 4374 OG1 THR 613 51.498 54.680 36.225 1.00 19.96 ATOM 4375CG2 THR 613 52.151 52.397 36.600 1.00 17.72 ATOM 4376 C THR 613 54.16455.608 35.989 1.00 22.43 ATOM 4377 O THR 613 54.456 55.660 34.796 1.0022.71 ATOM 4378 N GLY 614 54.095 56.696 36.743 1.00 24.21 ATOM 4379 CAGLY 614 54.392 57.987 36.150 1.00 22.90 ATOM 4380 C GLY 614 53.18858.640 35.501 1.00 22.97 ATOM 4381 O GLY 614 53.294 59.729 34.937 1.0021.49 ATOM 4382 N GLN 615 52.046 57.962 35.554 1.00 23.88 ATOM 4383 CAGLN 615 50.802 58.502 35.012 1.00 21.95 ATOM 4384 CB GLN 615 50.58158.015 33.574 1.00 22.47 ATOM 4385 CG GLN 615 50.505 56.523 33.379 1.0022.03 ATOM 4386 CD GLN 615 49.156 55.988 33.763 1.00 19.05 ATOM 4387 OE1GLN 615 48.129 56.540 33.362 1.00 19.51 ATOM 4388 NE2 GLN 615 49.14154.908 34.537 1.00 16.18 ATOM 4389 C GLN 615 49.689 58.095 35.989 1.0020.81 ATOM 4390 O GLN 615 49.891 57.215 36.825 1.00 20.69 ATOM 4391 NPRO 616 48.502 58.716 35.897 1.00 19.66 ATOM 4392 CD PRO 616 48.15759.932 35.138 1.00 21.70 ATOM 4393 CA PRO 616 47.427 58.379 36.836 1.0020.55 ATOM 4394 CB PRO 616 46.908 59.751 37.209 1.00 20.89 ATOM 4395 CGPRO 616 46.873 60.418 35.835 1.00 20.78 ATOM 4396 C PRO 616 46.26757.457 36.457 1.00 19.89 ATOM 4397 O PRO 616 45.445 57.136 37.314 1.0019.50 ATOM 4398 N ASN 617 46.183 57.029 35.206 1.00 18.92 ATOM 4399 CAASN 617 45.051 56.199 34.799 1.00 20.34 ATOM 4400 CB ASN 617 44.49856.699 33.462 1.00 23.41 ATOM 4401 CG ASN 617 44.426 58.205 33.391 1.0026.99 ATOM 4402 OD1 ASN 617 44.083 58.855 34.377 1.00 31.32 ATOM 4403ND2 ASN 617 44.732 58.761 32.219 1.00 31.42 ATOM 4404 C ASN 617 45.30354.708 34.664 1.00 17.45 ATOM 4405 O ASN 617 46.445 54.250 34.621 1.0017.50 ATOM 4406 N MET 618 44.208 53.957 34.603 1.00 16.22 ATOM 4407 CAMET 618 44.279 52.520 34.387 1.00 17.60 ATOM 4408 CB MET 618 42.98251.821 34.807 1.00 14.99 ATOM 4409 CG MET 618 42.792 51.646 36.305 1.0015.84 ATOM 4410 SD MET 618 41.282 50.709 36.700 1.00 17.39 ATOM 4411 CEMET 618 40.045 51.984 36.543 1.00 20.05 ATOM 4412 C MET 618 44.40252.465 32.872 1.00 16.95 ATOM 4413 O MET 618 43.843 53.315 32.178 1.0016.75 ATOM 4414 N SER 619 45.117 51.480 32.351 1.00 16.04 ATOM 4415 CASER 619 45.286 51.385 30.904 1.00 16.02 ATOM 4416 CB SER 619 46.42052.314 30.449 1.00 16.02 ATOM 4417 OG SER 619 46.691 52.155 29.067 1.0019.66 ATOM 4418 C SER 619 45.617 49.965 30.495 1.00 15.40 ATOM 4419 OSER 619 46.400 49.297 31.161 1.00 14.10 ATOM 4420 N ALA 620 45.02449.516 29.392 1.00 15.67 ATOM 4421 CA ALA 620 45.265 48.173 28.880 1.0017.19 ATOM 4422 CB ALA 620 44.053 47.695 28.092 1.00 15.24 ATOM 4423 CALA 620 46.509 48.124 27.991 1.00 17.50 ATOM 4424 O ALA 620 46.90947.052 27.533 1.00 16.59 ATOM 4425 N SER 621 47.124 49.282 27.755 1.0019.02 ATOM 4426 CA SER 621 48.310 49.356 26.896 1.00 20.17 ATOM 4427 CBSER 621 48.839 50.791 26.838 1.00 19.94 ATOM 4428 OG SER 621 47.94051.611 26.112 1.00 28.11 ATOM 4429 C SER 621 49.443 48.420 27.296 1.0018.71 ATOM 4430 O SER 621 50.023 47.752 26.448 1.00 19.01 ATOM 4431 NALA 622 49.761 48.373 28.584 1.00 18.30 ATOM 4432 CA ALA 622 50.84147.513 29.060 1.00 17.71 ATOM 4433 CB ALA 622 51.067 47.741 30.557 1.0017.13 ATOM 4434 C ALA 622 50.554 46.034 28.784 1.00 16.19 ATOM 4435 OALA 622 51.410 45.305 28.271 1.00 16.07 ATOM 4436 N MET 623 49.35045.591 29.122 1.00 15.56 ATOM 4437 CA MET 623 48.974 44.202 28.899 1.0015.10 ATOM 4438 CB MET 623 47.580 43.931 29.475 1.00 15.03 ATOM 4439 CGMET 623 47.133 42.489 29.348 1.00 18.59 ATOM 4440 SD MET 623 45.53042.188 30.123 1.00 19.23 ATOM 4441 CE MET 623 45.854 40.606 30.925 1.0019.84 ATOM 4442 C MET 623 49.008 43.868 27.402 1.00 16.05 ATOM 4443 OMET 623 49.480 42.802 27.012 1.00 17.32 ATOM 4444 N LEU 624 48.50844.774 26.566 1.00 15.21 ATOM 4445 CA LEU 624 48.515 44.543 25.120 1.0018.46 ATOM 4446 CB LEU 624 47.735 45.649 24.396 1.00 19.41 ATOM 4447 CGLEU 624 46.220 45.664 24.628 1.00 22.76 ATOM 4448 CD1 LEU 624 45.57646.786 23.827 1.00 21.15 ATOM 4449 CD2 LEU 624 45.634 44.315 24.214 1.0024.62 ATOM 4450 C LEU 624 49.956 44.487 24.598 1.00 19.43 ATOM 4451 OLEU 624 50.295 43.655 23.751 1.00 18.79 ATOM 4452 N SER 625 50.80245.375 25.112 1.00 19.19 ATOM 4453 CA SER 625 52.208 45.418 24.717 1.0019.92 ATOM 4454 CB SER 625 52.891 46.612 25.402 1.00 22.10 ATOM 4455 OGSER 625 54.286 46.618 25.176 1.00 27.80 ATOM 4456 C SER 625 52.89244.100 25.113 1.00 18.98 ATOM 4457 O SER 625 53.667 43.525 24.345 1.0019.48 ATOM 4458 N TYR 626 52.600 43.623 26.316 1.00 17.23 ATOM 4459 CATYR 626 53.169 42.370 26.803 1.00 17.45 ATOM 4460 CB TYR 626 52.62642.070 28.203 1.00 17.03 ATOM 4461 CG TYR 626 53.131 40.783 28.824 1.0016.24 ATOM 4462 CD1 TYR 626 54.122 40.798 29.806 1.00 18.36 ATOM 4463CE1 TYR 626 54.560 39.612 30.412 1.00 16.21 ATOM 4464 CD2 TYR 626 52.59039.551 28.454 1.00 16.60 ATOM 4465 CE2 TYR 626 53.018 38.367 29.046 1.0015.67 ATOM 4466 CZ TYR 626 53.998 38.402 30.026 1.00 17.59 ATOM 4467 OHTYR 626 54.385 37.225 30.630 1.00 17.16 ATOM 4468 C TYR 626 52.82041.206 25.858 1.00 18.35 ATOM 4469 O TYR 626 53.676 40.379 25.534 1.0017.96 ATOM 4470 N PHE 627 51.564 41.151 25.416 1.00 17.36 ATOM 4471 CAPHE 627 51.108 40.071 24.538 1.00 18.59 ATOM 4472 CB PHE 627 49.67939.657 24.914 1.00 15.88 ATOM 4473 CG PHE 627 49.585 38.913 26.208 1.0015.40 ATOM 4474 CD1 PHE 627 49.150 39.552 27.366 1.00 15.71 ATOM 4475CD2 PHE 627 49.952 37.573 26.278 1.00 15.04 ATOM 4476 CE1 PHE 627 49.08138.864 28.579 1.00 14.00 ATOM 4477 CE2 PHE 627 49.889 36.874 27.483 1.0015.01 ATOM 4478 CZ PHE 627 49.453 37.519 28.636 1.00 14.97 ATOM 4479 CPHE 627 51.151 40.323 23.030 1.00 18.84 ATOM 4480 O PHE 627 50.74139.464 22.254 1.00 19.04 ATOM 4481 N LYS 628 51.644 41.484 22.612 1.0019.54 ATOM 4482 CA LYS 628 51.705 41.819 21.190 1.00 19.75 ATOM 4483 CBLYS 628 52.556 43.079 20.989 1.00 22.03 ATOM 4484 CG LYS 628 52.86843.419 19.532 1.00 23.91 ATOM 4485 CD LYS 628 51.621 43.760 18.727 1.0027.23 ATOM 4486 CE LYS 628 52.002 44.196 17.306 1.00 30.31 ATOM 4487 NZLYS 628 50.817 44.449 16.440 1.00 30.49 ATOM 4488 C LYS 628 52.21740.692 20.283 1.00 20.01 ATOM 4489 O LYS 628 51.584 40.365 19.281 1.0021.94 ATOM 4490 N PRO 629 53.369 40.087 20.611 1.00 20.55 ATOM 4491 CDPRO 629 54.306 40.351 21.717 1.00 22.46 ATOM 4492 CA PRO 629 53.86739.008 19.749 1.00 21.49 ATOM 4493 CB PRO 629 55.151 38.566 20.450 1.0021.82 ATOM 4494 CG PRO 629 55.607 39.818 21.155 1.00 23.13 ATOM 4495 CPRO 629 52.857 37.867 19.613 1.00 20.35 ATOM 4496 O PRO 629 52.73237.256 18.553 1.00 19.97 ATOM 4497 N LEU 630 52.131 37.583 20.687 1.0019.10 ATOM 4498 CA LEU 630 51.150 36.510 20.649 1.00 18.86 ATOM 4499 CBLEU 630 50.695 36.135 22.059 1.00 17.73 ATOM 4500 CG LEU 630 49.72534.946 22.116 1.00 18.16 ATOM 4501 CD1 LEU 630 50.447 33.682 21.698 1.0017.06 ATOM 4502 CD2 LEU 630 49.167 34.789 23.525 1.00 17.08 ATOM 4503 CLEU 630 49.945 36.906 19.807 1.00 18.76 ATOM 4504 O LEU 630 49.44836.106 19.016 1.00 20.28 ATOM 4505 N LEU 631 49.480 38.140 19.972 1.0018.81 ATOM 4506 CA LEU 631 48.332 38.617 19.207 1.00 19.95 ATOM 4507 CBLEU 631 48.025 40.079 19.543 1.00 18.70 ATOM 4508 CG LEU 631 46.89640.731 18.735 1.00 21.74 ATOM 4509 CD1 LEU 631 45.584 40.002 18.990 1.0023.52 ATOM 4510 CD2 LEU 631 46.766 42.196 19.119 1.00 22.39 ATOM 4511 CLEU 631 48.599 38.482 17.709 1.00 21.61 ATOM 4512 O LEU 631 47.72538.048 16.955 1.00 18.83 ATOM 4513 N ASP 632 49.804 38.855 17.281 1.0021.33 ATOM 4514 CA ASP 632 50.160 38.756 15.869 1.00 21.95 ATOM 4515 CBASP 632 51.525 39.405 15.604 1.00 23.60 ATOM 4516 CG ASP 632 51.51640.903 15.839 1.00 24.22 ATOM 4517 OD1 ASP 632 50.469 41.541 15.604 1.0026.63 ATOM 4518 OD2 ASP 632 52.562 41.447 16.243 1.00 26.55 ATOM 4519 CASP 632 50.197 37.293 15.425 1.00 21.32 ATOM 4520 O ASP 632 49.74236.964 14.330 1.00 20.49 ATOM 4521 N TRP 633 50.736 36.418 16.271 1.0019.81 ATOM 4522 CA TRP 633 50.808 34.998 15.929 1.00 20.07 ATOM 4523 CBTRP 633 51.595 34.213 16.987 1.00 19.94 ATOM 4524 CG TRP 633 51.76132.756 16.632 1.00 21.13 ATOM 4525 CD2 TRP 633 50.902 31.674 17.019 1.0021.92 ATOM 4526 CE2 TRP 633 51.389 30.505 16.388 1.00 22.13 ATOM 4527CE3 TRP 633 49.766 31.578 17.836 1.00 22.40 ATOM 4528 CD1 TRP 633 52.71232.211 15.807 1.00 22.30 ATOM 4529 NE1 TRP 633 52.492 30.860 15.656 1.0021.61 ATOM 4530 CZ2 TRP 633 50.779 29.255 16.549 1.00 22.73 ATOM 4531CZ3 TRP 633 49.158 30.333 17.996 1.00 23.58 ATOM 4532 CH2 TRP 633 49.66929.189 17.354 1.00 24.12 ATOM 4533 C TRP 633 49.402 34.407 15.817 1.0020.16 ATOM 4534 O TRP 633 49.120 33.624 14.908 1.00 20.21 ATOM 4535 NLEU 634 48.528 34.788 16.745 1.00 18.10 ATOM 4536 CA LEU 634 47.15234.291 16.767 1.00 17.96 ATOM 4537 CB LEU 634 46.433 34.766 18.033 1.0013.19 ATOM 4538 CG LEU 634 46.823 34.058 19.331 1.00 15.98 ATOM 4539 CD1LEU 634 46.121 34.731 20.512 1.00 15.76 ATOM 4540 CD2 LEU 634 46.43332.585 19.242 1.00 17.65 ATOM 4541 C LEU 634 46.358 34.720 15.543 1.0017.44 ATOM 4542 O LEU 634 45.597 33.934 14.982 1.00 18.04 ATOM 4543 NARG 635 46.522 35.971 15.135 1.00 19.17 ATOM 4544 CA ARG 635 45.80936.459 13.965 1.00 20.10 ATOM 4545 CB ARG 635 46.057 37.955 13.776 1.0021.85 ATOM 4546 CG ARG 635 45.154 38.812 14.644 1.00 25.01 ATOM 4547 CDARG 635 45.529 40.272 14.572 1.00 29.62 ATOM 4548 NE ARG 635 44.54841.106 15.260 1.00 33.26 ATOM 4549 CZ ARG 635 44.745 42.381 15.571 1.0034.54 ATOM 4550 NH1 ARG 635 45.895 42.969 15.259 1.00 35.00 ATOM 4551NH2 ARG 635 43.791 43.069 16.185 1.00 36.75 ATOM 4552 C ARG 635 46.24035.688 12.728 1.00 19.78 ATOM 4553 O ARG 635 45.404 35.275 11.930 1.0019.55 ATOM 4554 N THR 636 47.544 35.485 12.577 1.00 20.54 ATOM 4555 CATHR 636 48.067 34.745 11.431 1.00 21.78 ATOM 4556 CB THR 636 49.60434.749 11.430 1.00 22.60 ATOM 4557 OG1 THR 636 50.072 36.101 11.362 1.0026.06 ATOM 4558 CG2 THR 636 50.142 33.960 10.241 1.00 23.85 ATOM 4559 CTHR 636 47.579 33.296 11.463 1.00 20.62 ATOM 4560 O THR 636 47.17032.747 10.439 1.00 19.63 ATOM 4561 N GLU 637 47.619 32.684 12.643 1.0019.42 ATOM 4562 CA GLU 637 47.176 31.299 12.804 1.00 18.86 ATOM 4563 CBGLU 637 47.517 30.791 14.211 1.00 19.68 ATOM 4564 CG GLU 637 46.99329.385 14.533 1.00 20.95 ATOM 4565 CD GLU 637 47.704 28.278 13.757 1.0024.76 ATOM 4566 OE1 GLU 637 48.584 28.589 12.924 1.00 25.29 ATOM 4567OE2 GLU 637 47.379 27.091 13.984 1.00 25.20 ATOM 4568 C GLU 637 45.67631.152 12.553 1.00 17.40 ATOM 4569 O GLU 637 45.258 30.279 11.794 1.0018.84 ATOM 4570 N ASN 638 44.867 32.001 13.183 1.00 17.45 ATOM 4571 CAASN 638 43.416 31.928 13.006 1.00 17.49 ATOM 4572 CB ASN 638 42.69132.889 13.962 1.00 15.50 ATOM 4573 CG ASN 638 42.730 32.411 15.408 1.0016.54 ATOM 4574 OD1 ASN 638 42.820 31.209 15.674 1.00 15.31 ATOM 4575ND2 ASN 638 42.652 33.348 16.348 1.00 12.94 ATOM 4576 C ASN 638 43.01532.235 11.571 1.00 18.74 ATOM 4577 O ASN 638 42.067 31.655 11.039 1.0016.61 ATOM 4578 N GLU 639 43.748 33.147 10.944 1.00 20.32 ATOM 4579 CAGLU 639 43.468 33.530 9.566 1.00 22.55 ATOM 4580 CB GLU 639 44.33534.729 9.178 1.00 23.65 ATOM 4581 CG GLU 639 44.290 35.079 7.704 1.0030.44 ATOM 4582 CD GLU 639 45.149 36.284 7.386 1.00 33.49 ATOM 4583 OE1GLU 639 44.809 37.389 7.863 1.00 34.20 ATOM 4584 OE2 GLU 639 46.16636.122 6.675 1.00 33.48 ATOM 4585 C GLU 639 43.703 32.382 8.581 1.0022.09 ATOM 4586 O GLU 639 42.873 32.118 7.712 1.00 21.43 ATOM 4587 N LEU640 44.825 31.688 8.722 1.00 22.49 ATOM 4588 CA LEU 640 45.118 30.6007.801 1.00 24.32 ATOM 4589 CB LEU 640 46.576 30.150 7.956 1.00 25.56ATOM 4590 CG LEU 640 47.046 29.348 9.162 1.00 26.95 ATOM 4591 CD1 LEU640 46.720 27.878 8.949 1.00 27.03 ATOM 4592 CD2 LEU 640 48.555 29.5199.316 1.00 29.34 ATOM 4593 C LEU 640 44.149 29.426 7.953 1.00 23.29 ATOM4594 O LEU 640 43.985 28.631 7.027 1.00 22.55 ATOM 4595 N HIS 641 43.49529.327 9.110 1.00 21.91 ATOM 4596 CA HIS 641 42.524 28.263 9.339 1.0022.74 ATOM 4597 CB HIS 641 42.622 27.728 10.772 1.00 23.20 ATOM 4598 CGHIS 641 43.812 26.856 11.000 1.00 24.45 ATOM 4599 CD2 HIS 641 44.11225.623 10.530 1.00 25.66 ATOM 4600 ND1 HIS 641 44.894 27.252 11.756 1.0028.28 ATOM 4601 CE1 HIS 641 45.810 26.301 11.742 1.00 26.29 ATOM 4602NE2 HIS 641 45.360 25.302 11.005 1.00 29.81 ATOM 4603 C HIS 641 41.10628.747 9.071 1.00 23.10 ATOM 4604 O HIS 641 40.145 27.988 9.217 1.0022.01 ATOM 4605 N GLY 642 40.986 30.012 8.678 1.00 22.53 ATOM 4606 CAGLY 642 39.683 30.582 8.381 1.00 22.30 ATOM 4607 C GLY 642 38.729 30.5909.561 1.00 23.68 ATOM 4608 O GLY 642 37.544 30.277 9.416 1.00 22.74 ATOM4609 N GLU 643 39.233 30.950 10.735 1.00 21.41 ATOM 4610 CA GLU 64338.386 30.981 11.919 1.00 21.09 ATOM 4611 CB GLU 643 39.235 31.10313.188 1.00 18.57 ATOM 4612 CG GLU 643 40.322 30.051 13.336 1.00 18.36ATOM 4613 CD GLU 643 39.780 28.639 13.541 1.00 16.54 ATOM 4614 OE1 GLU643 38.545 28.441 13.509 1.00 16.76 ATOM 4615 OE2 GLU 643 40.604 27.72413.733 1.00 18.63 ATOM 4616 C GLU 643 37.407 32.147 11.872 1.00 22.46ATOM 4617 O GLU 643 37.727 33.230 11.371 1.00 23.79 ATOM 4618 N LYS 64436.207 31.910 12.386 1.00 21.56 ATOM 4619 CA LYS 644 35.180 32.93812.472 1.00 22.52 ATOM 4620 CB LYS 644 33.816 32.367 12.090 1.00 25.95ATOM 4621 CG LYS 644 32.662 33.335 12.296 1.00 32.66 ATOM 4622 CD LYS644 31.336 32.666 11.974 1.00 37.37 ATOM 4623 CE LYS 644 30.164 33.60312.192 1.00 38.64 ATOM 4624 NZ LYS 644 28.883 32.959 11.777 1.00 42.06ATOM 4625 C LYS 644 35.170 33.347 13.940 1.00 22.34 ATOM 4626 O LYS 64434.633 32.626 14.779 1.00 22.63 ATOM 4627 N LEU 645 35.777 34.490 14.2501.00 21.01 ATOM 4628 CA LEU 645 35.846 34.965 15.630 1.00 21.37 ATOM4629 CB LEU 645 36.662 36.251 15.721 1.00 19.95 ATOM 4630 CG LEU 64538.110 36.202 15.233 1.00 21.57 ATOM 4631 CD1 LEU 645 38.774 37.54215.513 1.00 22.47 ATOM 4632 CD2 LEU 645 38.859 35.084 15.927 1.00 19.75ATOM 4633 C LEU 645 34.470 35.217 16.215 1.00 21.96 ATOM 4634 O LEU 64533.546 35.613 15.508 1.00 20.21 ATOM 4635 N GLY 646 34.339 34.987 17.5171.00 21.25 ATOM 4636 CA GLY 646 33.065 35.214 18.167 1.00 20.02 ATOM4637 C GLY 646 32.117 34.037 18.080 1.00 21.85 ATOM 4638 O GLY 64632.516 32.919 17.748 1.00 19.09 ATOM 4639 N TRP 647 30.850 34.302 18.3691.00 22.45 ATOM 4640 CA TRP 647 29.828 33.268 18.356 1.00 28.97 ATOM4641 CB TRP 647 29.778 32.601 19.734 1.00 23.61 ATOM 4642 CG TRP 64729.902 33.584 20.866 1.00 21.96 ATOM 4643 CD2 TRP 647 31.119 34.06221.459 1.00 19.96 ATOM 4644 CE2 TRP 647 30.761 35.004 22.452 1.00 19.26ATOM 4645 CE3 TRP 647 32.480 33.787 21.247 1.00 18.03 ATOM 4646 CD1 TRP647 28.883 34.238 21.507 1.00 20.08 ATOM 4647 NE1 TRP 647 29.392 35.08922.460 1.00 19.39 ATOM 4648 CZ2 TRP 647 31.713 35.675 23.231 1.00 17.35ATOM 4649 CZ3 TRP 647 33.428 34.453 22.022 1.00 19.00 ATOM 4650 CH2 TRP647 33.037 35.389 23.005 1.00 18.89 ATOM 4651 C TRP 647 28.462 33.84317.983 1.00 34.48 ATOM 4652 O TRP 647 27.676 34.217 18.849 1.00 35.78ATOM 4653 N PRO 648 28.166 33.914 16.675 1.00 41.48 ATOM 4654 CD PRO 64828.952 33.316 15.580 1.00 42.76 ATOM 4655 CA PRO 648 26.895 34.44316.166 1.00 44.45 ATOM 4656 CB PRO 648 27.033 34.263 14.656 1.00 45.15ATOM 4657 CG PRO 648 27.883 33.024 14.556 1.00 44.87 ATOM 4658 C PRO 64825.679 33.707 16.726 1.00 46.65 ATOM 4659 O PRO 648 24.898 34.348 17.4581.00 48.64 ATOM 4660 OXT PRO 648 25.526 32.501 16.429 1.00 48.70 ATOM4661 OH2 WAT 705 33.725 46.851 44.246 1.00 15.53 ATOM 4662 OH2 WAT 70632.992 26.241 34.112 1.00 12.73 ATOM 4663 OH2 WAT 707 24.332 47.64541.904 1.00 11.04 ATOM 4664 OH2 WAT 708 41.493 22.764 37.711 1.00 14.46ATOM 4665 OH2 WAT 709 57.554 41.574 37.486 1.00 16.47 ATOM 4666 OH2 WAT710 39.385 24.084 39.045 1.00 16.57 ATOM 4667 OH2 WAT 711 51.141 36.65937.992 1.00 13.96 ATOM 4668 OH2 WAT 712 53.148 51.275 33.059 1.00 23.13ATOM 4669 OH2 WAT 713 52.416 34.580 36.566 1.00 18.04 ATOM 4670 OH2 WAT714 16.540 45.049 50.781 1.00 15.93 ATOM 4671 OH2 WAT 715 47.597 46.86731.105 1.00 15.09 ATOM 4672 OH2 WAT 716 33.726 54.353 42.506 1.00 17.24ATOM 4673 OH2 WAT 717 33.205 41.739 37.987 1.00 14.76 ATOM 4674 OH2 WAT718 37.109 27.771 45.829 1.00 18.94 ATOM 4675 OH2 WAT 719 17.460 40.83743.030 1.00 16.41 ATOM 4676 OH2 WAT 720 40.996 49.596 48.874 1.00 12.40ATOM 4677 OH2 WAT 721 37.232 33.021 29.678 1.00 13.93 ATOM 4678 OH2 WAT722 48.355 52.277 48.594 1.00 16.39 ATOM 4679 OH2 WAT 723 44.253 25.37317.456 1.00 17.05 ATOM 4680 OH2 WAT 724 37.616 28.428 16.196 1.00 14.22ATOM 4681 OH2 WAT 725 31.807 45.250 42.894 1.00 12.95 ATOM 4682 OH2 WAT726 48.929 40.765 46.120 1.00 16.42 ATOM 4683 OH2 WAT 727 43.001 28.52514.577 1.00 19.16 ATOM 4684 OH2 WAT 728 36.297 33.649 19.024 1.00 16.26ATOM 4685 OH2 WAT 729 45.223 39.419 41.235 1.00 17.97 ATOM 4686 OH2 WAT730 19.069 49.921 43.313 1.00 22.26 ATOM 4687 OH2 WAT 731 18.652 48.39647.732 1.00 19.58 ATOM 4688 OH2 WAT 732 16.355 39.332 47.441 1.00 16.61ATOM 4689 OH2 WAT 734 27.725 37.511 46.838 1.00 11.65 ATOM 4690 OH2 WAT735 43.139 43.055 22.306 1.00 14.35 ATOM 4691 OH2 WAT 736 23.288 50.61841.612 1.00 18.93 ATOM 4692 OH2 WAT 737 40.575 28.769 39.893 1.00 24.17ATOM 4693 OH2 WAT 738 44.624 45.246 56.395 1.00 17.22 ATOM 4694 OH2 WAT739 42.886 25.680 33.406 1.00 14.64 ATOM 4695 OH2 WAT 740 36.434 24.09332.323 1.00 12.11 ATOM 4696 OH2 WAT 741 39.736 39.843 47.740 1.00 17.61ATOM 4697 OH2 WAT 742 47.972 45.541 61.312 1.00 27.55 ATOM 4698 OH2 WAT743 48.595 42.613 62.331 1.00 19.33 ATOM 4699 OH2 WAT 744 16.756 44.27647.836 1.00 17.52 ATOM 4700 OH2 WAT 745 50.833 52.475 32.781 1.00 22.48ATOM 4701 OH2 WAT 746 43.086 51.380 39.452 1.00 19.50 ATOM 4702 OH2 WAT747 43.065 37.312 51.242 1.00 19.15 ATOM 4703 OH2 WAT 748 36.377 29.55143.539 1.00 26.33 ATOM 4704 OH2 WAT 749 31.749 23.341 13.589 1.00 21.93ATOM 4705 OH2 WAT 750 51.017 32.405 13.102 1.00 23.70 ATOM 4706 OH2 WAT751 23.902 25.063 40.491 1.00 17.23 ATOM 4707 OH2 WAT 752 46.245 55.81748.913 1.00 17.11 ATOM 4708 OH2 WAT 753 17.325 38.625 44.796 1.00 17.92ATOM 4709 OH2 WAT 754 30.477 54.512 37.203 1.00 19.17 ATOM 4710 OH2 WAT755 30.153 29.098 39.015 1.00 13.90 ATOM 4711 OH2 WAT 756 40.602 56.39145.574 1.00 29.30 ATOM 4712 OH2 WAT 757 48.469 46.405 58.796 1.00 20.34ATOM 4713 OH2 WAT 758 23.341 22.303 39.374 1.00 19.80 ATOM 4714 OH2 WAT759 39.109 29.949 42.113 1.00 17.81 ATOM 4715 OH2 WAT 760 41.617 55.29234.623 1.00 19.28 ATOM 4716 OH2 WAT 761 50.433 32.980 35.395 1.00 27.78ATOM 4717 OH2 WAT 762 55.349 39.853 51.988 1.00 21.56 ATOM 4718 OH2 WAT763 17.829 47.302 45.052 1.00 19.63 ATOM 4719 OH2 WAT 764 41.437 43.59147.417 1.00 17.87 ATOM 4720 OH2 WAT 765 31.453 48.234 33.459 1.00 20.09ATOM 4721 OH2 WAT 766 35.895 29.226 13.339 1.00 19.08 ATOM 4722 OH2 WAT767 42.129 47.247 49.577 1.00 21.96 ATOM 4723 OH2 WAT 768 39.938 19.64628.365 1.00 16.90 ATOM 4724 OH2 WAT 770 53.052 28.858 13.534 1.00 29.07ATOM 4725 OH2 WAT 771 39.487 58.074 40.481 1.00 19.31 ATOM 4726 OH2 WAT772 34.677 20.856 49.093 1.00 29.57 ATOM 4727 OH2 WAT 773 17.419 31.21538.280 1.00 27.38 ATOM 4728 OH2 WAT 774 44.543 23.939 14.013 1.00 24.17ATOM 4729 OH2 WAT 775 31.307 56.780 49.243 1.00 27.95 ATOM 4730 OH2 WAT776 46.870 56.616 46.429 1.00 26.71 ATOM 4731 OH2 WAT 777 43.022 58.35937.108 1.00 24.23 ATOM 4732 OH2 WAT 778 40.838 33.568 7.092 1.00 29.87ATOM 4733 OH2 WAT 779 35.280 52.569 73.408 1.00 30.56 ATOM 4734 OH2 WAT780 14.847 39.443 36.394 1.00 22.09 ATOM 4735 OH2 WAT 781 39.543 32.05052.976 1.00 16.43 ATOM 4736 OH2 WAT 782 27.658 50.202 53.322 1.00 36.66ATOM 4737 OH2 WAT 783 49.665 26.157 11.610 1.00 31.59 ATOM 4738 OH2 WAT784 44.790 26.439 15.055 1.00 18.95 ATOM 4739 OH2 WAT 785 57.915 38.93252.077 1.00 23.38 ATOM 4740 OH2 WAT 786 34.219 51.188 61.855 1.00 27.39ATOM 4741 OH2 WAT 788 43.520 51.469 28.053 1.00 23.51 ATOM 4742 OH2 WAT789 20.741 25.871 29.764 1.00 25.31 ATOM 4743 OH2 WAT 790 31.996 32.52415.060 1.00 27.33 ATOM 4744 OH2 WAT 791 50.065 48.521 23.797 1.00 22.69ATOM 4745 OH2 WAT 793 40.065 53.867 45.877 1.00 28.99 ATOM 4746 OH2 WAT794 27.500 14.226 27.489 1.00 25.41 ATOM 4747 OH2 WAT 795 40.088 34.80711.689 1.00 31.73 ATOM 4748 OH2 WAT 796 39.102 11.125 33.545 1.00 21.19ATOM 4749 OH2 WAT 797 27.472 21.519 51.557 1.00 21.90 ATOM 4750 OH2 WAT798 66.482 40.320 37.672 1.00 26.30 ATOM 4751 OH2 WAT 799 22.957 49.91738.951 1.00 28.18 ATOM 4752 OH2 WAT 800 26.175 37.519 64.945 1.00 35.81ATOM 4753 OH2 WAT 801 34.181 10.599 28.257 1.00 20.76 ATOM 4754 OH2 WAT802 59.869 33.554 44.206 1.00 24.54 ATOM 4755 OH2 WAT 803 38.591 20.68631.734 1.00 19.19 ATOM 4756 OH2 WAT 804 40.781 21.352 12.247 1.00 34.63ATOM 4757 OH2 WAT 805 56.133 41.425 25.091 1.00 22.31 ATOM 4758 OH2 WAT806 37.118 27.351 50.493 1.00 21.88 ATOM 4759 OH2 WAT 807 42.654 46.73621.378 1.00 21.89 ATOM 4760 OH2 WAT 808 35.150 28.150 10.834 1.00 28.45ATOM 4761 OH2 WAT 809 29.291 19.889 23.346 1.00 24.18 ATOM 4762 OH2 WAT810 52.883 51.977 57.763 1.00 29.06 ATOM 4763 OH2 WAT 811 53.403 37.61861.414 1.00 27.12 ATOM 4764 OH2 WAT 812 11.989 35.114 47.917 1.00 33.35ATOM 4765 OH2 WAT 813 25.177 49.091 37.779 1.00 23.88 ATOM 4766 OH2 WAT814 43.929 19.517 20.685 1.00 25.16 ATOM 4767 OH2 WAT 815 36.157 15.29714.633 1.00 24.52 ATOM 4768 OH2 WAT 816 35.907 12.552 25.672 1.00 25.39ATOM 4769 OH2 WAT 817 39.592 55.524 36.450 1.00 25.79 ATOM 4770 OH2 WAT818 62.649 34.290 30.290 1.00 24.83 ATOM 4771 OH2 WAT 819 19.911 55.42450.600 1.00 37.80 ATOM 4772 OH2 WAT 820 50.799 29.874 12.353 1.00 25.54ATOM 4773 OH2 WAT 821 27.864 56.624 70.138 1.00 27.58 ATOM 4774 OH2 WAT823 27.817 17.957 50.119 1.00 32.04 ATOM 4775 OH2 WAT 824 56.121 37.45932.732 1.00 21.41 ATOM 4776 OH2 WAT 825 9.453 31.180 47.871 1.00 51.79ATOM 4777 OH2 WAT 826 41.647 54.559 62.566 1.00 39.79 ATOM 4778 OH2 WAT827 50.893 18.450 23.970 1.00 27.60 ATOM 4779 OH2 WAT 828 26.079 14.62012.464 1.00 24.55 ATOM 4780 OH2 WAT 829 69.963 44.562 41.439 1.00 32.79ATOM 4781 OH2 WAT 830 56.486 22.481 16.758 1.00 35.62 ATOM 4782 OH2 WAT831 26.101 20.243 49.585 1.00 24.90 ATOM 4783 OH2 WAT 832 16.729 33.27450.986 1.00 24.98 ATOM 4784 OH2 WAT 833 21.501 54.137 59.417 1.00 23.27ATOM 4785 OH2 WAT 834 47.542 53.259 64.127 1.00 45.51 ATOM 4786 OH2 WAT836 49.479 39.080 12.500 1.00 30.28 ATOM 4787 OH2 WAT 838 42.825 25.87937.780 1.00 23.21 ATOM 4788 OH2 WAT 839 50.943 24.947 57.867 1.00 32.14ATOM 4789 OH2 WAT 840 54.743 56.961 50.478 1.00 26.75 ATOM 4790 OH2 WAT841 40.544 53.741 32.431 1.00 34.46 ATOM 4791 OH2 WAT 842 26.547 47.64953.571 1.00 39.97 ATOM 4792 OH2 WAT 843 37.195 32.835 54.383 1.00 28.68ATOM 4793 OH2 WAT 844 58.053 39.110 31.973 1.00 18.62 ATOM 4794 OH2 WAT845 18.264 24.599 44.498 1.00 27.65 ATOM 4795 OH2 WAT 847 13.854 29.61037.456 1.00 44.84 ATOM 4796 OH2 WAT 849 22.552 38.833 31.917 1.00 48.29ATOM 4797 OH2 WAT 850 35.645 59.479 37.510 1.00 31.45 ATOM 4798 OH2 WAT851 24.548 59.962 64.794 1.00 38.37 ATOM 4799 OH2 WAT 852 30.633 55.27534.413 1.00 26.28 ATOM 4800 OH2 WAT 853 39.272 27.243 44.281 1.00 44.92ATOM 4801 OH2 WAT 854 32.053 46.154 71.549 1.00 34.74 ATOM 4802 OH2 WAT855 48.612 24.905 14.847 1.00 36.12 ATOM 4803 OH2 WAT 857 18.696 30.21440.372 1.00 32.39 ATOM 4804 OH2 WAT 858 67.928 43.317 39.467 1.00 25.41ATOM 4805 OH2 WAT 859 29.220 64.769 57.769 1.00 33.69 ATOM 4806 OH2 WAT860 50.268 24.002 37.829 1.00 31.48 ATOM 4807 OH2 WAT 861 50.197 23.76616.468 1.00 47.21 ATOM 4808 OH2 WAT 862 50.752 18.550 46.573 1.00 33.31ATOM 4809 OH2 WAT 863 54.737 36.999 16.598 1.00 28.84 ATOM 4810 OH2 WAT864 23.466 24.199 53.649 1.00 29.72 ATOM 4811 OH2 WAT 865 33.404 55.02125.847 1.00 52.41 ATOM 4812 OH2 WAT 866 42.687 31.048 44.149 1.00 40.21ATOM 4813 OH2 WAT 867 28.448 42.954 54.380 1.00 36.53 ATOM 4814 OH2 WAT868 14.997 43.707 34.454 1.00 43.03 ATOM 4815 OH2 WAT 869 14.328 39.15357.579 1.00 40.69 ATOM 4816 OH2 WAT 870 57.378 37.209 64.736 1.00 28.61ATOM 4817 OH2 WAT 871 20.536 32.124 29.526 1.00 31.13 ATOM 4818 OH2 WAT872 52.129 50.355 27.209 1.00 31.95 ATOM 4819 OH2 WAT 873 51.809 35.63162.337 1.00 31.87 ATOM 4820 OH2 WAT 874 47.029 21.316 50.899 1.00 28.63ATOM 4821 OH2 WAT 875 29.328 44.418 56.243 1.00 29.76 ATOM 4822 OH2 WAT876 40.553 19.067 31.054 1.00 31.19 ATOM 4823 OH2 WAT 877 56.608 42.97423.109 1.00 36.47 ATOM 4824 OH2 WAT 878 33.944 18.283 53.032 1.00 48.79ATOM 4825 OH2 WAT 879 27.295 18.819 26.051 1.00 23.88 ATOM 4826 OH2 WAT880 62.721 54.186 39.777 1.00 38.87 ATOM 4827 OH2 WAT 881 35.611 9.58850.038 1.00 41.90 ATOM 4828 OH2 WAT 882 38.082 58.167 33.104 1.00 35.67ATOM 4829 OH2 WAT 883 20.479 20.811 35.650 1.00 28.10 ATOM 4830 OH2 WAT884 64.071 48.661 47.710 1.00 36.23 ATOM 4831 OH2 WAT 885 62.169 33.11454.016 1.00 38.38 ATOM 4832 OH2 WAT 886 46.247 15.458 31.504 1.00 29.44ATOM 4833 OH2 WAT 887 15.161 50.744 53.893 1.00 46.81 ATOM 4834 OH2 WAT888 21.461 24.555 51.822 1.00 33.72 ATOM 4835 OH2 WAT 889 39.805 19.95314.067 1.00 34.19 ATOM 4836 OH2 WAT 890 44.630 68.730 56.107 1.00 44.36ATOM 4837 OH2 WAT 891 47.554 30.392 39.434 1.00 32.91 ATOM 4838 OH2 WAT892 32.135 20.873 14.262 1.00 29.57 ATOM 4839 OH2 WAT 893 69.474 42.04647.848 1.00 40.45 ATOM 4840 OH2 WAT 894 23.764 15.417 41.216 1.00 45.57ATOM 4841 OH2 WAT 895 30.804 11.274 25.353 1.00 36.15 ATOM 4842 OH2 WAT896 42.686 40.690 57.070 1.00 26.52 ATOM 4843 OH2 WAT 898 41.447 36.48613.521 1.00 40.39 ATOM 4844 OH2 WAT 899 38.960 38.628 60.048 1.00 40.06ATOM 4845 OH2 WAT 900 41.026 24.976 9.369 1.00 38.69 ATOM 4846 OH2 WAT902 55.833 48.047 27.058 1.00 38.88 ATOM 4847 OH2 WAT 903 33.909 34.36558.131 1.00 39.46 ATOM 4848 OH2 WAT 904 56.604 58.656 39.499 1.00 34.67ATOM 4849 OH2 WAT 905 57.413 45.071 24.624 1.00 33.81 ATOM 4850 OH2 WAT906 68.047 30.945 34.093 1.00 36.91 ATOM 4851 OH2 WAT 907 17.540 52.18246.933 1.00 26.43 ATOM 4852 OH2 WAT 908 35.513 31.206 66.336 1.00 25.73ATOM 4853 OH2 WAT 910 62.045 46.674 53.517 1.00 33.21 ATOM 4854 OH2 WAT911 46.903 38.348 67.243 1.00 32.49 ATOM 4855 OH2 WAT 912 60.188 33.75626.674 1.00 37.96 ATOM 4856 OH2 WAT 913 17.538 36.873 63.382 1.00 49.19ATOM 4857 OH2 WAT 914 23.983 36.615 25.955 1.00 28.20 ATOM 4858 OH2 WAT915 15.876 30.521 47.253 1.00 31.86 ATOM 4859 OH2 WAT 916 23.539 62.13563.215 1.00 37.75 ATOM 4860 OH2 WAT 917 50.546 48.552 64.034 1.00 38.09ATOM 4861 OH2 WAT 918 64.968 41.202 32.910 1.00 30.16 ATOM 4862 OH2 WAT919 47.342 55.129 71.525 1.00 41.35 ATOM 4863 OH2 WAT 920 15.582 44.03465.703 1.00 31.07 ATOM 4864 OH2 WAT 921 37.858 50.757 24.526 1.00 31.62ATOM 4865 OH2 WAT 922 37.372 23.617 9.556 1.00 39.44 ATOM 4866 OH2 WAT924 24.489 15.323 15.117 1.00 46.62 ATOM 4867 OH2 WAT 925 22.412 16.80337.659 1.00 43.70 ATOM 4868 OH2 WAT 926 29.507 54.047 43.644 1.00 35.52ATOM 4869 OH2 WAT 927 60.554 35.356 56.976 1.00 42.99 ATOM 4870 OH2 WAT929 20.021 33.589 59.004 1.00 30.36 ATOM 4871 OH2 WAT 930 19.473 19.17631.910 1.00 31.54 ATOM 4872 OH2 WAT 931 48.046 22.565 58.100 1.00 30.58ATOM 4873 OH2 WAT 932 43.806 63.606 53.022 1.00 40.90 ATOM 4874 OH2 WAT933 33.913 20.122 11.496 1.00 24.77 ATOM 4875 OH2 WAT 934 49.430 59.95552.495 1.00 37.32 ATOM 4876 OH2 WAT 935 63.827 32.863 45.133 1.00 49.52ATOM 4877 OH2 WAT 936 37.964 21.411 49.414 1.00 30.06 ATOM 4878 OH2 WAT937 27.725 14.522 39.223 1.00 39.88 ATOM 4879 OH2 WAT 938 15.164 38.82261.336 1.00 46.35 ATOM 4880 OH2 WAT 939 59.040 42.353 59.062 1.00 33.96ATOM 4881 OH2 WAT 940 47.109 42.149 69.895 1.00 45.88 ATOM 4882 OH2 WAT941 26.653 32.630 69.093 1.00 36.31 ATOM 4883 OH2 WAT 942 28.206 17.55922.902 1.00 32.76 ATOM 4884 OH2 WAT 943 26.970 50.327 70.960 1.00 48.12ATOM 4885 OH2 WAT 944 64.060 23.004 42.589 1.00 32.90 ATOM 4886 OH2 WAT945 47.727 33.598 7.895 1.00 35.65 ATOM 4887 OH2 WAT 946 34.742 23.79149.020 1.00 25.74 ATOM 4888 OH2 WAT 947 47.101 46.897 68.781 1.00 45.45ATOM 4889 OH2 WAT 948 41.870 11.724 30.722 1.00 27.02 ATOM 4890 OH2 WAT949 34.529 49.050 63.729 1.00 32.80 ATOM 4891 OH2 WAT 950 38.408 61.85351.628 1.00 49.43 ATOM 4892 OH2 WAT 951 44.952 50.165 71.454 1.00 36.16ATOM 4893 OH2 WAT 952 46.362 23.481 42.021 1.00 38.59 ATOM 4894 OH2 WAT953 22.997 57.578 62.984 1.00 48.56 ATOM 4895 OH2 WAT 954 53.705 20.32434.584 1.00 46.72 ATOM 4896 OH2 WAT 955 39.632 64.246 53.049 1.00 38.41ATOM 4897 OH2 WAT 956 20.296 21.770 47.578 1.00 38.44 ATOM 4898 OH2 WAT957 70.708 44.445 44.502 1.00 35.87 ATOM 4899 OH2 WAT 958 13.567 22.99235.251 1.00 36.22 ATOM 4900 OH2 WAT 959 61.462 37.840 59.404 1.00 32.38ATOM 4901 OH2 WAT 960 70.605 49.268 42.736 1.00 49.49 ATOM 4902 OH2 WAT961 27.001 13.873 45.582 1.00 34.49 ATOM 4903 OH2 WAT 962 40.837 53.26528.588 1.00 34.92 ATOM 4904 OH2 WAT 963 41.440 40.204 15.200 1.00 25.63ATOM 4905 OH2 WAT 964 47.029 18.253 59.807 1.00 47.20 ATOM 4906 OH2 WAT965 30.122 45.125 27.224 1.00 41.19 ATOM 4907 OH2 WAT 966 70.354 22.88432.301 1.00 45.44 ATOM 4908 OH2 WAT 967 54.548 57.173 32.638 1.00 33.64ATOM 4909 OH2 WAT 968 47.786 18.173 53.594 1.00 33.24 ATOM 4910 OH2 WAT969 38.400 16.790 14.876 1.00 37.75 ATOM 4911 OH2 WAT 970 28.970 12.15332.723 1.00 24.55 ATOM 4912 OH2 WAT 971 28.874 35.834 60.109 1.00 39.03ATOM 4913 OH2 WAT 972 47.546 23.630 12.714 1.00 51.51 ATOM 4914 OH2 WAT973 40.454 49.523 57.495 1.00 35.41 ATOM 4915 OH2 WAT 974 48.210 48.06165.137 1.00 47.07 ATOM 4916 OH2 WAT 975 37.958 26.212 47.790 1.00 44.98ATOM 4917 OH2 WAT 977 37.233 24.170 51.843 1.00 33.85 ATOM 4918 OH2 WAT978 33.749 56.149 48.597 1.00 30.36 ATOM 4919 OH2 WAT 979 48.361 43.39621.748 1.00 40.73 ATOM 4920 OH2 WAT 980 47.355 49.826 23.205 1.00 38.07ATOM 4921 OH2 WAT 982 37.732 7.064 33.535 1.00 48.68 ATOM 4922 OH2 WAT984 67.639 44.821 28.942 1.00 56.38 ATOM 4923 OH2 WAT 985 65.770 35.55535.108 1.00 50.64 ATOM 4924 OH2 WAT 986 30.693 20.715 65.019 1.00 32.06ATOM 4925 OH2 WAT 987 27.053 36.974 22.607 1.00 38.10 ATOM 4926 OH2 WAT988 19.163 25.611 48.320 1.00 25.80 ATOM 4927 OH2 WAT 989 48.005 58.79230.965 1.00 45.93 ATOM 4928 OH2 WAT 990 33.951 58.019 31.506 1.00 26.89ATOM 4929 OH2 WAT 991 60.149 48.327 52.415 1.00 42.30 ATOM 4930 OH2 WAT993 64.162 36.713 52.481 1.00 35.08 ATOM 4931 OH2 WAT 996 36.217 29.0757.223 1.00 43.08 ATOM 4932 OH2 WAT 997 49.801 51.068 30.170 1.00 33.40ATOM 4933 OH2 WAT 998 11.053 37.371 34.418 1.00 31.32 ATOM 4934 OH2 WAT999 44.601 23.087 39.455 1.00 47.23 ATOM 4935 OH2 WAT 1000 50.726 38.37768.058 1.00 47.19 ATOM 4936 OH2 WAT 1002 60.312 35.422 29.042 1.00 30.62ATOM 4937 OH2 WAT 1003 20.479 31.153 57.519 1.00 37.20 ATOM 4938 OH2 WAT1004 20.277 29.204 31.044 1.00 31.69 ATOM 4939 OH2 WAT 1005 20.94352.359 61.162 1.00 36.05 ATOM 4940 OH2 WAT 1006 44.819 20.699 43.3121.00 49.10 ATOM 4941 OH2 WAT 1008 34.011 36.177 53.463 1.00 33.13 ATOM4942 OH2 WAT 1010 55.158 53.328 33.223 1.00 28.59 ATOM 4943 OH2 WAT 101255.826 39.714 64.610 1.00 34.66 ATOM 4944 OH2 WAT 1014 66.327 38.14749.052 1.00 26.67 ATOM 4945 OH2 WAT 1017 30.997 50.156 52.375 1.00 35.44ATOM 4946 OH2 WAT 1020 13.998 44.255 63.276 1.00 37.79 ATOM 4947 OH2 WAT1021 54.863 22.503 53.859 1.00 37.14 ATOM 4948 OH2 WAT 1022 17.11928.668 38.825 1.00 36.01 ATOM 4949 OH2 WAT 1024 36.501 20.637 51.7051.00 45.60 ATOM 4950 OH2 WAT 1025 48.817 20.944 30.325 1.00 27.83 ATOM4951 OH2 WAT 1027 14.381 45.600 52.809 1.00 44.10 ATOM 4952 OH2 WAT 103235.525 5.074 31.109 1.00 41.37 ATOM 4953 OH2 WAT 1033 29.779 34.31953.582 1.00 28.70 ATOM 4954 OH2 WAT 1034 47.328 38.726 9.716 1.00 49.35ATOM 4955 OH2 WAT 1035 44.854 34.535 67.215 1.00 48.50 ATOM 4956 OH2 WAT1037 26.055 45.081 34.982 1.00 35.09 ATOM 4957 OH2 WAT 1040 11.14137.010 54.220 1.00 43.27 ATOM 4958 OH2 WAT 1041 29.634 41.348 52.3461.00 40.29 ATOM 4959 OH2 WAT 1042 36.989 26.821 9.501 1.00 47.61 ATOM4960 OH2 WAT 1043 57.297 28.427 29.996 1.00 42.70 ATOM 4961 OH2 WAT 104415.339 49.780 56.964 1.00 42.68 ATOM 4962 OH2 WAT 1045 46.946 51.78370.089 1.00 52.87 ATOM 4963 OH2 WAT 1047 43.735 26.720 48.439 1.00 32.56ATOM 4964 OH2 WAT 1049 59.084 48.736 30.360 1.00 45.92 ATOM 4965 OH2 WAT1051 47.217 61.277 55.003 1.00 50.60 ATOM 4966 OH2 WAT 1052 42.85426.577 64.396 1.00 40.89 ATOM 4967 OH2 WAT 1053 56.373 17.507 47.8141.00 44.29 ATOM 4968 OH2 WAT 1056 58.449 30.554 63.214 1.00 46.73 ATOM4969 OH2 WAT 1057 25.498 11.492 25.912 1.00 40.95 ATOM 4970 OH2 WAT 105844.975 29.368 39.403 1.00 43.65 ATOM 4971 OH2 WAT 1059 25.317 25.26557.780 1.00 47.77 ATOM 4972 OH2 WAT 1061 28.989 59.107 55.188 1.00 46.96ATOM 4973 OH2 WAT 1062 62.109 32.898 43.133 1.00 29.76 ATOM 4974 OH2 WAT1063 68.950 47.081 42.243 1.00 32.59 ATOM 4975 OH2 WAT 1066 53.06554.350 56.726 1.00 53.35 ATOM 4976 OH2 WAT 1068 44.519 16.873 20.8601.00 43.15 ATOM 4977 OH2 WAT 1070 45.839 26.154 61.550 1.00 36.80 ATOM4978 OH2 WAT 1072 36.197 36.508 12.204 1.00 33.71 ATOM 4979 OH2 WAT 107335.351 41.501 68.026 1.00 45.11 ATOM 4980 OH2 WAT 1074 65.633 34.80351.451 1.00 38.53 ATOM 4981 OH2 WAT 1078 41.335 38.420 54.710 0.50 29.72ATOM 4982 OH2 WAT 1079 29.512 38.685 22.833 1.00 39.63 ATOM 4983 OH2 WAT1080 14.118 37.523 50.894 1.00 39.63 ATOM 4984 OH2 WAT 1081 48.55654.366 25.635 1.00 42.49 ATOM 4985 OH2 WAT 1082 40.975 25.862 40.8061.00 24.48 ATOM 4986 OH2 WAT 1083 40.345 57.934 37.750 1.00 22.44 ATOM4987 OH2 WAT 1084 54.691 59.362 48.731 1.00 33.75 ATOM 4988 OH2 WAT 108553.736 57.789 52.852 1.00 40.58 ATOM 4989 OH2 WAT 1086 15.708 33.12254.732 1.00 44.11 ATOM 4990 OH2 WAT 1087 22.243 32.265 27.402 1.00 38.80ATOM 4991 OH2 WAT 1088 47.611 17.171 32.905 1.00 43.63 ATOM 4992 OH2 WAT1089 58.379 48.121 27.949 1.00 43.58 ATOM 4993 OH2 WAT 1092 57.48859.756 41.894 1.00 54.98 ATOM 4994 OH2 WAT 1093 37.216 31.175 68.4181.00 28.64 ATOM 4995 OH2 WAT 1094 37.762 33.656 69.811 1.00 40.47 ATOM4996 OH2 WAT 1095 65.445 43.712 34.681 1.00 47.01 ATOM 4997 OH2 WAT 109728.164 21.093 19.000 1.00 34.17 ATOM 4998 OH2 WAT 1098 18.673 33.16561.660 1.00 40.84 ATOM 4999 OH2 WAT 1100 51.193 61.127 51.030 1.00 39.94ATOM 5000 OH2 WAT 1101 56.432 43.982 59.555 1.00 39.42 ATOM 5001 OH2 WAT1102 56.968 41.831 63.701 1.00 42.73 ATOM 5002 OH2 WAT 1103 34.40549.957 71.786 1.00 35.15 ATOM 5003 OH2 WAT 1104 41.241 9.964 32.536 1.0031.00 ATOM 5004 OH2 WAT 1105 21.105 21.857 50.569 1.00 43.38 ATOM 5005OH2 WAT 1106 23.670 20.267 50.750 1.00 41.28 ATOM 5006 OH2 WAT 110829.571 9.657 34.297 1.00 39.24 ATOM 5007 OH2 WAT 1109 27.460 9.06736.007 1.00 35.51 ATOM 5008 OH2 WAT 1111 24.692 47.272 35.502 1.00 33.10ATOM 5009 OH2 WAT 1113 29.462 58.167 41.963 1.00 39.41 ATOM 5010 OH2 WAT1115 26.304 58.757 54.952 1.00 54.54 ATOM 5011 OH2 WAT 1116 22.93460.561 60.251 1.00 49.35 ATOM 5012 OH2 WAT 1117 39.244 37.381 55.8071.00 42.76 ATOM 5013 OH2 WAT 1119 37.428 43.614 61.340 1.00 41.53 ATOM5014 OH2 WAT 1121 17.907 30.515 55.600 1.00 52.02 ATOM 5015 OH2 WAT 112233.636 10.725 25.760 1.00 26.11 ATOM 5016 OH2 WAT 1123 37.687 60.19239.575 1.00 27.92 ATOM 5017 OH2 WAT 1124 40.750 44.964 49.691 1.00 25.17ATOM 5018 OH2 WAT 1125 70.584 38.077 47.755 1.00 37.02 ATOM 5019 OH2 WAT1126 15.603 41.927 47.692 1.00 28.52 ATOM 5020 OH2 WAT 1127 25.20643.505 32.164 1.00 33.23 ATOM 5021 OH2 WAT 1128 26.442 21.223 54.1771.00 26.91 ATOM 5022 OH2 WAT 1130 42.766 41.142 51.475 1.00 46.99 ATOM5023 OH2 WAT 1131 43.109 61.103 37.679 1.00 41.65 ATOM 5024 OH2 WAT 113214.570 30.169 45.086 1.00 42.30 ATOM 5025 OH2 WAT 1133 34.157 38.58324.573 1.00 28.21 ATOM 5026 OH2 WAT 1135 35.943 44.155 50.435 1.00 35.21ATOM 5027 OH2 WAT 1137 15.347 36.178 62.387 1.00 48.01 ATOM 5028 OH2 WAT1142 30.780 45.800 61.426 1.00 46.24 ATOM 5029 OH2 WAT 1144 56.00049.811 57.192 1.00 33.19 ATOM 5030 OH2 WAT 1145 50.931 47.015 21.7181.00 41.76 ATOM 5031 OH2 WAT 1148 41.181 13.664 41.675 1.00 36.85 ATOM5032 OH2 WAT 1149 26.829 13.900 42.000 1.00 51.60 ATOM 5033 OH2 WAT 115038.428 50.689 49.680 1.00 38.37 ATOM 5034 OH2 WAT 1151 13.307 43.10237.676 1.00 40.57 ATOM 5035 OH2 WAT 1153 32.376 39.513 22.416 1.00 42.97ATOM 5036 OH2 WAT 1155 14.863 50.906 47.090 1.00 49.79 ATOM 5037 OH2 WAT1156 39.040 11.571 36.195 1.00 42.49 ATOM 5038 OH2 WAT 1157 55.76018.990 54.253 1.00 46.82 ATOM 5039 OH2 WAT 1159 29.811 44.316 51.7751.00 29.84 ATOM 5040 OH2 WAT 1160 26.254 30.191 18.160 1.00 47.30 ATOM5041 OH2 WAT 1163 50.589 53.935 30.727 1.00 41.87 ATOM 5042 OH2 WAT 116426.778 17.598 17.107 1.00 39.40 ATOM 5043 OH2 WAT 1166 57.293 56.49151.361 1.00 36.42 ATOM 5044 OH2 WAT 1167 55.900 43.483 62.013 1.00 33.17ATOM 5045 OH2 WAT 1170 45.416 56.601 68.328 1.00 39.64 ATOM 5046 OH2 WAT1171 45.090 53.796 27.563 1.00 44.12 ATOM 5047 OH2 WAT 1172 25.95027.760 17.747 1.00 47.76 ATOM 5048 OH2 WAT 1174 21.716 34.736 25.9151.00 39.70 ATOM 5049 OH2 WAT 1177 28.580 48.024 33.877 1.00 34.88 ATOM5050 OH2 WAT 1178 45.395 19.823 49.333 1.00 48.96 ATOM 5051 OH2 WAT 118066.122 32.218 43.068 1.00 46.26 ATOM 5052 OH2 WAT 1181 61.892 29.58616.389 1.00 40.21 ATOM 5053 OH2 WAT 1183 15.358 27.450 47.492 1.00 49.59ATOM 5054 OH2 WAT 1184 13.556 47.284 49.126 1.00 53.43 ATOM 5055 OH2 WAT1185 47.096 19.628 33.301 1.00 39.63 ATOM 5056 OH2 WAT 1186 15.74033.792 31.449 1.00 55.70 ATOM 5057 OH2 WAT 1189 28.976 26.719 60.4401.00 42.03 ATOM 5058 OH2 WAT 1190 18.223 23.257 49.730 1.00 49.11 ATOM5059 OH2 WAT 1191 51.509 56.989 54.192 1.00 38.61 ATOM 5060 OH2 WAT 119343.560 45.405 17.563 1.00 36.62 ATOM 5061 OH2 WAT 1204 30.518 43.63425.079 1.00 47.04 ATOM 5062 OH2 WAT 1208 21.476 24.864 27.340 1.00 34.36ATOM 5063 OH2 WAT 1209 17.760 41.993 33.261 1.00 55.66 ATOM 5064 OH2 WAT1212 46.798 63.405 52.749 1.00 51.44 ATOM 5065 OH2 WAT 1219 34.61751.206 58.460 1.00 49.36 ATOM 5066 OH2 WAT 1220 24.104 41.582 29.5521.00 45.40 ATOM 5067 OH2 WAT 1223 23.863 21.524 53.424 1.00 45.78 ATOM5068 OH2 WAT 1224 50.956 18.524 42.578 1.00 40.01 ATOM 5069 OH2 WAT 122649.969 19.920 49.613 1.00 44.84 ATOM 5070 OH2 WAT 1229 49.709 30.62833.104 1.00 41.21 ATOM 5071 OH2 WAT 1230 31.240 38.559 20.375 1.00 47.94ATOM 5072 OH2 WAT 1232 23.399 22.619 27.338 1.00 34.56 ATOM 5073 OH2 WAT1233 48.110 31.839 37.064 1.00 42.29 ATOM 5074 OH2 WAT 1236 47.24845.427 20.268 1.00 40.26 ATOM 5075 OH2 WAT 1237 19.590 16.455 39.6341.00 45.25 ATOM 5076 OH2 WAT 1239 40.962 60.463 74.404 1.00 45.01 ATOM5077 OH2 WAT 1243 46.981 33.979 68.748 1.00 49.24 ATOM 5078 OH2 WAT 124461.241 43.880 58.980 1.00 42.97 ATOM 5079 OH2 WAT 1250 35.115 51.05523.889 1.00 51.05 ATOM 5080 OH2 WAT 1255 12.571 50.793 52.116 0.50 33.17ATOM 5081 OH2 WAT 1266 25.841 9.552 44.564 1.00 55.17 ATOM 5082 OH2 WAT1268 61.336 50.541 51.337 1.00 45.61 ATOM 5083 OH2 WAT 1273 23.93929.659 26.509 1.00 42.88 ATOM 5084 OH2 WAT 1275 59.410 55.437 44.5991.00 42.16 ATOM 5085 OH2 WAT 1278 64.290 43.553 53.436 1.00 38.01 ATOM5086 OH2 WAT 1279 36.463 61.861 41.741 1.00 31.97 ATOM 5087 OH2 WAT 128237.884 28.719 70.368 1.00 50.75 ATOM 5088 OH2 WAT 1286 21.758 53.62263.516 1.00 46.95 ATOM 5089 OH2 WAT 1288 49.866 23.754 32.094 1.00 47.08ATOM 5090 OH2 WAT 1289 46.816 19.829 38.612 1.00 41.12 ATOM 5091 OH2 WAT1294 41.690 12.743 36.520 1.00 45.23 ATOM 5092 OH2 WAT 1302 47.38223.700 60.586 1.00 42.72 ATOM 5093 OH2 WAT 1303 65.406 53.318 38.1291.00 42.46 ATOM 5094 OH2 WAT 1304 16.963 19.384 30.420 1.00 49.48 ATOM5095 OH2 WAT 1308 63.085 28.921 19.779 1.00 53.97 ATOM 5096 OH2 WAT 130923.293 21.221 25.162 1.00 40.04 ATOM 5097 OH2 WAT 1312 47.167 34.52737.872 1.00 27.27 ATOM 5098 OH2 WAT 1314 10.864 37.430 37.980 1.00 28.15ATOM 5099 OH2 WAT 1315 44.856 27.880 46.189 1.00 30.95 ATOM 5100 OH2 WAT1317 58.272 25.539 24.981 1.00 32.58 ATOM 5101 OH2 WAT 1318 18.82050.334 62.005 1.00 36.58 ATOM 5102 OH2 WAT 1319 30.841 37.131 59.1111.00 46.56 ATOM 5103 OH2 WAT 1320 29.617 62.035 68.933 1.00 44.43 ATOM5104 OH2 WAT 1321 46.544 35.226 40.439 1.00 40.06 ATOM 5105 OH2 WAT 132228.073 10.853 25.663 1.00 40.56 ATOM 5106 OH2 WAT 1323 42.441 29.12246.515 1.00 39.18 ATOM 5107 OH2 WAT 1324 32.503 25.207 20.281 1.00 30.43ATOM 5108 OH2 WAT 1325 45.433 45.115 68.057 1.00 34.28 ATOM 5109 OH2 WAT1326 60.152 17.493 35.180 1.00 31.13 ATOM 5110 OH2 WAT 1327 18.39827.449 35.882 1.00 37.64 ATOM 5111 OH2 WAT 1328 25.504 31.112 20.4381.00 38.34 ATOM 5112 OH2 WAT 1329 30.779 47.918 51.067 1.00 35.49 ATOM5113 OH2 WAT 1330 19.913 28.817 33.764 1.00 31.28 ATOM 5114 OH2 WAT 133141.767 10.738 28.096 1.00 41.34 ATOM 5115 OH2 WAT 1332 26.547 23.24056.068 1.00 41.06 ATOM 5116 OH2 WAT 1333 33.925 58.939 47.024 1.00 34.77ATOM 5117 OH2 WAT 1334 22.602 51.105 36.733 1.00 43.04 ATOM 5118 OH2 WAT1335 22.996 38.949 26.371 1.00 38.28 ATOM 5119 OH2 WAT 1336 29.16220.497 16.594 1.00 43.76 ATOM 5120 OH2 WAT 1337 20.274 17.838 34.2141.00 44.34 ATOM 5121 OH2 WAT 1338 39.624 36.468 69.824 1.00 40.01 ATOM5122 OH2 WAT 1339 37.483 51.842 59.120 1.00 44.97 ATOM 5123 OH2 WAT 134024.717 29.196 23.868 1.00 34.46 ATOM 5124 OH2 WAT 1341 44.042 21.49647.701 1.00 33.63 ATOM 5125 OH2 WAT 1342 13.466 35.511 57.867 1.00 42.68ATOM 5126 OH2 WAT 1343 55.772 29.777 32.992 1.00 44.58 ATOM 5127 OH2 WAT1344 14.280 32.060 49.325 1.00 38.28 ATOM 5128 OH2 WAT 1345 45.44350.731 25.094 1.00 46.95 ATOM 5129 OH2 WAT 1346 68.409 39.510 47.8371.00 41.69 ATOM 5130 OH2 WAT 1347 39.778 58.278 43.142 1.00 32.41 ATOM5131 OH2 WAT 1348 29.470 22.597 20.692 1.00 48.08 ATOM 5132 OH2 WAT 134924.093 35.444 64.264 1.00 35.01 ATOM 5133 OH2 WAT 1351 26.090 30.61228.125 1.00 36.91 ATOM 5134 OH2 WAT 1352 17.332 33.459 57.443 1.00 41.72ATOM 5135 OH2 WAT 1353 56.042 23.489 25.469 1.00 43.75 ATOM 5136 OH2 WAT1354 42.787 43.334 56.083 1.00 40.09 ATOM 5137 OH2 WAT 1355 50.83026.069 35.611 1.00 40.02 ATOM 5138 OH2 WAT 1356 38.381 12.374 24.7311.00 44.11 ATOM 5139 OH2 WAT 1357 44.282 44.869 20.284 1.00 42.34 ATOM5140 OH2 WAT 1359 34.183 42.608 20.745 1.00 46.91 ATOM 5141 OH2 WAT 136031.973 57.138 43.492 1.00 43.69 ATOM 5142 OH2 WAT 1361 47.127 28.96763.758 1.00 39.75 ATOM 5143 OH2 WAT 1362 16.760 48.273 38.728 1.00 43.33ATOM 5144 OH2 WAT 1363 31.959 52.844 61.725 1.00 48.88 ATOM 5145 OH2 WAT1364 48.548 41.547 13.592 1.00 46.21 ATOM 5146 OH2 WAT 1365 28.67625.375 20.616 1.00 37.11 ATOM 5147 OH2 WAT 1366 29.885 56.396 44.8581.00 36.90 ATOM 5148 OH2 WAT 1367 40.319 47.450 20.023 1.00 43.96 ATOM5149 OH2 WAT 1368 38.503 60.152 44.332 1.00 32.68 ATOM 5150 OH2 WAT 136944.801 17.250 50.502 1.00 43.13 ATOM 5151 OH2 WAT 1370 37.328 23.95749.049 1.00 45.36 ATOM 5152 OH2 WAT 1371 24.009 57.807 55.904 1.00 42.44ATOM 5153 OH2 WAT 1372 28.513 45.956 53.486 1.00 46.34 ATOM 5154 OH2 WAT1373 49.030 36.730 6.520 1.00 45.48 ATOM 5155 OH2 WAT 1374 38.498 35.62850.765 1.00 26.69 ATOM 5156 OH2 WAT 1375 39.668 33.298 50.610 1.00 33.61ATOM 5157 OH2 WAT 1376 52.375 26.835 60.266 1.00 44.32 ATOM 5158 OH2 WAT1377 55.500 25.818 58.095 1.00 44.59 ATOM 5159 OH2 WAT 1378 30.11636.834 19.045 1.00 39.93 ATOM 5160 OH2 WAT 1381 43.493 27.126 35.5651.00 48.96 ATOM 5161 OH2 WAT 1382 33.586 58.999 44.339 1.00 41.52 ATOM5162 OH2 WAT 1383 35.232 41.723 71.023 1.00 46.74 ATOM 5163 OH2 WAT 138471.095 37.535 44.165 1.00 41.47 ATOM 5164 OH2 WAT 1386 48.253 57.47371.974 1.00 43.72 ATOM 5165 C1 NAG 691 38.666 22.463 66.650 0.50 29.58ATOM 5166 C2 NAG 691 39.962 22.246 67.525 0.50 29.55 ATOM 5167 C3 NAG691 39.524 21.408 68.772 0.50 29.52 ATOM 5168 C4 NAG 691 38.496 22.25969.550 0.50 29.70 ATOM 5169 C5 NAG 691 37.241 22.504 68.605 0.50 30.07ATOM 5170 C6 NAG 691 36.157 23.293 69.219 0.50 28.97 ATOM 5171 C7 NAG691 42.209 21.838 66.543 0.50 29.68 ATOM 5172 C8 NAG 691 43.027 20.91165.781 0.50 29.38 ATOM 5173 N2 NAG 691 40.925 21.438 66.776 0.50 28.28ATOM 5174 O3 NAG 691 40.679 21.179 69.596 0.50 29.08 ATOM 5175 O4 NAG691 38.067 21.525 70.710 0.50 31.81 ATOM 5176 O5 NAG 691 37.742 23.24567.408 0.50 28.44 ATOM 5177 O6 NAG 691 34.965 23.182 68.486 0.50 29.28ATOM 5178 O7 NAG 691 42.632 22.844 66.920 0.50 30.40 ATOM 5179 C1 NAG692 26.823 46.501 73.110 0.25 30.78 ATOM 5180 C2 NAG 692 26.060 47.36774.194 0.25 29.79 ATOM 5181 C3 NAG 692 26.339 46.684 75.578 0.25 28.68ATOM 5182 C4 NAG 692 25.778 45.248 75.517 0.25 28.12 ATOM 5183 C5 NAG692 26.546 44.463 74.365 0.25 28.47 ATOM 5184 C6 NAG 692 26.141 43.05474.189 0.25 27.89 ATOM 5185 C7 NAG 692 27.924 49.127 74.485 0.25 29.38ATOM 5186 C8 NAG 692 28.176 50.560 74.479 0.25 29.34 ATOM 5187 N2 NAG692 26.610 48.755 74.247 0.25 29.38 ATOM 5188 O3 NAG 692 25.663 47.43776.598 0.25 28.79 ATOM 5189 O4 NAG 692 26.031 44.601 76.779 0.25 26.69ATOM 5190 O5 NAG 692 26.263 45.191 73.097 0.25 29.85 ATOM 5191 O6 NAG692 26.884 42.425 73.176 0.25 25.82 ATOM 5192 O7 NAG 692 28.778 48.37674.677 0.25 28.91 ATOM 5193 C1 NAG 693 45.844 65.857 60.275 0.50 34.64ATOM 5194 C2 NAG 693 47.343 66.335 60.338 0.50 33.61 ATOM 5195 C3 NAG693 48.225 65.046 60.320 0.50 33.54 ATOM 5196 C4 NAG 693 47.874 64.22861.582 0.50 33.12 ATOM 5197 C5 NAG 693 46.335 63.825 61.490 0.50 32.64ATOM 5198 C6 NAG 693 45.829 63.006 62.614 0.50 32.29 ATOM 5199 C7 NAG693 47.847 68.449 59.114 0.50 33.80 ATOM 5200 C8 NAG 693 48.147 69.02657.814 0.50 33.51 ATOM 5201 N2 NAG 693 47.658 67.096 59.127 0.50 33.78ATOM 5202 O3 NAG 693 49.604 65.442 60.373 0.50 34.37 ATOM 5203 O4 NAG693 48.672 63.030 61.597 0.50 32.73 ATOM 5204 O5 NAG 693 45.563 65.10561.455 0.50 32.95 ATOM 5205 O6 NAG 693 46.059 63.613 63.861 0.50 33.79ATOM 5206 O7 NAG 693 47.775 69.104 60.061 0.50 34.69 ATOM 5207 C1 NAG694 34.333 4.445 43.451 0.50 42.09 ATOM 5208 C2 NAG 694 35.344 3.23743.321 0.50 40.59 ATOM 5209 C3 NAG 694 36.776 3.873 43.266 0.50 40.44ATOM 5210 C4 NAG 694 36.837 4.763 42.008 0.50 39.57 ATOM 5211 C5 NAG 69435.747 5.912 42.160 0.50 40.19 ATOM 5212 C6 NAG 694 35.697 6.867 41.0380.50 39.67 ATOM 5213 C7 NAG 694 35.390 1.041 44.522 0.50 38.40 ATOM 5214C8 NAG 694 35.318 0.390 45.820 0.50 37.85 ATOM 5215 N2 NAG 694 35.2892.407 44.534 0.50 39.83 ATOM 5216 O3 NAG 694 37.745 2.817 43.151 0.5041.14 ATOM 5217 O4 NAG 694 38.143 5.361 41.930 0.50 39.45 ATOM 5218 O5NAG 694 34.422 5.231 42.261 0.50 40.94 ATOM 5219 O6 NAG 694 36.230 8.11841.399 0.50 40.94 ATOM 5220 O7 NAG 694 35.527 0.432 43.553 0.50 39.01ATOM 5221 C1 NAG 695 56.458 28.072 65.509 0.25 31.56 ATOM 5222 C2 NAG695 56.666 26.508 65.432 0.25 30.72 ATOM 5223 C3 NAG 695 56.499 25.96966.893 0.25 29.54 ATOM 5224 C4 NAG 695 57.609 26.616 67.754 0.25 29.02ATOM 5225 C5 NAG 695 57.392 28.194 67.738 0.25 28.93 ATOM 5226 C6 NAG695 58.361 28.972 68.535 0.25 29.26 ATOM 5227 C7 NAG 695 55.782 25.46563.341 0.25 29.26 ATOM 5228 C8 NAG 695 54.608 24.896 62.697 0.25 29.00ATOM 5229 N2 NAG 695 55.599 25.907 64.623 0.25 29.43 ATOM 5230 O3 NAG695 56.674 24.544 66.875 0.25 30.87 ATOM 5231 O4 NAG 695 57.485 26.13769.107 0.25 27.69 ATOM 5232 O5 NAG 695 57.504 28.627 66.310 0.25 30.15ATOM 5233 O6 NAG 695 57.844 30.233 68.885 0.25 30.07 ATOM 5234 O7 NAG695 56.794 25.529 62.791 0.25 29.27 ATOM 5235 C1 NAG 696 43.763 59.78331.843 0.50 32.65 ATOM 5236 C2 NAG 696 43.513 59.801 30.283 0.50 33.89ATOM 5237 C3 NAG 696 42.464 60.933 30.025 0.50 34.52 ATOM 5238 C4 NAG696 41.169 60.556 30.774 0.50 34.29 ATOM 5239 C5 NAG 696 41.517 60.47632.322 0.50 33.83 ATOM 5240 C6 NAG 696 40.400 60.153 33.216 0.50 33.87ATOM 5241 C7 NAG 696 45.496 59.327 28.856 0.50 33.72 ATOM 5242 C8 NAG696 46.660 59.906 28.211 0.50 33.27 ATOM 5243 N2 NAG 696 44.730 60.19829.572 0.50 33.67 ATOM 5244 O3 NAG 696 42.197 61.001 28.614 0.50 36.84ATOM 5245 O4 NAG 696 40.196 61.589 30.553 0.50 36.06 ATOM 5246 O5 NAG696 42.537 59.408 32.458 0.50 34.67 ATOM 5247 O6 NAG 696 40.731 60.43434.555 0.50 33.99 ATOM 5248 O7 NAG 696 45.250 58.204 28.755 0.50 33.63ATOM 5249 C ACY 700 42.190 36.698 47.868 1.00 17.87 ATOM 5250 O ACY 70043.358 36.429 48.383 1.00 17.41 ATOM 5251 OXT ACY 700 41.942 37.48446.891 1.00 16.00 ATOM 5252 CH3 ACY 700 41.037 35.966 48.550 1.00 16.17ATOM 5253 O1 MSA 702 40.494 34.478 45.311 1.00 21.85 ATOM 5254 O2 MSA702 42.778 34.136 45.475 1.00 27.34 ATOM 5255 C1 MSA 702 41.675 34.38944.805 1.00 25.81 ATOM 5256 N1 MSA 702 41.988 34.537 43.491 1.00 23.47ATOM 5257 C2 MSA 702 40.825 34.645 42.578 1.00 24.59 ATOM 5258 C3 MSA702 41.603 34.810 41.280 1.00 26.22 ATOM 5259 C4 MSA 702 39.846 33.46742.340 1.00 22.86 ATOM 5260 O3 MSA 702 38.793 33.259 41.647 1.00 21.49ATOM 5261 O4 MSA 702 40.179 32.410 43.024 1.00 21.93 ATOM 5262 ZN + 2ZN2 701 43.817 38.308 46.652 1.00 16.34 ATOM 5263 CL CL 703 29.18528.250 36.073 1.00 16.51 ATOM 5264 CL CL 704 36.287 45.320 44.617 1.0016.56 END

TABLE B Co-ordinates of an underglycosylated tACEΔ36NJ ACE-lisinoprilcomplex REMARK coordinates from minimization refinement REMARKrefinement resolution: 47.14-2.0 A REMARK starting r = 0.1816 free_r =0.2186 REMARK final r = 0.1814 free_r = 0.2188 REMARK rmsd bonds =0.005621 rmsd angles = 1.23822 REMARK wa = 0.450786 REMARK target = mlfcycles = 1 steps = 10 REMARK sg = P2(1)2(1)2(1) a = 56.472 b = 84.899 c= 133.990 alpha = 90 beta = 90 gamma = 90 REMARK anomalous f′ f″library: CNS_XRAYLIB: anom_cu.lib REMARK reflection file = ../dm10_2A.cvREMARK ncs = none REMARK B-correction resolution: 6.0-2.0 REMARK initialB-factor correction applied to fobs: REMARK  B11 =  1.410 B22 =  0.301B33 =  −1.711 REMARK  B12 =  0.000 B13 =  0.000 B23 =    0.000 REMARKB-factor correction applied to coordinate array B: 0.605 REMARK bulksolvent: density level = 0.336734 e/A{circumflex over ( )}3, B-factor =42.5542 A{circumflex over ( )}2 REMARK reflections with |Fobs|/sigma_F <0.0 rejected REMARK reflections with |Fobs| > 10000 * rms(Fobs) rejectedREMARK anomalous diffraction data was input REMARK theoretical totalnumber of refl. in resol. range: 84079 (100.0%) REMARK number ofunobserved reflections (no entry or |F| = 0): 821 (5.7%) REMARK numberof reflections rejected:   0 ( 0.0% ) REMARK total number of reflectionsused: 79258 ( 94.3% ) REMARK number of reflections in working set: 76164( 90.6% ) REMARK number of reflections in test set:  3094 ( 3.7% )CRYST1 56.472 84.899 133.990 90.00 90.00 90.00 P 21 21 21 REMARKVERSION: 1.1 ATOM 1 CB ALA 71 34.080 71.619 65.828 1.00 37.03 ATOM 2 CALA 71 36.046 70.116 66.197 1.00 37.52 ATOM 3 O ALA 71 35.940 68.88966.147 1.00 37.50 ATOM 4 N ALA 71 35.606 72.021 67.727 1.00 37.87 ATOM 5CA ALA 71 34.977 70.970 66.876 1.00 37.06 ATOM 6 N GLU 72 37.077 70.77665.680 1.00 36.64 ATOM 7 CA GLU 72 38.178 70.092 65.008 1.00 37.31 ATOM8 CB GLU 72 39.088 71.119 64.323 1.00 37.75 ATOM 9 CG GLU 72 40.07170.565 63.292 1.00 41.00 ATOM 10 CD GLU 72 39.421 70.271 61.945 1.0042.37 ATOM 11 OE1 GLU 72 38.580 71.081 61.495 1.00 42.32 ATOM 12 OE2 GLU72 39.764 69.237 61.329 1.00 44.26 ATOM 13 C GLU 72 38.973 69.307 66.0511.00 37.09 ATOM 14 O GLU 72 39.518 68.241 65.758 1.00 36.65 ATOM 15 NALA 73 39.030 69.841 67.270 1.00 35.26 ATOM 16 CA ALA 73 39.751 69.19368.361 1.00 33.85 ATOM 17 CB ALA 73 39.874 70.140 69.549 1.00 34.20 ATOM18 C ALA 73 39.018 67.921 68.779 1.00 32.78 ATOM 19 O ALA 73 39.64066.900 69.076 1.00 32.36 ATOM 20 N GLU 74 37.692 67.996 68.807 1.0031.76 ATOM 21 CA GLU 74 36.867 66.849 69.169 1.00 32.74 ATOM 22 CB GLU74 35.393 67.257 69.234 1.00 34.51 ATOM 23 CG GLU 74 34.783 67.21670.619 1.00 39.69 ATOM 24 CD GLU 74 33.360 67.750 70.636 1.00 43.24 ATOM25 OE1 GLU 74 32.467 67.110 70.032 1.00 44.62 ATOM 26 OE2 GLU 74 33.13968.819 71.249 1.00 44.03 ATOM 27 C GLU 74 37.036 65.758 68.118 1.0031.08 ATOM 28 O GLU 74 36.987 64.568 68.422 1.00 30.67 ATOM 29 N ALA 7537.242 66.185 66.877 1.00 29.99 ATOM 30 CA ALA 75 37.399 65.267 65.7541.00 28.87 ATOM 31 CB ALA 75 37.351 66.043 64.442 1.00 27.23 ATOM 32 CALA 75 38.669 64.421 65.814 1.00 27.10 ATOM 33 O ALA 75 38.608 63.20165.663 1.00 26.57 ATOM 34 N SER 76 39.817 65.060 66.027 1.00 26.04 ATOM35 CA SER 76 41.078 64.326 66.089 1.00 25.45 ATOM 36 CB SER 76 42.26865.290 66.137 1.00 26.93 ATOM 37 OG SER 76 42.278 66.033 67.338 1.0032.77 ATOM 38 C SER 76 41.101 63.404 67.302 1.00 23.44 ATOM 39 O SER 7641.710 62.337 67.265 1.00 25.13 ATOM 40 N LYS 77 40.438 63.823 68.3731.00 22.27 ATOM 41 CA LYS 77 40.354 63.024 69.589 1.00 21.77 ATOM 42 CBLYS 77 39.744 63.856 70.717 1.00 25.02 ATOM 43 CG LYS 77 39.406 63.06971.974 1.00 28.89 ATOM 44 CD LYS 77 38.810 63.983 73.038 1.00 34.02 ATOM45 CE LYS 77 37.827 63.235 73.916 1.00 36.45 ATOM 46 NZ LYS 77 36.68362.717 73.107 1.00 39.31 ATOM 47 C LYS 77 39.484 61.798 69.315 1.0020.85 ATOM 48 O LYS 77 39.791 60.691 69.758 1.00 19.15 ATOM 49 N PHE 7838.395 62.005 68.582 1.00 20.00 ATOM 50 CA PHE 78 37.497 60.912 68.2321.00 20.44 ATOM 51 CB PHE 78 36.323 61.433 67.399 1.00 20.72 ATOM 52 CGPHE 78 35.490 60.344 66.779 1.00 22.38 ATOM 53 CD1 PHE 78 34.602 59.60567.550 1.00 21.45 ATOM 54 CD2 PHE 78 35.612 60.045 65.427 1.00 21.21ATOM 55 CE1 PHE 78 33.845 58.580 66.985 1.00 23.63 ATOM 56 CE2 PHE 7834.860 59.021 64.853 1.00 24.14 ATOM 57 CZ PHE 78 33.976 58.288 65.6321.00 21.01 ATOM 58 C PHE 78 38.274 59.878 67.421 1.00 19.50 ATOM 59 OPHE 78 38.222 58.680 67.702 1.00 19.55 ATOM 60 N VAL 79 39.004 60.35866.418 1.00 20.22 ATOM 61 CA VAL 79 39.790 59.484 65.556 1.00 21.86 ATOM62 CB VAL 79 40.528 60.312 64.473 1.00 23.18 ATOM 63 CG1 VAL 79 41.69559.532 63.902 1.00 27.20 ATOM 64 CG2 VAL 79 39.555 60.661 63.355 1.0023.07 ATOM 65 C VAL 79 40.782 58.648 66.365 1.00 22.62 ATOM 66 O VAL 7940.920 57.445 66.132 1.00 22.22 ATOM 67 N GLU 80 41.459 59.280 67.3201.00 22.66 ATOM 68 CA GLU 80 42.418 58.570 68.165 1.00 22.34 ATOM 69 CBGLU 80 43.117 59.544 69.122 1.00 25.90 ATOM 70 CG GLU 80 43.893 60.65268.424 1.00 31.05 ATOM 71 CD GLU 80 44.564 61.606 69.399 1.00 35.35 ATOM72 OE1 GLU 80 43.881 62.088 70.333 1.00 36.66 ATOM 73 OE2 GLU 80 45.77261.880 69.225 1.00 37.98 ATOM 74 C GLU 80 41.726 57.475 68.977 1.0020.25 ATOM 75 O GLU 80 42.209 56.345 69.046 1.00 18.55 ATOM 76 N GLU 8140.595 57.811 69.595 1.00 18.66 ATOM 77 CA GLU 81 39.863 56.836 70.3991.00 19.96 ATOM 78 CB GLU 81 38.702 57.512 71.134 1.00 21.24 ATOM 79 CGGLU 81 39.168 58.560 72.135 1.00 23.95 ATOM 80 CD GLU 81 38.027 59.25872.845 1.00 26.18 ATOM 81 OE1 GLU 81 36.854 58.937 72.564 1.00 27.70ATOM 82 OE2 GLU 81 38.311 60.133 73.691 1.00 28.83 ATOM 83 C GLU 8139.352 55.704 69.514 1.00 18.59 ATOM 84 O GLU 81 39.428 54.529 69.8811.00 16.88 ATOM 85 N TYR 82 38.839 56.060 68.341 1.00 17.35 ATOM 86 CATYR 82 38.345 55.059 67.410 1.00 17.12 ATOM 87 CB TYR 82 37.807 55.72666.143 1.00 15.74 ATOM 88 CG TYR 82 37.428 54.730 65.071 1.00 15.18 ATOM89 CD1 TYR 82 36.303 53.918 65.217 1.00 13.96 ATOM 90 CE1 TYR 82 35.95752.986 64.244 1.00 13.99 ATOM 91 CD2 TYR 82 38.204 54.583 63.924 1.0014.71 ATOM 92 CE2 TYR 82 37.871 53.652 62.942 1.00 16.19 ATOM 93 CZ TYR82 36.744 52.862 63.108 1.00 15.36 ATOM 94 OH TYR 82 36.388 51.96962.131 1.00 14.06 ATOM 95 C TYR 82 39.469 54.089 67.027 1.00 16.14 ATOM96 O TYR 82 39.279 52.876 67.018 1.00 15.38 ATOM 97 N ASP 83 40.64254.630 66.719 1.00 17.88 ATOM 98 CA ASP 83 41.770 53.798 66.315 1.0019.78 ATOM 99 CB ASP 83 42.938 54.670 65.855 1.00 21.25 ATOM 100 CG ASP83 44.049 53.855 65.214 1.00 27.73 ATOM 101 OD1 ASP 83 43.791 53.21464.168 1.00 30.70 ATOM 102 OD2 ASP 83 45.178 53.846 65.752 1.00 28.73ATOM 103 C ASP 83 42.267 52.835 67.394 1.00 20.18 ATOM 104 O ASP 8342.446 51.645 67.132 1.00 19.78 ATOM 105 N ARG 84 42.497 53.338 68.6041.00 19.30 ATOM 106 CA ARG 84 42.994 52.461 69.656 1.00 21.26 ATOM 107CB ARG 84 43.473 53.271 70.871 1.00 22.61 ATOM 108 CG ARG 84 42.50654.308 71.400 1.00 24.22 ATOM 109 CD ARG 84 43.054 54.955 72.673 1.0024.57 ATOM 110 NE ARG 84 44.153 55.891 72.435 1.00 24.09 ATOM 111 CZ ARG84 44.020 57.216 72.424 1.00 22.92 ATOM 112 NH1 ARG 84 42.833 57.77272.633 1.00 23.01 ATOM 113 NH2 ARG 84 45.078 57.990 72.228 1.00 22.71ATOM 114 C ARG 84 41.987 51.395 70.075 1.00 19.10 ATOM 115 O ARG 8442.372 50.264 70.352 1.00 17.70 ATOM 116 N THR 85 40.702 51.739 70.1011.00 18.78 ATOM 117 CA THR 85 39.685 50.762 70.482 1.00 18.36 ATOM 118CB THR 85 38.350 51.447 70.903 1.00 18.42 ATOM 119 OG1 THR 85 37.84652.253 69.829 1.00 18.84 ATOM 120 CG2 THR 85 38.565 52.321 72.135 1.0019.44 ATOM 121 C THR 85 39.406 49.762 69.353 1.00 18.86 ATOM 122 O THR85 39.099 48.597 69.610 1.00 18.81 ATOM 123 N SER 86 39.516 50.21468.107 1.00 19.00 ATOM 124 CA SER 86 39.269 49.338 66.962 1.00 19.38ATOM 125 CB SER 86 39.279 50.142 65.660 1.00 17.79 ATOM 126 OG SER 8638.175 51.031 65.605 1.00 18.69 ATOM 127 C SER 86 40.305 48.219 66.8851.00 20.96 ATOM 128 O SER 86 39.966 47.060 66.630 1.00 21.64 ATOM 129 NGLN 87 41.566 48.569 67.109 1.00 21.67 ATOM 130 CA GLN 87 42.647 47.59367.068 1.00 23.50 ATOM 131 CB GLN 87 43.958 48.246 67.494 1.00 25.78ATOM 132 CG GLN 87 44.498 49.257 66.514 1.00 30.26 ATOM 133 CD GLN 8745.770 49.899 67.014 1.00 33.27 ATOM 134 OE1 GLN 87 46.693 49.212 67.4531.00 35.56 ATOM 135 NE2 GLN 87 45.831 51.225 66.947 1.00 35.59 ATOM 136C GLN 87 42.370 46.401 67.978 1.00 23.44 ATOM 137 O GLN 87 42.576 45.25267.593 1.00 23.72 ATOM 138 N VAL 88 41.908 46.684 69.190 1.00 23.72 ATOM139 CA VAL 88 41.616 45.635 70.154 1.00 22.98 ATOM 140 CB VAL 88 41.31646.234 71.546 1.00 24.62 ATOM 141 CG1 VAL 88 41.060 45.114 72.549 1.0024.67 ATOM 142 CG2 VAL 88 42.486 47.102 72.004 1.00 23.17 ATOM 143 C VAL88 40.432 44.769 69.725 1.00 23.12 ATOM 144 O VAL 88 40.536 43.54369.672 1.00 21.83 ATOM 145 N VAL 89 39.306 45.406 69.417 1.00 21.91 ATOM146 CA VAL 89 38.114 44.673 69.010 1.00 22.14 ATOM 147 CB VAL 89 36.88945.623 68.873 1.00 22.30 ATOM 148 CG1 VAL 89 37.197 46.738 67.901 1.0025.90 ATOM 149 CG2 VAL 89 35.675 44.844 68.406 1.00 25.67 ATOM 150 C VAL89 38.317 43.904 67.700 1.00 21.76 ATOM 151 O VAL 89 37.875 42.76267.576 1.00 20.11 ATOM 152 N TRP 90 38.980 44.526 66.728 1.00 21.83 ATOM153 CA TRP 90 39.224 43.868 65.448 1.00 22.98 ATOM 154 CB TRP 90 39.75944.873 64.419 1.00 24.28 ATOM 155 CG TRP 90 38.739 45.905 63.988 1.0028.97 ATOM 156 CD2 TRP 90 38.805 46.752 62.832 1.00 30.58 ATOM 157 CE2TRP 90 37.665 47.586 62.859 1.00 31.50 ATOM 158 CE3 TRP 90 39.717 46.89061.777 1.00 31.93 ATOM 159 CD1 TRP 90 37.593 46.250 64.645 1.00 30.90ATOM 160 NE1 TRP 90 36.943 47.257 63.975 1.00 30.56 ATOM 161 CZ2 TRP 9037.411 48.546 61.871 1.00 32.79 ATOM 162 CZ3 TRP 90 39.464 47.847 60.7921.00 33.43 ATOM 163 CH2 TRP 90 38.319 48.662 60.850 1.00 32.95 ATOM 164C TRP 90 40.207 42.714 65.622 1.00 21.98 ATOM 165 O TRP 90 40.089 41.69264.957 1.00 22.45 ATOM 166 N ASN 91 41.175 42.870 66.518 1.00 22.59 ATOM167 CA ASN 91 42.137 41.799 66.744 1.00 23.45 ATOM 168 CB ASN 91 43.25342.245 67.690 1.00 22.82 ATOM 169 CG ASN 91 44.153 41.091 68.103 1.0025.02 ATOM 170 OD1 ASN 91 43.810 40.313 68.993 1.00 26.35 ATOM 171 ND2ASN 91 45.301 40.961 67.442 1.00 25.21 ATOM 172 C ASN 91 41.434 40.57767.321 1.00 24.29 ATOM 173 O ASN 91 41.721 39.443 66.929 1.00 24.22 ATOM174 N GLU 92 40.511 40.813 68.249 1.00 23.78 ATOM 175 CA GLU 92 39.76739.726 68.863 1.00 24.44 ATOM 176 CB GLU 92 38.940 40.242 70.046 1.0027.98 ATOM 177 CG GLU 92 39.655 40.108 71.386 1.00 32.87 ATOM 178 CD GLU92 38.998 40.903 72.502 1.00 33.99 ATOM 179 OE1 GLU 92 37.797 40.69172.771 1.00 36.12 ATOM 180 OE2 GLU 92 39.690 41.740 73.116 1.00 35.60ATOM 181 C GLU 92 38.859 39.041 67.857 1.00 24.09 ATOM 182 O GLU 9238.731 37.817 67.867 1.00 25.43 ATOM 183 N TYR 93 38.230 39.824 66.9871.00 22.66 ATOM 184 CA TYR 93 37.343 39.253 65.982 1.00 22.78 ATOM 185CB TYR 93 36.609 40.346 65.202 1.00 23.71 ATOM 186 CG TYR 93 35.73939.782 64.102 1.00 24.71 ATOM 187 CD1 TYR 93 34.533 39.149 64.398 1.0025.73 ATOM 188 CE1 TYR 93 33.759 38.563 63.398 1.00 27.34 ATOM 189 CD2TYR 93 36.152 39.820 62.771 1.00 27.78 ATOM 190 CE2 TYR 93 35.389 39.23561.761 1.00 28.66 ATOM 191 CZ TYR 93 34.194 38.608 62.083 1.00 28.76ATOM 192 OH TYR 93 33.441 38.020 61.093 1.00 30.77 ATOM 193 C TYR 9338.140 38.401 65.002 1.00 21.84 ATOM 194 O TYR 93 37.705 37.319 64.6081.00 20.79 ATOM 195 N ALA 94 39.304 38.902 64.605 1.00 21.93 ATOM 196 CAALA 94 40.160 38.185 63.669 1.00 23.19 ATOM 197 CB ALA 94 41.438 38.98463.415 1.00 21.92 ATOM 198 C ALA 94 40.501 36.803 64.223 1.00 22.67 ATOM199 O ALA 94 40.570 35.824 63.480 1.00 23.01 ATOM 200 N ALA 95 40.70136.733 65.536 1.00 24.22 ATOM 201 CA ALA 95 41.041 35.482 66.210 1.0024.36 ATOM 202 CB ALA 95 41.354 35.757 67.676 1.00 28.15 ATOM 203 C ALA95 39.922 34.455 66.105 1.00 24.75 ATOM 204 O ALA 95 40.147 33.31165.707 1.00 25.33 ATOM 205 N ALA 96 38.715 34.867 66.474 1.00 24.39 ATOM206 CA ALA 96 37.563 33.978 66.421 1.00 24.27 ATOM 207 CB ALA 96 36.35034.670 67.026 1.00 23.28 ATOM 208 C ALA 96 37.266 33.552 64.984 1.0023.78 ATOM 209 O ALA 96 36.898 32.403 64.724 1.00 23.70 ATOM 210 N ASN97 37.426 34.483 64.051 1.00 21.38 ATOM 211 CA ASN 97 37.162 34.20062.647 1.00 22.12 ATOM 212 CB ASN 97 37.224 35.506 61.845 1.00 20.92ATOM 213 CG ASN 97 36.706 35.353 60.433 1.00 22.34 ATOM 214 OD1 ASN 9735.908 34.459 60.140 1.00 20.62 ATOM 215 ND2 ASN 97 37.144 36.243 59.5481.00 20.25 ATOM 216 C ASN 97 38.192 33.189 62.142 1.00 21.72 ATOM 217 OASN 97 37.863 32.270 61.393 1.00 21.75 ATOM 218 N TRP 98 39.437 33.35362.576 1.00 21.37 ATOM 219 CA TRP 98 40.502 32.449 62.172 1.00 23.30ATOM 220 CB TRP 98 41.856 32.963 62.676 1.00 21.74 ATOM 221 CG TRP 9842.995 32.002 62.444 1.00 23.76 ATOM 222 CD2 TRP 98 43.871 31.960 61.3051.00 22.12 ATOM 223 CE2 TRP 98 44.772 30.891 61.510 1.00 23.47 ATOM 224CE3 TRP 98 43.979 32.720 60.131 1.00 21.74 ATOM 225 CD1 TRP 98 43.39030.985 63.266 1.00 23.18 ATOM 226 NE1 TRP 98 44.456 30.314 62.712 1.0024.63 ATOM 227 CZ2 TRP 98 45.772 30.562 60.584 1.00 21.94 ATOM 228 CZ3TRP 98 44.973 32.392 59.209 1.00 20.39 ATOM 229 CH2 TRP 98 45.856 31.32059.444 1.00 20.85 ATOM 230 C TRP 98 40.251 31.041 62.702 1.00 23.90 ATOM231 O TRP 98 40.306 30.061 61.953 1.00 21.48 ATOM 232 N ASN 99 39.96330.945 63.997 1.00 25.31 ATOM 233 CA ASN 99 39.716 29.648 64.619 1.0024.92 ATOM 234 CB ASN 99 39.393 29.820 66.103 1.00 24.71 ATOM 235 CG ASN99 40.545 30.430 66.874 1.00 25.68 ATOM 236 OD1 ASN 99 41.690 30.39766.423 1.00 26.00 ATOM 237 ND2 ASN 99 40.252 30.980 68.046 1.00 25.62ATOM 238 C ASN 99 38.594 28.901 63.922 1.00 24.14 ATOM 239 O ASN 9938.627 27.674 63.820 1.00 24.01 ATOM 240 N TYR 100 37.600 29.633 63.4331.00 23.70 ATOM 241 CA TYR 100 36.504 28.978 62.738 1.00 23.65 ATOM 242CB TYR 100 35.312 29.912 62.567 1.00 27.83 ATOM 243 CG TYR 100 34.17529.198 61.890 1.00 30.19 ATOM 244 CD1 TYR 100 33.577 28.097 62.496 1.0031.92 ATOM 245 CE1 TYR 100 32.587 27.378 61.856 1.00 35.09 ATOM 246 CD2TYR 100 33.746 29.567 60.617 1.00 32.59 ATOM 247 CE2 TYR 100 32.74628.848 59.961 1.00 33.60 ATOM 248 CZ TYR 100 32.173 27.755 60.591 1.0034.32 ATOM 249 OH TYR 100 31.182 27.031 59.973 1.00 36.77 ATOM 250 C TYR100 36.943 28.492 61.360 1.00 22.55 ATOM 251 O TYR 100 36.656 27.36260.971 1.00 20.86 ATOM 252 N ASN 101 37.628 29.360 60.622 1.00 21.15ATOM 253 CA ASN 101 38.114 29.029 59.286 1.00 20.76 ATOM 254 CB ASN 10138.798 30.251 58.655 1.00 19.09 ATOM 255 CG ASN 101 37.838 31.110 57.8531.00 18.55 ATOM 256 OD1 ASN 101 37.829 31.067 56.624 1.00 19.63 ATOM 257ND2 ASN 101 37.018 31.892 58.546 1.00 18.23 ATOM 258 C ASN 101 39.08927.852 59.295 1.00 20.96 ATOM 259 O ASN 101 39.149 27.084 58.332 1.0021.16 ATOM 260 N THR 102 39.851 27.714 60.378 1.00 19.64 ATOM 261 CA THR102 40.826 26.635 60.488 1.00 19.80 ATOM 262 CB THR 102 42.158 27.15261.056 1.00 18.90 ATOM 263 OG1 THR 102 41.937 27.725 62.347 1.00 19.19ATOM 264 CG2 THR 102 42.756 28.207 60.137 1.00 21.98 ATOM 265 C THR 10240.356 25.450 61.339 1.00 21.84 ATOM 266 O THR 102 41.139 24.549 61.6421.00 21.38 ATOM 267 N ASN 103 39.084 25.454 61.724 1.00 22.72 ATOM 268CA ASN 103 38.514 24.365 62.518 1.00 24.63 ATOM 269 CB ASN 103 39.14924.313 63.919 1.00 26.53 ATOM 270 CG ASN 103 38.705 23.085 64.720 1.0029.25 ATOM 271 OD1 ASN 103 38.126 22.147 64.171 1.00 29.00 ATOM 272 ND2ASN 103 38.989 23.088 66.020 1.00 31.72 ATOM 273 C ASN 103 37.012 24.56762.626 1.00 23.73 ATOM 274 O ASN 103 36.502 25.032 63.643 1.00 24.12ATOM 275 N ILE 104 36.313 24.224 61.551 1.00 25.67 ATOM 276 CA ILE 10434.867 24.367 61.489 1.00 27.61 ATOM 277 CB ILE 104 34.338 24.109 60.0591.00 28.22 ATOM 278 CG2 ILE 104 32.821 24.281 60.027 1.00 29.99 ATOM 279CG1 ILE 104 35.005 25.069 59.072 1.00 29.22 ATOM 280 CD1 ILE 104 34.56024.879 57.626 1.00 29.37 ATOM 281 C ILE 104 34.169 23.403 62.439 1.0028.58 ATOM 282 O ILE 104 34.079 22.207 62.168 1.00 28.13 ATOM 283 N THR105 33.683 23.936 63.555 1.00 30.58 ATOM 284 CA THR 105 32.968 23.14364.549 1.00 31.89 ATOM 285 CB THR 105 33.843 22.821 65.775 1.00 31.98ATOM 286 OG1 THR 105 34.107 24.026 66.506 1.00 33.11 ATOM 287 CG2 THR105 35.162 22.194 65.341 1.00 32.86 ATOM 288 C THR 105 31.783 23.97165.017 1.00 32.44 ATOM 289 O THR 105 31.752 25.188 64.827 1.00 32.52ATOM 290 N THR 106 30.803 23.319 65.623 1.00 33.00 ATOM 291 CA THR 10629.640 24.044 66.109 1.00 33.81 ATOM 292 CB THR 106 28.570 23.072 66.6621.00 34.97 ATOM 293 OG1 THR 106 27.463 23.818 67.184 1.00 37.98 ATOM 294CG2 THR 106 29.155 22.199 67.752 1.00 34.76 ATOM 295 C THR 106 30.09325.020 67.198 1.00 32.47 ATOM 296 O THR 106 29.512 26.094 67.361 1.0031.96 ATOM 297 N GLU 107 31.153 24.655 67.917 1.00 31.54 ATOM 298 CA GLU107 31.687 25.501 68.985 1.00 32.42 ATOM 299 CB GLU 107 32.731 24.74069.809 1.00 34.68 ATOM 300 CG GLU 107 32.272 23.390 70.349 1.00 40.20ATOM 301 CD GLU 107 32.542 22.243 69.385 1.00 42.52 ATOM 302 OE1 GLU 10731.917 22.202 68.304 1.00 44.41 ATOM 303 OE2 GLU 107 33.390 21.38369.710 1.00 44.47 ATOM 304 C GLU 107 32.327 26.783 68.445 1.00 31.96ATOM 305 O GLU 107 31.980 27.883 68.875 1.00 31.54 ATOM 306 N THR 10833.272 26.641 67.516 1.00 30.47 ATOM 307 CA THR 108 33.935 27.807 66.9391.00 29.64 ATOM 308 CB THR 108 35.056 27.402 65.946 1.00 29.18 ATOM 309OG1 THR 108 34.534 26.500 64.964 1.00 30.34 ATOM 310 CG2 THR 108 36.21026.741 66.683 1.00 26.97 ATOM 311 C THR 108 32.916 28.689 66.219 1.0029.12 ATOM 312 O THR 108 33.050 29.911 66.201 1.00 29.17 ATOM 313 N SER109 31.895 28.069 65.631 1.00 28.85 ATOM 314 CA SER 109 30.851 28.82264.937 1.00 29.69 ATOM 315 CB SER 109 29.809 27.885 64.321 1.00 29.41ATOM 316 OG SER 109 30.254 27.336 63.098 1.00 31.41 ATOM 317 C SER 10930.144 29.737 65.923 1.00 30.53 ATOM 318 O SER 109 29.992 30.936 65.6791.00 27.87 ATOM 319 N LYS 110 29.715 29.150 67.036 1.00 31.92 ATOM 320CA LYS 110 29.002 29.876 68.077 1.00 33.73 ATOM 321 CB LYS 110 28.65328.927 69.229 1.00 35.14 ATOM 322 CG LYS 110 27.472 29.384 70.080 1.0038.08 ATOM 323 CD LYS 110 27.054 28.310 71.080 1.00 39.49 ATOM 324 CELYS 110 25.706 28.637 71.707 1.00 40.76 ATOM 325 NZ LYS 110 25.25427.575 72.650 1.00 40.35 ATOM 326 C LYS 110 29.820 31.053 68.595 1.0032.96 ATOM 327 O LYS 110 29.301 32.157 68.747 1.00 33.66 ATOM 328 N ILE111 31.101 30.820 68.858 1.00 32.50 ATOM 329 CA ILE 111 31.972 31.87669.357 1.00 31.17 ATOM 330 CB ILE 111 33.354 31.318 69.722 1.00 30.98ATOM 331 CG2 ILE 111 34.278 32.448 70.166 1.00 29.81 ATOM 332 CG1 ILE111 33.205 30.271 70.828 1.00 31.92 ATOM 333 CD1 ILE 111 34.494 29.56071.183 1.00 31.87 ATOM 334 C ILE 111 32.138 33.002 68.334 1.00 30.85ATOM 335 O ILE 111 32.164 34.180 68.693 1.00 31.16 ATOM 336 N LEU 11232.247 32.635 67.061 1.00 29.75 ATOM 337 CA LEU 112 32.404 33.629 66.0071.00 28.55 ATOM 338 CB LEU 112 32.644 32.948 64.656 1.00 27.63 ATOM 339CG LEU 112 32.720 33.872 63.430 1.00 26.14 ATOM 340 CD1 LEU 112 33.78934.938 63.643 1.00 22.46 ATOM 341 CD2 LEU 112 33.021 33.046 62.187 1.0024.13 ATOM 342 C LEU 112 31.178 34.529 65.917 1.00 29.28 ATOM 343 O LEU112 31.303 35.754 65.907 1.00 29.00 ATOM 344 N LEU 113 29.997 33.92165.853 1.00 29.16 ATOM 345 CA LEU 113 28.754 34.680 65.761 1.00 29.91ATOM 346 CB LEU 113 27.552 33.730 65.669 1.00 29.27 ATOM 347 CG LEU 11327.451 32.874 64.397 1.00 29.32 ATOM 348 CD1 LEU 113 26.281 31.90564.514 1.00 30.07 ATOM 349 CD2 LEU 113 27.279 33.777 63.179 1.00 29.18ATOM 350 C LEU 113 28.590 35.624 66.950 1.00 31.04 ATOM 351 O LEU 11327.976 36.685 66.831 1.00 30.89 ATOM 352 N GLN 114 29.143 35.234 68.0951.00 32.01 ATOM 353 CA GLN 114 29.074 36.057 69.297 1.00 33.69 ATOM 354CB GLN 114 29.403 35.218 70.537 1.00 35.55 ATOM 355 CG GLN 114 28.38334.113 70.801 1.00 40.14 ATOM 356 CD GLN 114 28.764 33.207 71.960 1.0043.52 ATOM 357 OE1 GLN 114 28.850 33.644 73.110 1.00 44.43 ATOM 358 NE2GLN 114 28.996 31.932 71.658 1.00 44.83 ATOM 359 C GLN 114 30.060 37.20869.157 1.00 33.40 ATOM 360 O GLN 114 29.773 38.336 69.555 1.00 32.65ATOM 361 N LYS 115 31.224 36.918 68.587 1.00 33.87 ATOM 362 CA LYS 11532.235 37.944 68.369 1.00 33.82 ATOM 363 CB LYS 115 33.547 37.318 67.8891.00 36.05 ATOM 364 CG LYS 115 34.622 37.276 68.960 1.00 39.80 ATOM 365CD LYS 115 34.924 38.684 69.443 1.00 42.99 ATOM 366 CE LYS 115 35.90338.699 70.598 1.00 45.69 ATOM 367 NZ LYS 115 36.078 40.092 71.099 1.0048.43 ATOM 368 C LYS 115 31.718 38.937 67.335 1.00 32.81 ATOM 369 O LYS115 32.132 40.094 67.310 1.00 30.93 ATOM 370 N ASN 116 30.813 38.47266.480 1.00 32.71 ATOM 371 CA ASN 116 30.215 39.325 65.458 1.00 33.77ATOM 372 CB ASN 116 29.223 38.530 64.602 1.00 34.22 ATOM 373 CG ASN 11629.855 37.950 63.356 1.00 35.11 ATOM 374 OD1 ASN 116 30.356 38.68362.502 1.00 35.08 ATOM 375 ND2 ASN 116 29.827 36.627 63.239 1.00 37.76ATOM 376 C ASN 116 29.465 40.459 66.146 1.00 33.07 ATOM 377 O ASN 11629.675 41.632 65.847 1.00 32.40 ATOM 378 N MET 117 28.586 40.086 67.0701.00 33.09 ATOM 379 CA MET 117 27.783 41.044 67.812 1.00 32.98 ATOM 380CB MET 117 26.843 40.299 68.764 1.00 34.71 ATOM 381 CG MET 117 25.38240.289 68.317 1.00 39.02 ATOM 382 SD MET 117 25.127 39.995 66.544 1.0041.96 ATOM 383 CE MET 117 23.347 40.015 66.451 1.00 41.75 ATOM 384 C MET117 28.638 42.039 68.585 1.00 31.36 ATOM 385 O MET 117 28.287 43.21268.697 1.00 29.55 ATOM 386 N GLN 118 29.768 41.576 69.106 1.00 31.05ATOM 387 CA GLN 118 30.653 42.447 69.868 1.00 31.16 ATOM 388 CB GLN 11831.741 41.625 70.563 1.00 34.52 ATOM 389 CG GLN 118 31.195 40.567 71.5091.00 38.71 ATOM 390 CD GLN 118 32.270 39.974 72.402 1.00 41.62 ATOM 391OE1 GLN 118 33.294 39.485 71.922 1.00 43.74 ATOM 392 NE2 GLN 118 32.03940.013 73.711 1.00 42.41 ATOM 393 C GLN 118 31.298 43.519 68.999 1.0029.23 ATOM 394 O GLN 118 31.318 44.698 69.365 1.00 28.92 ATOM 395 N ILE119 31.822 43.120 67.846 1.00 25.46 ATOM 396 CA ILE 119 32.457 44.08166.957 1.00 24.61 ATOM 397 CB ILE 119 33.281 43.365 65.853 1.00 25.09ATOM 398 CG2 ILE 119 32.362 42.581 64.923 1.00 24.21 ATOM 399 CG1 ILE119 34.096 44.392 65.071 1.00 25.85 ATOM 400 CD1 ILE 119 35.175 43.77964.208 1.00 26.22 ATOM 401 C ILE 119 31.401 44.995 66.329 1.00 22.47ATOM 402 O ILE 119 31.674 46.153 66.003 1.00 22.00 ATOM 403 N ALA 12030.187 44.481 66.171 1.00 21.10 ATOM 404 CA ALA 120 29.109 45.283 65.5991.00 22.02 ATOM 405 CB ALA 120 27.902 44.401 65.294 1.00 20.08 ATOM 406C ALA 120 28.734 46.359 66.616 1.00 22.84 ATOM 407 O ALA 120 28.41047.490 66.264 1.00 22.93 ATOM 408 N ASN 121 28.790 45.987 67.888 1.0021.65 ATOM 409 CA ASN 121 28.468 46.901 68.970 1.00 23.13 ATOM 410 CBASN 121 28.572 46.166 70.300 1.00 27.59 ATOM 411 CG ASN 121 27.64946.732 71.342 1.00 34.63 ATOM 412 OD1 ASN 121 28.016 47.635 72.096 1.0039.08 ATOM 413 ND2 ASN 121 26.427 46.206 71.389 1.00 38.10 ATOM 414 CASN 121 29.428 48.086 68.951 1.00 21.02 ATOM 415 O ASN 121 29.020 49.24169.101 1.00 20.93 ATOM 416 N HIS 122 30.710 47.789 68.776 1.00 17.91ATOM 417 CA HIS 122 31.739 48.817 68.716 1.00 17.11 ATOM 418 CB HIS 12233.122 48.152 68.661 1.00 15.18 ATOM 419 CG HIS 122 34.235 49.093 68.3271.00 16.93 ATOM 420 CD2 HIS 122 35.035 49.844 69.119 1.00 15.16 ATOM 421ND1 HIS 122 34.617 49.363 67.031 1.00 18.07 ATOM 422 CE1 HIS 122 35.60650.240 67.041 1.00 18.19 ATOM 423 NE2 HIS 122 35.879 50.547 68.296 1.0015.55 ATOM 424 C HIS 122 31.520 49.698 67.487 1.00 17.81 ATOM 425 O HIS122 31.628 50.925 67.556 1.00 18.93 ATOM 426 N THR 123 31.213 49.06666.360 1.00 17.71 ATOM 427 CA THR 123 30.983 49.794 65.117 1.00 18.02ATOM 428 CB THR 123 30.700 48.823 63.956 1.00 17.98 ATOM 429 OG1 THR 12331.807 47.926 63.810 1.00 16.69 ATOM 430 CG2 THR 123 30.494 49.59162.646 1.00 18.45 ATOM 431 C THR 123 29.808 50.758 65.260 1.00 18.44ATOM 432 O THR 123 29.872 51.903 64.817 1.00 18.36 ATOM 433 N LEU 12428.737 50.292 65.886 1.00 19.48 ATOM 434 CA LEU 124 27.556 51.123 66.0831.00 21.69 ATOM 435 CB LEU 124 26.407 50.264 66.625 1.00 22.76 ATOM 436CG LEU 124 25.009 50.870 66.792 1.00 25.84 ATOM 437 CD1 LEU 124 24.63451.743 65.596 1.00 26.67 ATOM 438 CD2 LEU 124 24.015 49.731 66.952 1.0028.14 ATOM 439 C LEU 124 27.849 52.293 67.028 1.00 22.10 ATOM 440 O LEU124 27.395 53.414 66.805 1.00 22.48 ATOM 441 N LYS 125 28.619 52.02968.077 1.00 21.30 ATOM 442 CA LYS 125 28.968 53.061 69.044 1.00 21.15ATOM 443 CB LYS 125 29.826 52.468 70.165 1.00 22.88 ATOM 444 CG LYS 12530.218 53.462 71.247 1.00 24.84 ATOM 445 CD LYS 125 31.157 52.829 72.2671.00 27.95 ATOM 446 CE LYS 125 31.480 53.799 73.392 1.00 30.77 ATOM 447NZ LYS 125 31.992 55.102 72.875 1.00 33.91 ATOM 448 C LYS 125 29.72754.203 68.377 1.00 20.96 ATOM 449 O LYS 125 29.344 55.367 68.492 1.0020.95 ATOM 450 N TYR 126 30.805 53.869 67.675 1.00 18.64 ATOM 451 CA TYR126 31.598 54.893 67.020 1.00 17.79 ATOM 452 CB TYR 126 33.026 54.38866.782 1.00 18.37 ATOM 453 CG TYR 126 33.817 54.315 68.071 1.00 20.45ATOM 454 CD1 TYR 126 33.687 53.226 68.934 1.00 20.37 ATOM 455 CE1 TYR126 34.326 53.209 70.171 1.00 21.90 ATOM 456 CD2 TYR 126 34.618 55.38368.476 1.00 20.13 ATOM 457 CE2 TYR 126 35.260 55.376 69.710 1.00 21.70ATOM 458 CZ TYR 126 35.107 54.290 70.552 1.00 21.90 ATOM 459 OH TYR 12635.717 54.301 71.783 1.00 22.74 ATOM 460 C TYR 126 30.983 55.411 65.7331.00 16.79 ATOM 461 O TYR 126 31.168 56.573 65.383 1.00 17.06 ATOM 462 NGLY 127 30.239 54.554 65.038 1.00 17.21 ATOM 463 CA GLY 127 29.59654.977 63.806 1.00 16.33 ATOM 464 C GLY 127 28.534 56.020 64.099 1.0017.87 ATOM 465 O GLY 127 28.366 56.984 63.351 1.00 17.27 ATOM 466 N THR128 27.815 55.825 65.199 1.00 17.84 ATOM 467 CA THR 128 26.774 56.75965.607 1.00 19.72 ATOM 468 CB THR 128 25.997 56.216 66.826 1.00 19.70ATOM 469 OG1 THR 128 25.413 54.951 66.487 1.00 21.12 ATOM 470 CG2 THR128 24.896 57.188 67.244 1.00 20.40 ATOM 471 C THR 128 27.409 58.10765.958 1.00 20.53 ATOM 472 O THR 128 26.887 59.161 65.599 1.00 20.68ATOM 473 N GLN 129 28.542 58.064 66.655 1.00 21.83 ATOM 474 CA GLN 12929.262 59.280 67.038 1.00 21.59 ATOM 475 CB GLN 129 30.455 58.939 67.9381.00 26.47 ATOM 476 CG GLN 129 30.215 59.095 69.432 1.00 31.89 ATOM 477CD GLN 129 31.440 58.719 70.262 1.00 34.85 ATOM 478 OE1 GLN 129 31.60857.567 70.666 1.00 35.57 ATOM 479 NE2 GLN 129 32.310 59.693 70.504 1.0036.98 ATOM 480 C GLN 129 29.781 60.020 65.810 1.00 20.77 ATOM 481 O GLN129 29.638 61.238 65.698 1.00 19.33 ATOM 482 N ALA 130 30.389 59.27064.896 1.00 18.52 ATOM 483 CA ALA 130 30.956 59.831 63.673 1.00 17.79ATOM 484 CB ALA 130 31.622 58.722 62.858 1.00 17.56 ATOM 485 C ALA 13029.927 60.561 62.815 1.00 16.56 ATOM 486 O ALA 130 30.245 61.547 62.1561.00 16.12 ATOM 487 N ARG 131 28.697 60.066 62.817 1.00 17.47 ATOM 488CA ARG 131 27.634 60.680 62.036 1.00 19.03 ATOM 489 CB ARG 131 26.43659.736 61.952 1.00 18.10 ATOM 490 CG ARG 131 26.676 58.528 61.066 1.0018.60 ATOM 491 CD ARG 131 25.435 57.669 60.979 1.00 20.30 ATOM 492 NEARG 131 25.604 56.546 60.062 1.00 17.51 ATOM 493 CZ ARG 131 24.64255.679 59.766 1.00 19.71 ATOM 494 NH1 ARG 131 23.441 55.803 60.317 1.0017.67 ATOM 495 NH2 ARG 131 24.877 54.692 58.910 1.00 19.33 ATOM 496 CARG 131 27.188 62.030 62.599 1.00 21.80 ATOM 497 O ARG 131 26.512 62.80161.913 1.00 20.73 ATOM 498 N LYS 132 27.562 62.309 63.844 1.00 22.02ATOM 499 CA LYS 132 27.195 63.569 64.479 1.00 24.28 ATOM 500 CB LYS 13227.232 63.425 66.002 1.00 25.70 ATOM 501 CG LYS 132 26.128 62.535 66.5531.00 31.41 ATOM 502 CD LYS 132 26.278 62.309 68.048 1.00 33.41 ATOM 503CE LYS 132 25.149 61.442 68.580 1.00 36.75 ATOM 504 NZ LYS 132 25.39860.989 69.977 1.00 38.85 ATOM 505 C LYS 132 28.113 64.698 64.036 1.0024.23 ATOM 506 O LYS 132 27.815 65.872 64.255 1.00 24.28 ATOM 507 N PHE133 29.235 64.344 63.417 1.00 25.03 ATOM 508 CA PHE 133 30.178 65.34762.928 1.00 26.68 ATOM 509 CB PHE 133 31.606 64.786 62.822 1.00 26.18ATOM 510 CG PHE 133 32.297 64.597 64.140 1.00 26.01 ATOM 511 CD1 PHE 13332.189 63.396 64.833 1.00 26.90 ATOM 512 CD2 PHE 133 33.063 65.62564.686 1.00 27.15 ATOM 513 CE1 PHE 133 32.837 63.218 66.057 1.00 28.34ATOM 514 CE2 PHE 133 33.714 65.461 65.909 1.00 26.84 ATOM 515 CZ PHE 13333.602 64.256 66.595 1.00 27.99 ATOM 516 C PHE 133 29.766 65.801 61.5401.00 27.95 ATOM 517 O PHE 133 29.350 64.989 60.714 1.00 28.75 ATOM 518 NASP 134 29.876 67.099 61.281 1.00 29.55 ATOM 519 CA ASP 134 29.56167.611 59.957 1.00 30.26 ATOM 520 CB ASP 134 29.048 69.051 60.007 1.0032.19 ATOM 521 CG ASP 134 28.560 69.538 58.648 1.00 32.97 ATOM 522 OD1ASP 134 29.035 69.008 57.620 1.00 33.76 ATOM 523 OD2 ASP 134 27.71070.450 58.602 1.00 35.71 ATOM 524 C ASP 134 30.896 67.577 59.231 1.0030.16 ATOM 525 O ASP 134 31.721 68.478 59.381 1.00 30.39 ATOM 526 N VAL135 31.110 66.522 58.457 1.00 31.36 ATOM 527 CA VAL 135 32.353 66.35457.722 1.00 31.74 ATOM 528 CB VAL 135 32.308 65.059 56.880 1.00 32.36ATOM 529 CG1 VAL 135 33.587 64.904 56.083 1.00 33.06 ATOM 530 CG2 VAL135 32.113 63.864 57.794 1.00 31.68 ATOM 531 C VAL 135 32.660 67.54956.820 1.00 32.14 ATOM 532 O VAL 135 33.824 67.884 56.599 1.00 32.77ATOM 533 N ASN 136 31.615 68.194 56.310 1.00 32.14 ATOM 534 CA ASN 13631.790 69.346 55.432 1.00 34.09 ATOM 535 CB ASN 136 30.430 69.871 54.9611.00 34.55 ATOM 536 CG ASN 136 29.697 68.881 54.079 1.00 36.54 ATOM 537OD1 ASN 136 30.246 68.397 53.089 1.00 34.66 ATOM 538 ND2 ASN 136 28.44968.575 54.433 1.00 35.78 ATOM 539 C ASN 136 32.555 70.478 56.103 1.0034.86 ATOM 540 O ASN 136 33.238 71.251 55.436 1.00 34.66 ATOM 541 N GLN137 32.445 70.568 57.424 1.00 36.37 ATOM 542 CA GLN 137 33.114 71.62858.171 1.00 37.67 ATOM 543 CB GLN 137 32.192 72.122 59.290 1.00 40.06ATOM 544 CG GLN 137 30.886 72.738 58.797 1.00 43.99 ATOM 545 CD GLN 13731.108 73.973 57.939 1.00 47.20 ATOM 546 OE1 GLN 137 31.777 74.92258.355 1.00 49.72 ATOM 547 NE2 GLN 137 30.540 73.970 56.736 1.00 49.42ATOM 548 C GLN 137 34.471 71.237 58.756 1.00 36.89 ATOM 549 O GLN 13735.136 72.057 59.389 1.00 36.28 ATOM 550 N LEU 138 34.886 69.992 58.5391.00 36.72 ATOM 551 CA LEU 138 36.162 69.516 59.061 1.00 35.87 ATOM 552CB LEU 138 36.140 67.991 59.166 1.00 36.10 ATOM 553 CG LEU 138 36.21667.413 60.585 1.00 36.93 ATOM 554 CD1 LEU 138 35.438 68.279 61.565 1.0036.66 ATOM 555 CD2 LEU 138 35.678 65.994 60.576 1.00 37.81 ATOM 556 CLEU 138 37.330 69.980 58.198 1.00 36.49 ATOM 557 O LEU 138 37.350 69.76456.987 1.00 37.24 ATOM 558 N GLN 139 38.310 70.612 58.837 1.00 36.86ATOM 559 CA GLN 139 39.476 71.144 58.140 1.00 37.44 ATOM 560 CB GLN 13940.141 72.224 58.995 1.00 39.57 ATOM 561 CG GLN 139 40.513 73.479 58.2251.00 43.68 ATOM 562 CD GLN 139 39.295 74.262 57.761 1.00 46.04 ATOM 563OE1 GLN 139 38.423 73.729 57.070 1.00 48.18 ATOM 564 NE2 GLN 139 39.23075.535 58.138 1.00 46.25 ATOM 565 C GLN 139 40.516 70.094 57.755 1.0036.44 ATOM 566 O GLN 139 40.868 69.970 56.583 1.00 37.59 ATOM 567 N ASN140 41.016 69.353 58.739 1.00 35.34 ATOM 568 CA ASN 140 42.018 68.32058.486 1.00 34.29 ATOM 569 CB ASN 140 42.428 67.659 59.807 1.00 35.01ATOM 570 CG ASN 140 43.640 66.763 59.660 1.00 36.54 ATOM 571 OD1 ASN 14043.676 65.880 58.801 1.00 37.38 ATOM 572 ND2 ASN 140 44.643 66.98260.504 1.00 38.59 ATOM 573 C ASN 140 41.443 67.273 57.529 1.00 33.04ATOM 574 O ASN 140 40.438 66.632 57.838 1.00 32.86 ATOM 575 N THR 14142.082 67.094 56.376 1.00 31.07 ATOM 576 CA THR 141 41.599 66.135 55.3861.00 30.83 ATOM 577 CB THR 141 42.347 66.287 54.038 1.00 31.28 ATOM 578OG1 THR 141 43.753 66.108 54.238 1.00 31.57 ATOM 579 CG2 THR 141 42.08967.668 53.438 1.00 31.26 ATOM 580 C THR 141 41.681 64.674 55.835 1.0030.16 ATOM 581 O THR 141 40.809 63.875 55.504 1.00 30.19 ATOM 582 N THR142 42.722 64.323 56.582 1.00 29.65 ATOM 583 CA THR 142 42.866 62.95157.061 1.00 28.87 ATOM 584 CB THR 142 44.242 62.733 57.722 1.00 30.00ATOM 585 OG1 THR 142 45.266 62.851 56.726 1.00 31.45 ATOM 586 CG2 THR142 44.324 61.354 58.366 1.00 29.44 ATOM 587 C THR 142 41.760 62.62758.064 1.00 27.94 ATOM 588 O THR 142 41.151 61.558 58.005 1.00 27.97ATOM 589 N ILE 143 41.499 63.555 58.979 1.00 25.97 ATOM 590 CA ILE 14340.451 63.367 59.979 1.00 25.63 ATOM 591 CB ILE 143 40.415 64.552 60.9751.00 26.33 ATOM 592 CG2 ILE 143 39.202 64.438 61.888 1.00 24.81 ATOM 593CG1 ILE 143 41.709 64.584 61.792 1.00 27.36 ATOM 594 CD1 ILE 143 41.94163.340 62.619 1.00 29.54 ATOM 595 C ILE 143 39.101 63.283 59.273 1.0025.21 ATOM 596 O ILE 143 38.248 62.463 59.612 1.00 24.06 ATOM 597 N LYS144 38.930 64.153 58.285 1.00 24.13 ATOM 598 CA LYS 144 37.716 64.23757.489 1.00 23.56 ATOM 599 CB LYS 144 37.868 65.405 56.502 1.00 25.02ATOM 600 CG LYS 144 36.692 65.695 55.598 1.00 27.86 ATOM 601 CD LYS 14436.894 67.050 54.915 1.00 31.18 ATOM 602 CE LYS 144 35.905 67.295 53.7821.00 32.81 ATOM 603 NZ LYS 144 34.486 67.288 54.224 1.00 35.78 ATOM 604C LYS 144 37.468 62.918 56.752 1.00 22.05 ATOM 605 O LYS 144 36.34962.402 56.734 1.00 22.03 ATOM 606 N ARG 145 38.524 62.371 56.164 1.0021.34 ATOM 607 CA ARG 145 38.435 61.118 55.421 1.00 20.58 ATOM 608 CBARG 145 39.750 60.871 54.676 1.00 20.47 ATOM 609 CG ARG 145 39.74759.672 53.734 1.00 19.28 ATOM 610 CD ARG 145 41.005 59.671 52.875 1.0017.58 ATOM 611 NE ARG 145 41.122 58.488 52.023 1.00 16.82 ATOM 612 CZARG 145 40.350 58.238 50.969 1.00 18.88 ATOM 613 NH1 ARG 145 39.39159.092 50.627 1.00 18.08 ATOM 614 NH2 ARG 145 40.541 57.133 50.252 1.0015.35 ATOM 615 C ARG 145 38.119 59.933 56.337 1.00 21.54 ATOM 616 O ARG145 37.294 59.081 56.002 1.00 19.52 ATOM 617 N ILE 146 38.775 59.88057.493 1.00 20.89 ATOM 618 CA ILE 146 38.543 58.793 58.436 1.00 20.61ATOM 619 CB ILE 146 39.550 58.843 59.611 1.00 20.86 ATOM 620 CG2 ILE 14639.105 57.904 60.729 1.00 18.26 ATOM 621 CG1 ILE 146 40.942 58.44559.109 1.00 21.92 ATOM 622 CD1 ILE 146 42.034 58.531 60.163 1.00 23.09ATOM 623 C ILE 146 37.124 58.833 58.991 1.00 20.19 ATOM 624 O ILE 14636.433 57.814 59.024 1.00 20.23 ATOM 625 N ILE 147 36.687 60.013 59.4161.00 19.22 ATOM 626 CA ILE 147 35.352 60.161 59.973 1.00 19.37 ATOM 627CB ILE 147 35.132 61.590 60.536 1.00 19.10 ATOM 628 CG2 ILE 147 33.65761.806 60.859 1.00 19.65 ATOM 629 CG1 ILE 147 35.991 61.780 61.794 1.0018.67 ATOM 630 CD1 ILE 147 35.771 63.090 62.519 1.00 20.74 ATOM 631 CILE 147 34.259 59.820 58.960 1.00 18.50 ATOM 632 O ILE 147 33.278 59.16659.305 1.00 16.03 ATOM 633 N ALA 148 34.426 60.259 57.716 1.00 19.76ATOM 634 CA ALA 148 33.432 59.961 56.685 1.00 20.41 ATOM 635 CB ALA 14833.838 60.592 55.348 1.00 19.63 ATOM 636 C ALA 148 33.305 58.447 56.5351.00 19.95 ATOM 637 O ALA 148 32.203 57.917 56.406 1.00 21.03 ATOM 638 NLYS 149 34.438 57.752 56.566 1.00 19.67 ATOM 639 CA LYS 149 34.44656.300 56.435 1.00 19.12 ATOM 640 CB LYS 149 35.886 55.802 56.246 1.0021.29 ATOM 641 CG LYS 149 36.016 54.302 55.997 1.00 25.45 ATOM 642 CDLYS 149 37.389 53.971 55.418 1.00 29.29 ATOM 643 CE LYS 149 37.51152.506 55.013 1.00 29.09 ATOM 644 NZ LYS 149 37.592 51.592 56.184 1.0031.55 ATOM 645 C LYS 149 33.802 55.601 57.633 1.00 18.43 ATOM 646 O LYS149 33.088 54.606 57.469 1.00 18.62 ATOM 647 N VAL 150 34.042 56.12258.835 1.00 17.00 ATOM 648 CA VAL 150 33.475 55.528 60.041 1.00 16.77ATOM 649 CB VAL 150 34.145 56.106 61.316 1.00 18.58 ATOM 650 CG1 VAL 15033.532 55.480 62.573 1.00 17.11 ATOM 651 CG2 VAL 150 35.641 55.82561.276 1.00 17.68 ATOM 652 C VAL 150 31.956 55.701 60.127 1.00 15.66ATOM 653 O VAL 150 31.291 54.974 60.861 1.00 14.92 ATOM 654 N GLN 15131.407 56.656 59.379 1.00 15.58 ATOM 655 CA GLN 151 29.958 56.875 59.3711.00 16.33 ATOM 656 CB GLN 151 29.608 58.196 58.674 1.00 17.28 ATOM 657CG GLN 151 30.272 59.437 59.263 1.00 19.28 ATOM 658 CD GLN 151 29.80260.723 58.597 1.00 22.98 ATOM 659 OE1 GLN 151 29.570 60.758 57.388 1.0024.55 ATOM 660 NE2 GLN 151 29.677 61.790 59.381 1.00 23.47 ATOM 661 CGLN 151 29.237 55.719 58.656 1.00 16.52 ATOM 662 O GLN 151 28.014 55.59558.732 1.00 16.41 ATOM 663 N ASP 152 29.997 54.887 57.950 1.00 14.56ATOM 664 CA ASP 152 29.436 53.732 57.242 1.00 16.29 ATOM 665 CB ASP 15230.237 53.457 55.965 1.00 15.31 ATOM 666 CG ASP 152 29.661 52.317 55.1311.00 17.15 ATOM 667 OD1 ASP 152 28.797 51.560 55.623 1.00 16.35 ATOM 668OD2 ASP 152 30.095 52.172 53.970 1.00 18.62 ATOM 669 C ASP 152 29.55252.545 58.198 1.00 16.49 ATOM 670 O ASP 152 30.641 52.022 58.408 1.0016.64 ATOM 671 N LEU 153 28.429 52.126 58.772 1.00 17.15 ATOM 672 CA LEU153 28.423 51.023 59.731 1.00 18.78 ATOM 673 CB LEU 153 27.197 51.12260.640 1.00 19.19 ATOM 674 CG LEU 153 26.729 52.501 61.112 1.00 22.36ATOM 675 CD1 LEU 153 25.611 52.330 62.137 1.00 22.96 ATOM 676 CD2 LEU153 27.881 53.260 61.715 1.00 20.38 ATOM 677 C LEU 153 28.417 49.65059.080 1.00 18.93 ATOM 678 O LEU 153 28.600 48.635 59.756 1.00 18.52ATOM 679 N GLU 154 28.207 49.617 57.769 1.00 19.03 ATOM 680 CA GLU 15428.133 48.360 57.049 1.00 19.00 ATOM 681 CB GLU 154 29.505 47.674 57.0331.00 23.48 ATOM 682 CG GLU 154 30.375 48.165 55.867 1.00 32.92 ATOM 683CD GLU 154 31.838 47.766 55.981 1.00 38.33 ATOM 684 OE1 GLU 154 32.12246.597 56.317 1.00 44.51 ATOM 685 OE2 GLU 154 32.709 48.622 55.720 1.0042.26 ATOM 686 C GLU 154 27.046 47.508 57.704 1.00 16.46 ATOM 687 O GLU154 25.984 48.038 58.020 1.00 16.75 ATOM 688 N ARG 155 27.285 46.22057.939 1.00 14.21 ATOM 689 CA ARG 155 26.238 45.381 58.525 1.00 15.38ATOM 690 CB ARG 155 26.698 43.921 58.607 1.00 16.09 ATOM 691 CG ARG 15527.670 43.615 59.735 1.00 14.62 ATOM 692 CD ARG 155 28.101 42.156 59.6851.00 16.01 ATOM 693 NE ARG 155 28.976 41.887 58.550 1.00 18.81 ATOM 694CZ ARG 155 29.461 40.686 58.244 1.00 21.66 ATOM 695 NH1 ARG 155 29.15039.629 58.989 1.00 20.13 ATOM 696 NH2 ARG 155 30.274 40.547 57.204 1.0022.28 ATOM 697 C ARG 155 25.728 45.838 59.896 1.00 16.17 ATOM 698 O ARG155 24.567 45.602 60.246 1.00 15.50 ATOM 699 N ALA 156 26.586 46.49660.668 1.00 17.02 ATOM 700 CA ALA 156 26.185 46.963 61.994 1.00 18.35ATOM 701 CB ALA 156 27.380 47.563 62.722 1.00 17.23 ATOM 702 C ALA 15625.031 47.969 61.954 1.00 19.07 ATOM 703 O ALA 156 24.495 48.341 62.9971.00 19.97 ATOM 704 N ALA 157 24.645 48.409 60.759 1.00 17.62 ATOM 705CA ALA 157 23.534 49.354 60.635 1.00 17.85 ATOM 706 CB ALA 157 23.62050.104 59.311 1.00 15.36 ATOM 707 C ALA 157 22.186 48.647 60.739 1.0017.21 ATOM 708 O ALA 157 21.155 49.286 60.946 1.00 18.26 ATOM 709 N LEU158 22.197 47.327 60.591 1.00 17.55 ATOM 710 CA LEU 158 20.970 46.53660.656 1.00 17.62 ATOM 711 CB LEU 158 21.209 45.132 60.090 1.00 16.43ATOM 712 CG LEU 158 21.510 44.911 58.609 1.00 15.07 ATOM 713 CD1 LEU 15821.931 43.465 58.404 1.00 15.08 ATOM 714 CD2 LEU 158 20.282 45.24357.777 1.00 13.17 ATOM 715 C LEU 158 20.430 46.377 62.073 1.00 17.49ATOM 716 O LEU 158 21.196 46.258 63.020 1.00 18.06 ATOM 717 N PRO 15919.096 46.374 62.229 1.00 18.66 ATOM 718 CD PRO 159 18.053 46.623 61.2151.00 18.39 ATOM 719 CA PRO 159 18.508 46.207 63.561 1.00 18.87 ATOM 720CB PRO 159 17.014 46.153 63.273 1.00 19.07 ATOM 721 CG PRO 159 16.87347.046 62.062 1.00 20.37 ATOM 722 C PRO 159 19.038 44.877 64.098 1.0020.43 ATOM 723 O PRO 159 19.318 43.966 63.317 1.00 20.96 ATOM 724 N ALA160 19.183 44.770 65.415 1.00 20.67 ATOM 725 CA ALA 160 19.698 43.56066.052 1.00 21.14 ATOM 726 CB ALA 160 19.397 43.600 67.554 1.00 20.94ATOM 727 C ALA 160 19.183 42.246 65.459 1.00 21.41 ATOM 728 O ALA 16019.958 41.329 65.193 1.00 20.22 ATOM 729 N GLN 161 17.873 42.154 65.2611.00 22.76 ATOM 730 CA GLN 161 17.268 40.941 64.724 1.00 24.75 ATOM 731CB GLN 161 15.749 41.106 64.668 1.00 27.09 ATOM 732 CG GLN 161 14.99339.854 64.268 1.00 34.37 ATOM 733 CD GLN 161 13.498 39.986 64.496 1.0038.16 ATOM 734 OE1 GLN 161 13.044 40.152 65.631 1.00 40.84 ATOM 735 NE2GLN 161 12.724 39.914 63.417 1.00 39.81 ATOM 736 C GLN 161 17.813 40.57963.340 1.00 24.20 ATOM 737 O GLN 161 18.220 39.437 63.105 1.00 22.98ATOM 738 N GLU 162 17.822 41.550 62.432 1.00 22.26 ATOM 739 CA GLU 16218.323 41.330 61.079 1.00 23.01 ATOM 740 CB GLU 162 18.034 42.545 60.1871.00 25.38 ATOM 741 CG GLU 162 16.629 42.608 59.583 1.00 30.24 ATOM 742CD GLU 162 15.545 42.908 60.604 1.00 33.50 ATOM 743 OE1 GLU 162 15.24642.031 61.441 1.00 37.24 ATOM 744 OE2 GLU 162 14.989 44.025 60.564 1.0035.02 ATOM 745 C GLU 162 19.827 41.053 61.066 1.00 20.41 ATOM 746 O GLU162 20.311 40.262 60.262 1.00 19.24 ATOM 747 N LEU 163 20.567 41.70561.956 1.00 20.49 ATOM 748 CA LEU 163 22.008 41.504 62.001 1.00 19.77ATOM 749 CB LEU 163 22.655 42.455 63.013 1.00 19.73 ATOM 750 CG LEU 16324.177 42.335 63.191 1.00 20.15 ATOM 751 CD1 LEU 163 24.890 42.50661.856 1.00 20.35 ATOM 752 CD2 LEU 163 24.651 43.385 64.183 1.00 20.52ATOM 753 C LEU 163 22.373 40.062 62.336 1.00 20.22 ATOM 754 O LEU 16323.242 39.469 61.690 1.00 18.49 ATOM 755 N GLU 164 21.715 39.487 63.3381.00 21.24 ATOM 756 CA GLU 164 22.033 38.114 63.702 1.00 22.56 ATOM 757CB GLU 164 21.368 37.715 65.031 1.00 25.63 ATOM 758 CG GLU 164 19.93137.253 64.946 1.00 32.73 ATOM 759 CD GLU 164 19.410 36.719 66.280 1.0036.98 ATOM 760 OE1 GLU 164 18.266 36.215 66.315 1.00 39.72 ATOM 761 OE2GLU 164 20.141 36.805 67.292 1.00 37.47 ATOM 762 C GLU 164 21.629 37.15962.583 1.00 19.87 ATOM 763 O GLU 164 22.330 36.191 62.309 1.00 19.06ATOM 764 N GLU 165 20.511 37.436 61.923 1.00 18.96 ATOM 765 CA GLU 16520.076 36.575 60.829 1.00 19.42 ATOM 766 CB GLU 165 18.677 36.962 60.3541.00 19.49 ATOM 767 CG GLU 165 18.230 36.176 59.138 1.00 22.13 ATOM 768CD GLU 165 16.817 36.502 58.721 1.00 23.77 ATOM 769 OE1 GLU 165 16.36837.642 58.976 1.00 25.48 ATOM 770 OE2 GLU 165 16.163 35.622 58.122 1.0023.74 ATOM 771 C GLU 165 21.069 36.659 59.664 1.00 19.62 ATOM 772 O GLU165 21.405 35.645 59.050 1.00 19.06 ATOM 773 N TYR 166 21.536 37.86959.372 1.00 18.74 ATOM 774 CA TYR 166 22.499 38.083 58.298 1.00 19.37ATOM 775 CB TYR 166 22.767 39.579 58.117 1.00 18.92 ATOM 776 CG TYR 16623.762 39.899 57.021 1.00 18.54 ATOM 777 CD1 TYR 166 23.522 39.51655.699 1.00 17.98 ATOM 778 CE1 TYR 166 24.431 39.816 54.685 1.00 18.12ATOM 779 CD2 TYR 166 24.938 40.591 57.302 1.00 19.19 ATOM 780 CE2 TYR166 25.853 40.898 56.296 1.00 19.67 ATOM 781 CZ TYR 166 25.593 40.50854.992 1.00 19.53 ATOM 782 OH TYR 166 26.492 40.814 53.997 1.00 20.23ATOM 783 C TYR 166 23.815 37.365 58.603 1.00 19.45 ATOM 784 O TYR 16624.375 36.681 57.742 1.00 17.70 ATOM 785 N ASN 167 24.313 37.524 59.8271.00 19.79 ATOM 786 CA ASN 167 25.563 36.874 60.197 1.00 19.29 ATOM 787CB ASN 167 25.980 37.248 61.623 1.00 20.64 ATOM 788 CG ASN 167 26.48038.678 61.729 1.00 21.06 ATOM 789 OD1 ASN 167 27.214 39.156 60.864 1.0022.90 ATOM 790 ND2 ASN 167 26.096 39.361 62.798 1.00 20.86 ATOM 791 CASN 167 25.448 35.364 60.077 1.00 19.16 ATOM 792 O ASN 167 26.378 34.70659.619 1.00 19.57 ATOM 793 N LYS 168 24.308 34.813 60.483 1.00 19.46ATOM 794 CA LYS 168 24.116 33.370 60.403 1.00 20.23 ATOM 795 CB LYS 16822.864 32.929 61.172 1.00 20.58 ATOM 796 CG LYS 168 22.625 31.428 61.0561.00 24.70 ATOM 797 CD LYS 168 21.400 30.961 61.813 1.00 28.42 ATOM 798CE LYS 168 21.048 29.527 61.414 1.00 30.39 ATOM 799 NZ LYS 168 22.23528.626 61.471 1.00 30.19 ATOM 800 C LYS 168 24.006 32.930 58.950 1.0018.98 ATOM 801 O LYS 168 24.485 31.859 58.580 1.00 17.60 ATOM 802 N ILE169 23.363 33.760 58.135 1.00 18.74 ATOM 803 CA ILE 169 23.213 33.47356.715 1.00 19.75 ATOM 804 CB ILE 169 22.464 34.615 55.987 1.00 20.57ATOM 805 CG2 ILE 169 22.651 34.489 54.480 1.00 22.22 ATOM 806 CG1 ILE169 20.975 34.585 56.341 1.00 23.21 ATOM 807 CD1 ILE 169 20.236 33.38555.798 1.00 23.57 ATOM 808 C ILE 169 24.603 33.331 56.096 1.00 17.44ATOM 809 O ILE 169 24.903 32.337 55.443 1.00 17.43 ATOM 810 N LEU 17025.445 34.338 56.305 1.00 16.93 ATOM 811 CA LEU 170 26.802 34.321 55.7711.00 17.48 ATOM 812 CB LEU 170 27.555 35.582 56.195 1.00 16.14 ATOM 813CG LEU 170 27.069 36.914 55.617 1.00 16.26 ATOM 814 CD1 LEU 170 27.89938.051 56.203 1.00 15.60 ATOM 815 CD2 LEU 170 27.182 36.895 54.098 1.0015.95 ATOM 816 C LEU 170 27.561 33.091 56.257 1.00 19.23 ATOM 817 O LEU170 28.222 32.398 55.479 1.00 18.65 ATOM 818 N LEU 171 27.464 32.82757.553 1.00 19.55 ATOM 819 CA LEU 171 28.135 31.687 58.150 1.00 20.58ATOM 820 CB LEU 171 27.824 31.621 59.647 1.00 23.73 ATOM 821 CG LEU 17128.435 30.447 60.413 1.00 27.50 ATOM 822 CD1 LEU 171 29.939 30.62560.513 1.00 27.87 ATOM 823 CD2 LEU 171 27.812 30.371 61.801 1.00 30.52ATOM 824 C LEU 171 27.698 30.386 57.481 1.00 20.07 ATOM 825 O LEU 17128.537 29.561 57.109 1.00 20.05 ATOM 826 N ASP 172 26.389 30.206 57.3281.00 17.76 ATOM 827 CA ASP 172 25.864 28.988 56.723 1.00 18.58 ATOM 828CB ASP 172 24.336 28.926 56.843 1.00 19.17 ATOM 829 CG ASP 172 23.85928.732 58.280 1.00 20.25 ATOM 830 OD1 ASP 172 24.644 28.263 59.129 1.0020.96 ATOM 831 OD2 ASP 172 22.680 29.035 58.554 1.00 22.31 ATOM 832 CASP 172 26.267 28.823 55.260 1.00 18.13 ATOM 833 O ASP 172 26.537 27.70954.819 1.00 18.79 ATOM 834 N MET 173 26.301 29.915 54.501 1.00 17.04ATOM 835 CA MET 173 26.695 29.810 53.098 1.00 16.32 ATOM 836 CB MET 17326.486 31.141 52.354 1.00 13.73 ATOM 837 CG MET 173 25.021 31.532 52.1781.00 13.28 ATOM 838 SD MET 173 24.730 32.777 50.896 1.00 14.85 ATOM 839CE MET 173 25.634 34.204 51.591 1.00 10.81 ATOM 840 C MET 173 28.15929.388 52.998 1.00 16.03 ATOM 841 O MET 173 28.510 28.516 52.205 1.0015.12 ATOM 842 N GLU 174 29.008 30.003 53.812 1.00 16.72 ATOM 843 CA GLU174 30.430 29.686 53.796 1.00 20.27 ATOM 844 CB GLU 174 31.197 30.59454.757 1.00 22.24 ATOM 845 CG GLU 174 32.675 30.254 54.819 1.00 28.10ATOM 846 CD GLU 174 33.359 30.397 53.470 1.00 31.42 ATOM 847 OE1 GLU 17433.614 31.552 53.059 1.00 33.86 ATOM 848 OE2 GLU 174 33.631 29.36152.817 1.00 30.70 ATOM 849 C GLU 174 30.692 28.233 54.171 1.00 19.72ATOM 850 O GLU 174 31.497 27.551 53.533 1.00 19.19 ATOM 851 N THR 17530.016 27.770 55.216 1.00 19.54 ATOM 852 CA THR 175 30.176 26.401 55.6861.00 19.81 ATOM 853 CB THR 175 29.389 26.174 56.991 1.00 20.87 ATOM 854OG1 THR 175 29.833 27.111 57.978 1.00 22.15 ATOM 855 CG2 THR 175 29.61324.761 57.513 1.00 23.20 ATOM 856 C THR 175 29.694 25.414 54.635 1.0019.62 ATOM 857 O THR 175 30.392 24.447 54.315 1.00 21.27 ATOM 858 N THR176 28.501 25.660 54.101 1.00 16.70 ATOM 859 CA THR 176 27.923 24.79453.076 1.00 16.77 ATOM 860 CB THR 176 26.594 25.375 52.546 1.00 17.25ATOM 861 OG1 THR 176 25.646 25.467 53.620 1.00 16.27 ATOM 862 CG2 THR176 26.028 24.488 51.428 1.00 13.62 ATOM 863 C THR 176 28.882 24.62051.895 1.00 16.32 ATOM 864 O THR 176 29.088 23.512 51.408 1.00 17.12ATOM 865 N TYR 177 29.467 25.720 51.439 1.00 16.42 ATOM 866 CA TYR 17730.396 25.675 50.316 1.00 17.56 ATOM 867 CB TYR 177 30.773 27.103 49.8851.00 15.76 ATOM 868 CG TYR 177 31.734 27.166 48.708 1.00 15.72 ATOM 869CD1 TYR 177 31.265 27.155 47.392 1.00 14.57 ATOM 870 CE1 TYR 177 32.15227.198 46.301 1.00 14.15 ATOM 871 CD2 TYR 177 33.114 27.220 48.912 1.0015.54 ATOM 872 CE2 TYR 177 34.009 27.259 47.834 1.00 12.96 ATOM 873 CZTYR 177 33.521 27.248 46.534 1.00 15.16 ATOM 874 OH TYR 177 34.40227.283 45.477 1.00 14.20 ATOM 875 C TYR 177 31.673 24.897 50.651 1.0018.31 ATOM 876 O TYR 177 32.072 23.998 49.913 1.00 18.88 ATOM 877 N SER178 32.304 25.251 51.768 1.00 18.65 ATOM 878 CA SER 178 33.555 24.62852.188 1.00 20.78 ATOM 879 CB SER 178 34.201 25.451 53.306 1.00 21.43ATOM 880 OG SER 178 34.760 26.650 52.796 1.00 24.23 ATOM 881 C SER 17833.522 23.163 52.613 1.00 21.32 ATOM 882 O SER 178 34.577 22.541 52.7391.00 21.59 ATOM 883 N VAL 179 32.338 22.604 52.835 1.00 20.55 ATOM 884CA VAL 179 32.253 21.206 53.242 1.00 21.42 ATOM 885 CB VAL 179 31.54121.049 54.616 1.00 23.05 ATOM 886 CG1 VAL 179 32.268 21.866 55.672 1.0021.20 ATOM 887 CG2 VAL 179 30.085 21.474 54.509 1.00 22.91 ATOM 888 CVAL 179 31.527 20.337 52.218 1.00 21.32 ATOM 889 O VAL 179 31.367 19.13552.421 1.00 21.62 ATOM 890 N ALA 180 31.106 20.941 51.113 1.00 20.29ATOM 891 CA ALA 180 30.393 20.203 50.081 1.00 19.37 ATOM 892 CB ALA 18029.855 21.169 49.026 1.00 18.54 ATOM 893 C ALA 180 31.285 19.157 49.4241.00 18.64 ATOM 894 O ALA 180 32.479 19.384 49.224 1.00 19.38 ATOM 895 NTHR 181 30.692 18.013 49.095 1.00 19.37 ATOM 896 CA THR 181 31.41316.925 48.442 1.00 20.39 ATOM 897 CB THR 181 31.749 15.781 49.434 1.0021.11 ATOM 898 OG1 THR 181 30.534 15.211 49.931 1.00 24.35 ATOM 899 CG2THR 181 32.576 16.301 50.603 1.00 21.45 ATOM 900 C THR 181 30.579 16.33447.309 1.00 19.99 ATOM 901 O THR 181 29.353 16.463 47.288 1.00 18.79ATOM 902 N VAL 182 31.257 15.694 46.362 1.00 20.53 ATOM 903 CA VAL 18230.601 15.053 45.227 1.00 20.87 ATOM 904 CB VAL 182 31.084 15.655 43.8901.00 18.48 ATOM 905 CG1 VAL 182 30.321 15.021 42.724 1.00 18.85 ATOM 906CG2 VAL 182 30.882 17.166 43.897 1.00 16.20 ATOM 907 C VAL 182 30.98713.584 45.307 1.00 22.10 ATOM 908 O VAL 182 32.167 13.249 45.261 1.0021.07 ATOM 909 N CYS 183 29.989 12.714 45.435 1.00 26.01 ATOM 910 CA CYS183 30.247 11.285 45.580 1.00 29.42 ATOM 911 C CYS 183 29.855 10.40644.398 1.00 31.72 ATOM 912 O CYS 183 28.976 10.755 43.607 1.00 31.89ATOM 913 CB CYS 183 29.514 10.743 46.811 1.00 28.21 ATOM 914 SG CYS 18329.634 11.717 48.345 1.00 30.87 ATOM 915 N HIS 184 30.518 9.252 44.3101.00 35.55 ATOM 916 CA HIS 184 30.247 8.250 43.284 1.00 37.73 ATOM 917CB HIS 184 31.542 7.526 42.894 1.00 38.32 ATOM 918 CG HIS 184 32.4238.311 41.970 1.00 39.50 ATOM 919 CD2 HIS 184 33.641 8.871 42.163 1.0040.09 ATOM 920 ND1 HIS 184 32.082 8.580 40.661 1.00 39.50 ATOM 921 CE1HIS 184 33.053 9.267 40.087 1.00 40.74 ATOM 922 NE2 HIS 184 34.012 9.45640.977 1.00 41.17 ATOM 923 C HIS 184 29.267 7.251 43.896 1.00 39.60 ATOM924 O HIS 184 29.012 7.282 45.095 1.00 38.09 ATOM 925 N PRO 185 28.7126.348 43.082 1.00 42.45 ATOM 926 CD PRO 185 28.759 6.347 41.608 1.0043.76 ATOM 927 CA PRO 185 27.762 5.347 43.588 1.00 43.42 ATOM 928 CB PRO185 27.433 4.539 42.341 1.00 44.10 ATOM 929 CG PRO 185 27.503 5.61441.253 1.00 44.49 ATOM 930 C PRO 185 28.305 4.467 44.722 1.00 44.53 ATOM931 O PRO 185 27.545 3.951 45.540 1.00 44.42 ATOM 932 N ASN 186 29.6174.276 44.744 1.00 46.05 ATOM 933 CA ASN 186 30.217 3.474 45.795 1.0047.57 ATOM 934 CB ASN 186 31.688 3.146 45.466 1.00 48.59 ATOM 935 CG ASN186 32.413 4.289 44.776 1.00 49.30 ATOM 936 OD1 ASN 186 32.309 5.43345.193 1.00 50.36 ATOM 937 ND2 ASN 186 33.142 3.979 43.698 1.00 49.33ATOM 938 C ASN 186 30.140 4.201 47.144 1.00 47.63 ATOM 939 O ASN 18629.211 4.005 47.946 1.00 49.72 ATOM 940 N GLY 187 31.125 5.059 47.3771.00 46.81 ATOM 941 CA GLY 187 31.186 5.818 48.609 1.00 43.76 ATOM 942 CGLY 187 32.326 6.797 48.480 1.00 41.12 ATOM 943 O GLY 187 32.640 7.51949.421 1.00 42.63 ATOM 944 N SER 188 32.951 6.800 47.306 1.00 38.37 ATOM945 CA SER 188 34.065 7.691 47.030 1.00 36.56 ATOM 946 CB SER 188 34.8047.249 45.768 1.00 37.67 ATOM 947 OG SER 188 35.648 6.153 46.049 1.0042.41 ATOM 948 C SER 188 33.530 9.100 46.839 1.00 33.64 ATOM 949 O SER188 32.904 9.408 45.824 1.00 31.94 ATOM 950 N CYS 189 33.757 9.94647.835 1.00 31.40 ATOM 951 CA CYS 189 33.320 11.329 47.768 1.00 29.46ATOM 952 C CYS 189 34.555 12.190 47.586 1.00 27.90 ATOM 953 O CYS 18935.591 11.948 48.202 1.00 28.50 ATOM 954 CB CYS 189 32.598 11.731 49.0511.00 29.56 ATOM 955 SG CYS 189 31.084 10.792 49.428 1.00 31.98 ATOM 956N LEU 190 34.445 13.191 46.726 1.00 24.76 ATOM 957 CA LEU 190 35.56314.079 46.472 1.00 22.68 ATOM 958 CB LEU 190 35.873 14.143 44.970 1.0022.93 ATOM 959 CG LEU 190 36.414 12.907 44.247 1.00 22.92 ATOM 960 CD1LEU 190 35.367 11.804 44.233 1.00 23.79 ATOM 961 CD2 LEU 190 36.79413.293 42.820 1.00 23.49 ATOM 962 C LEU 190 35.263 15.481 46.971 1.0021.66 ATOM 963 O LEU 190 34.128 15.954 46.880 1.00 18.61 ATOM 964 N GLN191 36.285 16.133 47.508 1.00 20.57 ATOM 965 CA GLN 191 36.157 17.50247.976 1.00 21.68 ATOM 966 CB GLN 191 37.052 17.737 49.193 1.00 22.65ATOM 967 CG GLN 191 36.635 16.951 50.422 1.00 27.39 ATOM 968 CD GLN 19137.541 17.213 51.609 1.00 28.93 ATOM 969 OE1 GLN 191 38.750 16.99251.543 1.00 31.20 ATOM 970 NE2 GLN 191 36.958 17.685 52.703 1.00 31.79ATOM 971 C GLN 191 36.629 18.361 46.804 1.00 20.53 ATOM 972 O GLN 19137.304 17.857 45.902 1.00 17.89 ATOM 973 N LEU 192 36.279 19.646 46.8141.00 18.80 ATOM 974 CA LEU 192 36.683 20.538 45.736 1.00 17.83 ATOM 975CB LEU 192 36.197 21.964 46.004 1.00 17.41 ATOM 976 CG LEU 192 36.56922.988 44.926 1.00 15.82 ATOM 977 CD1 LEU 192 35.877 22.630 43.615 1.0018.76 ATOM 978 CD2 LEU 192 36.164 24.377 45.378 1.00 17.28 ATOM 979 CLEU 192 38.199 20.540 45.568 1.00 19.20 ATOM 980 O LEU 192 38.713 20.28444.483 1.00 19.52 ATOM 981 N GLU 193 38.914 20.837 46.644 1.00 20.67ATOM 982 CA GLU 193 40.366 20.860 46.590 1.00 24.08 ATOM 983 CB GLU 19340.894 22.208 47.099 1.00 25.06 ATOM 984 CG GLU 193 40.261 23.400 46.3871.00 30.04 ATOM 985 CD GLU 193 41.009 24.704 46.605 1.00 32.48 ATOM 986OE1 GLU 193 41.103 25.165 47.764 1.00 34.10 ATOM 987 OE2 GLU 193 41.50425.270 45.606 1.00 34.77 ATOM 988 C GLU 193 40.916 19.718 47.441 1.0024.65 ATOM 989 O GLU 193 40.514 19.542 48.590 1.00 24.48 ATOM 990 N PRO194 41.831 18.914 46.877 1.00 24.86 ATOM 991 CD PRO 194 42.651 17.96747.659 1.00 24.60 ATOM 992 CA PRO 194 42.361 19.042 45.516 1.00 23.62ATOM 993 CB PRO 194 43.821 18.693 45.705 1.00 24.03 ATOM 994 CG PRO 19443.704 17.508 46.641 1.00 24.48 ATOM 995 C PRO 194 41.694 18.072 44.5391.00 22.86 ATOM 996 O PRO 194 41.957 18.116 43.337 1.00 21.75 ATOM 997 NASP 195 40.840 17.201 45.067 1.00 21.42 ATOM 998 CA ASP 195 40.17616.177 44.267 1.00 22.19 ATOM 999 CB ASP 195 39.183 15.395 45.130 1.0021.92 ATOM 1000 CG ASP 195 39.844 14.746 46.330 1.00 27.22 ATOM 1001 OD1ASP 195 40.997 14.287 46.197 1.00 27.92 ATOM 1002 OD2 ASP 195 39.20814.687 47.402 1.00 30.18 ATOM 1003 C ASP 195 39.488 16.623 42.985 1.0021.21 ATOM 1004 O ASP 195 39.953 16.301 41.893 1.00 23.11 ATOM 1005 NLEU 196 38.383 17.351 43.107 1.00 19.29 ATOM 1006 CA LEU 196 37.66217.793 41.921 1.00 18.52 ATOM 1007 CB LEU 196 36.360 18.487 42.324 1.0016.88 ATOM 1008 CG LEU 196 35.342 17.535 42.964 1.00 19.05 ATOM 1009 CD1LEU 196 34.224 18.325 43.620 1.00 19.51 ATOM 1010 CD2 LEU 196 34.79316.583 41.901 1.00 19.00 ATOM 1011 C LEU 196 38.519 18.708 41.061 1.0017.36 ATOM 1012 O LEU 196 38.435 18.675 39.837 1.00 16.52 ATOM 1013 NTHR 197 39.346 19.517 41.713 1.00 17.60 ATOM 1014 CA THR 197 40.23120.440 41.016 1.00 17.78 ATOM 1015 CB THR 197 41.020 21.316 42.023 1.0018.34 ATOM 1016 OG1 THR 197 40.137 22.295 42.592 1.00 22.95 ATOM 1017CG2 THR 197 42.172 22.032 41.334 1.00 22.61 ATOM 1018 C THR 197 41.20519.679 40.120 1.00 18.14 ATOM 1019 O THR 197 41.460 20.089 38.987 1.0015.11 ATOM 1020 N ASN 198 41.747 18.575 40.633 1.00 18.47 ATOM 1021 CAASN 198 42.679 17.760 39.860 1.00 19.73 ATOM 1022 CB ASN 198 43.29816.648 40.721 1.00 24.67 ATOM 1023 CG ASN 198 44.208 17.185 41.815 1.0030.01 ATOM 1024 OD1 ASN 198 44.853 18.223 41.655 1.00 32.67 ATOM 1025ND2 ASN 198 44.282 16.460 42.930 1.00 33.72 ATOM 1026 C ASN 198 41.96817.128 38.669 1.00 16.49 ATOM 1027 O ASN 198 42.514 17.091 37.569 1.0017.40 ATOM 1028 N VAL 199 40.754 16.626 38.889 1.00 15.82 ATOM 1029 CAVAL 199 39.988 16.013 37.806 1.00 14.87 ATOM 1030 CB VAL 199 38.60515.504 38.290 1.00 15.42 ATOM 1031 CG1 VAL 199 37.766 15.069 37.091 1.0015.86 ATOM 1032 CG2 VAL 199 38.776 14.317 39.255 1.00 14.36 ATOM 1033 CVAL 199 39.771 17.013 36.666 1.00 14.32 ATOM 1034 O VAL 199 39.96516.688 35.491 1.00 11.80 ATOM 1035 N MET 200 39.366 18.231 37.016 1.0014.83 ATOM 1036 CA MET 200 39.123 19.259 36.008 1.00 14.38 ATOM 1037 CBMET 200 38.524 20.517 36.650 1.00 12.52 ATOM 1038 CG MET 200 37.12820.328 37.233 1.00 12.28 ATOM 1039 SD MET 200 35.935 19.690 36.045 1.0014.88 ATOM 1040 CE MET 200 35.797 21.097 34.903 1.00 12.30 ATOM 1041 CMET 200 40.405 19.632 35.274 1.00 13.50 ATOM 1042 O MET 200 40.37519.989 34.099 1.00 13.68 ATOM 1043 N ALA 201 41.533 19.535 35.966 1.0012.51 ATOM 1044 CA ALA 201 42.814 19.891 35.372 1.00 14.22 ATOM 1045 CBALA 201 43.762 20.372 36.465 1.00 12.68 ATOM 1046 C ALA 201 43.50118.794 34.556 1.00 14.13 ATOM 1047 O ALA 201 44.239 19.092 33.619 1.0013.71 ATOM 1048 N THR 202 43.246 17.534 34.889 1.00 13.05 ATOM 1049 CATHR 202 43.932 16.442 34.211 1.00 14.28 ATOM 1050 CB THR 202 44.67715.579 35.243 1.00 13.91 ATOM 1051 OG1 THR 202 43.734 15.052 36.182 1.0016.38 ATOM 1052 CG2 THR 202 45.702 16.412 35.995 1.00 14.07 ATOM 1053 CTHR 202 43.105 15.512 33.329 1.00 14.85 ATOM 1054 O THR 202 43.63114.920 32.382 1.00 13.44 ATOM 1055 N SER 203 41.824 15.356 33.637 1.0014.42 ATOM 1056 CA SER 203 40.993 14.482 32.821 1.00 15.37 ATOM 1057 CBSER 203 39.620 14.296 33.458 1.00 15.43 ATOM 1058 OG SER 203 38.77113.571 32.585 1.00 16.22 ATOM 1059 C SER 203 40.817 15.043 31.410 1.0017.26 ATOM 1060 O SER 203 40.718 16.258 31.216 1.00 15.56 ATOM 1061 NARG 204 40.788 14.143 30.431 1.00 17.39 ATOM 1062 CA ARG 204 40.59814.503 29.030 1.00 19.50 ATOM 1063 CB ARG 204 41.869 14.206 28.224 1.0021.26 ATOM 1064 CG ARG 204 42.743 15.424 27.899 1.00 24.82 ATOM 1065 CDARG 204 42.745 16.460 29.009 1.00 25.90 ATOM 1066 NE ARG 204 43.95017.284 29.001 1.00 25.48 ATOM 1067 CZ ARG 204 44.225 18.207 29.921 1.0026.92 ATOM 1068 NH1 ARG 204 45.345 18.908 29.852 1.00 26.07 ATOM 1069NH2 ARG 204 43.372 18.437 30.908 1.00 28.93 ATOM 1070 C ARG 204 39.42513.679 28.497 1.00 19.23 ATOM 1071 O ARG 204 39.299 13.448 27.292 1.0018.09 ATOM 1072 N LYS 205 38.575 13.231 29.416 1.00 19.44 ATOM 1073 CALYS 205 37.397 12.444 29.069 1.00 20.20 ATOM 1074 CB LYS 205 37.34011.175 29.922 1.00 20.93 ATOM 1075 CG LYS 205 38.602 10.323 29.803 1.0026.30 ATOM 1076 CD LYS 205 38.426 8.924 30.380 1.00 29.11 ATOM 1077 CELYS 205 37.499 8.077 29.518 1.00 32.25 ATOM 1078 NZ LYS 205 37.474 6.65229.959 1.00 35.02 ATOM 1079 C LYS 205 36.160 13.304 29.303 1.00 18.71ATOM 1080 O LYS 205 35.854 13.680 30.440 1.00 17.01 ATOM 1081 N TYR 20635.457 13.608 28.215 1.00 16.75 ATOM 1082 CA TYR 206 34.263 14.45328.241 1.00 16.98 ATOM 1083 CB TYR 206 33.550 14.383 26.884 1.00 16.42ATOM 1084 CG TYR 206 32.574 15.513 26.617 1.00 16.97 ATOM 1085 CD1 TYR206 32.941 16.599 25.821 1.00 15.01 ATOM 1086 CE1 TYR 206 32.044 17.62125.539 1.00 16.36 ATOM 1087 CD2 TYR 206 31.275 15.485 27.135 1.00 15.21ATOM 1088 CE2 TYR 206 30.370 16.509 26.862 1.00 15.72 ATOM 1089 CZ TYR206 30.761 17.573 26.061 1.00 17.54 ATOM 1090 OH TYR 206 29.874 18.59025.772 1.00 19.58 ATOM 1091 C TYR 206 33.273 14.106 29.350 1.00 16.80ATOM 1092 O TYR 206 32.772 14.990 30.039 1.00 16.60 ATOM 1093 N GLU 20732.980 12.819 29.514 1.00 16.66 ATOM 1094 CA GLU 207 32.029 12.38730.533 1.00 15.78 ATOM 1095 CB GLU 207 31.584 10.941 30.268 1.00 16.34ATOM 1096 CG GLU 207 30.808 10.730 28.962 1.00 17.93 ATOM 1097 CD GLU207 29.479 11.488 28.917 1.00 21.81 ATOM 1098 OE1 GLU 207 28.742 11.47529.925 1.00 20.91 ATOM 1099 OE2 GLU 207 29.166 12.089 27.863 1.00 22.78ATOM 1100 C GLU 207 32.565 12.511 31.960 1.00 14.53 ATOM 1101 O GLU 20731.798 12.773 32.886 1.00 15.02 ATOM 1102 N ASP 208 33.867 12.312 32.1471.00 13.86 ATOM 1103 CA ASP 208 34.445 12.422 33.489 1.00 14.82 ATOM1104 CB ASP 208 35.870 11.854 33.531 1.00 16.21 ATOM 1105 CG ASP 20835.912 10.338 33.365 1.00 20.87 ATOM 1106 OD1 ASP 208 34.883 9.67433.606 1.00 23.51 ATOM 1107 OD2 ASP 208 36.984 9.805 33.011 1.00 22.35ATOM 1108 C ASP 208 34.460 13.890 33.920 1.00 13.51 ATOM 1109 O ASP 20834.160 14.216 35.068 1.00 10.65 ATOM 1110 N LEU 209 34.808 14.771 32.9881.00 12.89 ATOM 1111 CA LEU 209 34.838 16.200 33.269 1.00 12.10 ATOM1112 CB LEU 209 35.407 16.951 32.063 1.00 11.37 ATOM 1113 CG LEU 20936.907 16.746 31.811 1.00 10.29 ATOM 1114 CD1 LEU 209 37.298 17.35330.474 1.00 9.40 ATOM 1115 CD2 LEU 209 37.705 17.380 32.950 1.00 9.04ATOM 1116 C LEU 209 33.421 16.684 33.575 1.00 13.60 ATOM 1117 O LEU 20933.210 17.517 34.460 1.00 12.24 ATOM 1118 N LEU 210 32.452 16.145 32.8431.00 12.89 ATOM 1119 CA LEU 210 31.058 16.516 33.033 1.00 13.89 ATOM1120 CB LEU 210 30.193 15.862 31.951 1.00 16.04 ATOM 1121 CG LEU 21028.700 16.200 31.985 1.00 17.33 ATOM 1122 CD1 LEU 210 28.515 17.71131.938 1.00 18.83 ATOM 1123 CD2 LEU 210 28.003 15.543 30.803 1.00 18.20ATOM 1124 C LEU 210 30.561 16.100 34.415 1.00 14.94 ATOM 1125 O LEU 21029.848 16.849 35.089 1.00 13.44 ATOM 1126 N TRP 211 30.938 14.895 34.8291.00 14.27 ATOM 1127 CA TRP 211 30.543 14.377 36.133 1.00 14.75 ATOM1128 CB TRP 211 31.191 13.003 36.380 1.00 17.05 ATOM 1129 CG TRP 21130.897 12.452 37.745 1.00 19.27 ATOM 1130 CD2 TRP 211 31.702 12.60038.925 1.00 19.31 ATOM 1131 CE2 TRP 211 30.996 12.007 39.991 1.00 20.70ATOM 1132 CE3 TRP 211 32.950 13.183 39.183 1.00 20.90 ATOM 1133 CD1 TRP211 29.772 11.788 38.133 1.00 21.04 ATOM 1134 NE1 TRP 211 29.822 11.51739.482 1.00 21.92 ATOM 1135 CZ2 TRP 211 31.496 11.977 41.301 1.00 23.12ATOM 1136 CZ3 TRP 211 33.448 13.154 40.485 1.00 21.37 ATOM 1137 CH2 TRP211 32.720 12.556 41.526 1.00 21.61 ATOM 1138 C TRP 211 30.977 15.35037.236 1.00 13.96 ATOM 1139 O TRP 211 30.183 15.722 38.096 1.00 11.98ATOM 1140 N ALA 212 32.244 15.753 37.200 1.00 13.24 ATOM 1141 CA ALA 21232.790 16.673 38.195 1.00 13.44 ATOM 1142 CB ALA 212 34.313 16.74338.057 1.00 12.36 ATOM 1143 C ALA 212 32.194 18.076 38.081 1.00 13.04ATOM 1144 O ALA 212 31.875 18.707 39.091 1.00 13.12 ATOM 1145 N TRP 21332.050 18.560 36.851 1.00 13.51 ATOM 1146 CA TRP 213 31.503 19.89636.601 1.00 13.80 ATOM 1147 CB TRP 213 31.554 20.212 35.099 1.00 13.04ATOM 1148 CG TRP 213 31.128 21.614 34.756 1.00 12.05 ATOM 1149 CD2 TRP213 29.800 22.062 34.454 1.00 12.15 ATOM 1150 CE2 TRP 213 29.870 23.45834.233 1.00 13.44 ATOM 1151 CE3 TRP 213 28.556 21.421 34.352 1.00 12.18ATOM 1152 CD1 TRP 213 31.925 22.723 34.704 1.00 14.22 ATOM 1153 NE1 TRP213 31.177 23.834 34.390 1.00 12.82 ATOM 1154 CZ2 TRP 213 28.741 24.22733.915 1.00 12.19 ATOM 1155 CZ3 TRP 213 27.434 22.184 34.035 1.00 12.97ATOM 1156 CH2 TRP 213 27.536 23.574 33.821 1.00 12.27 ATOM 1157 C TRP213 30.058 20.014 37.094 1.00 13.65 ATOM 1158 O TRP 213 29.711 20.94437.824 1.00 12.41 ATOM 1159 N GLU 214 29.223 19.065 36.678 1.00 14.41ATOM 1160 CA GLU 214 27.815 19.043 37.055 1.00 15.02 ATOM 1161 CB GLU214 27.067 18.017 36.200 1.00 16.55 ATOM 1162 CG GLU 214 25.569 17.94536.459 1.00 19.62 ATOM 1163 CD GLU 214 24.851 19.220 36.077 1.00 21.05ATOM 1164 OE1 GLU 214 25.063 19.698 34.944 1.00 24.80 ATOM 1165 OE2 GLU214 24.068 19.743 36.901 1.00 24.78 ATOM 1166 C GLU 214 27.636 18.70438.533 1.00 15.51 ATOM 1167 O GLU 214 26.829 19.320 39.232 1.00 14.95ATOM 1168 N GLY 215 28.398 17.722 39.002 1.00 15.44 ATOM 1169 CA GLY 21528.302 17.307 40.389 1.00 15.35 ATOM 1170 C GLY 215 28.587 18.422 41.3731.00 15.21 ATOM 1171 O GLY 215 27.857 18.604 42.345 1.00 15.46 ATOM 1172N TRP 216 29.650 19.176 41.121 1.00 15.46 ATOM 1173 CA TRP 216 30.00920.267 42.011 1.00 14.95 ATOM 1174 CB TRP 216 31.285 20.965 41.528 1.0014.52 ATOM 1175 CG TRP 216 31.676 22.122 42.404 1.00 13.26 ATOM 1176 CD2TRP 216 31.967 22.071 43.807 1.00 14.02 ATOM 1177 CE2 TRP 216 32.20723.399 44.233 1.00 14.00 ATOM 1178 CE3 TRP 216 32.046 21.033 44.747 1.0013.78 ATOM 1179 CD1 TRP 216 31.755 23.437 42.045 1.00 11.53 ATOM 1180NE1 TRP 216 32.073 24.210 43.138 1.00 12.94 ATOM 1181 CZ2 TRP 216 32.51923.717 45.558 1.00 13.90 ATOM 1182 CZ3 TRP 216 32.357 21.349 46.068 1.0015.08 ATOM 1183 CH2 TRP 216 32.589 22.684 46.459 1.00 16.36 ATOM 1184 CTRP 216 28.874 21.276 42.111 1.00 14.83 ATOM 1185 O TRP 216 28.56021.768 43.193 1.00 16.29 ATOM 1186 N ARG 217 28.253 21.575 40.978 1.0014.63 ATOM 1187 CA ARG 217 27.159 22.528 40.959 1.00 14.60 ATOM 1188 CBARG 217 26.903 22.978 39.517 1.00 12.12 ATOM 1189 CG ARG 217 28.04223.875 39.021 1.00 13.34 ATOM 1190 CD ARG 217 28.071 24.122 37.520 1.0012.75 ATOM 1191 NE ARG 217 29.163 25.043 37.206 1.00 12.99 ATOM 1192 CZARG 217 30.458 24.750 37.326 1.00 11.14 ATOM 1193 NH1 ARG 217 31.37325.658 37.033 1.00 12.84 ATOM 1194 NH2 ARG 217 30.844 23.544 37.714 1.0012.36 ATOM 1195 C ARG 217 25.905 21.958 41.622 1.00 15.54 ATOM 1196 OARG 217 25.174 22.680 42.293 1.00 15.86 ATOM 1197 N ASP 218 25.67220.657 41.459 1.00 16.94 ATOM 1198 CA ASP 218 24.515 20.012 42.077 1.0017.27 ATOM 1199 CB ASP 218 24.403 18.543 41.652 1.00 16.71 ATOM 1200 CGASP 218 24.061 18.372 40.185 1.00 19.76 ATOM 1201 OD1 ASP 218 23.64419.355 39.531 1.00 21.08 ATOM 1202 OD2 ASP 218 24.194 17.233 39.691 1.0019.39 ATOM 1203 C ASP 218 24.624 20.048 43.601 1.00 16.65 ATOM 1204 OASP 218 23.633 20.251 44.300 1.00 18.01 ATOM 1205 N LYS 219 25.83619.846 44.108 1.00 17.48 ATOM 1206 CA LYS 219 26.068 19.814 45.550 1.0018.13 ATOM 1207 CB LYS 219 27.184 18.817 45.867 1.00 18.30 ATOM 1208 CGLYS 219 26.905 17.403 45.361 1.00 20.52 ATOM 1209 CD LYS 219 25.60016.846 45.927 1.00 21.52 ATOM 1210 CE LYS 219 25.657 16.721 47.445 1.0023.83 ATOM 1211 NZ LYS 219 26.779 15.849 47.890 1.00 24.81 ATOM 1212 CLYS 219 26.376 21.151 46.221 1.00 18.56 ATOM 1213 O LYS 219 25.86421.430 47.302 1.00 19.73 ATOM 1214 N ALA 220 27.221 21.972 45.607 1.0018.09 ATOM 1215 CA ALA 220 27.552 23.264 46.207 1.00 17.10 ATOM 1216 CBALA 220 28.988 23.656 45.867 1.00 16.84 ATOM 1217 C ALA 220 26.58524.350 45.739 1.00 15.48 ATOM 1218 O ALA 220 25.976 25.038 46.553 1.0016.35 ATOM 1219 N GLY 221 26.444 24.486 44.425 1.00 14.00 ATOM 1220 CAGLY 221 25.561 25.491 43.868 1.00 12.74 ATOM 1221 C GLY 221 24.11825.433 44.344 1.00 15.22 ATOM 1222 O GLY 221 23.598 26.412 44.886 1.0015.26 ATOM 1223 N ARG 222 23.461 24.295 44.147 1.00 14.02 ATOM 1224 CAARG 222 22.068 24.157 44.556 1.00 15.84 ATOM 1225 CB ARG 222 21.53222.774 44.160 1.00 16.90 ATOM 1226 CG ARG 222 21.412 22.572 42.655 1.0016.24 ATOM 1227 CD ARG 222 20.870 21.182 42.318 1.00 20.12 ATOM 1228 NEARG 222 20.609 21.044 40.888 1.00 23.09 ATOM 1229 CZ ARG 222 20.39919.884 40.269 1.00 25.88 ATOM 1230 NH1 ARG 222 20.417 18.746 40.952 1.0024.84 ATOM 1231 NH2 ARG 222 20.182 19.860 38.960 1.00 26.85 ATOM 1232 CARG 222 21.846 24.385 46.050 1.00 14.53 ATOM 1233 O ARG 222 20.81324.918 46.452 1.00 15.21 ATOM 1234 N ALA 223 22.821 23.991 46.861 1.0013.97 ATOM 1235 CA ALA 223 22.729 24.133 48.310 1.00 14.89 ATOM 1236 CBALA 223 23.818 23.284 48.980 1.00 14.97 ATOM 1237 C ALA 223 22.82225.581 48.794 1.00 15.26 ATOM 1238 O ALA 223 22.443 25.891 49.923 1.0015.20 ATOM 1239 N ILE 224 23.328 26.470 47.949 1.00 14.59 ATOM 1240 CAILE 224 23.444 27.871 48.338 1.00 13.97 ATOM 1241 CB ILE 224 24.65128.545 47.629 1.00 13.29 ATOM 1242 CG2 ILE 224 24.713 30.027 47.970 1.0011.18 ATOM 1243 CG1 ILE 224 25.950 27.852 48.051 1.00 15.89 ATOM 1244CD1 ILE 224 26.228 27.904 49.550 1.00 14.70 ATOM 1245 C ILE 224 22.16328.644 48.007 1.00 13.79 ATOM 1246 O ILE 224 21.842 29.638 48.655 1.0014.26 ATOM 1247 N LEU 225 21.422 28.167 47.014 1.00 13.03 ATOM 1248 CALEU 225 20.203 28.834 46.578 1.00 13.73 ATOM 1249 CB LEU 225 19.52128.011 45.481 1.00 13.73 ATOM 1250 CG LEU 225 18.230 28.616 44.922 1.0015.14 ATOM 1251 CD1 LEU 225 18.513 29.995 44.338 1.00 13.02 ATOM 1252CD2 LEU 225 17.646 27.684 43.865 1.00 15.05 ATOM 1253 C LEU 225 19.18829.170 47.673 1.00 15.99 ATOM 1254 O LEU 225 18.557 30.228 47.626 1.0016.45 ATOM 1255 N GLN 226 19.022 28.296 48.661 1.00 17.25 ATOM 1256 CAGLN 226 18.053 28.578 49.717 1.00 17.93 ATOM 1257 CB GLN 226 17.86027.365 50.629 1.00 18.12 ATOM 1258 CG GLN 226 19.093 26.934 51.392 1.0021.07 ATOM 1259 CD GLN 226 18.752 26.031 52.566 1.00 25.37 ATOM 1260 OE1GLN 226 19.475 25.083 52.869 1.00 28.28 ATOM 1261 NE2 GLN 226 17.65126.334 53.242 1.00 25.39 ATOM 1262 C GLN 226 18.422 29.787 50.570 1.0018.27 ATOM 1263 O GLN 226 17.552 30.381 51.207 1.00 18.35 ATOM 1264 NPHE 227 19.702 30.158 50.579 1.00 17.08 ATOM 1265 CA PHE 227 20.15631.298 51.376 1.00 17.03 ATOM 1266 CB PHE 227 21.531 31.015 52.001 1.0017.75 ATOM 1267 CG PHE 227 21.594 29.756 52.820 1.00 19.66 ATOM 1268 CD1PHE 227 22.214 28.617 52.315 1.00 18.54 ATOM 1269 CD2 PHE 227 21.05829.715 54.102 1.00 19.80 ATOM 1270 CE1 PHE 227 22.303 27.457 53.077 1.0020.33 ATOM 1271 CE2 PHE 227 21.138 28.560 54.874 1.00 20.11 ATOM 1272 CZPHE 227 21.763 27.428 54.362 1.00 21.23 ATOM 1273 C PHE 227 20.27732.631 50.635 1.00 15.96 ATOM 1274 O PHE 227 20.123 33.686 51.243 1.0014.83 ATOM 1275 N TYR 228 20.552 32.588 49.332 1.00 14.81 ATOM 1276 CATYR 228 20.786 33.813 48.566 1.00 13.93 ATOM 1277 CB TYR 228 21.16333.484 47.114 1.00 12.40 ATOM 1278 CG TYR 228 22.287 34.363 46.617 1.0011.13 ATOM 1279 CD1 TYR 228 23.561 34.271 47.181 1.00 10.09 ATOM 1280CE1 TYR 228 24.596 35.119 46.780 1.00 9.24 ATOM 1281 CD2 TYR 228 22.07335.327 45.628 1.00 12.00 ATOM 1282 CE2 TYR 228 23.105 36.184 45.218 1.009.28 ATOM 1283 CZ TYR 228 24.361 36.073 45.803 1.00 10.33 ATOM 1284 OHTYR 228 25.380 36.927 45.447 1.00 9.24 ATOM 1285 C TYR 228 19.750 34.93048.561 1.00 14.20 ATOM 1286 O TYR 228 20.095 36.092 48.787 1.00 13.92ATOM 1287 N PRO 229 18.476 34.615 48.287 1.00 15.32 ATOM 1288 CD PRO 22917.850 33.355 47.841 1.00 14.61 ATOM 1289 CA PRO 229 17.504 35.71348.288 1.00 14.32 ATOM 1290 CB PRO 229 16.183 35.001 48.005 1.00 14.50ATOM 1291 CG PRO 229 16.612 33.854 47.114 1.00 14.48 ATOM 1292 C PRO 22917.487 36.503 49.603 1.00 15.12 ATOM 1293 O PRO 229 17.378 37.731 49.5921.00 14.15 ATOM 1294 N LYS 230 17.612 35.803 50.730 1.00 15.42 ATOM 1295CA LYS 230 17.598 36.463 52.038 1.00 15.89 ATOM 1296 CB LYS 230 17.45935.441 53.166 1.00 16.82 ATOM 1297 CG LYS 230 16.964 36.061 54.462 1.0019.46 ATOM 1298 CD LYS 230 15.624 36.737 54.200 1.00 24.16 ATOM 1299 CELYS 230 14.959 37.224 55.463 1.00 28.11 ATOM 1300 NZ LYS 230 13.63037.824 55.153 1.00 26.83 ATOM 1301 C LYS 230 18.871 37.272 52.240 1.0014.81 ATOM 1302 O LYS 230 18.852 38.364 52.811 1.00 12.92 ATOM 1303 NTYR 231 19.979 36.714 51.774 1.00 14.42 ATOM 1304 CA TYR 231 21.27037.375 51.848 1.00 11.87 ATOM 1305 CB TYR 231 22.330 36.466 51.223 1.0011.76 ATOM 1306 CG TYR 231 23.525 37.197 50.660 1.00 10.89 ATOM 1307 CD1TYR 231 24.499 37.736 51.500 1.00 9.98 ATOM 1308 CE1 TYR 231 25.61238.397 50.976 1.00 12.44 ATOM 1309 CD2 TYR 231 23.683 37.341 49.279 1.0011.71 ATOM 1310 CE2 TYR 231 24.788 38.004 48.745 1.00 12.56 ATOM 1311 CZTYR 231 25.750 38.523 49.597 1.00 11.83 ATOM 1312 OH TYR 231 26.87039.120 49.071 1.00 11.18 ATOM 1313 C TYR 231 21.191 38.699 51.080 1.0011.12 ATOM 1314 O TYR 231 21.616 39.741 51.575 1.00 12.14 ATOM 1315 NVAL 232 20.654 38.646 49.864 1.00 11.62 ATOM 1316 CA VAL 232 20.51639.833 49.019 1.00 10.85 ATOM 1317 CB VAL 232 19.900 39.455 47.648 1.0011.31 ATOM 1318 CG1 VAL 232 19.439 40.697 46.900 1.00 10.40 ATOM 1319CG2 VAL 232 20.934 38.699 46.821 1.00 11.64 ATOM 1320 C VAL 232 19.65840.904 49.698 1.00 12.40 ATOM 1321 O VAL 232 19.992 42.096 49.682 1.0011.44 ATOM 1322 N GLU 233 18.557 40.473 50.303 1.00 12.62 ATOM 1323 CAGLU 233 17.661 41.389 50.995 1.00 14.05 ATOM 1324 CB GLU 233 16.43740.617 51.506 1.00 17.42 ATOM 1325 CG GLU 233 15.557 41.381 52.487 1.0022.94 ATOM 1326 CD GLU 233 14.322 40.593 52.907 1.00 27.83 ATOM 1327 OE1GLU 233 14.416 39.355 53.069 1.00 29.39 ATOM 1328 OE2 GLU 233 13.25641.216 53.089 1.00 32.62 ATOM 1329 C GLU 233 18.367 42.098 52.155 1.0012.54 ATOM 1330 O GLU 233 18.313 43.320 52.273 1.00 13.58 ATOM 1331 NLEU 234 19.043 41.328 52.999 1.00 12.59 ATOM 1332 CA LEU 234 19.73841.885 54.153 1.00 12.98 ATOM 1333 CB LEU 234 20.149 40.758 55.106 1.0013.67 ATOM 1334 CG LEU 234 18.968 40.015 55.738 1.00 16.89 ATOM 1335 CD1LEU 234 19.464 38.803 56.512 1.00 16.48 ATOM 1336 CD2 LEU 234 18.20040.964 56.650 1.00 16.76 ATOM 1337 C LEU 234 20.952 42.750 53.820 1.0012.60 ATOM 1338 O LEU 234 21.145 43.801 54.430 1.00 11.00 ATOM 1339 NILE 235 21.774 42.328 52.862 1.00 10.69 ATOM 1340 CA ILE 235 22.94543.130 52.522 1.00 10.15 ATOM 1341 CB ILE 235 23.963 42.341 51.654 1.0011.30 ATOM 1342 CG2 ILE 235 23.383 42.074 50.252 1.00 8.24 ATOM 1343 CG1ILE 235 25.283 43.124 51.589 1.00 9.63 ATOM 1344 CD1 ILE 235 26.42642.355 50.948 1.00 9.83 ATOM 1345 C ILE 235 22.525 44.422 51.820 1.009.51 ATOM 1346 O ILE 235 23.177 45.456 51.970 1.00 9.55 ATOM 1347 N ASN236 21.430 44.372 51.066 1.00 9.09 ATOM 1348 CA ASN 236 20.925 45.57050.398 1.00 10.19 ATOM 1349 CB ASN 236 19.825 45.225 49.385 1.00 10.23ATOM 1350 CG ASN 236 20.371 44.929 48.001 1.00 11.26 ATOM 1351 OD1 ASN236 21.501 45.293 47.677 1.00 10.18 ATOM 1352 ND2 ASN 236 19.557 44.29047.167 1.00 12.22 ATOM 1353 C ASN 236 20.356 46.525 51.453 1.00 11.01ATOM 1354 O ASN 236 20.569 47.738 51.387 1.00 10.90 ATOM 1355 N GLN 23719.630 45.969 52.421 1.00 12.58 ATOM 1356 CA GLN 237 19.038 46.76953.489 1.00 12.11 ATOM 1357 CB GLN 237 18.264 45.876 54.460 1.00 14.23ATOM 1358 CG GLN 237 17.428 46.638 55.483 1.00 14.79 ATOM 1359 CD GLN237 16.781 45.714 56.502 1.00 18.93 ATOM 1360 OE1 GLN 237 16.567 44.53256.233 1.00 20.61 ATOM 1361 NE2 GLN 237 16.455 46.254 57.672 1.00 17.63ATOM 1362 C GLN 237 20.149 47.498 54.239 1.00 12.36 ATOM 1363 O GLN 23720.038 48.687 54.537 1.00 12.83 ATOM 1364 N ALA 238 21.218 46.771 54.5491.00 10.55 ATOM 1365 CA ALA 238 22.353 47.361 55.245 1.00 10.94 ATOM1366 CB ALA 238 23.431 46.316 55.473 1.00 7.92 ATOM 1367 C ALA 23822.909 48.509 54.408 1.00 11.58 ATOM 1368 O ALA 238 23.205 49.578 54.9311.00 12.66 ATOM 1369 N ALA 239 23.045 48.280 53.104 1.00 11.03 ATOM 1370CA ALA 239 23.569 49.302 52.207 1.00 12.87 ATOM 1371 CB ALA 239 23.64748.762 50.779 1.00 11.95 ATOM 1372 C ALA 239 22.719 50.570 52.245 1.0013.46 ATOM 1373 O ALA 239 23.257 51.677 52.337 1.00 12.98 ATOM 1374 NARG 240 21.396 50.408 52.180 1.00 13.34 ATOM 1375 CA ARG 240 20.49151.556 52.204 1.00 13.67 ATOM 1376 CB ARG 240 19.037 51.122 51.959 1.0012.51 ATOM 1377 CG ARG 240 18.763 50.570 50.559 1.00 14.85 ATOM 1378 CDARG 240 17.266 50.496 50.262 1.00 13.15 ATOM 1379 NE ARG 240 16.53149.731 51.269 1.00 15.23 ATOM 1380 CZ ARG 240 16.450 48.405 51.307 1.0017.70 ATOM 1381 NH1 ARG 240 17.060 47.665 50.380 1.00 15.68 ATOM 1382NH2 ARG 240 15.759 47.814 52.278 1.00 16.05 ATOM 1383 C ARG 240 20.58352.299 53.533 1.00 13.93 ATOM 1384 O ARG 240 20.502 53.526 53.571 1.0013.67 ATOM 1385 N LEU 241 20.753 51.553 54.619 1.00 14.68 ATOM 1386 CALEU 241 20.853 52.155 55.941 1.00 15.52 ATOM 1387 CB LEU 241 20.73151.075 57.025 1.00 14.97 ATOM 1388 CG LEU 241 19.324 50.472 57.150 1.0016.48 ATOM 1389 CD1 LEU 241 19.332 49.281 58.102 1.00 14.35 ATOM 1390CD2 LEU 241 18.361 51.552 57.644 1.00 17.43 ATOM 1391 C LEU 241 22.15952.927 56.096 1.00 15.83 ATOM 1392 O LEU 241 22.331 53.695 57.047 1.0015.43 ATOM 1393 N ASN 242 23.074 52.729 55.152 1.00 14.16 ATOM 1394 CAASN 242 24.350 53.426 55.185 1.00 13.59 ATOM 1395 CB ASN 242 25.50052.423 55.067 1.00 12.71 ATOM 1396 CG ASN 242 25.778 51.711 56.384 1.0015.20 ATOM 1397 OD1 ASN 242 26.069 52.354 57.395 1.00 14.44 ATOM 1398ND2 ASN 242 25.678 50.385 56.382 1.00 13.74 ATOM 1399 C ASN 242 24.46354.516 54.120 1.00 13.25 ATOM 1400 O ASN 242 25.540 55.063 53.894 1.0013.69 ATOM 1401 N GLY 243 23.346 54.820 53.462 1.00 13.09 ATOM 1402 CAGLY 243 23.341 55.876 52.462 1.00 14.67 ATOM 1403 C GLY 243 23.44255.495 50.997 1.00 12.85 ATOM 1404 O GLY 243 23.392 56.375 50.137 1.0013.08 ATOM 1405 N TYR 244 23.595 54.207 50.701 1.00 12.73 ATOM 1406 CATYR 244 23.697 53.752 49.312 1.00 12.34 ATOM 1407 CB TYR 244 24.71552.609 49.200 1.00 10.80 ATOM 1408 CG TYR 244 26.115 52.990 49.633 1.0012.14 ATOM 1409 CD1 TYR 244 26.589 52.660 50.901 1.00 11.88 ATOM 1410CE1 TYR 244 27.870 53.038 51.316 1.00 10.81 ATOM 1411 CD2 TYR 244 26.95653.711 48.783 1.00 9.56 ATOM 1412 CE2 TYR 244 28.237 54.096 49.189 1.0010.67 ATOM 1413 CZ TYR 244 28.684 53.757 50.455 1.00 10.80 ATOM 1414 OHTYR 244 29.937 54.150 50.864 1.00 13.51 ATOM 1415 C TYR 244 22.33753.281 48.802 1.00 12.43 ATOM 1416 O TYR 244 21.401 53.121 49.585 1.0015.41 ATOM 1417 N VAL 245 22.215 53.064 47.493 1.00 13.45 ATOM 1418 CAVAL 245 20.945 52.596 46.937 1.00 13.11 ATOM 1419 CB VAL 245 20.75253.071 45.476 1.00 15.33 ATOM 1420 CG1 VAL 245 20.670 54.595 45.446 1.0017.06 ATOM 1421 CG2 VAL 245 21.894 52.589 44.604 1.00 15.86 ATOM 1422 CVAL 245 20.807 51.073 47.015 1.00 11.99 ATOM 1423 O VAL 245 19.69750.549 47.045 1.00 13.05 ATOM 1424 N ASP 246 21.936 50.368 47.047 1.009.74 ATOM 1425 CA ASP 246 21.946 48.907 47.163 1.00 10.63 ATOM 1426 CBASP 246 21.378 48.233 45.896 1.00 9.06 ATOM 1427 CG ASP 246 22.20248.520 44.644 1.00 11.98 ATOM 1428 OD1 ASP 246 23.385 48.125 44.586 1.0010.98 ATOM 1429 OD2 ASP 246 21.658 49.140 43.708 1.00 10.66 ATOM 1430 CASP 246 23.373 48.424 47.444 1.00 9.60 ATOM 1431 O ASP 246 24.308 49.21947.429 1.00 11.47 ATOM 1432 N ALA 247 23.538 47.130 47.706 1.00 9.86ATOM 1433 CA ALA 247 24.858 46.577 48.007 1.00 10.45 ATOM 1434 CB ALA247 24.738 45.084 48.336 1.00 9.21 ATOM 1435 C ALA 247 25.895 46.78746.894 1.00 9.94 ATOM 1436 O ALA 247 27.072 47.006 47.177 1.00 10.23ATOM 1437 N GLY 248 25.465 46.701 45.638 1.00 9.68 ATOM 1438 CA GLY 24826.388 46.894 44.527 1.00 9.78 ATOM 1439 C GLY 248 26.974 48.297 44.5511.00 12.15 ATOM 1440 O GLY 248 28.177 48.499 44.354 1.00 11.20 ATOM 1441N ASP 249 26.103 49.271 44.790 1.00 12.09 ATOM 1442 CA ASP 249 26.49450.674 44.873 1.00 12.50 ATOM 1443 CB ASP 249 25.246 51.506 45.210 1.0012.82 ATOM 1444 CG ASP 249 25.528 52.995 45.337 1.00 13.95 ATOM 1445 OD1ASP 249 26.395 53.521 44.610 1.00 13.98 ATOM 1446 OD2 ASP 249 24.85153.647 46.159 1.00 13.82 ATOM 1447 C ASP 249 27.562 50.795 45.961 1.0012.92 ATOM 1448 O ASP 249 28.640 51.350 45.741 1.00 11.95 ATOM 1449 NSER 250 27.255 50.251 47.133 1.00 13.21 ATOM 1450 CA SER 250 28.17850.277 48.259 1.00 13.25 ATOM 1451 CB SER 250 27.585 49.479 49.424 1.0014.69 ATOM 1452 OG SER 250 28.391 49.595 50.583 1.00 18.32 ATOM 1453 CSER 250 29.557 49.705 47.876 1.00 12.60 ATOM 1454 O SER 250 30.58750.324 48.143 1.00 11.74 ATOM 1455 N TRP 251 29.574 48.530 47.251 1.0010.27 ATOM 1456 CA TRP 251 30.840 47.908 46.847 1.00 11.25 ATOM 1457 CBTRP 251 30.587 46.525 46.236 1.00 10.10 ATOM 1458 CG TRP 251 30.16345.479 47.223 1.00 10.89 ATOM 1459 CD2 TRP 251 29.970 44.084 46.957 1.0010.95 ATOM 1460 CE2 TRP 251 29.587 43.475 48.174 1.00 12.43 ATOM 1461CE3 TRP 251 30.086 43.288 45.808 1.00 9.38 ATOM 1462 CD1 TRP 251 29.89545.657 48.554 1.00 10.57 ATOM 1463 NE1 TRP 251 29.549 44.457 49.129 1.0012.56 ATOM 1464 CZ2 TRP 251 29.317 42.101 48.276 1.00 11.07 ATOM 1465CZ3 TRP 251 29.817 41.923 45.909 1.00 10.48 ATOM 1466 CH2 TRP 251 29.43741.345 47.135 1.00 9.03 ATOM 1467 C TRP 251 31.641 48.751 45.852 1.0010.66 ATOM 1468 O TRP 251 32.847 48.926 46.009 1.00 11.21 ATOM 1469 NARG 252 30.972 49.266 44.824 1.00 10.93 ATOM 1470 CA ARG 252 31.65450.075 43.824 1.00 10.15 ATOM 1471 CB ARG 252 30.691 50.462 42.686 1.0010.20 ATOM 1472 CG ARG 252 30.225 49.288 41.810 1.00 9.68 ATOM 1473 CDARG 252 29.435 49.763 40.580 1.00 10.48 ATOM 1474 NE ARG 252 28.19550.475 40.912 1.00 10.26 ATOM 1475 CZ ARG 252 27.039 49.892 41.215 1.0012.09 ATOM 1476 NH1 ARG 252 25.973 50.633 41.506 1.00 10.42 ATOM 1477NH2 ARG 252 26.940 48.569 41.217 1.00 10.98 ATOM 1478 C ARG 252 32.27151.337 44.440 1.00 11.46 ATOM 1479 O ARG 252 33.296 51.821 43.969 1.0010.38 ATOM 1480 N SER 253 31.657 51.852 45.505 1.00 13.01 ATOM 1481 CASER 253 32.147 53.065 46.157 1.00 13.62 ATOM 1482 CB SER 253 31.22453.465 47.309 1.00 12.96 ATOM 1483 OG SER 253 31.473 52.676 48.460 1.0016.21 ATOM 1484 C SER 253 33.575 52.932 46.685 1.00 12.79 ATOM 1485 OSER 253 34.253 53.935 46.893 1.00 12.73 ATOM 1486 N MET 254 34.02551.699 46.903 1.00 14.11 ATOM 1487 CA MET 254 35.378 51.462 47.406 1.0014.12 ATOM 1488 CB MET 254 35.622 49.960 47.620 1.00 16.31 ATOM 1489 CGMET 254 34.751 49.331 48.699 1.00 19.32 ATOM 1490 SD MET 254 35.23147.629 49.106 1.00 25.77 ATOM 1491 CE MET 254 34.333 46.745 47.898 1.0017.52 ATOM 1492 C MET 254 36.440 52.013 46.457 1.00 12.73 ATOM 1493 OMET 254 37.585 52.214 46.849 1.00 14.95 ATOM 1494 N TYR 255 36.06152.251 45.207 1.00 11.95 ATOM 1495 CA TYR 255 37.001 52.782 44.227 1.0010.96 ATOM 1496 CB TYR 255 36.734 52.180 42.840 1.00 10.71 ATOM 1497 CGTYR 255 37.055 50.711 42.767 1.00 10.53 ATOM 1498 CD1 TYR 255 36.12049.755 43.159 1.00 10.46 ATOM 1499 CE1 TYR 255 36.441 48.401 43.183 1.0010.93 ATOM 1500 CD2 TYR 255 38.326 50.276 42.389 1.00 11.13 ATOM 1501CE2 TYR 255 38.661 48.915 42.415 1.00 11.62 ATOM 1502 CZ TYR 255 37.71147.987 42.817 1.00 11.67 ATOM 1503 OH TYR 255 38.039 46.653 42.896 1.0010.68 ATOM 1504 C TYR 255 36.976 54.305 44.139 1.00 10.20 ATOM 1505 OTYR 255 37.845 54.898 43.505 1.00 11.25 ATOM 1506 N GLU 256 35.98554.932 44.767 1.00 10.48 ATOM 1507 CA GLU 256 35.874 56.396 44.750 1.0011.92 ATOM 1508 CB GLU 256 36.950 57.018 45.649 1.00 12.76 ATOM 1509 CGGLU 256 36.925 56.528 47.097 1.00 16.04 ATOM 1510 CD GLU 256 37.92557.263 47.993 1.00 20.13 ATOM 1511 OE1 GLU 256 39.145 57.187 47.736 1.0019.80 ATOM 1512 OE2 GLU 256 37.487 57.917 48.959 1.00 23.10 ATOM 1513 CGLU 256 36.040 56.925 43.327 1.00 11.30 ATOM 1514 O GLU 256 36.70357.935 43.100 1.00 12.11 ATOM 1515 N THR 257 35.430 56.236 42.371 1.0011.67 ATOM 1516 CA THR 257 35.537 56.607 40.965 1.00 11.88 ATOM 1517 CBTHR 257 36.511 55.649 40.239 1.00 13.99 ATOM 1518 OG1 THR 257 37.78855.701 40.889 1.00 13.92 ATOM 1519 CG2 THR 257 36.679 56.043 38.775 1.0013.03 ATOM 1520 C THR 257 34.167 56.555 40.296 1.00 11.09 ATOM 1521 OTHR 257 33.691 55.490 39.918 1.00 10.49 ATOM 1522 N PRO 258 33.51457.719 40.154 1.00 11.64 ATOM 1523 CD PRO 258 33.992 59.028 40.638 1.0011.87 ATOM 1524 CA PRO 258 32.186 57.842 39.539 1.00 12.51 ATOM 1525 CBPRO 258 31.953 59.352 39.526 1.00 13.07 ATOM 1526 CG PRO 258 32.70359.817 40.754 1.00 13.28 ATOM 1527 C PRO 258 32.072 57.226 38.143 1.0012.84 ATOM 1528 O PRO 258 31.014 56.719 37.762 1.00 13.80 ATOM 1529 NSER 259 33.164 57.270 37.387 1.00 12.06 ATOM 1530 CA SER 259 33.18256.728 36.030 1.00 13.03 ATOM 1531 CB SER 259 34.154 57.536 35.170 1.0015.05 ATOM 1532 OG SER 259 35.466 57.473 35.707 1.00 14.74 ATOM 1533 CSER 259 33.588 55.254 35.987 1.00 12.40 ATOM 1534 O SER 259 33.83054.708 34.917 1.00 11.54 ATOM 1535 N LEU 260 33.649 54.615 37.150 1.0012.21 ATOM 1536 CA LEU 260 34.060 53.214 37.243 1.00 12.51 ATOM 1537 CBLEU 260 33.766 52.665 38.648 1.00 11.05 ATOM 1538 CG LEU 260 34.28251.236 38.891 1.00 13.73 ATOM 1539 CD1 LEU 260 35.808 51.214 38.751 1.0010.71 ATOM 1540 CD2 LEU 260 33.870 50.751 40.275 1.00 12.15 ATOM 1541 CLEU 260 33.465 52.256 36.207 1.00 13.15 ATOM 1542 O LEU 260 34.20551.578 35.485 1.00 9.99 ATOM 1543 N GLU 261 32.138 52.187 36.131 1.0011.55 ATOM 1544 CA GLU 261 31.512 51.266 35.190 1.00 13.22 ATOM 1545 CBGLU 261 29.985 51.292 35.353 1.00 12.14 ATOM 1546 CG GLU 261 29.55450.650 36.671 1.00 15.06 ATOM 1547 CD GLU 261 28.065 50.396 36.774 1.0016.56 ATOM 1548 OE1 GLU 261 27.388 50.379 35.727 1.00 20.06 ATOM 1549OE2 GLU 261 27.574 50.197 37.906 1.00 17.33 ATOM 1550 C GLU 261 31.92351.495 33.740 1.00 13.12 ATOM 1551 O GLU 261 32.193 50.538 33.011 1.0011.67 ATOM 1552 N GLN 262 31.988 52.752 33.320 1.00 11.67 ATOM 1553 CAGLN 262 32.395 53.042 31.952 1.00 13.82 ATOM 1554 CB GLN 262 32.12854.508 31.607 1.00 15.74 ATOM 1555 CG GLN 262 30.659 54.915 31.661 1.0024.70 ATOM 1556 CD GLN 262 30.455 56.378 31.298 1.00 29.02 ATOM 1557 OE1GLN 262 30.558 56.762 30.132 1.00 35.05 ATOM 1558 NE2 GLN 262 30.18357.205 32.300 1.00 32.50 ATOM 1559 C GLN 262 33.883 52.733 31.760 1.0012.94 ATOM 1560 O GLN 262 34.285 52.213 30.715 1.00 11.76 ATOM 1561 NASP 263 34.696 53.059 32.764 1.00 11.79 ATOM 1562 CA ASP 263 36.13152.805 32.689 1.00 12.07 ATOM 1563 CB ASP 263 36.845 53.238 33.975 1.0012.41 ATOM 1564 CG ASP 263 36.890 54.742 34.145 1.00 13.78 ATOM 1565 OD1ASP 263 36.821 55.453 33.127 1.00 14.89 ATOM 1566 OD2 ASP 263 37.01555.211 35.296 1.00 15.49 ATOM 1567 C ASP 263 36.410 51.328 32.469 1.0013.01 ATOM 1568 O ASP 263 37.190 50.957 31.593 1.00 11.20 ATOM 1569 NLEU 264 35.773 50.495 33.284 1.00 12.13 ATOM 1570 CA LEU 264 35.95849.055 33.207 1.00 13.22 ATOM 1571 CB LEU 264 35.259 48.379 34.393 1.0012.89 ATOM 1572 CG LEU 264 35.758 48.893 35.750 1.00 17.46 ATOM 1573 CD1LEU 264 35.091 48.124 36.883 1.00 15.64 ATOM 1574 CD2 LEU 264 37.28148.756 35.826 1.00 18.10 ATOM 1575 C LEU 264 35.449 48.498 31.884 1.0013.15 ATOM 1576 O LEU 264 36.049 47.591 31.318 1.00 12.41 ATOM 1577 NGLU 265 34.348 49.051 31.387 1.00 15.01 ATOM 1578 CA GLU 265 33.78848.612 30.114 1.00 18.16 ATOM 1579 CB GLU 265 32.457 49.326 29.856 1.0020.13 ATOM 1580 CG GLU 265 31.833 49.068 28.485 1.00 26.44 ATOM 1581 CDGLU 265 31.578 47.599 28.209 1.00 31.50 ATOM 1582 OE1 GLU 265 31.05746.900 29.108 1.00 33.66 ATOM 1583 OE2 GLU 265 31.886 47.145 27.085 1.0034.88 ATOM 1584 C GLU 265 34.773 48.889 28.966 1.00 18.71 ATOM 1585 OGLU 265 34.969 48.038 28.094 1.00 17.84 ATOM 1586 N ARG 266 35.38950.072 28.971 1.00 16.94 ATOM 1587 CA ARG 266 36.355 50.425 27.932 1.0017.44 ATOM 1588 CB ARG 266 36.840 51.873 28.101 1.00 20.53 ATOM 1589 CGARG 266 35.900 52.936 27.550 1.00 22.86 ATOM 1590 CD ARG 266 36.53454.323 27.645 1.00 23.46 ATOM 1591 NE ARG 266 36.579 54.824 29.016 1.0025.90 ATOM 1592 CZ ARG 266 35.566 55.437 29.623 1.00 28.47 ATOM 1593 NH1ARG 266 34.423 55.634 28.979 1.00 29.44 ATOM 1594 NH2 ARG 266 35.69355.851 30.876 1.00 30.11 ATOM 1595 C ARG 266 37.554 49.486 27.986 1.0015.99 ATOM 1596 O ARG 266 38.055 49.042 26.955 1.00 15.42 ATOM 1597 NLEU 267 38.014 49.188 29.197 1.00 15.40 ATOM 1598 CA LEU 267 39.15448.299 29.372 1.00 13.76 ATOM 1599 CB LEU 267 39.539 48.228 30.853 1.0013.89 ATOM 1600 CG LEU 267 40.091 49.539 31.438 1.00 13.95 ATOM 1601 CD1LEU 267 40.200 49.433 32.952 1.00 12.21 ATOM 1602 CD2 LEU 267 41.46249.849 30.815 1.00 12.02 ATOM 1603 C LEU 267 38.836 46.907 28.830 1.0015.08 ATOM 1604 O LEU 267 39.655 46.296 28.135 1.00 13.11 ATOM 1605 NPHE 268 37.642 46.412 29.136 1.00 14.37 ATOM 1606 CA PHE 268 37.23345.098 28.658 1.00 14.85 ATOM 1607 CB PHE 268 35.841 44.735 29.172 1.0015.58 ATOM 1608 CG PHE 268 35.308 43.453 28.590 1.00 19.42 ATOM 1609 CD1PHE 268 35.795 42.219 29.026 1.00 17.97 ATOM 1610 CD2 PHE 268 34.37343.480 27.561 1.00 17.52 ATOM 1611 CE1 PHE 268 35.360 41.036 28.439 1.0020.24 ATOM 1612 CE2 PHE 268 33.932 42.301 26.966 1.00 20.46 ATOM 1613 CZPHE 268 34.428 41.076 27.407 1.00 20.47 ATOM 1614 C PHE 268 37.22245.061 27.132 1.00 15.22 ATOM 1615 O PHE 268 37.717 44.113 26.521 1.0015.06 ATOM 1616 N GLN 269 36.649 46.094 26.521 1.00 14.71 ATOM 1617 CAGLN 269 36.570 46.174 25.066 1.00 15.04 ATOM 1618 CB GLN 269 35.79747.427 24.642 1.00 18.56 ATOM 1619 CG GLN 269 34.296 47.359 24.893 1.0023.06 ATOM 1620 CD GLN 269 33.650 46.149 24.238 1.00 25.97 ATOM 1621 OE1GLN 269 33.962 45.805 23.098 1.00 27.07 ATOM 1622 NE2 GLN 269 32.73645.506 24.953 1.00 27.62 ATOM 1623 C GLN 269 37.936 46.172 24.389 1.0014.54 ATOM 1624 O GLN 269 38.082 45.640 23.297 1.00 13.32 ATOM 1625 NGLU 270 38.936 46.767 25.030 1.00 15.04 ATOM 1626 CA GLU 270 40.26946.802 24.445 1.00 17.22 ATOM 1627 CB GLU 270 41.152 47.805 25.188 1.0020.98 ATOM 1628 CG GLU 270 40.700 49.238 25.008 1.00 27.35 ATOM 1629 CDGLU 270 41.710 50.229 25.524 1.00 33.16 ATOM 1630 OE1 GLU 270 42.86250.199 25.039 1.00 38.02 ATOM 1631 OE2 GLU 270 41.356 51.040 26.409 1.0036.92 ATOM 1632 C GLU 270 40.952 45.437 24.412 1.00 15.82 ATOM 1633 OGLU 270 41.820 45.196 23.573 1.00 14.50 ATOM 1634 N LEU 271 40.56744.548 25.320 1.00 13.35 ATOM 1635 CA LEU 271 41.156 43.214 25.356 1.0015.36 ATOM 1636 CB LEU 271 41.353 42.771 26.805 1.00 16.31 ATOM 1637 CGLEU 271 42.710 43.258 27.322 1.00 19.74 ATOM 1638 CD1 LEU 271 42.55244.028 28.610 1.00 19.63 ATOM 1639 CD2 LEU 271 43.631 42.059 27.493 1.0019.25 ATOM 1640 C LEU 271 40.340 42.177 24.583 1.00 15.26 ATOM 1641 OLEU 271 40.684 40.993 24.545 1.00 15.34 ATOM 1642 N GLN 272 39.26742.637 23.951 1.00 15.74 ATOM 1643 CA GLN 272 38.395 41.772 23.163 1.0016.76 ATOM 1644 CB GLN 272 37.193 42.572 22.663 1.00 18.77 ATOM 1645 CGGLN 272 36.064 42.594 23.656 1.00 19.01 ATOM 1646 CD GLN 272 35.33941.272 23.691 1.00 20.95 ATOM 1647 OE1 GLN 272 34.458 41.017 22.869 1.0024.44 ATOM 1648 NE2 GLN 272 35.717 40.412 24.627 1.00 20.60 ATOM 1649 CGLN 272 39.099 41.109 21.986 1.00 18.21 ATOM 1650 O GLN 272 38.98039.899 21.780 1.00 19.85 ATOM 1651 N PRO 273 39.831 41.892 21.181 1.0019.01 ATOM 1652 CD PRO 273 39.939 43.364 21.145 1.00 19.93 ATOM 1653 CAPRO 273 40.525 41.290 20.042 1.00 18.86 ATOM 1654 CB PRO 273 41.32142.465 19.473 1.00 20.13 ATOM 1655 CG PRO 273 40.387 43.624 19.711 1.0018.58 ATOM 1656 C PRO 273 41.418 40.135 20.480 1.00 19.29 ATOM 1657 OPRO 273 41.425 39.067 19.864 1.00 20.36 ATOM 1658 N LEU 274 42.16140.351 21.558 1.00 17.91 ATOM 1659 CA LEU 274 43.062 39.335 22.073 1.0015.61 ATOM 1660 CB LEU 274 43.958 39.950 23.148 1.00 19.23 ATOM 1661 CGLEU 274 45.126 39.145 23.717 1.00 21.54 ATOM 1662 CD1 LEU 274 45.84738.382 22.608 1.00 24.13 ATOM 1663 CD2 LEU 274 46.079 40.107 24.415 1.0022.56 ATOM 1664 C LEU 274 42.294 38.128 22.622 1.00 15.23 ATOM 1665 OLEU 274 42.626 36.987 22.305 1.00 13.78 ATOM 1666 N TYR 275 41.26438.369 23.432 1.00 12.57 ATOM 1667 CA TYR 275 40.494 37.255 23.977 1.0012.75 ATOM 1668 CB TYR 275 39.449 37.723 24.988 1.00 11.47 ATOM 1669 CGTYR 275 38.643 36.554 25.512 1.00 11.88 ATOM 1670 CD1 TYR 275 39.24535.574 26.298 1.00 9.65 ATOM 1671 CE1 TYR 275 38.544 34.449 26.711 1.0011.95 ATOM 1672 CD2 TYR 275 37.306 36.382 25.151 1.00 10.41 ATOM 1673CE2 TYR 275 36.591 35.258 25.556 1.00 10.77 ATOM 1674 CZ TYR 275 37.21634.299 26.335 1.00 11.79 ATOM 1675 OH TYR 275 36.518 33.196 26.758 1.0012.85 ATOM 1676 C TYR 275 39.779 36.457 22.890 1.00 12.15 ATOM 1677 OTYR 275 39.819 35.230 22.886 1.00 11.27 ATOM 1678 N LEU 276 39.11637.155 21.976 1.00 12.64 ATOM 1679 CA LEU 276 38.400 36.478 20.903 1.0012.64 ATOM 1680 CB LEU 276 37.689 37.499 20.016 1.00 12.92 ATOM 1681 CGLEU 276 36.589 38.299 20.719 1.00 15.08 ATOM 1682 CD1 LEU 276 35.96539.298 19.744 1.00 13.79 ATOM 1683 CD2 LEU 276 35.534 37.338 21.267 1.0016.31 ATOM 1684 C LEU 276 39.316 35.601 20.057 1.00 12.23 ATOM 1685 OLEU 276 38.913 34.530 19.608 1.00 13.24 ATOM 1686 N ASN 277 40.54436.054 19.834 1.00 10.74 ATOM 1687 CA ASN 277 41.479 35.269 19.041 1.0011.60 ATOM 1688 CB ASN 277 42.654 36.139 18.593 1.00 11.61 ATOM 1689 CGASN 277 42.393 36.814 17.257 1.00 16.00 ATOM 1690 OD1 ASN 277 42.44236.164 16.207 1.00 14.40 ATOM 1691 ND2 ASN 277 42.094 38.115 17.287 1.0013.69 ATOM 1692 C ASN 277 41.962 34.051 19.827 1.00 11.77 ATOM 1693 OASN 277 42.124 32.969 19.266 1.00 11.85 ATOM 1694 N LEU 278 42.18034.227 21.125 1.00 10.50 ATOM 1695 CA LEU 278 42.624 33.116 21.958 1.0010.97 ATOM 1696 CB LEU 278 42.955 33.600 23.372 1.00 8.91 ATOM 1697 CGLEU 278 43.363 32.498 24.359 1.00 11.30 ATOM 1698 CD1 LEU 278 44.73231.924 23.970 1.00 9.95 ATOM 1699 CD2 LEU 278 43.404 33.067 25.770 1.009.64 ATOM 1700 C LEU 278 41.496 32.089 22.023 1.00 9.88 ATOM 1701 O LEU278 41.733 30.886 21.922 1.00 9.70 ATOM 1702 N HIS 279 40.274 32.58922.193 1.00 9.53 ATOM 1703 CA HIS 279 39.068 31.762 22.272 1.00 10.82ATOM 1704 CB HIS 279 37.836 32.667 22.421 1.00 10.16 ATOM 1705 CG HIS279 36.526 31.938 22.379 1.00 10.69 ATOM 1706 CD2 HIS 279 35.770 31.52821.333 1.00 7.62 ATOM 1707 ND1 HIS 279 35.821 31.601 23.516 1.00 12.88ATOM 1708 CE1 HIS 279 34.685 31.019 23.172 1.00 7.41 ATOM 1709 NE2 HIS279 34.629 30.963 21.853 1.00 10.98 ATOM 1710 C HIS 279 38.914 30.88621.030 1.00 10.36 ATOM 1711 O HIS 279 38.667 29.685 21.133 1.00 10.76ATOM 1712 N ALA 280 39.066 31.489 19.857 1.00 10.79 ATOM 1713 CA ALA 28038.931 30.752 18.601 1.00 11.15 ATOM 1714 CB ALA 280 38.930 31.72317.429 1.00 9.52 ATOM 1715 C ALA 280 40.032 29.705 18.422 1.00 11.20ATOM 1716 O ALA 280 39.780 28.600 17.938 1.00 10.26 ATOM 1717 N TYR 28141.255 30.053 18.810 1.00 11.54 ATOM 1718 CA TYR 281 42.373 29.12018.692 1.00 11.98 ATOM 1719 CB TYR 281 43.685 29.823 19.052 1.00 10.00ATOM 1720 CG TYR 281 44.895 28.914 19.065 1.00 12.10 ATOM 1721 CD1 TYR281 45.461 28.446 17.879 1.00 13.19 ATOM 1722 CE1 TYR 281 46.567 27.59417.895 1.00 11.96 ATOM 1723 CD2 TYR 281 45.465 28.507 20.271 1.00 10.46ATOM 1724 CE2 TYR 281 46.564 27.660 20.299 1.00 12.98 ATOM 1725 CZ TYR281 47.112 27.205 19.109 1.00 14.87 ATOM 1726 OH TYR 281 48.212 26.36719.146 1.00 14.76 ATOM 1727 C TYR 281 42.156 27.909 19.606 1.00 12.24ATOM 1728 O TYR 281 42.339 26.764 19.189 1.00 12.81 ATOM 1729 N VAL 28241.764 28.167 20.852 1.00 11.07 ATOM 1730 CA VAL 282 41.517 27.09321.809 1.00 10.51 ATOM 1731 CB VAL 282 41.246 27.656 23.231 1.00 10.61ATOM 1732 CG1 VAL 282 40.816 26.529 24.181 1.00 8.01 ATOM 1733 CG2 VAL282 42.504 28.335 23.760 1.00 10.58 ATOM 1734 C VAL 282 40.331 26.24021.359 1.00 11.07 ATOM 1735 O VAL 282 40.357 25.012 21.462 1.00 11.90ATOM 1736 N ARG 283 39.291 26.893 20.859 1.00 9.21 ATOM 1737 CA ARG 28338.113 26.179 20.379 1.00 10.93 ATOM 1738 CB ARG 283 37.077 27.18619.859 1.00 9.04 ATOM 1739 CG ARG 283 35.802 26.566 19.293 1.00 7.71ATOM 1740 CD ARG 283 34.800 27.655 18.923 1.00 8.79 ATOM 1741 NE ARG 28335.371 28.597 17.966 1.00 8.59 ATOM 1742 CZ ARG 283 34.837 29.773 17.6511.00 12.17 ATOM 1743 NH1 ARG 283 33.702 30.174 18.219 1.00 8.02 ATOM1744 NH2 ARG 283 35.445 30.552 16.763 1.00 9.21 ATOM 1745 C ARG 28338.520 25.191 19.268 1.00 11.88 ATOM 1746 O ARG 283 38.026 24.065 19.2101.00 11.57 ATOM 1747 N ARG 284 39.432 25.615 18.396 1.00 12.83 ATOM 1748CA ARG 284 39.905 24.759 17.305 1.00 13.40 ATOM 1749 CB ARG 284 40.81525.557 16.362 1.00 12.91 ATOM 1750 CG ARG 284 41.550 24.721 15.314 1.0016.01 ATOM 1751 CD ARG 284 40.608 24.122 14.274 1.00 14.55 ATOM 1752 NEARG 284 39.864 25.154 13.555 1.00 13.70 ATOM 1753 CZ ARG 284 39.07324.917 12.513 1.00 15.26 ATOM 1754 NH1 ARG 284 38.433 25.921 11.927 1.0012.96 ATOM 1755 NH2 ARG 284 38.930 23.679 12.049 1.00 13.60 ATOM 1756 CARG 284 40.657 23.546 17.866 1.00 13.94 ATOM 1757 O ARG 284 40.45222.414 17.416 1.00 14.76 ATOM 1758 N ALA 285 41.517 23.781 18.852 1.0012.64 ATOM 1759 CA ALA 285 42.277 22.698 19.468 1.00 12.04 ATOM 1760 CBALA 285 43.289 23.259 20.453 1.00 12.45 ATOM 1761 C ALA 285 41.34921.709 20.172 1.00 13.35 ATOM 1762 O ALA 285 41.596 20.500 20.162 1.0014.01 ATOM 1763 N LEU 286 40.287 22.220 20.791 1.00 11.56 ATOM 1764 CALEU 286 39.330 21.356 21.478 1.00 12.33 ATOM 1765 CB LEU 286 38.36422.189 22.326 1.00 10.45 ATOM 1766 CG LEU 286 38.952 22.846 23.583 1.0013.14 ATOM 1767 CD1 LEU 286 37.884 23.713 24.255 1.00 11.79 ATOM 1768CD2 LEU 286 39.452 21.767 24.548 1.00 9.81 ATOM 1769 C LEU 286 38.55320.529 20.453 1.00 11.97 ATOM 1770 O LEU 286 38.225 19.368 20.693 1.0012.10 ATOM 1771 N HIS 287 38.257 21.146 19.315 1.00 12.58 ATOM 1772 CAHIS 287 37.544 20.482 18.229 1.00 13.37 ATOM 1773 CB HIS 287 37.35121.476 17.073 1.00 13.36 ATOM 1774 CG HIS 287 36.674 20.902 15.863 1.0012.74 ATOM 1775 CD2 HIS 287 35.383 20.956 15.455 1.00 10.37 ATOM 1776ND1 HIS 287 37.361 20.238 14.868 1.00 12.14 ATOM 1777 CE1 HIS 287 36.52519.914 13.897 1.00 10.26 ATOM 1778 NE2 HIS 287 35.319 20.339 14.228 1.0014.44 ATOM 1779 C HIS 287 38.401 19.294 17.790 1.00 14.98 ATOM 1780 OHIS 287 37.898 18.196 17.561 1.00 14.57 ATOM 1781 N ARG 288 39.70719.529 17.701 1.00 15.29 ATOM 1782 CA ARG 288 40.666 18.506 17.305 1.0017.69 ATOM 1783 CB ARG 288 42.068 19.112 17.249 1.00 21.34 ATOM 1784 CGARG 288 42.685 19.208 15.862 1.00 27.31 ATOM 1785 CD ARG 288 43.74920.293 15.841 1.00 29.77 ATOM 1786 NE ARG 288 44.569 20.250 17.048 1.0029.56 ATOM 1787 CZ ARG 288 45.157 21.311 17.586 1.00 29.93 ATOM 1788 NH1ARG 288 45.019 22.505 17.021 1.00 30.44 ATOM 1789 NH2 ARG 288 45.87421.183 18.696 1.00 31.11 ATOM 1790 C ARG 288 40.674 17.329 18.276 1.0017.37 ATOM 1791 O ARG 288 40.713 16.169 17.861 1.00 16.21 ATOM 1792 NHIS 289 40.629 17.629 19.571 1.00 17.16 ATOM 1793 CA HIS 289 40.66816.587 20.590 1.00 17.12 ATOM 1794 CB HIS 289 41.281 17.132 21.882 1.0018.15 ATOM 1795 CG HIS 289 41.421 16.098 22.954 1.00 21.15 ATOM 1796 CD2HIS 289 40.616 15.780 23.997 1.00 21.55 ATOM 1797 ND1 HIS 289 42.46215.195 22.985 1.00 22.19 ATOM 1798 CE1 HIS 289 42.292 14.363 23.997 1.0021.47 ATOM 1799 NE2 HIS 289 41.179 14.697 24.627 1.00 25.04 ATOM 1800 CHIS 289 39.352 15.904 20.947 1.00 16.83 ATOM 1801 O HIS 289 39.29814.681 21.043 1.00 16.83 ATOM 1802 N TYR 290 38.294 16.683 21.153 1.0016.34 ATOM 1803 CA TYR 290 37.016 16.110 21.549 1.00 15.13 ATOM 1804 CBTYR 290 36.333 17.025 22.571 1.00 14.53 ATOM 1805 CG TYR 290 37.07317.093 23.894 1.00 14.22 ATOM 1806 CD1 TYR 290 37.842 18.208 24.237 1.0012.56 ATOM 1807 CE1 TYR 290 38.547 18.255 25.445 1.00 12.09 ATOM 1808CD2 TYR 290 37.025 16.026 24.791 1.00 13.17 ATOM 1809 CE2 TYR 290 37.72116.062 25.995 1.00 13.22 ATOM 1810 CZ TYR 290 38.480 17.175 26.316 1.0014.11 ATOM 1811 OH TYR 290 39.186 17.186 27.496 1.00 13.69 ATOM 1812 CTYR 290 36.042 15.746 20.434 1.00 16.43 ATOM 1813 O TYR 290 34.98015.180 20.703 1.00 16.48 ATOM 1814 N GLY 291 36.395 16.068 19.194 1.0017.05 ATOM 1815 CA GLY 291 35.535 15.730 18.072 1.00 15.48 ATOM 1816 CGLY 291 34.611 16.813 17.552 1.00 13.32 ATOM 1817 O GLY 291 34.11117.647 18.305 1.00 11.67 ATOM 1818 N ALA 292 34.369 16.781 16.248 1.0013.25 ATOM 1819 CA ALA 292 33.504 17.755 15.590 1.00 13.14 ATOM 1820 CBALA 292 33.530 17.532 14.077 1.00 15.01 ATOM 1821 C ALA 292 32.06517.708 16.099 1.00 13.40 ATOM 1822 O ALA 292 31.362 18.713 16.056 1.0012.55 ATOM 1823 N GLN 293 31.625 16.545 16.575 1.00 12.64 ATOM 1824 CAGLN 293 30.265 16.407 17.081 1.00 13.50 ATOM 1825 CB GLN 293 29.88814.919 17.199 1.00 13.51 ATOM 1826 CG GLN 293 29.794 14.161 15.863 1.0012.95 ATOM 1827 CD GLN 293 28.496 14.423 15.109 1.00 14.29 ATOM 1828 OE1GLN 293 27.607 15.121 15.597 1.00 13.82 ATOM 1829 NE2 GLN 293 28.38213.853 13.909 1.00 12.74 ATOM 1830 C GLN 293 30.071 17.091 18.436 1.0014.40 ATOM 1831 O GLN 293 28.938 17.278 18.879 1.00 15.91 ATOM 1832 NHIS 294 31.168 17.487 19.081 1.00 13.64 ATOM 1833 CA HIS 294 31.08818.118 20.397 1.00 14.94 ATOM 1834 CB HIS 294 31.831 17.248 21.413 1.0014.73 ATOM 1835 CG HIS 294 31.381 15.820 21.403 1.00 17.46 ATOM 1836 CD2HIS 294 32.001 14.693 20.977 1.00 16.75 ATOM 1837 ND1 HIS 294 30.11315.438 21.787 1.00 19.13 ATOM 1838 CE1 HIS 294 29.970 14.139 21.592 1.0018.70 ATOM 1839 NE2 HIS 294 31.100 13.664 21.101 1.00 18.34 ATOM 1840 CHIS 294 31.593 19.559 20.476 1.00 15.34 ATOM 1841 O HIS 294 31.47520.204 21.519 1.00 16.59 ATOM 1842 N ILE 295 32.147 20.066 19.379 1.0013.77 ATOM 1843 CA ILE 295 32.654 21.435 19.352 1.00 13.59 ATOM 1844 CBILE 295 34.209 21.474 19.346 1.00 13.71 ATOM 1845 CG2 ILE 295 34.69522.905 19.124 1.00 14.49 ATOM 1846 CG1 ILE 295 34.763 20.904 20.656 1.0014.93 ATOM 1847 CD1 ILE 295 34.360 21.684 21.906 1.00 14.38 ATOM 1848 CILE 295 32.154 22.141 18.107 1.00 13.18 ATOM 1849 O ILE 295 32.43721.712 16.994 1.00 15.59 ATOM 1850 N ASN 296 31.395 23.214 18.297 1.0012.79 ATOM 1851 CA ASN 296 30.878 23.992 17.175 1.00 13.84 ATOM 1852 CBASN 296 29.535 24.632 17.549 1.00 13.94 ATOM 1853 CG ASN 296 28.94325.462 16.419 1.00 17.67 ATOM 1854 OD1 ASN 296 29.597 25.724 15.408 1.0016.28 ATOM 1855 ND2 ASN 296 27.700 25.890 16.595 1.00 20.03 ATOM 1856 CASN 296 31.917 25.076 16.897 1.00 13.19 ATOM 1857 O ASN 296 32.12325.966 17.724 1.00 13.14 ATOM 1858 N LEU 297 32.570 25.001 15.742 1.0012.09 ATOM 1859 CA LEU 297 33.608 25.964 15.386 1.00 13.05 ATOM 1860 CBLEU 297 34.308 25.528 14.097 1.00 14.01 ATOM 1861 CG LEU 297 35.17624.265 14.185 1.00 14.42 ATOM 1862 CD1 LEU 297 35.551 23.810 12.787 1.0014.91 ATOM 1863 CD2 LEU 297 36.426 24.540 15.017 1.00 11.68 ATOM 1864 CLEU 297 33.130 27.408 15.253 1.00 13.77 ATOM 1865 O LEU 297 33.94528.321 15.103 1.00 13.21 ATOM 1866 N GLU 298 31.818 27.621 15.304 1.0013.89 ATOM 1867 CA GLU 298 31.275 28.975 15.210 1.00 16.15 ATOM 1868 CBGLU 298 30.452 29.133 13.926 1.00 18.06 ATOM 1869 CG GLU 298 31.22728.791 12.659 1.00 23.45 ATOM 1870 CD GLU 298 30.389 28.914 11.394 1.0027.52 ATOM 1871 OE1 GLU 298 29.209 28.504 11.411 1.00 30.58 ATOM 1872OE2 GLU 298 30.915 29.407 10.376 1.00 29.39 ATOM 1873 C GLU 298 30.40329.282 16.424 1.00 15.59 ATOM 1874 O GLU 298 29.621 30.236 16.414 1.0015.76 ATOM 1875 N GLY 299 30.538 28.472 17.472 1.00 12.59 ATOM 1876 CAGLY 299 29.732 28.683 18.659 1.00 11.43 ATOM 1877 C GLY 299 30.51428.756 19.956 1.00 12.49 ATOM 1878 O GLY 299 31.749 28.812 19.945 1.0012.02 ATOM 1879 N PRO 300 29.815 28.762 21.104 1.00 11.77 ATOM 1880 CDPRO 300 28.348 28.749 21.265 1.00 11.48 ATOM 1881 CA PRO 300 30.48428.829 22.406 1.00 12.78 ATOM 1882 CB PRO 300 29.341 29.164 23.358 1.0013.30 ATOM 1883 CG PRO 300 28.183 28.440 22.741 1.00 13.51 ATOM 1884 CPRO 300 31.176 27.513 22.761 1.00 13.23 ATOM 1885 O PRO 300 30.85726.465 22.204 1.00 11.48 ATOM 1886 N ILE 301 32.118 27.581 23.693 1.0012.03 ATOM 1887 CA ILE 301 32.870 26.412 24.137 1.00 12.06 ATOM 1888 CBILE 301 34.329 26.807 24.481 1.00 12.23 ATOM 1889 CG2 ILE 301 35.08725.601 25.038 1.00 11.68 ATOM 1890 CG1 ILE 301 35.017 27.390 23.241 1.0011.62 ATOM 1891 CD1 ILE 301 36.392 27.983 23.521 1.00 9.44 ATOM 1892 CILE 301 32.236 25.807 25.388 1.00 12.04 ATOM 1893 O ILE 301 31.88026.535 26.318 1.00 10.31 ATOM 1894 N PRO 302 32.066 24.469 25.421 1.0011.07 ATOM 1895 CD PRO 302 32.244 23.489 24.336 1.00 12.03 ATOM 1896 CAPRO 302 31.472 23.833 26.602 1.00 11.31 ATOM 1897 CB PRO 302 31.52922.348 26.257 1.00 10.99 ATOM 1898 CG PRO 302 31.324 22.358 24.774 1.0012.05 ATOM 1899 C PRO 302 32.319 24.201 27.826 1.00 9.53 ATOM 1900 O PRO302 33.537 24.067 27.809 1.00 9.50 ATOM 1901 N ALA 303 31.655 24.65728.879 1.00 10.56 ATOM 1902 CA ALA 303 32.313 25.124 30.097 1.00 10.69ATOM 1903 CB ALA 303 31.274 25.775 31.005 1.00 8.77 ATOM 1904 C ALA 30333.164 24.162 30.914 1.00 11.62 ATOM 1905 O ALA 303 33.903 24.603 31.7921.00 10.65 ATOM 1906 N HIS 304 33.084 22.863 30.644 1.00 12.09 ATOM 1907CA HIS 304 33.866 21.903 31.428 1.00 12.58 ATOM 1908 CB HIS 304 33.01720.657 31.721 1.00 11.82 ATOM 1909 CG HIS 304 32.640 19.875 30.500 1.0014.31 ATOM 1910 CD2 HIS 304 32.678 18.544 30.246 1.00 12.99 ATOM 1911ND1 HIS 304 32.127 20.466 29.365 1.00 15.10 ATOM 1912 CE1 HIS 304 31.86619.534 28.465 1.00 13.57 ATOM 1913 NE2 HIS 304 32.191 18.359 28.975 1.0014.81 ATOM 1914 C HIS 304 35.189 21.465 30.801 1.00 12.09 ATOM 1915 OHIS 304 35.922 20.670 31.392 1.00 10.75 ATOM 1916 N LEU 305 35.51622.004 29.631 1.00 12.26 ATOM 1917 CA LEU 305 36.728 21.590 28.924 1.0011.26 ATOM 1918 CB LEU 305 36.394 21.420 27.443 1.00 9.94 ATOM 1919 CGLEU 305 35.159 20.564 27.149 1.00 10.57 ATOM 1920 CD1 LEU 305 34.89620.538 25.642 1.00 10.40 ATOM 1921 CD2 LEU 305 35.377 19.153 27.697 1.009.11 ATOM 1922 C LEU 305 37.968 22.466 29.043 1.00 12.64 ATOM 1923 O LEU305 38.973 22.197 28.380 1.00 12.19 ATOM 1924 N LEU 306 37.922 23.49029.889 1.00 13.29 ATOM 1925 CA LEU 306 39.051 24.405 30.001 1.00 14.22ATOM 1926 CB LEU 306 38.537 25.846 30.141 1.00 11.93 ATOM 1927 CG LEU306 37.738 26.440 28.970 1.00 14.40 ATOM 1928 CD1 LEU 306 38.488 26.21227.652 1.00 12.20 ATOM 1929 CD2 LEU 306 36.353 25.805 28.910 1.00 14.99ATOM 1930 C LEU 306 40.104 24.122 31.076 1.00 14.70 ATOM 1931 O LEU 30641.017 24.925 31.267 1.00 15.61 ATOM 1932 N GLY 307 39.980 22.989 31.7651.00 14.31 ATOM 1933 CA GLY 307 40.955 22.613 32.777 1.00 12.37 ATOM1934 C GLY 307 40.767 23.242 34.145 1.00 14.30 ATOM 1935 O GLY 30741.596 23.064 35.045 1.00 12.62 ATOM 1936 N ASN 308 39.668 23.967 34.3071.00 11.75 ATOM 1937 CA ASN 308 39.373 24.644 35.558 1.00 12.13 ATOM1938 CB ASN 308 39.906 26.086 35.480 1.00 10.17 ATOM 1939 CG ASN 30839.427 26.967 36.622 1.00 11.14 ATOM 1940 OD1 ASN 308 38.327 27.52236.573 1.00 10.87 ATOM 1941 ND2 ASN 308 40.254 27.104 37.655 1.00 9.94ATOM 1942 C ASN 308 37.867 24.597 35.812 1.00 10.98 ATOM 1943 O ASN 30837.069 24.750 34.894 1.00 10.76 ATOM 1944 N MET 309 37.493 24.369 37.0661.00 10.81 ATOM 1945 CA MET 309 36.094 24.255 37.453 1.00 11.22 ATOM1946 CB MET 309 35.984 24.189 38.984 1.00 12.08 ATOM 1947 CG MET 30934.568 23.932 39.491 1.00 12.10 ATOM 1948 SD MET 309 33.855 22.42038.792 1.00 12.04 ATOM 1949 CE MET 309 34.496 21.188 39.955 1.00 12.99ATOM 1950 C MET 309 35.189 25.365 36.925 1.00 12.07 ATOM 1951 O MET 30934.038 25.110 36.562 1.00 11.18 ATOM 1952 N TRP 310 35.709 26.588 36.8771.00 10.53 ATOM 1953 CA TRP 310 34.928 27.735 36.418 1.00 11.65 ATOM1954 CB TRP 310 35.020 28.856 37.456 1.00 10.85 ATOM 1955 CG TRP 31034.629 28.367 38.808 1.00 10.71 ATOM 1956 CD2 TRP 310 35.509 27.87939.825 1.00 10.32 ATOM 1957 CE2 TRP 310 34.702 27.370 40.866 1.00 10.65ATOM 1958 CE3 TRP 310 36.905 27.815 39.954 1.00 11.66 ATOM 1959 CD1 TRP310 33.360 28.153 39.266 1.00 9.51 ATOM 1960 NE1 TRP 310 33.396 27.55040.498 1.00 9.82 ATOM 1961 CZ2 TRP 310 35.243 26.805 42.028 1.00 10.04ATOM 1962 CZ3 TRP 310 37.446 27.251 41.106 1.00 12.67 ATOM 1963 CH2 TRP310 36.613 26.752 42.129 1.00 12.66 ATOM 1964 C TRP 310 35.379 28.24535.054 1.00 12.14 ATOM 1965 O TRP 310 34.840 29.233 34.544 1.00 10.52ATOM 1966 N ALA 311 36.351 27.554 34.460 1.00 11.25 ATOM 1967 CA ALA 31136.890 27.949 33.166 1.00 11.45 ATOM 1968 CB ALA 311 35.817 27.80332.076 1.00 13.28 ATOM 1969 C ALA 311 37.372 29.395 33.240 1.00 11.09ATOM 1970 O ALA 311 37.296 30.128 32.256 1.00 10.98 ATOM 1971 N GLN 31237.862 29.804 34.410 1.00 11.21 ATOM 1972 CA GLN 312 38.346 31.16834.594 1.00 10.89 ATOM 1973 CB GLN 312 38.201 31.603 36.057 1.00 10.80ATOM 1974 CG GLN 312 39.053 30.838 37.052 1.00 11.00 ATOM 1975 CD GLN312 38.662 31.139 38.488 1.00 12.63 ATOM 1976 OE1 GLN 312 37.508 30.95138.876 1.00 10.11 ATOM 1977 NE2 GLN 312 39.621 31.610 39.283 1.00 12.95ATOM 1978 C GLN 312 39.794 31.302 34.138 1.00 12.02 ATOM 1979 O GLN 31240.249 32.398 33.809 1.00 10.55 ATOM 1980 N THR 313 40.510 30.182 34.1411.00 12.20 ATOM 1981 CA THR 313 41.898 30.117 33.687 1.00 13.97 ATOM1982 CB THR 313 42.914 30.108 34.859 1.00 15.24 ATOM 1983 OG1 THR 31342.544 29.117 35.826 1.00 18.23 ATOM 1984 CG2 THR 313 42.951 31.46835.527 1.00 19.92 ATOM 1985 C THR 313 41.998 28.814 32.903 1.00 12.84ATOM 1986 O THR 313 41.464 27.790 33.328 1.00 11.11 ATOM 1987 N TRP 31442.660 28.864 31.751 1.00 12.37 ATOM 1988 CA TRP 314 42.778 27.69630.884 1.00 12.96 ATOM 1989 CB TRP 314 42.357 28.060 29.464 1.00 12.27ATOM 1990 CG TRP 314 41.057 28.797 29.339 1.00 13.71 ATOM 1991 CD2 TRP314 40.534 29.392 28.145 1.00 13.32 ATOM 1992 CE2 TRP 314 39.244 29.88228.450 1.00 13.06 ATOM 1993 CE3 TRP 314 41.027 29.551 26.844 1.00 12.97ATOM 1994 CD1 TRP 314 40.094 28.957 30.299 1.00 12.24 ATOM 1995 NE1 TRP314 39.002 29.606 29.772 1.00 12.13 ATOM 1996 CZ2 TRP 314 38.442 30.51927.502 1.00 12.07 ATOM 1997 CZ3 TRP 314 40.227 30.186 25.899 1.00 14.41ATOM 1998 CH2 TRP 314 38.947 30.659 26.236 1.00 13.57 ATOM 1999 C TRP314 44.184 27.111 30.823 1.00 14.49 ATOM 2000 O TRP 314 44.492 26.33029.922 1.00 13.65 ATOM 2001 N SER 315 45.029 27.489 31.775 1.00 15.57ATOM 2002 CA SER 315 46.414 27.021 31.818 1.00 16.96 ATOM 2003 CB SER315 47.093 27.539 33.091 1.00 18.01 ATOM 2004 OG SER 315 46.977 28.94733.186 1.00 26.11 ATOM 2005 C SER 315 46.568 25.500 31.768 1.00 15.01ATOM 2006 O SER 315 47.487 24.980 31.135 1.00 12.81 ATOM 2007 N ASN 31645.663 24.794 32.434 1.00 15.19 ATOM 2008 CA ASN 316 45.742 23.34532.504 1.00 14.93 ATOM 2009 CB ASN 316 44.837 22.849 33.632 1.00 16.81ATOM 2010 CG ASN 316 45.348 23.284 35.005 1.00 19.36 ATOM 2011 OD1 ASN316 46.503 23.037 35.345 1.00 20.13 ATOM 2012 ND2 ASN 316 44.496 23.93935.787 1.00 17.72 ATOM 2013 C ASN 316 45.527 22.542 31.224 1.00 14.44ATOM 2014 O ASN 316 45.772 21.341 31.212 1.00 13.76 ATOM 2015 N ILE 31745.078 23.187 30.152 1.00 12.82 ATOM 2016 CA ILE 317 44.925 22.47628.883 1.00 13.82 ATOM 2017 CB ILE 317 43.533 22.691 28.230 1.00 14.54ATOM 2018 CG2 ILE 317 42.447 22.099 29.126 1.00 15.01 ATOM 2019 CG1 ILE317 43.301 24.175 27.945 1.00 14.21 ATOM 2020 CD1 ILE 317 42.110 24.43327.049 1.00 15.28 ATOM 2021 C ILE 317 46.004 22.933 27.898 1.00 13.81ATOM 2022 O ILE 317 45.836 22.823 26.686 1.00 13.91 ATOM 2023 N TYR 31847.115 23.443 28.429 1.00 14.69 ATOM 2024 CA TYR 318 48.228 23.89927.595 1.00 16.96 ATOM 2025 CB TYR 318 49.406 24.338 28.471 1.00 17.55ATOM 2026 CG TYR 318 50.637 24.733 27.682 1.00 20.39 ATOM 2027 CD1 TYR318 50.690 25.942 26.995 1.00 19.75 ATOM 2028 CE1 TYR 318 51.802 26.29026.233 1.00 22.32 ATOM 2029 CD2 TYR 318 51.734 23.875 27.590 1.00 21.99ATOM 2030 CE2 TYR 318 52.850 24.212 26.831 1.00 23.31 ATOM 2031 CZ TYR318 52.878 25.421 26.157 1.00 23.13 ATOM 2032 OH TYR 318 53.983 25.76425.411 1.00 24.51 ATOM 2033 C TYR 318 48.691 22.787 26.645 1.00 17.99ATOM 2034 O TYR 318 48.996 23.038 25.480 1.00 17.00 ATOM 2035 N ASP 31948.735 21.561 27.154 1.00 18.60 ATOM 2036 CA ASP 319 49.157 20.40326.369 1.00 21.85 ATOM 2037 CB ASP 319 49.104 19.140 27.232 1.00 24.07ATOM 2038 CG ASP 319 47.724 18.888 27.806 1.00 29.24 ATOM 2039 OD1 ASP319 47.207 19.781 28.507 1.00 34.33 ATOM 2040 OD2 ASP 319 47.149 17.80527.558 1.00 33.51 ATOM 2041 C ASP 319 48.298 20.192 25.122 1.00 21.74ATOM 2042 O ASP 319 48.768 19.645 24.124 1.00 20.42 ATOM 2043 N LEU 32047.041 20.622 25.180 1.00 19.73 ATOM 2044 CA LEU 320 46.141 20.45924.045 1.00 19.44 ATOM 2045 CB LEU 320 44.684 20.371 24.523 1.00 19.37ATOM 2046 CG LEU 320 44.255 19.241 25.471 1.00 20.20 ATOM 2047 CD1 LEU320 42.774 19.397 25.798 1.00 19.42 ATOM 2048 CD2 LEU 320 44.515 17.88824.830 1.00 18.15 ATOM 2049 C LEU 320 46.253 21.588 23.025 1.00 17.85ATOM 2050 O LEU 320 45.823 21.434 21.882 1.00 17.25 ATOM 2051 N VAL 32146.845 22.711 23.426 1.00 16.88 ATOM 2052 CA VAL 321 46.944 23.86422.531 1.00 17.25 ATOM 2053 CB VAL 321 46.073 25.038 23.063 1.00 15.70ATOM 2054 CG1 VAL 321 44.683 24.538 23.413 1.00 15.29 ATOM 2055 CG2 VAL321 46.726 25.665 24.285 1.00 13.63 ATOM 2056 C VAL 321 48.352 24.40722.270 1.00 18.75 ATOM 2057 O VAL 321 48.501 25.476 21.670 1.00 20.66ATOM 2058 N VAL 322 49.379 23.684 22.705 1.00 19.31 ATOM 2059 CA VAL 32250.752 24.145 22.514 1.00 20.26 ATOM 2060 CB VAL 322 51.767 23.05222.933 1.00 22.20 ATOM 2061 CG1 VAL 322 51.500 21.770 22.172 1.00 24.86ATOM 2062 CG2 VAL 322 53.187 23.540 22.692 1.00 23.70 ATOM 2063 C VAL322 51.029 24.591 21.072 1.00 19.64 ATOM 2064 O VAL 322 50.878 23.81620.130 1.00 19.00 ATOM 2065 N PRO 323 51.426 25.864 20.888 1.00 18.76ATOM 2066 CD PRO 323 51.505 26.903 21.931 1.00 17.26 ATOM 2067 CA PRO323 51.725 26.429 19.566 1.00 19.32 ATOM 2068 CB PRO 323 52.142 27.86319.890 1.00 19.18 ATOM 2069 CG PRO 323 51.348 28.170 21.135 1.00 17.09ATOM 2070 C PRO 323 52.812 25.665 18.809 1.00 20.64 ATOM 2071 O PRO 32352.647 25.336 17.634 1.00 20.49 ATOM 2072 N PHE 324 53.927 25.398 19.4791.00 21.43 ATOM 2073 CA PHE 324 55.019 24.660 18.854 1.00 22.71 ATOM2074 CB PHE 324 56.245 25.560 18.668 1.00 22.22 ATOM 2075 CG PHE 32455.991 26.751 17.789 1.00 20.95 ATOM 2076 CD1 PHE 324 55.631 27.97718.339 1.00 20.89 ATOM 2077 CD2 PHE 324 56.088 26.642 16.408 1.00 20.89ATOM 2078 CE1 PHE 324 55.371 29.073 17.526 1.00 21.44 ATOM 2079 CE2 PHE324 55.829 27.734 15.586 1.00 20.48 ATOM 2080 CZ PHE 324 55.471 28.95116.144 1.00 20.58 ATOM 2081 C PHE 324 55.376 23.458 19.712 1.00 23.69ATOM 2082 O PHE 324 56.267 23.526 20.557 1.00 21.84 ATOM 2083 N PRO 32554.670 22.334 19.505 1.00 26.08 ATOM 2084 CD PRO 325 53.612 22.15718.495 1.00 26.36 ATOM 2085 CA PRO 325 54.888 21.091 20.251 1.00 28.73ATOM 2086 CB PRO 325 53.790 20.168 19.714 1.00 27.79 ATOM 2087 CG PRO325 53.588 20.660 18.319 1.00 27.78 ATOM 2088 C PRO 325 56.290 20.50020.110 1.00 30.60 ATOM 2089 O PRO 325 56.732 19.732 20.968 1.00 30.52ATOM 2090 N SER 326 56.991 20.858 19.038 1.00 31.95 ATOM 2091 CA SER 32658.346 20.356 18.837 1.00 35.76 ATOM 2092 CB SER 326 58.885 20.78617.472 1.00 37.39 ATOM 2093 OG SER 326 58.203 20.118 16.424 1.00 41.03ATOM 2094 C SER 326 59.261 20.883 19.940 1.00 36.95 ATOM 2095 O SER 32660.355 20.363 20.152 1.00 36.99 ATOM 2096 N ALA 327 58.809 21.925 20.6311.00 37.24 ATOM 2097 CA ALA 327 59.575 22.517 21.720 1.00 38.79 ATOM2098 CB ALA 327 59.564 24.039 21.610 1.00 38.45 ATOM 2099 C ALA 32758.937 22.078 23.033 1.00 40.49 ATOM 2100 O ALA 327 58.143 22.811 23.6231.00 41.01 ATOM 2101 N PRO 328 59.283 20.870 23.509 1.00 41.45 ATOM 2102CD PRO 328 60.341 19.988 22.982 1.00 41.86 ATOM 2103 CA PRO 328 58.73720.330 24.757 1.00 42.79 ATOM 2104 CB PRO 328 59.317 18.919 24.799 1.0042.30 ATOM 2105 CG PRO 328 60.663 19.112 24.175 1.00 42.39 ATOM 2106 CPRO 328 59.111 21.150 25.989 1.00 42.72 ATOM 2107 O PRO 328 60.20621.712 26.072 1.00 42.49 ATOM 2108 N ALA 329 58.186 21.218 26.939 1.0042.80 ATOM 2109 CA ALA 329 58.410 21.954 28.173 1.00 43.32 ATOM 2110 CBALA 329 57.310 22.996 28.373 1.00 43.71 ATOM 2111 C ALA 329 58.41920.967 29.329 1.00 42.69 ATOM 2112 O ALA 329 57.621 20.027 29.359 1.0041.34 ATOM 2113 N MET 330 59.325 21.173 30.278 1.00 42.76 ATOM 2114 CAMET 330 59.417 20.288 31.425 1.00 42.98 ATOM 2115 CB MET 330 60.52520.743 32.372 1.00 44.14 ATOM 2116 CG MET 330 61.873 20.155 32.054 1.0045.52 ATOM 2117 SD MET 330 63.030 20.380 33.396 1.00 50.91 ATOM 2118 CEMET 330 62.368 19.255 34.608 1.00 49.99 ATOM 2119 C MET 330 58.12020.194 32.208 1.00 43.28 ATOM 2120 O MET 330 57.295 21.109 32.194 1.0044.37 ATOM 2121 N ASP 331 57.951 19.068 32.889 1.00 42.06 ATOM 2122 CAASP 331 56.784 18.835 33.718 1.00 41.71 ATOM 2123 CB ASP 331 56.65217.339 34.010 1.00 43.19 ATOM 2124 CG ASP 331 55.319 16.978 34.623 1.0044.69 ATOM 2125 OD1 ASP 331 54.829 17.742 35.482 1.00 45.38 ATOM 2126OD2 ASP 331 54.771 15.920 34.252 1.00 46.02 ATOM 2127 C ASP 331 57.06819.606 35.006 1.00 40.79 ATOM 2128 O ASP 331 57.739 19.096 35.907 1.0039.06 ATOM 2129 N THR 332 56.581 20.842 35.077 1.00 39.46 ATOM 2130 CATHR 332 56.817 21.678 36.247 1.00 39.60 ATOM 2131 CB THR 332 56.13223.054 36.106 1.00 40.44 ATOM 2132 OG1 THR 332 56.580 23.698 34.907 1.0044.22 ATOM 2133 CG2 THR 332 56.497 23.963 37.287 1.00 43.44 ATOM 2134 CTHR 332 56.376 21.042 37.559 1.00 38.30 ATOM 2135 O THR 332 57.12021.075 38.537 1.00 37.12 ATOM 2136 N THR 333 55.181 20.457 37.584 1.0037.24 ATOM 2137 CA THR 333 54.694 19.819 38.799 1.00 35.98 ATOM 2138 CBTHR 333 53.238 19.345 38.638 1.00 35.93 ATOM 2139 OG1 THR 333 52.38420.485 38.467 1.00 35.53 ATOM 2140 CG2 THR 333 52.798 18.557 39.857 1.0035.95 ATOM 2141 C THR 333 55.584 18.628 39.139 1.00 35.83 ATOM 2142 OTHR 333 55.983 18.447 40.292 1.00 35.49 ATOM 2143 N ALA 334 55.90017.818 38.132 1.00 35.47 ATOM 2144 CA ALA 334 56.753 16.652 38.338 1.0034.53 ATOM 2145 CB ALA 334 56.918 15.875 37.032 1.00 35.72 ATOM 2146 CALA 334 58.116 17.078 38.869 1.00 33.83 ATOM 2147 O ALA 334 58.71416.387 39.693 1.00 34.31 ATOM 2148 N ALA 335 58.602 18.221 38.391 1.0032.92 ATOM 2149 CA ALA 335 59.897 18.745 38.818 1.00 31.60 ATOM 2150 CBALA 335 60.295 19.935 37.946 1.00 30.64 ATOM 2151 C ALA 335 59.86719.158 40.289 1.00 30.59 ATOM 2152 O ALA 335 60.750 18.791 41.056 1.0029.04 ATOM 2153 N MET 336 58.848 19.919 40.680 1.00 31.65 ATOM 2154 CAMET 336 58.720 20.361 42.069 1.00 33.03 ATOM 2155 CB MET 336 57.45421.205 42.242 1.00 31.27 ATOM 2156 CG MET 336 57.523 22.564 41.568 1.0029.31 ATOM 2157 SD MET 336 55.990 23.505 41.708 1.00 26.33 ATOM 2158 CEMET 336 56.044 23.993 43.446 1.00 23.57 ATOM 2159 C MET 336 58.67119.158 43.008 1.00 33.75 ATOM 2160 O MET 336 59.380 19.104 44.015 1.0032.69 ATOM 2161 N LEU 337 57.828 18.190 42.665 1.00 36.37 ATOM 2162 CALEU 337 57.679 16.976 43.457 1.00 38.17 ATOM 2163 CB LEU 337 56.50916.148 42.921 1.00 38.76 ATOM 2164 CG LEU 337 55.116 16.781 43.006 1.0039.29 ATOM 2165 CD1 LEU 337 54.152 16.026 42.106 1.00 39.59 ATOM 2166CD2 LEU 337 54.630 16.771 44.449 1.00 39.05 ATOM 2167 C LEU 337 58.96416.155 43.403 1.00 39.59 ATOM 2168 O LEU 337 59.437 15.656 44.425 1.0040.32 ATOM 2169 N ALA 338 59.524 16.027 42.203 1.00 40.41 ATOM 2170 CAALA 338 60.750 15.267 41.994 1.00 41.35 ATOM 2171 CB ALA 338 61.19515.374 40.538 1.00 41.73 ATOM 2172 C ALA 338 61.881 15.713 42.912 1.0041.96 ATOM 2173 O ALA 338 62.699 14.895 43.332 1.00 42.58 ATOM 2174 NGLN 339 61.942 17.006 43.219 1.00 41.77 ATOM 2175 CA GLN 339 63.00017.490 44.094 1.00 40.98 ATOM 2176 CB GLN 339 63.871 18.519 43.369 1.0042.73 ATOM 2177 CG GLN 339 63.134 19.520 42.516 1.00 44.71 ATOM 2178 CDGLN 339 64.047 20.143 41.476 1.00 45.98 ATOM 2179 OE1 GLN 339 65.09620.697 41.806 1.00 46.01 ATOM 2180 NE2 GLN 339 63.656 20.046 40.210 1.0046.19 ATOM 2181 C GLN 339 62.518 18.029 45.434 1.00 39.28 ATOM 2182 OGLN 339 62.990 19.054 45.923 1.00 39.85 ATOM 2183 N GLY 340 61.56717.305 46.014 1.00 38.07 ATOM 2184 CA GLY 340 61.023 17.625 47.322 1.0035.18 ATOM 2185 C GLY 340 60.537 19.011 47.696 1.00 33.08 ATOM 2186 OGLY 340 60.742 19.433 48.834 1.00 32.07 ATOM 2187 N TRP 341 59.90519.731 46.775 1.00 31.21 ATOM 2188 CA TRP 341 59.390 21.049 47.128 1.0030.14 ATOM 2189 CB TRP 341 58.899 21.808 45.887 1.00 29.67 ATOM 2190 CGTRP 341 59.982 22.541 45.158 1.00 29.21 ATOM 2191 CD2 TRP 341 60.03323.948 44.884 1.00 30.13 ATOM 2192 CE2 TRP 341 61.235 24.193 44.182 1.0030.52 ATOM 2193 CE3 TRP 341 59.181 25.025 45.163 1.00 29.73 ATOM 2194CD1 TRP 341 61.119 22.007 44.627 1.00 29.98 ATOM 2195 NE1 TRP 341 61.87722.992 44.039 1.00 29.90 ATOM 2196 CZ2 TRP 341 61.608 25.474 43.754 1.0029.27 ATOM 2197 CZ3 TRP 341 59.551 26.298 44.738 1.00 30.55 ATOM 2198CH2 TRP 341 60.757 26.509 44.039 1.00 30.31 ATOM 2199 C TRP 341 58.22520.821 48.085 1.00 28.38 ATOM 2200 O TRP 341 57.478 19.857 47.936 1.0027.83 ATOM 2201 N THR 342 58.086 21.695 49.075 1.00 27.38 ATOM 2202 CATHR 342 57.001 21.583 50.045 1.00 26.99 ATOM 2203 CB THR 342 57.52721.284 51.463 1.00 26.84 ATOM 2204 OG1 THR 342 58.278 22.410 51.937 1.0025.96 ATOM 2205 CG2 THR 342 58.416 20.046 51.458 1.00 27.25 ATOM 2206 CTHR 342 56.277 22.918 50.107 1.00 26.48 ATOM 2207 O THR 342 56.78423.926 49.622 1.00 25.97 ATOM 2208 N PRO 343 55.075 22.942 50.702 1.0025.99 ATOM 2209 CD PRO 343 54.229 21.824 51.158 1.00 24.91 ATOM 2210 CAPRO 343 54.352 24.211 50.787 1.00 25.66 ATOM 2211 CB PRO 343 53.12823.846 51.620 1.00 24.24 ATOM 2212 CG PRO 343 52.849 22.444 51.163 1.0023.75 ATOM 2213 C PRO 343 55.214 25.287 51.446 1.00 25.07 ATOM 2214 OPRO 343 55.196 26.446 51.036 1.00 24.95 ATOM 2215 N ARG 344 55.98124.897 52.460 1.00 25.30 ATOM 2216 CA ARG 344 56.836 25.846 53.160 1.0026.37 ATOM 2217 CB ARG 344 57.483 25.189 54.383 1.00 29.20 ATOM 2218 CGARG 344 57.856 26.180 55.485 1.00 34.03 ATOM 2219 CD ARG 344 58.58525.495 56.634 1.00 38.59 ATOM 2220 NE ARG 344 58.774 26.369 57.794 1.0042.13 ATOM 2221 CZ ARG 344 57.793 26.785 58.593 1.00 43.28 ATOM 2222 NH1ARG 344 56.535 26.416 58.364 1.00 44.54 ATOM 2223 NH2 ARG 344 58.07027.563 59.631 1.00 42.82 ATOM 2224 C ARG 344 57.914 26.395 52.227 1.0026.08 ATOM 2225 O ARG 344 58.199 27.590 52.243 1.00 24.97 ATOM 2226 NARG 345 58.509 25.521 51.416 1.00 26.26 ATOM 2227 CA ARG 345 59.54225.944 50.468 1.00 26.55 ATOM 2228 CB ARG 345 59.986 24.772 49.584 1.0028.67 ATOM 2229 CG ARG 345 61.485 24.491 49.595 1.00 35.65 ATOM 2230 CDARG 345 62.322 25.714 49.229 1.00 39.10 ATOM 2231 NE ARG 345 62.66925.799 47.808 1.00 43.47 ATOM 2232 CZ ARG 345 63.388 24.894 47.149 1.0043.78 ATOM 2233 NH1 ARG 345 63.840 23.814 47.771 1.00 45.20 ATOM 2234NH2 ARG 345 63.681 25.079 45.870 1.00 45.37 ATOM 2235 C ARG 345 58.94827.020 49.573 1.00 24.15 ATOM 2236 O ARG 345 59.558 28.063 49.330 1.0023.46 ATOM 2237 N MET 346 57.746 26.736 49.084 1.00 22.01 ATOM 2238 CAMET 346 57.024 27.634 48.199 1.00 21.13 ATOM 2239 CB MET 346 55.66027.023 47.864 1.00 22.10 ATOM 2240 CG MET 346 55.773 25.773 46.989 1.0020.75 ATOM 2241 SD MET 346 54.316 24.724 47.003 1.00 22.63 ATOM 2242 CEMET 346 53.205 25.656 45.917 1.00 19.78 ATOM 2243 C MET 346 56.86929.039 48.775 1.00 19.41 ATOM 2244 O MET 346 57.169 30.018 48.098 1.0020.08 ATOM 2245 N PHE 347 56.418 29.148 50.021 1.00 18.55 ATOM 2246 CAPHE 347 56.260 30.469 50.621 1.00 19.25 ATOM 2247 CB PHE 347 55.38830.400 51.879 1.00 17.54 ATOM 2248 CG PHE 347 53.931 30.168 51.587 1.0016.26 ATOM 2249 CD1 PHE 347 53.434 28.882 51.430 1.00 14.65 ATOM 2250CD2 PHE 347 53.064 31.244 51.421 1.00 16.74 ATOM 2251 CE1 PHE 347 52.09128.669 51.109 1.00 17.04 ATOM 2252 CE2 PHE 347 51.721 31.041 51.100 1.0015.45 ATOM 2253 CZ PHE 347 51.236 29.754 50.942 1.00 13.62 ATOM 2254 CPHE 347 57.607 31.109 50.938 1.00 19.50 ATOM 2255 O PHE 347 57.73332.334 50.931 1.00 19.74 ATOM 2256 N LYS 348 58.612 30.281 51.212 1.0019.37 ATOM 2257 CA LYS 348 59.949 30.789 51.499 1.00 20.13 ATOM 2258 CBLYS 348 60.871 29.653 51.964 1.00 23.49 ATOM 2259 CG LYS 348 60.64729.188 53.404 1.00 26.94 ATOM 2260 CD LYS 348 61.173 30.215 54.405 1.0030.04 ATOM 2261 CE LYS 348 61.057 29.722 55.840 1.00 30.37 ATOM 2262 NZLYS 348 61.712 30.663 56.797 1.00 32.04 ATOM 2263 C LYS 348 60.51731.434 50.234 1.00 19.83 ATOM 2264 O LYS 348 61.180 32.466 50.303 1.0018.66 ATOM 2265 N GLU 349 60.263 30.823 49.077 1.00 19.90 ATOM 2266 CAGLU 349 60.746 31.383 47.817 1.00 19.84 ATOM 2267 CB GLU 349 60.44930.444 46.644 1.00 22.36 ATOM 2268 CG GLU 349 61.320 29.196 46.568 1.0026.40 ATOM 2269 CD GLU 349 62.807 29.505 46.643 1.00 29.00 ATOM 2270 OE1GLU 349 63.241 30.541 46.083 1.00 29.80 ATOM 2271 OE2 GLU 349 63.54328.701 47.253 1.00 30.47 ATOM 2272 C GLU 349 60.074 32.730 47.565 1.0019.20 ATOM 2273 O GLU 349 60.723 33.688 47.140 1.00 19.59 ATOM 2274 NALA 350 58.770 32.798 47.820 1.00 18.23 ATOM 2275 CA ALA 350 58.01634.035 47.633 1.00 17.72 ATOM 2276 CB ALA 350 56.529 33.796 47.903 1.0017.17 ATOM 2277 C ALA 350 58.556 35.102 48.582 1.00 18.51 ATOM 2278 OALA 350 58.763 36.249 48.189 1.00 18.51 ATOM 2279 N ASP 351 58.79034.718 49.835 1.00 17.68 ATOM 2280 CA ASP 351 59.316 35.653 50.823 1.0017.98 ATOM 2281 CB ASP 351 59.481 34.950 52.179 1.00 18.35 ATOM 2282 CGASP 351 59.841 35.912 53.306 1.00 21.38 ATOM 2283 OD1 ASP 351 59.09436.886 53.542 1.00 21.06 ATOM 2284 OD2 ASP 351 60.871 35.688 53.972 1.0023.40 ATOM 2285 C ASP 351 60.658 36.193 50.322 1.00 17.98 ATOM 2286 OASP 351 60.945 37.386 50.449 1.00 16.96 ATOM 2287 N ASP 352 61.46835.312 49.733 1.00 17.61 ATOM 2288 CA ASP 352 62.776 35.702 49.207 1.0017.44 ATOM 2289 CB ASP 352 63.544 34.464 48.718 1.00 16.88 ATOM 2290 CGASP 352 64.886 34.819 48.100 1.00 20.01 ATOM 2291 OD1 ASP 352 64.98634.843 46.857 1.00 20.73 ATOM 2292 OD2 ASP 352 65.842 35.089 48.858 1.0022.68 ATOM 2293 C ASP 352 62.668 36.724 48.074 1.00 16.59 ATOM 2294 OASP 352 63.456 37.665 48.001 1.00 16.83 ATOM 2295 N PHE 353 61.68736.546 47.196 1.00 16.60 ATOM 2296 CA PHE 353 61.516 37.481 46.094 1.0015.67 ATOM 2297 CB PHE 353 60.393 37.022 45.151 1.00 15.02 ATOM 2298 CGPHE 353 60.498 37.599 43.760 1.00 13.85 ATOM 2299 CD1 PHE 353 60.63336.766 42.655 1.00 15.98 ATOM 2300 CD2 PHE 353 60.491 38.977 43.558 1.0014.55 ATOM 2301 CE1 PHE 353 60.763 37.292 41.363 1.00 13.57 ATOM 2302CE2 PHE 353 60.622 39.515 42.272 1.00 15.24 ATOM 2303 CZ PHE 353 60.75938.668 41.173 1.00 14.14 ATOM 2304 C PHE 353 61.212 38.874 46.647 1.0014.39 ATOM 2305 O PHE 353 61.808 39.863 46.212 1.00 15.75 ATOM 2306 NPHE 354 60.301 38.964 47.612 1.00 14.89 ATOM 2307 CA PHE 354 59.98040.269 48.191 1.00 15.05 ATOM 2308 CB PHE 354 58.864 40.149 49.238 1.0014.19 ATOM 2309 CG PHE 354 57.481 40.060 48.645 1.00 14.57 ATOM 2310 CD1PHE 354 56.876 38.824 48.428 1.00 13.09 ATOM 2311 CD2 PHE 354 56.79741.217 48.275 1.00 14.46 ATOM 2312 CE1 PHE 354 55.613 38.738 47.852 1.0012.80 ATOM 2313 CE2 PHE 354 55.528 41.144 47.695 1.00 14.78 ATOM 2314 CZPHE 354 54.935 39.901 47.484 1.00 14.26 ATOM 2315 C PHE 354 61.20340.959 48.811 1.00 15.63 ATOM 2316 O PHE 354 61.448 42.141 48.555 1.0016.90 ATOM 2317 N THR 355 61.973 40.233 49.620 1.00 17.16 ATOM 2318 CATHR 355 63.155 40.824 50.243 1.00 17.44 ATOM 2319 CB THR 355 63.79839.887 51.306 1.00 19.33 ATOM 2320 OG1 THR 355 64.122 38.624 50.713 1.0022.32 ATOM 2321 CG2 THR 355 62.845 39.675 52.476 1.00 19.21 ATOM 2322 CTHR 355 64.207 41.179 49.202 1.00 16.79 ATOM 2323 O THR 355 64.96842.130 49.387 1.00 17.18 ATOM 2324 N SER 356 64.242 40.429 48.102 1.0016.97 ATOM 2325 CA SER 356 65.215 40.702 47.045 1.00 16.07 ATOM 2326 CBSER 356 65.127 39.651 45.930 1.00 17.08 ATOM 2327 OG SER 356 64.10539.961 44.991 1.00 20.08 ATOM 2328 C SER 356 64.942 42.087 46.471 1.0017.25 ATOM 2329 O SER 356 65.856 42.767 46.005 1.00 16.33 ATOM 2330 NLEU 357 63.677 42.503 46.514 1.00 16.63 ATOM 2331 CA LEU 357 63.28243.817 46.013 1.00 17.17 ATOM 2332 CB LEU 357 61.804 43.821 45.607 1.0016.38 ATOM 2333 CG LEU 357 61.378 42.907 44.458 1.00 16.10 ATOM 2334 CD1LEU 357 59.897 43.117 44.185 1.00 16.24 ATOM 2335 CD2 LEU 357 62.20243.212 43.211 1.00 13.65 ATOM 2336 C LEU 357 63.496 44.875 47.087 1.0016.00 ATOM 2337 O LEU 357 63.228 46.057 46.872 1.00 16.89 ATOM 2338 NGLY 358 63.978 44.445 48.246 1.00 15.89 ATOM 2339 CA GLY 358 64.19345.378 49.333 1.00 16.90 ATOM 2340 C GLY 358 62.928 45.537 50.163 1.0018.34 ATOM 2341 O GLY 358 62.866 46.386 51.054 1.00 19.04 ATOM 2342 NLEU 359 61.914 44.724 49.873 1.00 16.43 ATOM 2343 CA LEU 359 60.66344.790 50.618 1.00 17.52 ATOM 2344 CB LEU 359 59.510 44.258 49.757 1.0013.59 ATOM 2345 CG LEU 359 59.299 45.099 48.487 1.00 14.94 ATOM 2346 CD1LEU 359 58.221 44.490 47.588 1.00 12.02 ATOM 2347 CD2 LEU 359 58.92846.518 48.893 1.00 13.39 ATOM 2348 C LEU 359 60.786 44.014 51.938 1.0018.75 ATOM 2349 O LEU 359 61.807 43.369 52.194 1.00 18.11 ATOM 2350 NLEU 360 59.744 44.078 52.763 1.00 17.60 ATOM 2351 CA LEU 360 59.74143.432 54.075 1.00 17.15 ATOM 2352 CB LEU 360 58.661 44.064 54.958 1.0016.43 ATOM 2353 CG LEU 360 58.719 45.578 55.171 1.00 18.94 ATOM 2354 CD1LEU 360 57.401 46.059 55.780 1.00 18.12 ATOM 2355 CD2 LEU 360 59.91145.924 56.064 1.00 17.34 ATOM 2356 C LEU 360 59.546 41.925 54.109 1.0018.61 ATOM 2357 O LEU 360 58.764 41.364 53.342 1.00 19.09 ATOM 2358 NPRO 361 60.271 41.244 55.011 1.00 19.60 ATOM 2359 CD PRO 361 61.40541.728 55.824 1.00 19.10 ATOM 2360 CA PRO 361 60.130 39.795 55.121 1.0019.12 ATOM 2361 CB PRO 361 61.461 39.368 55.730 1.00 20.18 ATOM 2362 CGPRO 361 61.770 40.500 56.650 1.00 19.74 ATOM 2363 C PRO 361 58.96039.548 56.065 1.00 19.48 ATOM 2364 O PRO 361 58.636 40.407 56.887 1.0021.65 ATOM 2365 N VAL 362 58.305 38.404 55.945 1.00 20.31 ATOM 2366 CAVAL 362 57.202 38.123 56.855 1.00 21.83 ATOM 2367 CB VAL 362 56.38336.900 56.400 1.00 20.89 ATOM 2368 CG1 VAL 362 55.737 37.189 55.052 1.0019.57 ATOM 2369 CG2 VAL 362 57.278 35.670 56.325 1.00 19.33 ATOM 2370 CVAL 362 57.828 37.846 58.217 1.00 23.46 ATOM 2371 O VAL 362 58.91637.271 58.298 1.00 22.63 ATOM 2372 N PRO 363 57.157 38.266 59.305 1.0023.58 ATOM 2373 CD PRO 363 55.924 39.073 59.315 1.00 23.83 ATOM 2374 CAPRO 363 57.652 38.066 60.672 1.00 23.23 ATOM 2375 CB PRO 363 56.60238.777 61.529 1.00 23.92 ATOM 2376 CG PRO 363 56.060 39.835 60.608 1.0023.78 ATOM 2377 C PRO 363 57.778 36.597 61.049 1.00 22.63 ATOM 2378 OPRO 363 57.080 35.741 60.502 1.00 23.59 ATOM 2379 N PRO 364 58.68436.285 61.987 1.00 23.85 ATOM 2380 CD PRO 364 59.645 37.186 62.654 1.0023.46 ATOM 2381 CA PRO 364 58.872 34.897 62.422 1.00 21.89 ATOM 2382 CBPRO 364 59.831 35.039 63.603 1.00 23.26 ATOM 2383 CG PRO 364 60.67336.218 63.203 1.00 24.65 ATOM 2384 C PRO 364 57.533 34.289 62.837 1.0021.17 ATOM 2385 O PRO 364 57.256 33.119 62.570 1.00 20.23 ATOM 2386 NGLU 365 56.704 35.105 63.484 1.00 21.36 ATOM 2387 CA GLU 365 55.38834.681 63.957 1.00 22.68 ATOM 2388 CB GLU 365 54.691 35.860 64.644 1.0025.18 ATOM 2389 CG GLU 365 53.265 35.599 65.084 1.00 27.55 ATOM 2390 CDGLU 365 52.726 36.694 65.995 1.00 30.30 ATOM 2391 OE1 GLU 365 53.11837.871 65.821 1.00 29.38 ATOM 2392 OE2 GLU 365 51.898 36.378 66.876 1.0030.66 ATOM 2393 C GLU 365 54.511 34.131 62.832 1.00 23.65 ATOM 2394 OGLU 365 53.640 33.286 63.068 1.00 24.23 ATOM 2395 N PHE 366 54.75234.611 61.612 1.00 22.72 ATOM 2396 CA PHE 366 54.007 34.179 60.428 1.0020.44 ATOM 2397 CB PHE 366 54.516 34.930 59.191 1.00 20.08 ATOM 2398 CGPHE 366 53.982 34.397 57.880 1.00 19.61 ATOM 2399 CD1 PHE 366 52.81134.911 57.326 1.00 19.02 ATOM 2400 CD2 PHE 366 54.665 33.395 57.192 1.0018.91 ATOM 2401 CE1 PHE 366 52.327 34.438 56.106 1.00 17.67 ATOM 2402CE2 PHE 366 54.191 32.913 55.968 1.00 19.81 ATOM 2403 CZ PHE 366 53.02033.436 55.424 1.00 18.45 ATOM 2404 C PHE 366 54.161 32.681 60.196 1.0020.36 ATOM 2405 O PHE 366 53.182 31.968 59.962 1.00 20.59 ATOM 2406 NTRP 367 55.398 32.207 60.252 1.00 21.17 ATOM 2407 CA TRP 367 55.68030.792 60.033 1.00 23.44 ATOM 2408 CB TRP 367 57.193 30.571 59.936 1.0023.71 ATOM 2409 CG TRP 367 57.837 31.400 58.866 1.00 23.03 ATOM 2410 CD2TRP 367 57.716 31.214 57.450 1.00 21.94 ATOM 2411 CE2 TRP 367 58.45432.244 56.828 1.00 20.04 ATOM 2412 CE3 TRP 367 57.053 30.276 56.646 1.0021.24 ATOM 2413 CD1 TRP 367 58.620 32.503 59.041 1.00 22.06 ATOM 2414NE1 TRP 367 58.995 33.017 57.822 1.00 22.15 ATOM 2415 CZ2 TRP 367 58.55232.364 55.437 1.00 21.91 ATOM 2416 CZ3 TRP 367 57.149 30.394 55.260 1.0022.47 ATOM 2417 CH2 TRP 367 57.894 31.434 54.672 1.00 21.53 ATOM 2418 CTRP 367 55.096 29.898 61.124 1.00 25.38 ATOM 2419 O TRP 367 54.75328.741 60.877 1.00 26.15 ATOM 2420 N ASN 368 54.965 30.445 62.325 1.0026.99 ATOM 2421 CA ASN 368 54.439 29.683 63.446 1.00 29.40 ATOM 2422 CBASN 368 54.971 30.277 64.754 1.00 32.59 ATOM 2423 CG ASN 368 54.44729.558 65.979 1.00 36.43 ATOM 2424 OD1 ASN 368 53.351 29.842 66.458 1.0038.69 ATOM 2425 ND2 ASN 368 55.229 28.610 66.489 1.00 39.13 ATOM 2426 CASN 368 52.911 29.593 63.493 1.00 29.33 ATOM 2427 O ASN 368 52.36128.559 63.878 1.00 28.62 ATOM 2428 N LYS 369 52.224 30.655 63.082 1.0027.34 ATOM 2429 CA LYS 369 50.766 30.664 63.134 1.00 26.72 ATOM 2430 CBLYS 369 50.286 31.988 63.734 1.00 28.17 ATOM 2431 CG LYS 369 50.77832.222 65.163 1.00 30.11 ATOM 2432 CD LYS 369 50.173 33.486 65.756 1.0033.96 ATOM 2433 CE LYS 369 50.598 33.679 67.206 1.00 36.40 ATOM 2434 NZLYS 369 49.966 34.897 67.802 1.00 39.20 ATOM 2435 C LYS 369 50.01330.392 61.833 1.00 26.02 ATOM 2436 O LYS 369 48.821 30.084 61.864 1.0025.69 ATOM 2437 N SER 370 50.689 30.503 60.696 1.00 23.45 ATOM 2438 CASER 370 50.021 30.262 59.421 1.00 23.37 ATOM 2439 CB SER 370 50.89730.732 58.249 1.00 21.85 ATOM 2440 OG SER 370 51.005 32.143 58.202 1.0019.18 ATOM 2441 C SER 370 49.668 28.792 59.214 1.00 23.22 ATOM 2442 OSER 370 50.301 27.901 59.777 1.00 23.81 ATOM 2443 N MET 371 48.63928.549 58.411 1.00 23.49 ATOM 2444 CA MET 371 48.224 27.193 58.083 1.0024.10 ATOM 2445 CB MET 371 46.730 26.991 58.349 1.00 23.79 ATOM 2446 CGMET 371 46.260 25.564 58.100 1.00 23.95 ATOM 2447 SD MET 371 44.47525.392 57.941 1.00 26.45 ATOM 2448 CE MET 371 44.296 25.509 56.167 1.0026.30 ATOM 2449 C MET 371 48.506 27.061 56.588 1.00 24.40 ATOM 2450 OMET 371 47.671 27.417 55.755 1.00 24.50 ATOM 2451 N LEU 372 49.69126.559 56.257 1.00 25.00 ATOM 2452 CA LEU 372 50.099 26.409 54.865 1.0025.46 ATOM 2453 CB LEU 372 51.599 26.684 54.743 1.00 23.72 ATOM 2454 CGLEU 372 52.070 27.996 55.382 1.00 24.19 ATOM 2455 CD1 LEU 372 53.58128.097 55.296 1.00 23.40 ATOM 2456 CD2 LEU 372 51.408 29.184 54.688 1.0022.75 ATOM 2457 C LEU 372 49.770 25.044 54.267 1.00 26.72 ATOM 2458 OLEU 372 49.995 24.815 53.080 1.00 27.70 ATOM 2459 N GLU 373 49.23824.141 55.086 1.00 27.93 ATOM 2460 CA GLU 373 48.879 22.803 54.620 1.0029.95 ATOM 2461 CB GLU 373 49.850 21.750 55.164 1.00 32.89 ATOM 2462 CGGLU 373 51.281 21.859 54.689 1.00 38.75 ATOM 2463 CD GLU 373 52.09920.640 55.086 1.00 42.30 ATOM 2464 OE1 GLU 373 52.259 20.397 56.302 1.0044.27 ATOM 2465 OE2 GLU 373 52.573 19.918 54.181 1.00 43.48 ATOM 2466 CGLU 373 47.483 22.425 55.084 1.00 29.73 ATOM 2467 O GLU 373 47.01122.899 56.115 1.00 30.00 ATOM 2468 N LYS 374 46.824 21.562 54.324 1.0029.28 ATOM 2469 CA LYS 374 45.497 21.107 54.699 1.00 30.95 ATOM 2470 CBLYS 374 44.889 20.253 53.586 1.00 31.28 ATOM 2471 CG LYS 374 43.44419.847 53.822 1.00 31.52 ATOM 2472 CD LYS 374 42.926 19.049 52.631 1.0033.34 ATOM 2473 CE LYS 374 41.415 19.128 52.514 1.00 33.68 ATOM 2474 NZLYS 374 40.933 18.533 51.235 1.00 33.80 ATOM 2475 C LYS 374 45.69720.256 55.944 1.00 32.17 ATOM 2476 O LYS 374 46.520 19.342 55.948 1.0032.16 ATOM 2477 N PRO 375 44.975 20.567 57.030 1.00 33.39 ATOM 2478 CDPRO 375 44.183 21.784 57.276 1.00 33.07 ATOM 2479 CA PRO 375 45.12019.785 58.261 1.00 34.99 ATOM 2480 CB PRO 375 44.196 20.512 59.236 1.0034.90 ATOM 2481 CG PRO 375 44.299 21.933 58.777 1.00 33.52 ATOM 2482 CPRO 375 44.724 18.323 58.064 1.00 35.62 ATOM 2483 O PRO 375 43.81218.013 57.296 1.00 34.22 ATOM 2484 N THR 376 45.421 17.428 58.755 1.0037.71 ATOM 2485 CA THR 376 45.138 16.000 58.665 1.00 39.65 ATOM 2486 CBTHR 376 46.308 15.233 58.009 1.00 39.07 ATOM 2487 OG1 THR 376 47.49115.390 58.804 1.00 38.66 ATOM 2488 CG2 THR 376 46.575 15.762 56.608 1.0039.31 ATOM 2489 C THR 376 44.906 15.439 60.063 1.00 41.67 ATOM 2490 OTHR 376 45.345 14.333 60.379 1.00 42.78 ATOM 2491 N ASP 377 44.22116.211 60.900 1.00 42.52 ATOM 2492 CA ASP 377 43.946 15.781 62.264 1.0043.25 ATOM 2493 CB ASP 377 44.579 16.748 63.272 1.00 44.11 ATOM 2494 CGASP 377 44.103 18.181 63.093 1.00 44.64 ATOM 2495 OD1 ASP 377 42.87918.394 62.984 1.00 43.68 ATOM 2496 OD2 ASP 377 44.955 19.095 63.072 1.0044.31 ATOM 2497 C ASP 377 42.455 15.649 62.549 1.00 43.56 ATOM 2498 OASP 377 42.031 15.714 63.703 1.00 43.97 ATOM 2499 N GLY 378 41.66415.473 61.496 1.00 43.76 ATOM 2500 CA GLY 378 40.234 15.313 61.674 1.0045.10 ATOM 2501 C GLY 378 39.389 16.574 61.613 1.00 45.20 ATOM 2502 OGLY 378 38.160 16.480 61.553 1.00 46.83 ATOM 2503 N ARG 379 40.01817.747 61.629 1.00 43.58 ATOM 2504 CA ARG 379 39.248 18.985 61.569 1.0041.75 ATOM 2505 CB ARG 379 39.902 20.086 62.417 1.00 41.40 ATOM 2506 CGARG 379 41.307 20.489 62.025 1.00 41.01 ATOM 2507 CD ARG 379 41.89221.409 63.091 1.00 40.32 ATOM 2508 NE ARG 379 43.352 21.472 63.049 1.0042.06 ATOM 2509 CZ ARG 379 44.051 22.421 62.435 1.00 42.42 ATOM 2510 NH1ARG 379 43.431 23.409 61.801 1.00 42.84 ATOM 2511 NH2 ARG 379 45.37622.384 62.456 1.00 42.41 ATOM 2512 C ARG 379 39.017 19.488 60.150 1.0039.88 ATOM 2513 O ARG 379 39.884 19.385 59.284 1.00 39.95 ATOM 2514 NGLU 380 37.819 20.015 59.927 1.00 37.75 ATOM 2515 CA GLU 380 37.42420.552 58.635 1.00 35.59 ATOM 2516 CB GLU 380 35.913 20.375 58.456 1.0038.09 ATOM 2517 CG GLU 380 35.383 20.691 57.068 1.00 42.10 ATOM 2518 CDGLU 380 34.658 19.508 56.444 1.00 43.64 ATOM 2519 OE1 GLU 380 33.78918.911 57.120 1.00 45.08 ATOM 2520 OE2 GLU 380 34.951 19.179 55.277 1.0043.23 ATOM 2521 C GLU 380 37.793 22.034 58.633 1.00 31.78 ATOM 2522 OGLU 380 37.679 22.705 59.659 1.00 28.75 ATOM 2523 N VAL 381 38.24122.545 57.492 1.00 29.15 ATOM 2524 CA VAL 381 38.630 23.950 57.404 1.0026.32 ATOM 2525 CB VAL 381 40.169 24.112 57.499 1.00 24.57 ATOM 2526 CG1VAL 381 40.705 23.390 58.726 1.00 25.23 ATOM 2527 CG2 VAL 381 40.82423.560 56.247 1.00 25.89 ATOM 2528 C VAL 381 38.185 24.577 56.090 1.0024.82 ATOM 2529 O VAL 381 37.661 23.896 55.208 1.00 24.94 ATOM 2530 NVAL 382 38.383 25.887 55.975 1.00 23.19 ATOM 2531 CA VAL 382 38.07026.602 54.744 1.00 21.67 ATOM 2532 CB VAL 382 37.674 28.073 54.999 1.0021.80 ATOM 2533 CG1 VAL 382 37.563 28.811 53.674 1.00 20.55 ATOM 2534CG2 VAL 382 36.348 28.145 55.744 1.00 21.77 ATOM 2535 C VAL 382 39.40126.582 54.006 1.00 21.54 ATOM 2536 O VAL 382 40.341 27.267 54.402 1.0020.36 ATOM 2537 N CYS 383 39.492 25.779 52.953 1.00 21.15 ATOM 2538 CACYS 383 40.734 25.676 52.203 1.00 21.33 ATOM 2539 C CYS 383 41.07126.872 51.324 1.00 20.79 ATOM 2540 O CYS 383 42.241 27.238 51.206 1.0021.41 ATOM 2541 CB CYS 383 40.730 24.407 51.351 1.00 21.86 ATOM 2542 SGCYS 383 41.329 22.923 52.225 1.00 23.08 ATOM 2543 N HIS 384 40.05527.482 50.716 1.00 19.24 ATOM 2544 CA HIS 384 40.269 28.628 49.829 1.0017.16 ATOM 2545 CB HIS 384 38.957 29.376 49.584 1.00 13.14 ATOM 2546 CGHIS 384 39.027 30.345 48.447 1.00 13.04 ATOM 2547 CD2 HIS 384 39.47631.621 48.390 1.00 11.87 ATOM 2548 ND1 HIS 384 38.665 30.009 47.159 1.0012.76 ATOM 2549 CE1 HIS 384 38.888 31.036 46.360 1.00 14.29 ATOM 2550NE2 HIS 384 39.381 32.028 47.081 1.00 15.54 ATOM 2551 C HIS 384 41.30729.602 50.388 1.00 17.15 ATOM 2552 O HIS 384 41.058 30.293 51.375 1.0018.56 ATOM 2553 N ALA 385 42.465 29.653 49.738 1.00 15.37 ATOM 2554 CAALA 385 43.573 30.514 50.152 1.00 15.12 ATOM 2555 CB ALA 385 44.66330.492 49.081 1.00 12.93 ATOM 2556 C ALA 385 43.216 31.965 50.478 1.0013.38 ATOM 2557 O ALA 385 42.495 32.626 49.733 1.00 13.27 ATOM 2558 NSER 386 43.739 32.456 51.596 1.00 12.79 ATOM 2559 CA SER 386 43.50833.837 52.003 1.00 13.42 ATOM 2560 CB SER 386 42.123 33.988 52.651 1.0012.99 ATOM 2561 OG SER 386 41.970 33.130 53.765 1.00 14.28 ATOM 2562 CSER 386 44.602 34.324 52.954 1.00 13.14 ATOM 2563 O SER 386 45.26333.525 53.629 1.00 12.93 ATOM 2564 N ALA 387 44.800 35.640 52.979 1.0013.15 ATOM 2565 CA ALA 387 45.803 36.280 53.825 1.00 13.29 ATOM 2566 CBALA 387 46.653 37.239 53.003 1.00 13.06 ATOM 2567 C ALA 387 45.06437.033 54.920 1.00 14.39 ATOM 2568 O ALA 387 44.017 37.637 54.672 1.0015.15 ATOM 2569 N TRP 388 45.621 37.014 56.124 1.00 14.45 ATOM 2570 CATRP 388 44.981 37.641 57.272 1.00 15.44 ATOM 2571 CB TRP 388 44.55936.547 58.263 1.00 15.81 ATOM 2572 CG TRP 388 43.575 35.556 57.707 1.0015.75 ATOM 2573 CD2 TRP 388 42.297 35.219 58.261 1.00 17.72 ATOM 2574CE2 TRP 388 41.716 34.241 57.416 1.00 17.38 ATOM 2575 CE3 TRP 388 41.58435.649 59.391 1.00 18.07 ATOM 2576 CD1 TRP 388 43.717 34.789 56.581 1.0016.55 ATOM 2577 NE1 TRP 388 42.602 33.997 56.400 1.00 15.73 ATOM 2578CZ2 TRP 388 40.454 33.687 57.668 1.00 18.71 ATOM 2579 CZ3 TRP 388 40.32735.095 59.642 1.00 19.40 ATOM 2580 CH2 TRP 388 39.777 34.125 58.782 1.0018.61 ATOM 2581 C TRP 388 45.805 38.692 58.014 1.00 17.06 ATOM 2582 OTRP 388 46.989 38.499 58.298 1.00 17.43 ATOM 2583 N ASP 389 45.15239.807 58.328 1.00 16.13 ATOM 2584 CA ASP 389 45.764 40.900 59.073 1.0017.75 ATOM 2585 CB ASP 389 45.501 42.231 58.365 1.00 17.00 ATOM 2586 CGASP 389 46.187 43.399 59.041 1.00 16.49 ATOM 2587 OD1 ASP 389 46.52443.285 60.239 1.00 18.76 ATOM 2588 OD2 ASP 389 46.382 44.436 58.376 1.0014.01 ATOM 2589 C ASP 389 45.054 40.888 60.433 1.00 19.06 ATOM 2590 OASP 389 43.828 41.011 60.488 1.00 19.40 ATOM 2591 N PHE 390 45.80540.726 61.520 1.00 18.93 ATOM 2592 CA PHE 390 45.189 40.686 62.846 1.0022.25 ATOM 2593 CB PHE 390 45.850 39.603 63.709 1.00 21.51 ATOM 2594 CGPHE 390 45.477 38.208 63.294 1.00 23.36 ATOM 2595 CD1 PHE 390 45.99737.655 62.125 1.00 21.45 ATOM 2596 CD2 PHE 390 44.547 37.475 64.027 1.0022.78 ATOM 2597 CE1 PHE 390 45.595 36.395 61.687 1.00 23.06 ATOM 2598CE2 PHE 390 44.136 36.214 63.599 1.00 25.87 ATOM 2599 CZ PHE 390 44.66135.671 62.424 1.00 24.50 ATOM 2600 C PHE 390 45.170 42.026 63.573 1.0023.40 ATOM 2601 O PHE 390 44.937 42.096 64.785 1.00 21.79 ATOM 2602 NTYR 391 45.407 43.079 62.799 1.00 24.34 ATOM 2603 CA TYR 391 45.39944.468 63.253 1.00 26.72 ATOM 2604 CB TYR 391 43.957 44.944 63.445 1.0029.46 ATOM 2605 CG TYR 391 43.030 44.570 62.312 1.00 32.43 ATOM 2606 CD1TYR 391 42.389 43.336 62.297 1.00 34.89 ATOM 2607 CE1 TYR 391 41.53742.978 61.262 1.00 37.09 ATOM 2608 CD2 TYR 391 42.801 45.445 61.252 1.0035.38 ATOM 2609 CE2 TYR 391 41.951 45.095 60.204 1.00 37.31 ATOM 2610 CZTYR 391 41.321 43.860 60.221 1.00 37.51 ATOM 2611 OH TYR 391 40.45743.505 59.212 1.00 41.58 ATOM 2612 C TYR 391 46.205 44.861 64.487 1.0025.67 ATOM 2613 O TYR 391 45.776 45.725 65.247 1.00 27.20 ATOM 2614 NASN 392 47.360 44.243 64.696 1.00 24.64 ATOM 2615 CA ASN 392 48.20044.613 65.829 1.00 24.09 ATOM 2616 CB ASN 392 48.261 43.492 66.881 1.0023.53 ATOM 2617 CG ASN 392 48.960 42.241 66.380 1.00 22.41 ATOM 2618 OD1ASN 392 49.428 42.181 65.247 1.00 21.54 ATOM 2619 ND2 ASN 392 49.03241.229 67.236 1.00 23.26 ATOM 2620 C ASN 392 49.592 44.930 65.295 1.0024.22 ATOM 2621 O ASN 392 50.548 45.073 66.055 1.00 23.88 ATOM 2622 NGLY 393 49.679 45.040 63.969 1.00 22.80 ATOM 2623 CA GLY 393 50.93445.353 63.311 1.00 20.67 ATOM 2624 C GLY 393 52.025 44.319 63.515 1.0021.15 ATOM 2625 O GLY 393 53.178 44.560 63.170 1.00 20.78 ATOM 2626 NLYS 394 51.666 43.156 64.048 1.00 20.82 ATOM 2627 CA LYS 394 52.65742.118 64.308 1.00 22.60 ATOM 2628 CB LYS 394 52.909 42.024 65.818 1.0024.94 ATOM 2629 CG LYS 394 54.363 42.153 66.216 1.00 30.63 ATOM 2630 CDLYS 394 54.916 43.524 65.854 1.00 33.49 ATOM 2631 CE LYS 394 54.35544.606 66.757 1.00 35.47 ATOM 2632 NZ LYS 394 54.708 44.359 68.185 1.0037.56 ATOM 2633 C LYS 394 52.253 40.745 63.789 1.00 21.67 ATOM 2634 OLYS 394 53.079 40.001 63.261 1.00 22.03 ATOM 2635 N ASP 395 50.97340.427 63.940 1.00 21.32 ATOM 2636 CA ASP 395 50.425 39.134 63.553 1.0020.91 ATOM 2637 CB ASP 395 49.440 38.689 64.642 1.00 19.12 ATOM 2638 CGASP 395 49.053 37.227 64.534 1.00 19.78 ATOM 2639 OD1 ASP 395 49.34436.589 63.501 1.00 20.54 ATOM 2640 OD2 ASP 395 48.438 36.715 65.495 1.0021.66 ATOM 2641 C ASP 395 49.737 39.110 62.178 1.00 21.80 ATOM 2642 OASP 395 48.651 39.670 62.001 1.00 20.60 ATOM 2643 N PHE 396 50.37838.454 61.213 1.00 20.77 ATOM 2644 CA PHE 396 49.830 38.312 59.863 1.0020.20 ATOM 2645 CB PHE 396 50.634 39.132 58.849 1.00 19.48 ATOM 2646 CGPHE 396 51.005 40.501 59.330 1.00 19.47 ATOM 2647 CD1 PHE 396 52.21240.715 59.987 1.00 18.23 ATOM 2648 CD2 PHE 396 50.149 41.580 59.127 1.0019.80 ATOM 2649 CE1 PHE 396 52.564 41.989 60.436 1.00 16.62 ATOM 2650CE2 PHE 396 50.492 42.855 59.572 1.00 18.16 ATOM 2651 CZ PHE 396 51.70343.059 60.228 1.00 18.20 ATOM 2652 C PHE 396 49.945 36.832 59.514 1.0019.88 ATOM 2653 O PHE 396 50.942 36.193 59.847 1.00 22.26 ATOM 2654 NARG 397 48.945 36.281 58.840 1.00 19.00 ATOM 2655 CA ARG 397 48.98934.864 58.502 1.00 18.47 ATOM 2656 CB ARG 397 48.286 34.037 59.579 1.0019.59 ATOM 2657 CG ARG 397 48.542 34.466 61.009 1.00 19.93 ATOM 2658 CDARG 397 47.667 33.642 61.944 1.00 20.65 ATOM 2659 NE ARG 397 47.58834.223 63.280 1.00 23.90 ATOM 2660 CZ ARG 397 46.806 33.759 64.250 1.0024.44 ATOM 2661 NH1 ARG 397 46.033 32.702 64.033 1.00 25.15 ATOM 2662NH2 ARG 397 46.792 34.358 65.434 1.00 25.23 ATOM 2663 C ARG 397 48.32734.526 57.179 1.00 18.41 ATOM 2664 O ARG 397 47.504 35.279 56.661 1.0016.23 ATOM 2665 N ILE 398 48.683 33.359 56.653 1.00 17.80 ATOM 2666 CAILE 398 48.098 32.867 55.419 1.00 17.44 ATOM 2667 CB ILE 398 49.17232.720 54.310 1.00 17.61 ATOM 2668 CG2 ILE 398 48.685 31.774 53.217 1.0018.45 ATOM 2669 CG1 ILE 398 49.498 34.107 53.734 1.00 16.21 ATOM 2670CD1 ILE 398 50.554 34.110 52.628 1.00 14.34 ATOM 2671 C ILE 398 47.43731.524 55.724 1.00 17.31 ATOM 2672 O ILE 398 47.964 30.723 56.502 1.0017.20 ATOM 2673 N LYS 399 46.260 31.310 55.145 1.00 16.54 ATOM 2674 CALYS 399 45.506 30.074 55.326 1.00 17.03 ATOM 2675 CB LYS 399 44.15230.355 55.984 1.00 16.41 ATOM 2676 CG LYS 399 43.323 29.102 56.237 1.0016.93 ATOM 2677 CD LYS 399 41.871 29.433 56.562 1.00 18.85 ATOM 2678 CELYS 399 41.218 30.234 55.439 1.00 19.45 ATOM 2679 NZ LYS 399 41.42329.599 54.106 1.00 18.46 ATOM 2680 C LYS 399 45.294 29.498 53.934 1.0018.35 ATOM 2681 O LYS 399 44.492 30.013 53.149 1.00 17.47 ATOM 2682 NGLN 400 46.010 28.421 53.633 1.00 18.80 ATOM 2683 CA GLN 400 45.93627.809 52.316 1.00 17.16 ATOM 2684 CB GLN 400 46.963 28.505 51.413 1.0016.79 ATOM 2685 CG GLN 400 46.952 28.124 49.946 1.00 19.01 ATOM 2686 CDGLN 400 47.967 28.933 49.144 1.00 19.64 ATOM 2687 OE1 GLN 400 48.17130.118 49.401 1.00 19.74 ATOM 2688 NE2 GLN 400 48.598 28.296 48.163 1.0021.63 ATOM 2689 C GLN 400 46.236 26.313 52.382 1.00 17.92 ATOM 2690 OGLN 400 47.236 25.909 52.966 1.00 16.80 ATOM 2691 N CYS 401 45.36325.495 51.805 1.00 19.15 ATOM 2692 CA CYS 401 45.602 24.055 51.771 1.0021.48 ATOM 2693 C CYS 401 46.472 23.902 50.528 1.00 21.39 ATOM 2694 OCYS 401 46.039 23.417 49.485 1.00 23.39 ATOM 2695 CB CYS 401 44.28823.278 51.619 1.00 20.09 ATOM 2696 SG CYS 401 43.111 23.526 52.994 1.0023.70 ATOM 2697 N THR 402 47.706 24.363 50.663 1.00 21.55 ATOM 2698 CATHR 402 48.681 24.362 49.591 1.00 21.97 ATOM 2699 CB THR 402 50.02224.915 50.096 1.00 21.86 ATOM 2700 OG1 THR 402 49.800 26.175 50.744 1.0020.74 ATOM 2701 CG2 THR 402 50.995 25.103 48.936 1.00 20.95 ATOM 2702 CTHR 402 48.941 23.017 48.936 1.00 24.16 ATOM 2703 O THR 402 49.11221.999 49.612 1.00 24.28 ATOM 2704 N THR 403 48.965 23.036 47.608 1.0023.67 ATOM 2705 CA THR 403 49.249 21.859 46.802 1.00 23.28 ATOM 2706 CBTHR 403 48.158 21.620 45.739 1.00 24.61 ATOM 2707 OG1 THR 403 46.92221.312 46.390 1.00 25.63 ATOM 2708 CG2 THR 403 48.541 20.458 44.830 1.0026.73 ATOM 2709 C THR 403 50.571 22.162 46.108 1.00 23.10 ATOM 2710 OTHR 403 50.816 23.296 45.692 1.00 22.88 ATOM 2711 N VAL 404 51.42821.157 45.986 1.00 23.09 ATOM 2712 CA VAL 404 52.724 21.359 45.359 1.0023.31 ATOM 2713 CB VAL 404 53.762 20.342 45.887 1.00 23.84 ATOM 2714 CG1VAL 404 55.115 20.589 45.241 1.00 23.34 ATOM 2715 CG2 VAL 404 53.87020.457 47.395 1.00 22.82 ATOM 2716 C VAL 404 52.691 21.293 43.834 1.0023.74 ATOM 2717 O VAL 404 52.808 20.218 43.241 1.00 23.48 ATOM 2718 NASN 405 52.517 22.457 43.215 1.00 22.93 ATOM 2719 CA ASN 405 52.50022.602 41.762 1.00 22.84 ATOM 2720 CB ASN 405 51.186 22.099 41.154 1.0022.95 ATOM 2721 CG ASN 405 49.970 22.816 41.702 1.00 24.71 ATOM 2722 OD1ASN 405 49.970 24.036 41.861 1.00 24.62 ATOM 2723 ND2 ASN 405 48.91522.058 41.981 1.00 24.60 ATOM 2724 C ASN 405 52.705 24.078 41.423 1.0022.93 ATOM 2725 O ASN 405 52.654 24.938 42.306 1.00 19.22 ATOM 2726 NLEU 406 52.932 24.368 40.147 1.00 23.26 ATOM 2727 CA LEU 406 53.17325.738 39.709 1.00 24.41 ATOM 2728 CB LEU 406 53.514 25.762 38.214 1.0026.22 ATOM 2729 CG LEU 406 54.513 26.821 37.724 1.00 29.20 ATOM 2730 CD1LEU 406 54.502 26.848 36.196 1.00 27.25 ATOM 2731 CD2 LEU 406 54.16228.194 38.271 1.00 30.58 ATOM 2732 C LEU 406 51.984 26.664 39.971 1.0024.64 ATOM 2733 O LEU 406 52.162 27.808 40.393 1.00 23.62 ATOM 2734 NGLU 407 50.774 26.171 39.726 1.00 24.14 ATOM 2735 CA GLU 407 49.58426.987 39.927 1.00 24.63 ATOM 2736 CB GLU 407 48.324 26.185 39.589 1.0026.59 ATOM 2737 CG GLU 407 47.126 27.059 39.257 1.00 30.80 ATOM 2738 CDGLU 407 45.917 26.266 38.798 1.00 33.25 ATOM 2739 OE1 GLU 407 46.09425.139 38.293 1.00 33.52 ATOM 2740 OE2 GLU 407 44.787 26.780 38.927 1.0035.96 ATOM 2741 C GLU 407 49.499 27.525 41.357 1.00 23.70 ATOM 2742 OGLU 407 49.194 28.697 41.566 1.00 23.73 ATOM 2743 N ASP 408 49.77526.675 42.340 1.00 21.73 ATOM 2744 CA ASP 408 49.717 27.107 43.731 1.0021.63 ATOM 2745 CB ASP 408 49.541 25.899 44.653 1.00 23.21 ATOM 2746 CGASP 408 48.247 25.958 45.438 1.00 23.22 ATOM 2747 OD1 ASP 408 47.30126.620 44.963 1.00 25.47 ATOM 2748 OD2 ASP 408 48.166 25.340 46.519 1.0025.23 ATOM 2749 C ASP 408 50.944 27.926 44.138 1.00 20.39 ATOM 2750 OASP 408 50.922 28.635 45.146 1.00 19.37 ATOM 2751 N LEU 409 52.01627.831 43.360 1.00 18.98 ATOM 2752 CA LEU 409 53.209 28.611 43.659 1.0018.41 ATOM 2753 CB LEU 409 54.383 28.173 42.780 1.00 20.25 ATOM 2754 CGLEU 409 55.692 28.941 43.001 1.00 20.55 ATOM 2755 CD1 LEU 409 56.11328.815 44.447 1.00 21.00 ATOM 2756 CD2 LEU 409 56.778 28.404 42.083 1.0022.20 ATOM 2757 C LEU 409 52.849 30.067 43.362 1.00 17.90 ATOM 2758 OLEU 409 53.274 30.987 44.062 1.00 16.65 ATOM 2759 N VAL 410 52.05730.266 42.313 1.00 16.80 ATOM 2760 CA VAL 410 51.618 31.605 41.943 1.0016.49 ATOM 2761 CB VAL 410 50.920 31.600 40.561 1.00 16.89 ATOM 2762 CG1VAL 410 50.352 32.977 40.247 1.00 14.92 ATOM 2763 CG2 VAL 410 51.91931.198 39.491 1.00 15.83 ATOM 2764 C VAL 410 50.656 32.106 43.024 1.0015.73 ATOM 2765 O VAL 410 50.732 33.258 43.443 1.00 14.75 ATOM 2766 NVAL 411 49.763 31.232 43.484 1.00 15.97 ATOM 2767 CA VAL 411 48.81331.603 44.533 1.00 15.75 ATOM 2768 CB VAL 411 47.870 30.425 44.902 1.0015.53 ATOM 2769 CG1 VAL 411 47.006 30.805 46.114 1.00 11.21 ATOM 2770CG2 VAL 411 46.982 30.070 43.711 1.00 14.36 ATOM 2771 C VAL 411 49.56132.034 45.796 1.00 16.60 ATOM 2772 O VAL 411 49.194 33.015 46.445 1.0014.95 ATOM 2773 N ALA 412 50.610 31.296 46.146 1.00 16.80 ATOM 2774 CAALA 412 51.392 31.624 47.328 1.00 16.33 ATOM 2775 CB ALA 412 52.54130.632 47.490 1.00 17.31 ATOM 2776 C ALA 412 51.930 33.047 47.213 1.0016.81 ATOM 2777 O ALA 412 51.940 33.793 48.188 1.00 15.68 ATOM 2778 NHIS 413 52.386 33.419 46.018 1.00 16.29 ATOM 2779 CA HIS 413 52.90834.764 45.802 1.00 14.95 ATOM 2780 CB HIS 413 53.576 34.886 44.425 1.0014.73 ATOM 2781 CG HIS 413 54.942 34.282 44.362 1.00 14.13 ATOM 2782 CD2HIS 413 56.169 34.855 44.354 1.00 14.28 ATOM 2783 ND1 HIS 413 55.15532.920 44.333 1.00 13.46 ATOM 2784 CE1 HIS 413 56.454 32.681 44.310 1.0014.23 ATOM 2785 NE2 HIS 413 57.091 33.837 44.322 1.00 15.75 ATOM 2786 CHIS 413 51.768 35.765 45.910 1.00 13.28 ATOM 2787 O HIS 413 51.92336.834 46.493 1.00 11.46 ATOM 2788 N HIS 414 50.620 35.409 45.342 1.0014.51 ATOM 2789 CA HIS 414 49.447 36.276 45.391 1.00 13.47 ATOM 2790 CBHIS 414 48.235 35.570 44.775 1.00 15.00 ATOM 2791 CG HIS 414 46.97136.370 44.849 1.00 15.40 ATOM 2792 CD2 HIS 414 45.972 36.376 45.766 1.0013.24 ATOM 2793 ND1 HIS 414 46.647 37.339 43.923 1.00 14.33 ATOM 2794CE1 HIS 414 45.504 37.908 44.267 1.00 14.69 ATOM 2795 NE2 HIS 414 45.07537.341 45.381 1.00 12.08 ATOM 2796 C HIS 414 49.136 36.626 46.845 1.0014.00 ATOM 2797 O HIS 414 48.984 37.802 47.190 1.00 13.07 ATOM 2798 NGLU 415 49.049 35.599 47.690 1.00 12.38 ATOM 2799 CA GLU 415 48.74235.788 49.105 1.00 13.04 ATOM 2800 CB GLU 415 48.489 34.440 49.782 1.0011.80 ATOM 2801 CG GLU 415 47.322 33.650 49.205 1.00 12.84 ATOM 2802 CDGLU 415 46.014 34.422 49.240 1.00 12.28 ATOM 2803 OE1 GLU 415 45.83335.250 50.159 1.00 11.52 ATOM 2804 OE2 GLU 415 45.159 34.188 48.359 1.0012.50 ATOM 2805 C GLU 415 49.839 36.535 49.850 1.00 13.54 ATOM 2806 OGLU 415 49.551 37.346 50.726 1.00 14.84 ATOM 2807 N MET 416 51.09636.258 49.512 1.00 13.52 ATOM 2808 CA MET 416 52.208 36.941 50.167 1.0014.41 ATOM 2809 CB MET 416 53.542 36.304 49.767 1.00 14.35 ATOM 2810 CGMET 416 53.786 34.943 50.429 1.00 15.99 ATOM 2811 SD MET 416 54.13235.070 52.218 1.00 17.59 ATOM 2812 CE MET 416 55.885 35.543 52.156 1.0014.94 ATOM 2813 C MET 416 52.176 38.424 49.796 1.00 13.49 ATOM 2814 OMET 416 52.660 39.276 50.543 1.00 11.88 ATOM 2815 N GLY 417 51.59238.725 48.642 1.00 13.47 ATOM 2816 CA GLY 417 51.473 40.107 48.217 1.0011.88 ATOM 2817 C GLY 417 50.547 40.833 49.186 1.00 10.84 ATOM 2818 OGLY 417 50.774 41.995 49.517 1.00 10.89 ATOM 2819 N HIS 418 49.49940.146 49.639 1.00 11.02 ATOM 2820 CA HIS 418 48.555 40.732 50.595 1.0012.04 ATOM 2821 CB HIS 418 47.382 39.784 50.864 1.00 11.04 ATOM 2822 CGHIS 418 46.385 39.711 49.752 1.00 12.59 ATOM 2823 CD2 HIS 418 45.84238.648 49.112 1.00 9.69 ATOM 2824 ND1 HIS 418 45.783 40.830 49.214 1.0013.07 ATOM 2825 CE1 HIS 418 44.912 40.458 48.294 1.00 11.52 ATOM 2826NE2 HIS 418 44.928 39.140 48.213 1.00 12.75 ATOM 2827 C HIS 418 49.27141.003 51.916 1.00 11.39 ATOM 2828 O HIS 418 49.122 42.071 52.512 1.0011.43 ATOM 2829 N ILE 419 50.039 40.018 52.373 1.00 11.02 ATOM 2830 CAILE 419 50.788 40.147 53.619 1.00 11.33 ATOM 2831 CB ILE 419 51.61338.874 53.905 1.00 12.82 ATOM 2832 CG2 ILE 419 52.405 39.042 55.195 1.0012.45 ATOM 2833 CG1 ILE 419 50.681 37.658 53.991 1.00 12.12 ATOM 2834CD1 ILE 419 49.672 37.730 55.117 1.00 14.37 ATOM 2835 C ILE 419 51.73841.343 53.548 1.00 11.48 ATOM 2836 O ILE 419 51.853 42.113 54.500 1.0012.38 ATOM 2837 N GLN 420 52.417 41.496 52.417 1.00 11.52 ATOM 2838 CAGLN 420 53.347 42.607 52.245 1.00 13.30 ATOM 2839 CB GLN 420 54.00442.544 50.859 1.00 12.77 ATOM 2840 CG GLN 420 55.044 43.636 50.636 1.0014.92 ATOM 2841 CD GLN 420 56.256 43.491 51.546 1.00 14.49 ATOM 2842 OE1GLN 420 56.897 44.479 51.904 1.00 17.00 ATOM 2843 NE2 GLN 420 56.58542.255 51.908 1.00 14.95 ATOM 2844 C GLN 420 52.599 43.932 52.412 1.0013.79 ATOM 2845 O GLN 420 53.065 44.844 53.101 1.00 14.70 ATOM 2846 NTYR 421 51.435 44.035 51.780 1.00 13.96 ATOM 2847 CA TYR 421 50.63145.246 51.876 1.00 13.60 ATOM 2848 CB TYR 421 49.372 45.099 51.014 1.0010.92 ATOM 2849 CG TYR 421 49.037 46.321 50.179 1.00 11.34 ATOM 2850 CD1TYR 421 48.590 46.183 48.862 1.00 10.38 ATOM 2851 CE1 TYR 421 48.25547.287 48.093 1.00 8.53 ATOM 2852 CD2 TYR 421 49.140 47.611 50.706 1.0010.33 ATOM 2853 CE2 TYR 421 48.799 48.737 49.940 1.00 11.19 ATOM 2854 CZTYR 421 48.356 48.561 48.634 1.00 12.22 ATOM 2855 OH TYR 421 47.98549.647 47.872 1.00 10.08 ATOM 2856 C TYR 421 50.259 45.499 53.348 1.0013.85 ATOM 2857 O TYR 421 50.371 46.626 53.835 1.00 12.91 ATOM 2858 NPHE 422 49.823 44.451 54.049 1.00 15.40 ATOM 2859 CA PHE 422 49.46144.567 55.466 1.00 17.19 ATOM 2860 CB PHE 422 49.173 43.189 56.076 1.0015.34 ATOM 2861 CG PHE 422 47.925 42.526 55.559 1.00 15.78 ATOM 2862 CD1PHE 422 47.776 41.143 55.655 1.00 14.31 ATOM 2863 CD2 PHE 422 46.89643.272 54.994 1.00 14.76 ATOM 2864 CE1 PHE 422 46.621 40.510 55.197 1.0016.76 ATOM 2865 CE2 PHE 422 45.734 42.649 54.532 1.00 16.42 ATOM 2866 CZPHE 422 45.599 41.265 54.633 1.00 16.96 ATOM 2867 C PHE 422 50.61145.185 56.254 1.00 17.06 ATOM 2868 O PHE 422 50.412 46.105 57.045 1.0017.66 ATOM 2869 N MET 423 51.814 44.664 56.031 1.00 16.17 ATOM 2870 CAMET 423 53.000 45.134 56.737 1.00 17.00 ATOM 2871 CB MET 423 54.18144.190 56.486 1.00 18.15 ATOM 2872 CG MET 423 53.943 42.754 56.931 1.0019.99 ATOM 2873 SD MET 423 55.472 41.792 57.000 1.00 20.03 ATOM 2874 CEMET 423 55.783 41.471 55.247 1.00 18.10 ATOM 2875 C MET 423 53.41346.552 56.373 1.00 17.22 ATOM 2876 O MET 423 53.849 47.315 57.236 1.0016.52 ATOM 2877 N GLN 424 53.277 46.905 55.097 1.00 16.46 ATOM 2878 CAGLN 424 53.659 48.234 54.631 1.00 15.32 ATOM 2879 CB GLN 424 53.57948.301 53.102 1.00 16.47 ATOM 2880 CG GLN 424 54.640 47.495 52.360 1.0017.02 ATOM 2881 CD GLN 424 56.031 48.092 52.496 1.00 19.21 ATOM 2882 OE1GLN 424 56.184 49.288 52.757 1.00 16.73 ATOM 2883 NE2 GLN 424 57.05347.266 52.297 1.00 17.82 ATOM 2884 C GLN 424 52.836 49.377 55.224 1.0015.29 ATOM 2885 O GLN 424 53.372 50.455 55.482 1.00 15.54 ATOM 2886 NTYR 425 51.539 49.157 55.433 1.00 15.59 ATOM 2887 CA TYR 425 50.68750.213 55.980 1.00 15.62 ATOM 2888 CB TYR 425 49.454 50.432 55.078 1.0014.74 ATOM 2889 CG TYR 425 48.519 49.240 54.865 1.00 14.73 ATOM 2890 CD1TYR 425 48.073 48.457 55.935 1.00 11.96 ATOM 2891 CE1 TYR 425 47.11547.446 55.750 1.00 13.33 ATOM 2892 CD2 TYR 425 47.990 48.972 53.597 1.0014.45 ATOM 2893 CE2 TYR 425 47.033 47.969 53.401 1.00 14.29 ATOM 2894 CZTYR 425 46.599 47.213 54.481 1.00 15.26 ATOM 2895 OH TYR 425 45.63346.253 54.287 1.00 13.69 ATOM 2896 C TYR 425 50.235 49.999 57.420 1.0015.99 ATOM 2897 O TYR 425 49.311 50.662 57.887 1.00 15.53 ATOM 2898 NLYS 426 50.903 49.096 58.131 1.00 18.15 ATOM 2899 CA LYS 426 50.53548.777 59.509 1.00 19.68 ATOM 2900 CB LYS 426 51.446 47.669 60.053 1.0019.35 ATOM 2901 CG LYS 426 52.893 48.084 60.268 1.00 21.71 ATOM 2902 CDLYS 426 53.700 46.947 60.895 1.00 23.93 ATOM 2903 CE LYS 426 55.14547.355 61.133 1.00 25.11 ATOM 2904 NZ LYS 426 55.224 48.568 61.996 1.0030.09 ATOM 2905 C LYS 426 50.533 49.947 60.495 1.00 20.54 ATOM 2906 OLYS 426 49.903 49.864 61.550 1.00 20.64 ATOM 2907 N ASP 427 51.22151.034 60.160 1.00 21.79 ATOM 2908 CA ASP 427 51.281 52.177 61.064 1.0023.05 ATOM 2909 CB ASP 427 52.692 52.763 61.078 1.00 23.93 ATOM 2910 CGASP 427 53.698 51.805 61.664 1.00 26.63 ATOM 2911 OD1 ASP 427 53.39451.228 62.732 1.00 26.74 ATOM 2912 OD2 ASP 427 54.780 51.631 61.066 1.0026.70 ATOM 2913 C ASP 427 50.275 53.280 60.787 1.00 22.13 ATOM 2914 OASP 427 50.265 54.302 61.472 1.00 21.25 ATOM 2915 N LEU 428 49.43353.078 59.783 1.00 21.00 ATOM 2916 CA LEU 428 48.422 54.071 59.456 1.0020.38 ATOM 2917 CB LEU 428 48.002 53.953 57.988 1.00 20.36 ATOM 2918 CGLEU 428 49.012 54.228 56.874 1.00 18.26 ATOM 2919 CD1 LEU 428 48.31454.052 55.532 1.00 16.44 ATOM 2920 CD2 LEU 428 49.571 55.642 57.005 1.0017.84 ATOM 2921 C LEU 428 47.200 53.831 60.324 1.00 19.95 ATOM 2922 OLEU 428 47.041 52.754 60.899 1.00 20.02 ATOM 2923 N PRO 429 46.33254.846 60.457 1.00 20.13 ATOM 2924 CD PRO 429 46.480 56.257 60.062 1.0018.31 ATOM 2925 CA PRO 429 45.129 54.650 61.269 1.00 19.43 ATOM 2926 CBPRO 429 44.377 55.960 61.083 1.00 18.57 ATOM 2927 CG PRO 429 45.48756.952 60.980 1.00 19.44 ATOM 2928 C PRO 429 44.394 53.459 60.652 1.0019.56 ATOM 2929 O PRO 429 44.330 53.336 59.429 1.00 18.88 ATOM 2930 NVAL 430 43.851 52.591 61.495 1.00 19.81 ATOM 2931 CA VAL 430 43.15951.393 61.038 1.00 21.00 ATOM 2932 CB VAL 430 42.475 50.677 62.232 1.0023.09 ATOM 2933 CG1 VAL 430 41.214 51.418 62.644 1.00 23.83 ATOM 2934CG2 VAL 430 42.168 49.241 61.870 1.00 24.99 ATOM 2935 C VAL 430 42.13551.614 59.913 1.00 20.48 ATOM 2936 O VAL 430 42.021 50.789 59.006 1.0018.44 ATOM 2937 N ALA 431 41.405 52.724 59.957 1.00 20.17 ATOM 2938 CAALA 431 40.401 53.002 58.933 1.00 20.14 ATOM 2939 CB ALA 431 39.58754.236 59.311 1.00 21.04 ATOM 2940 C ALA 431 41.029 53.197 57.560 1.0019.75 ATOM 2941 O ALA 431 40.350 53.110 56.540 1.00 20.64 ATOM 2942 NLEU 432 42.330 53.456 57.537 1.00 19.42 ATOM 2943 CA LEU 432 43.02353.667 56.277 1.00 17.67 ATOM 2944 CB LEU 432 43.821 54.974 56.336 1.0017.92 ATOM 2945 CG LEU 432 43.038 56.238 56.721 1.00 16.23 ATOM 2946 CD1LEU 432 43.996 57.416 56.789 1.00 18.02 ATOM 2947 CD2 LEU 432 41.92956.512 55.703 1.00 17.85 ATOM 2948 C LEU 432 43.946 52.500 55.935 1.0018.33 ATOM 2949 O LEU 432 44.758 52.592 55.010 1.00 19.78 ATOM 2950 NARG 433 43.824 51.401 56.676 1.00 17.58 ATOM 2951 CA ARG 433 44.65450.231 56.410 1.00 19.13 ATOM 2952 CB ARG 433 44.894 49.428 57.695 1.0020.01 ATOM 2953 CG ARG 433 45.700 50.170 58.761 1.00 24.17 ATOM 2954 CDARG 433 46.094 49.238 59.910 1.00 25.60 ATOM 2955 NE ARG 433 46.57249.977 61.076 1.00 30.87 ATOM 2956 CZ ARG 433 47.022 49.413 62.196 1.0032.45 ATOM 2957 NH1 ARG 433 47.065 48.091 62.317 1.00 31.35 ATOM 2958NH2 ARG 433 47.423 50.177 63.203 1.00 33.39 ATOM 2959 C ARG 433 44.02949.333 55.339 1.00 17.92 ATOM 2960 O ARG 433 43.527 48.245 55.626 1.0016.81 ATOM 2961 N GLU 434 44.055 49.817 54.102 1.00 17.88 ATOM 2962 CAGLU 434 43.532 49.088 52.951 1.00 18.38 ATOM 2963 CB GLU 434 42.06249.454 52.704 1.00 21.40 ATOM 2964 CG GLU 434 41.126 49.146 53.866 1.0030.47 ATOM 2965 CD GLU 434 40.964 47.655 54.121 1.00 35.68 ATOM 2966 OE1GLU 434 41.691 46.848 53.498 1.00 39.78 ATOM 2967 OE2 GLU 434 40.10547.288 54.953 1.00 39.56 ATOM 2968 C GLU 434 44.369 49.490 51.741 1.0015.81 ATOM 2969 O GLU 434 45.184 50.408 51.827 1.00 14.18 ATOM 2970 NGLY 435 44.178 48.804 50.617 1.00 15.92 ATOM 2971 CA GLY 435 44.92649.153 49.419 1.00 14.49 ATOM 2972 C GLY 435 44.383 50.441 48.818 1.0014.11 ATOM 2973 O GLY 435 43.296 50.881 49.201 1.00 12.46 ATOM 2974 NALA 436 45.132 51.054 47.900 1.00 13.32 ATOM 2975 CA ALA 436 44.68752.293 47.248 1.00 13.39 ATOM 2976 CB ALA 436 45.571 52.601 46.044 1.0010.25 ATOM 2977 C ALA 436 43.230 52.066 46.828 1.00 11.87 ATOM 2978 OALA 436 42.389 52.956 46.927 1.00 12.19 ATOM 2979 N ASN 437 42.96550.864 46.329 1.00 12.23 ATOM 2980 CA ASN 437 41.619 50.400 45.989 1.0011.91 ATOM 2981 CB ASN 437 41.104 50.904 44.617 1.00 12.44 ATOM 2982 CGASN 437 41.809 50.287 43.430 1.00 10.41 ATOM 2983 OD1 ASN 437 42.02449.079 43.363 1.00 12.22 ATOM 2984 ND2 ASN 437 42.144 51.126 42.458 1.0010.38 ATOM 2985 C ASN 437 41.771 48.885 46.051 1.00 11.58 ATOM 2986 OASN 437 42.890 48.383 46.049 1.00 12.17 ATOM 2987 N PRO 438 40.66348.136 46.142 1.00 12.13 ATOM 2988 CD PRO 438 39.250 48.549 46.234 1.0010.54 ATOM 2989 CA PRO 438 40.789 46.677 46.220 1.00 10.70 ATOM 2990 CBPRO 438 39.338 46.205 46.162 1.00 12.07 ATOM 2991 CG PRO 438 38.60747.326 46.867 1.00 11.56 ATOM 2992 C PRO 438 41.674 46.026 45.160 1.0011.01 ATOM 2993 O PRO 438 42.343 45.031 45.441 1.00 9.92 ATOM 2994 N GLY439 41.682 46.591 43.955 1.00 10.86 ATOM 2995 CA GLY 439 42.494 46.04942.876 1.00 11.19 ATOM 2996 C GLY 439 43.984 46.073 43.175 1.00 11.99ATOM 2997 O GLY 439 44.710 45.135 42.830 1.00 10.62 ATOM 2998 N PHE 44044.452 47.148 43.806 1.00 11.06 ATOM 2999 CA PHE 440 45.866 47.26044.156 1.00 11.17 ATOM 3000 CB PHE 440 46.157 48.609 44.831 1.00 11.18ATOM 3001 CG PHE 440 46.364 49.745 43.864 1.00 12.13 ATOM 3002 CD1 PHE440 45.377 50.089 42.947 1.00 11.54 ATOM 3003 CD2 PHE 440 47.554 50.47243.871 1.00 12.86 ATOM 3004 CE1 PHE 440 45.572 51.146 42.045 1.00 11.15ATOM 3005 CE2 PHE 440 47.755 51.526 42.977 1.00 12.18 ATOM 3005 CZ PHE440 46.763 51.860 42.065 1.00 11.17 ATOM 3007 C PHE 440 46.275 46.13545.098 1.00 11.04 ATOM 3008 O PHE 440 47.326 45.519 44.926 1.00 10.51ATOM 3009 N HIS 441 45.445 45.873 46.104 1.00 10.42 ATOM 3010 CA HIS 44145.753 44.822 47.066 1.00 11.23 ATOM 3011 CB HIS 441 44.640 44.72048.116 1.00 11.68 ATOM 3012 CG HIS 441 45.144 44.607 49.523 1.00 11.91ATOM 3013 CD2 HIS 441 44.919 45.379 50.614 1.00 10.21 ATOM 3014 ND1 HIS441 45.976 43.589 49.941 1.00 10.64 ATOM 3015 CE1 HIS 441 46.237 43.73651.228 1.00 11.94 ATOM 3016 NE2 HIS 441 45.607 44.815 51.661 1.00 11.66ATOM 3017 C HIS 441 45.921 43.475 46.364 1.00 10.83 ATOM 3018 O HIS 44146.780 42.674 46.736 1.00 9.33 ATOM 3019 N GLU 442 45.106 43.241 45.3391.00 12.01 ATOM 3020 CA GLU 442 45.144 41.991 44.586 1.00 10.66 ATOM3021 CB GLU 442 43.838 41.819 43.801 1.00 11.06 ATOM 3022 CG GLU 44242.565 41.755 44.645 1.00 7.88 ATOM 3023 CD GLU 442 42.614 40.643 45.6771.00 8.56 ATOM 3024 OE1 GLU 442 43.226 39.598 45.376 1.00 8.96 ATOM 3025OE2 GLU 442 42.044 40.809 46.778 1.00 8.52 ATOM 3026 C GLU 442 46.32041.897 43.607 1.00 13.30 ATOM 3027 O GLU 442 46.815 40.807 43.323 1.0014.12 ATOM 3028 N ALA 443 46.782 43.038 43.105 1.00 14.06 ATOM 3029 CAALA 443 47.860 43.056 42.112 1.00 14.79 ATOM 3030 CB ALA 443 47.80144.369 41.336 1.00 13.68 ATOM 3031 C ALA 443 49.299 42.808 42.575 1.0014.18 ATOM 3032 O ALA 443 50.096 42.229 41.835 1.00 13.95 ATOM 3033 NILE 444 49.631 43.249 43.784 1.00 13.76 ATOM 3034 CA ILE 444 50.98943.119 44.311 1.00 13.53 ATOM 3035 CB ILE 444 51.035 43.500 45.810 1.0013.26 ATOM 3036 CG2 ILE 444 52.476 43.493 46.312 1.00 11.75 ATOM 3037CG1 ILE 444 50.430 44.898 46.002 1.00 11.55 ATOM 3038 CD1 ILE 444 51.09045.972 45.158 1.00 13.98 ATOM 3039 C ILE 444 51.671 41.757 44.116 1.0013.95 ATOM 3040 O ILE 444 52.710 41.666 43.454 1.00 10.36 ATOM 3041 NGLY 445 51.095 40.709 44.695 1.00 12.71 ATOM 3042 CA GLY 445 51.67839.389 44.562 1.00 12.69 ATOM 3043 C GLY 445 51.785 38.914 43.125 1.0013.85 ATOM 3044 O GLY 445 52.774 38.284 42.746 1.00 14.14 ATOM 3045 NASP 446 50.767 39.215 42.324 1.00 12.80 ATOM 3046 CA ASP 446 50.74238.805 40.923 1.00 12.50 ATOM 3047 CB ASP 446 49.398 39.181 40.282 1.009.49 ATOM 3048 CG ASP 446 48.261 38.259 40.714 1.00 10.86 ATOM 3049 OD1ASP 446 48.321 37.706 41.831 1.00 9.74 ATOM 3050 OD2 ASP 446 47.29338.098 39.946 1.00 11.31 ATOM 3051 C ASP 446 51.885 39.421 40.125 1.0013.90 ATOM 3052 O ASP 446 52.437 38.782 39.224 1.00 12.58 ATOM 3053 NVAL 447 52.230 40.665 40.452 1.00 13.86 ATOM 3054 CA VAL 447 53.30741.351 39.758 1.00 13.18 ATOM 3055 CB VAL 447 53.520 42.778 40.313 1.0013.78 ATOM 3056 CG1 VAL 447 54.745 43.414 39.661 1.00 13.13 ATOM 3057CG2 VAL 447 52.280 43.634 40.037 1.00 11.10 ATOM 3058 C VAL 447 54.60040.553 39.891 1.00 13.89 ATOM 3059 O VAL 447 55.263 40.274 38.897 1.0014.12 ATOM 3060 N LEU 448 54.954 40.184 41.119 1.00 13.93 ATOM 3061 CALEU 448 56.164 39.403 41.345 1.00 14.69 ATOM 3062 CB LEU 448 56.42439.217 42.845 1.00 13.90 ATOM 3063 CG LEU 448 57.185 40.346 43.548 1.0014.37 ATOM 3064 CD1 LEU 448 56.377 41.638 43.511 1.00 13.68 ATOM 3065CD2 LEU 448 57.474 39.937 44.980 1.00 14.99 ATOM 3066 C LEU 448 56.06838.040 40.665 1.00 14.58 ATOM 3067 O LEU 448 57.030 37.580 40.047 1.0016.65 ATOM 3068 N ALA 449 54.909 37.400 40.776 1.00 14.25 ATOM 3069 CAALA 449 54.696 36.094 40.161 1.00 14.13 ATOM 3070 CB ALA 449 53.30335.576 40.499 1.00 12.41 ATOM 3071 C ALA 449 54.890 36.143 38.639 1.0014.00 ATOM 3072 O ALA 449 55.241 35.136 38.020 1.00 14.32 ATOM 3073 NLEU 450 54.652 37.304 38.033 1.00 13.43 ATOM 3074 CA LEU 450 54.85037.440 36.592 1.00 13.96 ATOM 3075 CB LEU 450 54.473 38.853 36.121 1.0013.77 ATOM 3076 CG LEU 450 52.976 39.149 35.969 1.00 12.17 ATOM 3077 CD1LEU 450 52.758 40.620 35.637 1.00 9.82 ATOM 3078 CD2 LEU 450 52.39838.262 34.869 1.00 11.71 ATOM 3079 C LEU 450 56.325 37.165 36.283 1.0014.53 ATOM 3080 O LEU 450 56.651 36.443 35.339 1.00 15.40 ATOM 3081 NSER 451 57.212 37.745 37.085 1.00 13.59 ATOM 3082 CA SER 451 58.64437.540 36.900 1.00 15.77 ATOM 3083 CB SER 451 59.441 38.498 37.789 1.0014.12 ATOM 3084 OG SER 451 59.381 39.818 37.273 1.00 14.82 ATOM 3085 CSER 451 59.035 36.098 37.211 1.00 15.90 ATOM 3086 O SER 451 59.84335.501 36.501 1.00 16.58 ATOM 3087 N VAL 452 58.448 35.543 38.269 1.0016.02 ATOM 3088 CA VAL 452 58.722 34.169 38.674 1.00 17.43 ATOM 3089 CBVAL 452 57.903 33.786 39.933 1.00 16.72 ATOM 3090 CG1 VAL 452 58.10832.308 40.274 1.00 16.74 ATOM 3091 CG2 VAL 452 58.321 34.657 41.102 1.0018.21 ATOM 3092 C VAL 452 58.381 33.182 37.554 1.00 18.85 ATOM 3093 OVAL 452 59.101 32.205 37.337 1.00 18.12 ATOM 3094 N SER 453 57.28733.453 36.843 1.00 18.69 ATOM 3095 CA SER 453 56.820 32.590 35.755 1.0018.97 ATOM 3096 CB SER 453 55.402 33.001 35.336 1.00 18.72 ATOM 3097 OGSER 453 54.463 32.712 36.356 1.00 19.55 ATOM 3098 C SER 453 57.69332.523 34.506 1.00 18.98 ATOM 3099 O SER 453 57.559 31.593 33.707 1.0017.86 ATOM 3100 N THR 454 58.576 33.499 34.320 1.00 18.89 ATOM 3101 CATHR 454 59.426 33.499 33.138 1.00 19.78 ATOM 3102 CB THR 454 60.38534.699 33.123 1.00 18.87 ATOM 3103 OG1 THR 454 61.150 34.722 34.336 1.0019.79 ATOM 3104 CG2 THR 454 59.603 35.997 32.975 1.00 18.32 ATOM 3105 CTHR 454 60.239 32.217 33.041 1.00 21.57 ATOM 3106 O THR 454 60.73431.707 34.045 1.00 22.35 ATOM 3107 N PRO 455 60.378 31.673 31.822 1.0021.55 ATOM 3108 CD PRO 455 59.824 32.153 30.540 1.00 21.60 ATOM 3109 CAPRO 455 61.142 30.440 31.632 1.00 23.12 ATOM 3110 CB PRO 455 61.27830.354 30.113 1.00 22.44 ATOM 3111 CG PRO 455 59.972 30.933 29.641 1.0020.77 ATOM 3112 C PRO 455 62.489 30.489 32.338 1.00 23.94 ATOM 3113 OPRO 455 62.854 29.566 33.064 1.00 23.00 ATOM 3114 N LYS 456 63.21631.582 32.140 1.00 24.94 ATOM 3115 CA LYS 456 64.527 31.726 32.748 1.0025.77 ATOM 3116 CB LYS 456 65.186 33.029 32.289 1.00 28.54 ATOM 3117 CGLYS 456 66.708 32.960 32.293 1.00 33.33 ATOM 3118 CD LYS 456 67.34334.308 31.998 1.00 36.84 ATOM 3119 CE LYS 456 68.857 34.190 31.983 1.0039.24 ATOM 3120 NZ LYS 456 69.341 33.419 33.163 1.00 42.84 ATOM 3121 CLYS 456 64.479 31.679 34.274 1.00 25.66 ATOM 3122 O LYS 456 65.33431.055 34.905 1.00 24.62 ATOM 3123 N HIS 457 63.485 32.332 34.873 1.0023.14 ATOM 3124 CA HIS 457 63.386 32.325 36.326 1.00 22.18 ATOM 3125 CBHIS 457 62.312 33.299 36.817 1.00 22.71 ATOM 3126 CG HIS 457 62.32733.495 38.301 1.00 21.95 ATOM 3127 CD2 HIS 457 61.859 32.717 39.307 1.0024.49 ATOM 3128 ND1 HIS 457 62.959 34.560 38.904 1.00 21.90 ATOM 3129CE1 HIS 457 62.884 34.429 40.217 1.00 24.67 ATOM 3130 NE2 HIS 457 62.22233.317 40.488 1.00 24.22 ATOM 3131 C HIS 457 63.067 30.922 36.836 1.0021.29 ATOM 3132 O HIS 457 63.643 30.470 37.826 1.00 20.13 ATOM 3133 NLEU 458 62.136 30.243 36.170 1.00 21.42 ATOM 3134 CA LEU 458 61.76428.890 36.564 1.00 22.05 ATOM 3135 CB LEU 458 60.633 28.355 35.677 1.0021.29 ATOM 3136 CG LEU 458 59.243 28.976 35.857 1.00 21.21 ATOM 3137 CD1LEU 458 58.267 28.346 34.873 1.00 20.79 ATOM 3138 CD2 LEU 458 58.76828.762 37.294 1.00 20.98 ATOM 3139 C LEU 458 62.983 27.976 36.465 1.0022.14 ATOM 3140 O LEU 458 63.166 27.082 37.287 1.00 21.63 ATOM 3141 NHIS 459 63.820 28.213 35.461 1.00 23.49 ATOM 3142 CA HIS 459 65.01927.404 35.284 1.00 25.12 ATOM 3143 CB HIS 459 65.688 27.713 33.939 1.0026.57 ATOM 3144 CG HIS 459 66.953 26.941 33.701 1.00 32.18 ATOM 3145 CD2HIS 459 67.171 25.755 33.084 1.00 33.64 ATOM 3146 ND1 HIS 459 68.18027.358 34.173 1.00 34.37 ATOM 3147 CE1 HIS 459 69.099 26.461 33.859 1.0034.36 ATOM 3148 NE2 HIS 459 68.513 25.478 33.199 1.00 35.32 ATOM 3149 CHIS 459 65.985 27.657 36.441 1.00 23.17 ATOM 3150 O HIS 459 66.69826.751 36.867 1.00 22.80 ATOM 3151 N SER 460 65.991 28.882 36.963 1.0022.86 ATOM 3152 CA SER 460 66.870 29.218 38.083 1.00 22.31 ATOM 3153 CBSER 460 66.877 30.734 38.341 1.00 22.68 ATOM 3154 OG SER 460 65.73131.148 39.071 1.00 26.41 ATOM 3155 C SER 460 66.407 28.480 39.339 1.0021.77 ATOM 3156 O SER 460 67.176 28.297 40.283 1.00 18.91 ATOM 3157 NLEU 461 65.141 28.069 39.349 1.00 21.28 ATOM 3158 CA LEU 461 64.58927.326 40.480 1.00 23.33 ATOM 3159 CB LEU 461 63.103 27.652 40.678 1.0021.27 ATOM 3160 CG LEU 461 62.745 29.061 41.153 1.00 21.36 ATOM 3161 CD1LEU 461 61.230 29.193 41.235 1.00 21.05 ATOM 3162 CD2 LEU 461 63.38329.330 42.513 1.00 19.25 ATOM 3163 C LEU 461 64.748 25.839 40.197 1.0024.98 ATOM 3164 O LEU 461 64.394 24.992 41.022 1.00 25.06 ATOM 3165 NASN 462 65.280 25.543 39.012 1.00 27.22 ATOM 3166 CA ASN 462 65.51524.178 38.555 1.00 28.33 ATOM 3167 CB ASN 462 66.329 23.411 39.604 1.0030.22 ATOM 3168 CG ASN 462 67.032 22.196 39.026 1.00 32.38 ATOM 3169 OD1ASN 462 67.571 22.245 37.919 1.00 31.35 ATOM 3170 ND2 ASN 462 67.04321.102 39.780 1.00 33.86 ATOM 3171 C ASN 462 64.200 23.454 38.249 1.0029.21 ATOM 3172 O ASN 462 64.074 22.246 38.465 1.00 28.02 ATOM 3173 NLEU 463 63.227 24.200 37.731 1.00 29.99 ATOM 3174 CA LEU 463 61.92323.641 37.394 1.00 32.41 ATOM 3175 CB LEU 463 60.809 24.456 38.056 1.0031.50 ATOM 3176 CG LEU 463 60.935 24.584 39.579 1.00 31.61 ATOM 3177 CD1LEU 463 59.736 25.346 40.125 1.00 30.85 ATOM 3178 CD2 LEU 463 61.02823.200 40.214 1.00 30.38 ATOM 3179 C LEU 463 61.713 23.594 35.886 1.0034.49 ATOM 3180 O LEU 463 60.746 23.011 35.400 1.00 37.47 ATOM 3181 NLEU 464 62.622 24.223 35.155 1.00 36.34 ATOM 3182 CA LEU 464 62.58024.233 33.696 1.00 39.11 ATOM 3183 CB LEU 464 62.053 25.574 33.163 1.0039.04 ATOM 3184 CG LEU 464 60.557 25.635 32.834 1.00 39.75 ATOM 3185 CD1LEU 464 60.214 26.987 32.218 1.00 38.92 ATOM 3186 CD2 LEU 464 60.20824.511 31.865 1.00 38.93 ATOM 3187 C LEU 464 63.987 23.987 33.172 1.0040.46 ATOM 3188 O LEU 464 64.966 24.186 33.892 1.00 41.21 ATOM 3189 NSER 465 64.089 23.546 31.923 1.00 42.64 ATOM 3190 CA SER 465 65.39023.281 31.323 1.00 44.44 ATOM 3191 CB SER 465 65.500 21.805 30.926 1.0044.95 ATOM 3192 OG SER 465 64.454 21.428 30.048 1.00 47.16 ATOM 3193 CSER 465 65.618 24.166 30.105 1.00 44.78 ATOM 3194 O SER 465 66.20825.243 30.212 1.00 45.25 ATOM 3195 N GLY 470 64.492 32.666 21.953 1.0045.58 ATOM 3196 CA GLY 470 63.932 31.868 20.878 1.00 45.90 ATOM 3197 CGLY 470 62.479 32.197 20.591 1.00 45.14 ATOM 3198 O GLY 470 61.64132.185 21.493 1.00 45.19 ATOM 3199 N ALA 471 62.180 32.479 19.327 1.0044.31 ATOM 3200 CA ALA 471 60.829 32.832 18.904 1.00 42.77 ATOM 3201 CBALA 471 60.801 33.040 17.399 1.00 42.61 ATOM 3202 C ALA 471 59.77231.807 19.307 1.00 41.97 ATOM 3203 O ALA 471 58.822 32.140 20.017 1.0042.12 ATOM 3204 N GLU 472 59.933 30.567 18.855 1.00 40.07 ATOM 3205 CAGLU 472 58.974 29.515 19.168 1.00 38.02 ATOM 3206 CB GLU 472 59.36928.213 18.471 1.00 38.51 ATOM 3207 CG GLU 472 58.968 28.190 17.001 1.0039.98 ATOM 3208 CD GLU 472 59.374 26.913 16.293 1.00 40.39 ATOM 3209 OE1GLU 472 59.651 25.908 16.982 1.00 39.63 ATOM 3210 OE2 GLU 472 59.39726.915 15.043 1.00 40.40 ATOM 3211 C GLU 472 58.790 29.276 20.660 1.0037.16 ATOM 3212 O GLU 472 57.703 28.901 21.105 1.00 34.83 ATOM 3213 NHIS 473 59.847 29.487 21.435 1.00 35.29 ATOM 3214 CA HIS 473 59.74029.305 22.872 1.00 35.03 ATOM 3215 CB HIS 473 61.123 29.172 23.510 1.0037.48 ATOM 3216 CG HIS 473 61.817 27.889 23.179 1.00 40.71 ATOM 3217 CD2HIS 473 61.971 26.749 23.894 1.00 41.63 ATOM 3218 ND1 HIS 473 62.43527.665 21.967 1.00 41.83 ATOM 3219 CE1 HIS 473 62.939 26.444 21.951 1.0042.38 ATOM 3220 NE2 HIS 473 62.671 25.866 23.109 1.00 42.85 ATOM 3221 CHIS 473 58.993 30.497 23.464 1.00 33.66 ATOM 3222 O HIS 473 58.30530.361 24.474 1.00 33.56 ATOM 3223 N ASP 474 59.129 31.660 22.829 1.0031.69 ATOM 3224 CA ASP 474 58.448 32.864 23.289 1.00 31.39 ATOM 3225 CBASP 474 58.886 34.096 22.488 1.00 33.71 ATOM 3226 CG ASP 474 60.21934.644 22.939 1.00 36.85 ATOM 3227 OD1 ASP 474 60.417 34.795 24.163 1.0038.01 ATOM 3228 OD2 ASP 474 61.063 34.939 22.065 1.00 40.28 ATOM 3229 CASP 474 56.943 32.705 23.131 1.00 28.93 ATOM 3230 O ASP 474 56.18233.000 24.054 1.00 27.31 ATOM 3231 N ILE 475 56.525 32.252 21.950 1.0025.74 ATOM 3232 CA ILE 475 55.110 32.059 21.658 1.00 21.87 ATOM 3233 CBILE 475 54.893 31.631 20.183 1.00 21.83 ATOM 3234 CG2 ILE 475 53.39831.481 19.887 1.00 18.55 ATOM 3235 CG1 ILE 475 55.498 32.680 19.244 1.0020.20 ATOM 3236 CD1 ILE 475 54.942 34.083 19.432 1.00 18.72 ATOM 3237 CILE 475 54.522 31.009 22.591 1.00 20.48 ATOM 3238 O ILE 475 53.40531.171 23.081 1.00 19.85 ATOM 3239 N ASN 476 55.270 29.937 22.844 1.0018.44 ATOM 3240 CA ASN 476 54.795 28.894 23.746 1.00 19.25 ATOM 3241 CBASN 476 55.788 27.727 23.817 1.00 20.64 ATOM 3242 CG ASN 476 55.62126.738 22.670 1.00 22.25 ATOM 3243 OD1 ASN 476 54.645 26.785 21.917 1.0019.60 ATOM 3244 ND2 ASN 476 56.575 25.822 22.546 1.00 20.31 ATOM 3245 CASN 476 54.598 29.475 25.151 1.00 18.68 ATOM 3246 O ASN 476 53.60129.183 25.816 1.00 17.02 ATOM 3247 N PHE 477 55.554 30.288 25.598 1.0015.56 ATOM 3248 CA PHE 477 55.474 30.913 26.918 1.00 15.68 ATOM 3249 CBPHE 477 56.779 31.646 27.248 1.00 14.76 ATOM 3250 CG PHE 477 56.68832.527 28.465 1.00 14.35 ATOM 3251 CD1 PHE 477 56.384 31.987 29.711 1.0015.03 ATOM 3252 CD2 PHE 477 56.901 33.898 28.365 1.00 13.50 ATOM 3253CE1 PHE 477 56.294 32.798 30.841 1.00 14.00 ATOM 3254 CE2 PHE 477 56.81334.720 29.488 1.00 15.93 ATOM 3255 CZ PHE 477 56.509 34.167 30.730 1.0014.91 ATOM 3256 C PHE 477 54.318 31.908 26.980 1.00 14.40 ATOM 3257 OPHE 477 53.541 31.917 27.935 1.00 13.41 ATOM 3258 N LEU 478 54.22032.758 25.964 1.00 14.15 ATOM 3259 CA LEU 478 53.155 33.750 25.917 1.0014.48 ATOM 3260 CB LEU 478 53.317 34.647 24.688 1.00 12.70 ATOM 3261 CGLEU 478 54.454 35.664 24.818 1.00 13.21 ATOM 3262 CD1 LEU 478 54.63736.396 23.508 1.00 13.86 ATOM 3263 CD2 LEU 478 54.137 36.649 25.946 1.0014.40 ATOM 3264 C LEU 478 51.792 33.071 25.904 1.00 13.02 ATOM 3265 OLEU 478 50.833 33.585 26.476 1.00 11.74 ATOM 3266 N MET 479 51.70831.915 25.253 1.00 13.08 ATOM 3267 CA MET 479 50.448 31.183 25.199 1.0014.20 ATOM 3268 CB MET 479 50.547 29.989 24.242 1.00 14.09 ATOM 3269 CGMET 479 49.301 29.106 24.220 1.00 13.18 ATOM 3270 SD MET 479 47.78830.012 23.801 1.00 19.98 ATOM 3271 CE MET 479 48.041 30.307 22.061 1.0013.75 ATOM 3272 C MET 479 50.105 30.688 26.599 1.00 14.85 ATOM 3273 OMET 479 48.958 30.778 27.035 1.00 14.35 ATOM 3274 N LYS 480 51.10230.165 27.304 1.00 15.49 ATOM 3275 CA LYS 480 50.868 29.669 28.648 1.0017.00 ATOM 3276 CB LYS 480 52.136 29.016 29.221 1.00 19.28 ATOM 3277 CGLYS 480 51.911 28.409 30.600 1.00 26.30 ATOM 3278 CD LYS 480 52.93427.329 30.981 1.00 32.36 ATOM 3279 CE LYS 480 54.279 27.910 31.400 1.0035.11 ATOM 3280 NZ LYS 480 55.168 26.878 32.033 1.00 35.89 ATOM 3281 CLYS 480 50.395 30.804 29.553 1.00 14.63 ATOM 3282 O LYS 480 49.51330.613 30.386 1.00 16.02 ATOM 3283 N MET 481 50.971 31.988 29.374 1.0013.07 ATOM 3284 CA MET 481 50.602 33.147 30.178 1.00 12.02 ATOM 3285 CBMET 481 51.612 34.282 29.976 1.00 12.55 ATOM 3286 CG MET 481 53.01533.998 30.509 1.00 11.44 ATOM 3287 SD MET 481 53.051 33.565 32.265 1.0018.83 ATOM 3288 CE MET 481 52.416 35.085 33.001 1.00 12.30 ATOM 3289 CMET 481 49.202 33.644 29.821 1.00 12.65 ATOM 3290 O MET 481 48.43034.045 30.696 1.00 12.46 ATOM 3291 N ALA 482 48.886 33.619 28.531 1.0010.95 ATOM 3292 CA ALA 482 47.588 34.067 28.046 1.00 11.63 ATOM 3293 CBALA 482 47.596 34.125 26.530 1.00 11.09 ATOM 3294 C ALA 482 46.46333.152 28.524 1.00 13.21 ATOM 3295 O ALA 482 45.372 33.620 28.861 1.0010.82 ATOM 3296 N LEU 483 46.722 31.848 28.538 1.00 11.90 ATOM 3297 CALEU 483 45.712 30.897 28.978 1.00 14.01 ATOM 3298 CB LEU 483 46.26029.468 28.910 1.00 11.66 ATOM 3299 CG LEU 483 46.455 28.896 27.498 1.0010.77 ATOM 3300 CD1 LEU 483 47.098 27.517 27.587 1.00 8.72 ATOM 3301 CD2LEU 483 45.118 28.813 26.785 1.00 7.73 ATOM 3302 C LEU 483 45.268 31.23230.401 1.00 14.37 ATOM 3303 O LEU 483 44.158 30.898 30.814 1.00 14.12ATOM 3304 N ASP 484 46.142 31.894 31.147 1.00 15.19 ATOM 3305 CA ASP 48445.810 32.281 32.511 1.00 17.15 ATOM 3306 CB ASP 484 47.038 32.14633.416 1.00 19.74 ATOM 3307 CG ASP 484 46.787 32.653 34.830 1.00 26.92ATOM 3308 OD1 ASP 484 45.717 32.353 35.399 1.00 31.69 ATOM 3309 OD2 ASP484 47.667 33.344 35.383 1.00 30.93 ATOM 3310 C ASP 484 45.271 33.71132.560 1.00 16.03 ATOM 3311 O ASP 484 44.101 33.927 32.860 1.00 17.57ATOM 3312 N LYS 485 46.119 34.676 32.217 1.00 14.15 ATOM 3313 CA LYS 48545.772 36.094 32.265 1.00 12.86 ATOM 3314 CB LYS 485 47.042 36.93232.080 1.00 12.78 ATOM 3315 CG LYS 485 48.152 36.589 33.070 1.00 13.51ATOM 3316 CD LYS 485 47.721 36.847 34.509 1.00 13.07 ATOM 3317 CE LYS485 48.838 36.502 35.488 1.00 14.28 ATOM 3318 NZ LYS 485 48.482 36.83236.899 1.00 12.83 ATOM 3319 C LYS 485 44.690 36.616 31.319 1.00 12.35ATOM 3320 O LYS 485 43.823 37.382 31.739 1.00 12.38 ATOM 3321 N ILE 48644.744 36.233 30.047 1.00 11.02 ATOM 3322 CA ILE 486 43.753 36.70729.084 1.00 11.30 ATOM 3323 CB ILE 486 44.243 36.506 27.632 1.00 10.39ATOM 3324 CG2 ILE 486 43.126 36.849 26.649 1.00 9.22 ATOM 3325 CG1 ILE486 45.487 37.366 27.376 1.00 9.66 ATOM 3326 CD1 ILE 486 45.269 38.86327.555 1.00 12.52 ATOM 3327 C ILE 486 42.400 36.016 29.255 1.00 10.85ATOM 3328 O ILE 486 41.354 36.664 29.228 1.00 9.72 ATOM 3329 N ALA 48742.418 34.700 29.433 1.00 11.32 ATOM 3330 CA ALA 487 41.176 33.95429.610 1.00 10.28 ATOM 3331 CB ALA 487 41.484 32.464 29.773 1.00 9.81ATOM 3332 C ALA 487 40.390 34.462 30.823 1.00 10.73 ATOM 3333 O ALA 48739.161 34.432 30.836 1.00 11.37 ATOM 3334 N PHE 488 41.110 34.937 31.8341.00 10.32 ATOM 3335 CA PHE 488 40.500 35.426 33.067 1.00 11.62 ATOM3336 CB PHE 488 41.574 35.560 34.149 1.00 11.67 ATOM 3337 CG PHE 48841.027 35.846 35.523 1.00 14.14 ATOM 3338 CD1 PHE 488 40.310 34.87336.222 1.00 13.10 ATOM 3339 CD2 PHE 488 41.256 37.075 36.134 1.00 13.14ATOM 3340 CE1 PHE 488 39.834 35.122 37.510 1.00 13.40 ATOM 3341 CE2 PHE488 40.788 37.332 37.414 1.00 11.72 ATOM 3342 CZ PHE 488 40.076 36.35538.107 1.00 13.66 ATOM 3343 C PHE 488 39.765 36.763 32.931 1.00 11.30ATOM 3344 O PHE 488 38.809 37.022 33.662 1.00 10.92 ATOM 3345 N ILE 48940.208 37.604 32.000 1.00 11.64 ATOM 3346 CA ILE 489 39.600 38.91531.807 1.00 10.62 ATOM 3347 CB ILE 489 40.193 39.615 30.568 1.00 12.52ATOM 3348 CG2 ILE 489 39.378 40.870 30.215 1.00 11.83 ATOM 3349 CG1 ILE489 41.652 39.993 30.842 1.00 14.27 ATOM 3350 CD1 ILE 489 41.824 41.02931.952 1.00 13.73 ATOM 3351 C ILE 489 38.067 38.919 31.723 1.00 12.80ATOM 3352 O ILE 489 37.406 39.590 32.514 1.00 12.29 ATOM 3353 N PRO 49037.482 38.183 30.764 1.00 11.12 ATOM 3354 CD PRO 490 38.069 37.42929.644 1.00 10.46 ATOM 3355 CA PRO 490 36.020 38.185 30.683 1.00 10.14ATOM 3356 CB PRO 490 35.742 37.410 29.390 1.00 10.83 ATOM 3357 CG PRO490 36.942 36.516 29.258 1.00 12.17 ATOM 3358 C PRO 490 35.325 37.58631.911 1.00 9.58 ATOM 3359 O PRO 490 34.257 38.049 32.306 1.00 8.62 ATOM3360 N PHE 491 35.925 36.568 32.521 1.00 6.98 ATOM 3361 CA PHE 49135.321 35.969 33.709 1.00 9.75 ATOM 3362 CB PHE 491 36.067 34.703 34.1371.00 8.88 ATOM 3363 CG PHE 491 35.512 34.074 35.393 1.00 9.15 ATOM 3364CD1 PHE 491 34.374 33.271 35.344 1.00 8.95 ATOM 3365 CD2 PHE 491 36.10934.311 36.630 1.00 7.55 ATOM 3366 CE1 PHE 491 33.837 32.713 36.508 1.009.82 ATOM 3367 CE2 PHE 491 35.580 33.757 37.803 1.00 9.83 ATOM 3368 CZPHE 491 34.442 32.957 37.740 1.00 8.83 ATOM 3369 C PHE 491 35.329 36.94834.885 1.00 9.97 ATOM 3370 O PHE 491 34.312 37.127 35.558 1.00 10.66ATOM 3371 N SER 492 36.475 37.579 35.132 1.00 9.34 ATOM 3372 CA SER 49236.589 38.512 36.249 1.00 11.14 ATOM 3373 CB SER 492 38.046 38.94636.439 1.00 8.12 ATOM 3374 OG SER 492 38.534 39.643 35.307 1.00 11.50ATOM 3375 C SER 492 35.692 39.738 36.083 1.00 11.76 ATOM 3376 O SER 49235.327 40.391 37.064 1.00 13.67 ATOM 3377 N TYR 493 35.344 40.042 34.8401.00 11.79 ATOM 3378 CA TYR 493 34.482 41.177 34.527 1.00 12.20 ATOM3379 CB TYR 493 34.633 41.544 33.048 1.00 12.22 ATOM 3380 CG TYR 49333.904 42.801 32.642 1.00 13.21 ATOM 3381 CD1 TYR 493 34.295 44.04533.134 1.00 14.67 ATOM 3382 CE1 TYR 493 33.630 45.210 32.763 1.00 16.44ATOM 3383 CD2 TYR 493 32.821 42.751 31.764 1.00 13.82 ATOM 3384 CE2 TYR493 32.150 43.912 31.385 1.00 16.41 ATOM 3385 CZ TYR 493 32.561 45.13731.889 1.00 15.04 ATOM 3386 OH TYR 493 31.912 46.285 31.510 1.00 14.56ATOM 3387 C TYR 493 33.022 40.811 34.793 1.00 13.05 ATOM 3388 O TYR 49332.254 41.585 35.363 1.00 13.30 ATOM 3389 N LEU 494 32.670 39.604 34.3721.00 13.45 ATOM 3390 CA LEU 494 31.327 39.053 34.475 1.00 13.55 ATOM3391 CB LEU 494 31.319 37.739 33.685 1.00 16.41 ATOM 3392 CG LEU 49430.282 36.622 33.731 1.00 20.60 ATOM 3393 CD1 LEU 494 30.701 35.59032.689 1.00 21.31 ATOM 3394 CD2 LEU 494 30.192 35.977 35.100 1.00 15.36ATOM 3395 C LEU 494 30.741 38.834 35.874 1.00 11.95 ATOM 3396 O LEU 49429.566 39.112 36.102 1.00 11.20 ATOM 3397 N VAL 495 31.544 38.347 36.8101.00 10.36 ATOM 3398 CA VAL 495 31.019 38.055 38.141 1.00 10.58 ATOM3399 CB VAL 495 32.139 37.621 39.109 1.00 9.66 ATOM 3400 CG1 VAL 49531.549 37.318 40.486 1.00 9.24 ATOM 3401 CG2 VAL 495 32.833 36.37638.564 1.00 12.37 ATOM 3402 C VAL 495 30.197 39.171 38.785 1.00 9.62ATOM 3403 O VAL 495 29.047 38.955 39.154 1.00 7.39 ATOM 3404 N ASP 49630.768 40.360 38.919 1.00 9.30 ATOM 3405 CA ASP 496 30.012 41.435 39.5381.00 10.89 ATOM 3406 CB ASP 496 30.954 42.439 40.207 1.00 10.57 ATOM3407 CG ASP 496 31.513 41.909 41.526 1.00 9.77 ATOM 3408 OD1 ASP 49631.025 40.855 41.993 1.00 9.79 ATOM 3409 OD2 ASP 496 32.426 42.53242.098 1.00 9.45 ATOM 3410 C ASP 496 29.015 42.125 38.609 1.00 11.41ATOM 3411 O ASP 496 28.125 42.837 39.081 1.00 11.26 ATOM 3412 N GLN 49729.143 41.923 37.298 1.00 9.61 ATOM 3413 CA GLN 497 28.150 42.511 36.4001.00 11.24 ATOM 3414 CB GLN 497 28.471 42.231 34.926 1.00 11.55 ATOM3415 CG GLN 497 29.702 42.954 34.377 1.00 13.89 ATOM 3416 CD GLN 49729.672 44.459 34.613 1.00 16.12 ATOM 3417 OE1 GLN 497 28.615 45.08234.607 1.00 14.20 ATOM 3418 NE2 GLN 497 30.844 45.048 34.809 1.00 17.36ATOM 3419 C GLN 497 26.847 41.804 36.787 1.00 10.45 ATOM 3420 O GLN 49725.774 42.403 36.794 1.00 10.85 ATOM 3421 N TRP 498 26.961 40.520 37.1201.00 9.86 ATOM 3422 CA TRP 498 25.812 39.717 37.537 1.00 10.64 ATOM 3423CB TRP 498 26.189 38.231 37.571 1.00 9.73 ATOM 3424 CG TRP 498 25.05737.318 37.978 1.00 9.08 ATOM 3425 CD2 TRP 498 24.815 36.788 39.287 1.009.94 ATOM 3426 CE2 TRP 498 23.634 36.009 39.213 1.00 11.43 ATOM 3427 CE3TRP 498 25.480 36.898 40.518 1.00 9.53 ATOM 3428 CD1 TRP 498 24.04436.851 37.182 1.00 10.54 ATOM 3429 NE1 TRP 498 23.185 36.063 37.919 1.009.96 ATOM 3430 CZ2 TRP 498 23.105 35.343 40.325 1.00 10.04 ATOM 3431 CZ3TRP 498 24.950 36.232 41.629 1.00 13.16 ATOM 3432 CH2 TRP 498 23.77335.465 41.520 1.00 12.54 ATOM 3433 C TRP 498 25.333 40.151 38.928 1.009.68 ATOM 3434 O TRP 498 24.146 40.398 39.132 1.00 10.04 ATOM 3435 N ARG499 26.252 40.243 39.885 1.00 10.21 ATOM 3436 CA ARG 499 25.871 40.64341.240 1.00 11.86 ATOM 3437 CB ARG 499 27.038 40.468 42.222 1.00 11.07ATOM 3438 CG ARG 499 27.106 39.070 42.824 1.00 12.83 ATOM 3439 CD ARG499 27.992 39.005 44.062 1.00 12.47 ATOM 3440 NE ARG 499 29.395 39.25043.748 1.00 10.15 ATOM 3441 CZ ARG 499 30.409 38.744 44.439 1.00 12.88ATOM 3442 NH1 ARG 499 30.171 37.961 45.491 1.00 10.18 ATOM 3443 NH2 ARG499 31.657 39.000 44.067 1.00 10.68 ATOM 3444 C ARG 499 25.325 42.06541.336 1.00 12.18 ATOM 3445 O ARG 499 24.395 42.311 42.098 1.00 11.36ATOM 3446 N TRP 500 25.887 42.996 40.568 1.00 11.77 ATOM 3447 CA TRP 50025.391 44.368 40.605 1.00 12.08 ATOM 3448 CB TRP 500 26.202 45.28939.684 1.00 10.66 ATOM 3449 CG TRP 500 27.602 45.521 40.139 1.00 10.40ATOM 3450 CD2 TRP 500 28.677 46.051 39.357 1.00 11.41 ATOM 3451 CE2 TRP500 29.821 46.074 40.183 1.00 11.19 ATOM 3452 CE3 TRP 500 28.786 46.50438.034 1.00 11.44 ATOM 3453 CD1 TRP 500 28.119 45.261 41.374 1.00 9.78ATOM 3454 NE1 TRP 500 29.451 45.589 41.409 1.00 10.36 ATOM 3455 CZ2 TRP500 31.062 46.536 39.731 1.00 10.56 ATOM 3456 CZ3 TRP 500 30.021 46.96337.585 1.00 11.49 ATOM 3457 CH2 TRP 500 31.143 46.972 38.434 1.00 9.70ATOM 3458 C TRP 500 23.933 44.407 40.174 1.00 13.08 ATOM 3459 O TRP 50023.143 45.188 40.703 1.00 12.40 ATOM 3460 N ARG 501 23.581 43.565 39.2071.00 11.92 ATOM 3461 CA ARG 501 22.209 43.525 38.719 1.00 12.19 ATOM3462 CB ARG 501 22.176 42.962 37.298 1.00 13.67 ATOM 3463 CG ARG 50122.833 43.881 36.281 1.00 17.51 ATOM 3464 CD ARG 501 22.956 43.19934.929 1.00 23.14 ATOM 3465 NE ARG 501 21.650 42.807 34.407 1.00 28.87ATOM 3466 CZ ARG 501 21.443 41.731 33.656 1.00 30.18 ATOM 3467 NH1 ARG501 22.458 40.936 33.340 1.00 30.67 ATOM 3468 NH2 ARG 501 20.222 41.44833.223 1.00 31.24 ATOM 3469 C ARG 501 21.296 42.732 39.653 1.00 10.77ATOM 3470 O ARG 501 20.081 42.891 39.626 1.00 10.89 ATOM 3471 N VAL 50221.884 41.865 40.468 1.00 9.90 ATOM 3472 CA VAL 502 21.100 41.120 41.4391.00 10.52 ATOM 3473 CB VAL 502 21.896 39.940 42.034 1.00 9.49 ATOM 3474CG1 VAL 502 21.205 39.425 43.285 1.00 8.80 ATOM 3475 CG2 VAL 502 22.00838.812 41.002 1.00 12.29 ATOM 3476 C VAL 502 20.786 42.126 42.551 1.0012.15 ATOM 3477 O VAL 502 19.643 42.245 42.999 1.00 10.37 ATOM 3478 NPHE 503 21.815 42.865 42.965 1.00 11.50 ATOM 3479 CA PHE 503 21.67843.864 44.018 1.00 11.51 ATOM 3480 CB PHE 503 23.057 44.434 44.386 1.0010.31 ATOM 3481 CG PHE 503 23.939 43.463 45.144 1.00 11.73 ATOM 3482 CD1PHE 503 25.324 43.571 45.085 1.00 11.85 ATOM 3483 CD2 PHE 503 23.38442.451 45.925 1.00 12.62 ATOM 3484 CE1 PHE 503 26.146 42.693 45.787 1.0010.68 ATOM 3485 CE2 PHE 503 24.199 41.564 46.633 1.00 10.51 ATOM 3486 CZPHE 503 25.582 41.686 46.563 1.00 12.31 ATOM 3487 C PHE 503 20.71144.995 43.661 1.00 10.96 ATOM 3488 O PHE 503 19.896 45.384 44.497 1.009.00 ATOM 3489 N ASP 504 20.779 45.519 42.435 1.00 12.29 ATOM 3490 CAASP 504 19.866 46.599 42.058 1.00 12.07 ATOM 3491 CB ASP 504 20.45147.479 40.931 1.00 13.57 ATOM 3492 CG ASP 504 20.413 46.822 39.548 1.0013.98 ATOM 3493 OD1 ASP 504 19.775 45.766 39.358 1.00 14.51 ATOM 3494OD2 ASP 504 21.033 47.396 38.633 1.00 15.18 ATOM 3495 C ASP 504 18.47046.107 41.685 1.00 13.54 ATOM 3496 O ASP 504 17.615 46.892 41.278 1.0013.18 ATOM 3497 N GLY 505 18.239 44.805 41.833 1.00 14.58 ATOM 3498 CAGLY 505 16.929 44.244 41.540 1.00 15.30 ATOM 3499 C GLY 505 16.59043.920 40.095 1.00 16.54 ATOM 3500 O GLY 505 15.457 43.528 39.808 1.0017.31 ATOM 3501 N SER 506 17.547 44.088 39.185 1.00 15.04 ATOM 3502 CASER 506 17.324 43.793 37.770 1.00 15.72 ATOM 3503 CB SER 506 18.49844.294 36.925 1.00 15.59 ATOM 3504 OG SER 506 18.587 45.701 36.956 1.0022.52 ATOM 3505 C SER 506 17.167 42.292 37.541 1.00 15.40 ATOM 3506 OSER 506 16.505 41.869 36.594 1.00 15.35 ATOM 3507 N ILE 507 17.79741.496 38.401 1.00 13.34 ATOM 3508 CA ILE 507 17.731 40.041 38.303 1.0013.69 ATOM 3509 CB ILE 507 19.148 39.426 38.171 1.00 14.13 ATOM 3510 CG2ILE 507 19.057 37.904 38.086 1.00 11.80 ATOM 3511 CG1 ILE 507 19.85840.002 36.939 1.00 11.87 ATOM 3512 CD1 ILE 507 21.333 39.646 36.867 1.0010.97 ATOM 3513 C ILE 507 17.082 39.496 39.574 1.00 14.19 ATOM 3514 OILE 507 17.602 39.698 40.669 1.00 13.99 ATOM 3515 N THR 508 15.94638.815 39.428 1.00 13.82 ATOM 3516 CA THR 508 15.237 38.239 40.573 1.0013.91 ATOM 3517 CB THR 508 13.707 38.241 40.364 1.00 14.70 ATOM 3518 OG1THR 508 13.358 37.257 39.381 1.00 15.53 ATOM 3519 CG2 THR 508 13.23239.606 39.894 1.00 13.66 ATOM 3520 C THR 508 15.678 36.794 40.736 1.0014.81 ATOM 3521 O THR 508 16.327 36.241 39.846 1.00 11.64 ATOM 3522 NLYS 509 15.310 36.176 41.858 1.00 15.94 ATOM 3523 CA LYS 509 15.69434.790 42.106 1.00 17.89 ATOM 3524 CB LYS 509 15.249 34.334 43.502 1.0018.63 ATOM 3525 CG LYS 509 13.769 33.992 43.637 1.00 20.95 ATOM 3526 CDLYS 509 13.463 33.460 45.033 1.00 21.83 ATOM 3527 CE LYS 509 11.98833.146 45.204 1.00 23.26 ATOM 3528 NZ LYS 509 11.687 32.724 46.600 1.0023.66 ATOM 3529 C LYS 509 15.109 33.854 41.057 1.00 18.81 ATOM 3530 OLYS 509 15.497 32.690 40.979 1.00 20.85 ATOM 3531 N GLU 510 14.17134.353 40.257 1.00 18.47 ATOM 3532 CA GLU 510 13.574 33.535 39.206 1.0020.76 ATOM 3533 CB GLU 510 12.282 34.163 38.696 1.00 22.98 ATOM 3534 CGGLU 510 11.274 34.507 39.761 1.00 33.06 ATOM 3535 CD GLU 510 10.12035.306 39.196 1.00 36.53 ATOM 3536 OE1 GLU 510 10.366 36.379 38.599 1.0039.46 ATOM 3537 OE2 GLU 510 8.971 34.859 39.349 1.00 39.85 ATOM 3538 CGLU 510 14.536 33.437 38.025 1.00 20.25 ATOM 3539 O GLU 510 14.52632.452 37.283 1.00 19.03 ATOM 3540 N ASN 511 15.365 34.465 37.862 1.0017.63 ATOM 3541 CA ASN 511 16.298 34.522 36.746 1.00 17.82 ATOM 3542 CBASN 511 15.984 35.756 35.891 1.00 19.14 ATOM 3543 CG ASN 511 14.54135.779 35.410 1.00 25.49 ATOM 3544 OD1 ASN 511 14.080 34.843 34.756 1.0027.61 ATOM 3545 ND2 ASN 511 13.819 36.848 35.734 1.00 24.85 ATOM 3546 CASN 511 17.785 34.510 37.111 1.00 16.09 ATOM 3547 O ASN 511 18.63034.792 36.260 1.00 13.99 ATOM 3548 N TYR 512 18.102 34.187 38.363 1.0012.83 ATOM 3549 CA TYR 512 19.494 34.128 38.804 1.00 11.97 ATOM 3550 CBTYR 512 19.617 33.360 40.120 1.00 12.23 ATOM 3551 CG TYR 512 19.24934.090 41.390 1.00 12.34 ATOM 3552 CD1 TYR 512 19.016 33.370 42.561 1.0013.62 ATOM 3553 CE1 TYR 512 18.717 34.007 43.755 1.00 14.61 ATOM 3554CD2 TYR 512 19.172 35.484 41.446 1.00 12.45 ATOM 3555 CE2 TYR 512 18.87236.137 42.651 1.00 13.77 ATOM 3556 CZ TYR 512 18.647 35.381 43.799 1.0013.86 ATOM 3557 OH TYR 512 18.358 35.977 45.004 1.00 17.23 ATOM 3558 CTYR 512 20.385 33.396 37.798 1.00 12.56 ATOM 3559 O TYR 512 21.29933.970 37.199 1.00 10.13 ATOM 3560 N ASN 513 20.105 32.108 37.639 1.0011.91 ATOM 3561 CA ASN 513 20.894 31.247 36.776 1.00 11.83 ATOM 3562 CBASN 513 20.482 29.792 36.985 1.00 11.58 ATOM 3563 CG ASN 513 21.67228.859 36.980 1.00 11.83 ATOM 3564 OD1 ASN 513 22.613 29.054 37.743 1.0014.77 ATOM 3565 ND2 ASN 513 21.644 27.848 36.118 1.00 7.41 ATOM 3566 CASN 513 20.872 31.572 35.299 1.00 12.10 ATOM 3567 O ASN 513 21.91831.536 34.637 1.00 10.25 ATOM 3568 N GLN 514 19.690 31.882 34.775 1.0011.72 ATOM 3569 CA GLN 514 19.568 32.194 33.362 1.00 14.72 ATOM 3570 CBGLN 514 18.089 32.356 32.979 1.00 17.46 ATOM 3571 CG GLN 514 17.26031.066 33.144 1.00 23.70 ATOM 3572 CD GLN 514 16.576 30.934 34.510 1.0025.81 ATOM 3573 OE1 GLN 514 17.121 31.322 35.552 1.00 21.12 ATOM 3574NE2 GLN 514 15.375 30.363 34.502 1.00 29.42 ATOM 3575 C GLN 514 20.36933.446 32.994 1.00 14.10 ATOM 3576 O GLN 514 20.973 33.511 31.918 1.0013.15 ATOM 3577 N GLU 515 20.391 34.432 33.887 1.00 13.07 ATOM 3578 CAGLU 515 21.136 35.660 33.615 1.00 12.06 ATOM 3579 CB GLU 515 20.65636.802 34.519 1.00 16.07 ATOM 3580 CG GLU 515 19.244 37.290 34.190 1.0018.59 ATOM 3581 CD GLU 515 19.084 37.659 32.719 1.00 24.12 ATOM 3582 OE1GLU 515 19.829 38.544 32.235 1.00 24.75 ATOM 3583 OE2 GLU 515 18.21437.060 32.046 1.00 26.20 ATOM 3584 C GLU 515 22.626 35.420 33.805 1.0010.94 ATOM 3585 O GLU 515 23.454 36.089 33.190 1.00 12.49 ATOM 3586 NTRP 516 22.970 34.466 34.660 1.00 9.41 ATOM 3587 CA TRP 516 24.37434.135 34.873 1.00 9.43 ATOM 3588 CB TRP 516 24.513 33.135 36.030 1.009.02 ATOM 3589 CG TRP 516 25.865 32.477 36.148 1.00 10.43 ATOM 3590 CD2TRP 516 27.026 33.004 36.804 1.00 10.48 ATOM 3591 CE2 TRP 516 28.03732.019 36.718 1.00 10.91 ATOM 3592 CE3 TRP 516 27.311 34.210 37.458 1.0010.58 ATOM 3593 CD1 TRP 516 26.212 31.235 35.697 1.00 11.18 ATOM 3594NE1 TRP 516 27.514 30.951 36.038 1.00 12.53 ATOM 3595 CZ2 TRP 516 29.31432.201 37.263 1.00 11.44 ATOM 3596 CZ3 TRP 516 28.583 34.393 38.002 1.0011.75 ATOM 3597 CH2 TRP 516 29.568 33.390 37.899 1.00 11.65 ATOM 3598 CTRP 516 24.912 33.542 33.575 1.00 9.00 ATOM 3599 O TRP 516 25.971 33.94333.088 1.00 10.05 ATOM 3600 N TRP 517 24.167 32.605 32.993 1.00 9.12ATOM 3601 CA TRP 517 24.609 31.995 31.746 1.00 9.56 ATOM 3602 CB TRP 51723.855 30.689 31.497 1.00 8.95 ATOM 3603 CG TRP 517 24.458 29.614 32.3341.00 7.44 ATOM 3604 CD2 TRP 517 25.729 28.992 32.118 1.00 8.27 ATOM 3605CE2 TRP 517 25.994 28.176 33.240 1.00 7.79 ATOM 3606 CE3 TRP 517 26.67829.052 31.084 1.00 9.26 ATOM 3607 CD1 TRP 517 24.007 29.154 33.540 1.006.42 ATOM 3608 NE1 TRP 517 24.927 28.292 34.093 1.00 8.16 ATOM 3609 CZ2TRP 517 27.166 27.424 33.359 1.00 9.24 ATOM 3610 CZ3 TRP 517 27.84828.301 31.204 1.00 10.00 ATOM 3611 CH2 TRP 517 28.080 27.500 32.333 1.008.75 ATOM 3612 C TRP 517 24.549 32.927 30.538 1.00 10.22 ATOM 3613 O TRP517 25.321 32.769 29.593 1.00 10.24 ATOM 3614 N SER 518 23.654 33.90830.566 1.00 11.02 ATOM 3615 CA SER 518 23.588 34.863 29.467 1.00 13.01ATOM 3616 CB SER 518 22.407 35.823 29.631 1.00 14.72 ATOM 3617 OG SER518 21.187 35.175 29.332 1.00 22.10 ATOM 3618 C SER 518 24.887 35.66329.462 1.00 11.80 ATOM 3619 O SER 518 25.375 36.072 28.405 1.00 10.96ATOM 3620 N LEU 519 25.441 35.889 30.650 1.00 10.02 ATOM 3621 CA LEU 51926.685 36.638 30.763 1.00 11.52 ATOM 3622 CB LEU 519 26.828 37.21932.173 1.00 11.07 ATOM 3623 CG LEU 519 25.804 38.316 32.491 1.00 13.05ATOM 3624 CD1 LEU 519 25.934 38.733 33.949 1.00 12.54 ATOM 3625 CD2 LEU519 26.017 39.504 31.570 1.00 13.76 ATOM 3626 C LEU 519 27.876 35.74430.430 1.00 11.25 ATOM 3627 O LEU 519 28.826 36.179 29.773 1.00 10.48ATOM 3628 N ARG 520 27.817 34.497 30.887 1.00 10.34 ATOM 3629 CA ARG 52028.875 33.529 30.611 1.00 11.93 ATOM 3630 CB ARG 520 28.493 32.16031.186 1.00 10.95 ATOM 3631 CG ARG 520 28.568 32.095 32.713 1.00 10.19ATOM 3632 CD ARG 520 29.973 31.757 33.176 1.00 9.98 ATOM 3633 NE ARG 52030.136 30.320 33.403 1.00 11.36 ATOM 3634 CZ ARG 520 31.303 29.71733.615 1.00 12.10 ATOM 3635 NH1 ARG 520 31.342 28.404 33.827 1.00 10.85ATOM 3636 NH2 ARG 520 32.432 30.419 33.595 1.00 7.63 ATOM 3637 C ARG 52029.062 33.433 29.097 1.00 12.63 ATOM 3638 O ARG 520 30.186 33.326 28.5951.00 11.60 ATOM 3639 N LEU 521 27.944 33.472 28.378 1.00 11.30 ATOM 3640CA LEU 521 27.957 33.406 26.924 1.00 11.63 ATOM 3641 CB LEU 521 26.54533.129 26.387 1.00 11.64 ATOM 3642 CG LEU 521 26.436 33.222 24.858 1.0014.85 ATOM 3643 CD1 LEU 521 27.324 32.153 24.237 1.00 11.78 ATOM 3644CD2 LEU 521 24.988 33.049 24.405 1.00 13.95 ATOM 3645 C LEU 521 28.46034.717 26.328 1.00 10.66 ATOM 3646 O LEU 521 29.408 34.738 25.554 1.0012.28 ATOM 3647 N LYS 522 27.813 35.811 26.703 1.00 12.13 ATOM 3648 CALYS 522 28.159 37.127 26.180 1.00 14.27 ATOM 3649 CB LYS 522 27.26738.191 26.826 1.00 16.64 ATOM 3650 CG LYS 522 27.524 39.608 26.333 1.0019.99 ATOM 3651 CD LYS 522 26.592 40.589 27.029 1.00 21.89 ATOM 3652 CELYS 522 26.868 42.022 26.602 1.00 24.69 ATOM 3653 NZ LYS 522 25.92642.969 27.263 1.00 26.36 ATOM 3654 C LYS 522 29.620 37.528 26.354 1.0013.91 ATOM 3655 O LYS 522 30.242 38.026 25.418 1.00 13.31 ATOM 3656 NTYR 523 30.165 37.314 27.547 1.00 12.72 ATOM 3657 CA TYR 523 31.54437.699 27.820 1.00 13.45 ATOM 3658 CB TYR 523 31.648 38.236 29.254 1.0014.60 ATOM 3659 CG TYR 523 30.942 39.563 29.417 1.00 17.65 ATOM 3660 CD1TYR 523 29.840 39.699 30.259 1.00 19.64 ATOM 3661 CE1 TYR 523 29.14640.916 30.347 1.00 20.74 ATOM 3662 CD2 TYR 523 31.340 40.675 28.671 1.0020.48 ATOM 3663 CE2 TYR 523 30.662 41.880 28.752 1.00 20.67 ATOM 3664 CZTYR 523 29.567 41.994 29.587 1.00 21.24 ATOM 3665 OH TYR 523 28.89043.192 29.642 1.00 27.03 ATOM 3666 C TYR 523 32.604 36.628 27.576 1.0013.38 ATOM 3667 O TYR 523 33.616 36.899 26.930 1.00 12.98 ATOM 3668 NGLN 524 32.378 35.416 28.072 1.00 11.98 ATOM 3669 CA GLN 524 33.35534.336 27.891 1.00 11.74 ATOM 3670 CB GLN 524 33.367 33.425 29.114 1.0011.09 ATOM 3671 CG GLN 524 34.010 34.009 30.338 1.00 9.28 ATOM 3672 CDGLN 524 34.003 33.021 31.476 1.00 11.02 ATOM 3673 OE1 GLN 524 32.97932.832 32.135 1.00 12.58 ATOM 3674 NE2 GLN 524 35.138 32.356 31.696 1.007.73 ATOM 3675 C GLN 524 33.145 33.459 26.661 1.00 9.96 ATOM 3676 O GLN524 34.057 32.746 26.244 1.00 9.58 ATOM 3677 N GLY 525 31.950 33.49226.085 1.00 11.25 ATOM 3678 CA GLY 525 31.684 32.655 24.927 1.00 10.07ATOM 3679 C GLY 525 31.639 31.190 25.332 1.00 11.60 ATOM 3680 O GLY 52532.148 30.316 24.623 1.00 12.24 ATOM 3681 N LEU 526 31.044 30.921 26.4891.00 9.03 ATOM 3682 CA LEU 526 30.928 29.554 26.984 1.00 9.89 ATOM 3683CB LEU 526 31.560 29.421 28.374 1.00 9.34 ATOM 3684 CG LEU 526 33.03029.805 28.536 1.00 9.90 ATOM 3685 CD1 LEU 526 33.426 29.727 30.015 1.009.26 ATOM 3686 CD2 LEU 526 33.889 28.888 27.687 1.00 8.55 ATOM 3687 CLEU 526 29.470 29.146 27.082 1.00 11.13 ATOM 3688 O LEU 526 28.58029.998 27.174 1.00 11.49 ATOM 3689 N CYS 527 29.235 27.838 27.051 1.0010.63 ATOM 3690 CA CYS 527 27.894 27.288 27.177 1.00 11.97 ATOM 3691 CBCYS 527 27.352 26.801 25.815 1.00 10.95 ATOM 3692 SG CYS 527 28.39425.617 24.900 1.00 18.23 ATOM 3693 C CYS 527 27.936 26.137 28.173 1.0010.37 ATOM 3694 O CYS 527 28.964 25.482 28.346 1.00 10.79 ATOM 3695 NPRO 528 26.825 25.900 28.876 1.00 11.53 ATOM 3696 CD PRO 528 25.56326.667 28.912 1.00 11.52 ATOM 3697 CA PRO 528 26.818 24.800 29.844 1.0011.48 ATOM 3698 CB PRO 528 25.578 25.095 30.689 1.00 10.83 ATOM 3699 CGPRO 528 24.638 25.744 29.689 1.00 12.92 ATOM 3700 C PRO 528 26.72723.472 29.091 1.00 12.66 ATOM 3701 O PRO 528 25.890 23.317 28.199 1.0012.63 ATOM 3702 N PRO 529 27.599 22.504 29.426 1.00 11.66 ATOM 3703 CDPRO 529 28.616 22.533 30.490 1.00 13.05 ATOM 3704 CA PRO 529 27.58521.199 28.756 1.00 13.58 ATOM 3705 CB PRO 529 28.801 20.496 29.353 1.0013.06 ATOM 3706 CG PRO 529 28.864 21.064 30.732 1.00 12.29 ATOM 3707 CPRO 529 26.279 20.448 29.008 1.00 14.96 ATOM 3708 O PRO 529 25.88819.587 28.227 1.00 15.87 ATOM 3709 N VAL 530 25.613 20.787 30.108 1.0014.85 ATOM 3710 CA VAL 530 24.339 20.178 30.463 1.00 16.23 ATOM 3711 CBVAL 530 24.449 19.366 31.779 1.00 17.35 ATOM 3712 CG1 VAL 530 23.07019.037 32.314 1.00 17.95 ATOM 3713 CG2 VAL 530 25.222 18.084 31.525 1.0018.24 ATOM 3714 C VAL 530 23.326 21.306 30.642 1.00 16.73 ATOM 3715 OVAL 530 23.589 22.282 31.344 1.00 16.65 ATOM 3716 N PRO 531 22.15621.198 29.996 1.00 16.87 ATOM 3717 CD PRO 531 21.626 20.094 29.180 1.0018.50 ATOM 3718 CA PRO 531 21.165 22.269 30.149 1.00 17.92 ATOM 3719 CBPRO 531 19.994 21.785 29.292 1.00 19.57 ATOM 3720 CG PRO 531 20.13620.284 29.328 1.00 21.45 ATOM 3721 C PRO 531 20.796 22.473 31.617 1.0018.39 ATOM 3722 O PRO 531 20.591 21.510 32.361 1.00 16.67 ATOM 3723 NARG 532 20.735 23.732 32.039 1.00 17.31 ATOM 3724 CA ARG 532 20.40624.037 33.423 1.00 18.29 ATOM 3725 CB ARG 532 20.853 25.460 33.770 1.0016.22 ATOM 3726 CG ARG 532 22.199 25.856 33.165 1.00 15.05 ATOM 3727 CDARG 532 23.254 24.770 33.337 1.00 15.19 ATOM 3728 NE ARG 532 23.59024.508 34.735 1.00 14.35 ATOM 3729 CZ ARG 532 23.800 23.293 35.228 1.0015.95 ATOM 3730 NH1 ARG 532 23.698 22.228 34.433 1.00 13.26 ATOM 3731NH2 ARG 532 24.127 23.138 36.506 1.00 12.05 ATOM 3732 C ARG 532 18.90623.883 33.650 1.00 20.23 ATOM 3733 O ARG 532 18.105 24.076 32.733 1.0019.63 ATOM 3734 N THR 533 18.530 23.532 34.876 1.00 21.65 ATOM 3735 CATHR 533 17.124 23.340 35.220 1.00 23.17 ATOM 3736 CB THR 533 16.81921.857 35.519 1.00 24.29 ATOM 3737 OG1 THR 533 17.679 21.393 36.570 1.0025.97 ATOM 3738 CG2 THR 533 17.031 21.006 34.277 1.00 25.60 ATOM 3739 CTHR 533 16.753 24.153 36.447 1.00 23.60 ATOM 3740 O THR 533 17.62924.635 37.171 1.00 21.92 ATOM 3741 N GLN 534 15.452 24.300 36.681 1.0024.71 ATOM 3742 CA GLN 534 14.973 25.052 37.832 1.00 26.41 ATOM 3743 CBGLN 534 13.440 25.044 37.872 1.00 28.54 ATOM 3744 CG GLN 534 12.84525.925 38.964 1.00 33.07 ATOM 3745 CD GLN 534 12.569 25.166 40.249 1.0036.01 ATOM 3746 OE1 GLN 534 13.114 24.084 40.475 1.00 38.09 ATOM 3747NE2 GLN 534 11.722 25.735 41.104 1.00 36.23 ATOM 3748 C GLN 534 15.55024.404 39.087 1.00 25.91 ATOM 3749 O GLN 534 15.444 23.192 39.279 1.0028.56 ATOM 3750 N GLY 535 16.173 25.211 39.936 1.00 24.41 ATOM 3751 CAGLY 535 16.775 24.673 41.140 1.00 20.69 ATOM 3752 C GLY 535 18.28124.852 41.105 1.00 18.98 ATOM 3753 O GLY 535 18.934 24.861 42.146 1.0020.39 ATOM 3754 N ASP 536 18.842 24.986 39.906 1.00 16.53 ATOM 3755 CAASP 536 20.281 25.186 39.778 1.00 15.72 ATOM 3756 CB ASP 536 20.76124.930 38.341 1.00 14.56 ATOM 3757 CG ASP 536 20.792 23.451 37.980 1.0015.32 ATOM 3758 OD1 ASP 536 20.996 22.613 38.883 1.00 16.51 ATOM 3759OD2 ASP 536 20.632 23.131 36.784 1.00 15.49 ATOM 3760 C ASP 536 20.63526.620 40.157 1.00 13.62 ATOM 3761 O ASP 536 19.855 27.539 39.930 1.0015.72 ATOM 3762 N PHE 537 21.809 26.794 40.747 1.00 12.29 ATOM 3763 CAPHE 537 22.308 28.109 41.139 1.00 11.39 ATOM 3764 CB PHE 537 21.91328.443 42.583 1.00 10.12 ATOM 3765 CG PHE 537 22.366 29.807 43.042 1.009.09 ATOM 3766 CD1 PHE 537 22.014 30.950 42.335 1.00 9.35 ATOM 3767 CD2PHE 537 23.151 29.943 44.189 1.00 12.40 ATOM 3768 CE1 PHE 537 22.43332.218 42.759 1.00 12.30 ATOM 3769 CE2 PHE 537 23.578 31.205 44.627 1.0011.45 ATOM 3770 CZ PHE 537 23.217 32.344 43.908 1.00 12.12 ATOM 3771 CPHE 537 23.817 27.983 41.008 1.00 9.37 ATOM 3772 O PHE 537 24.548 27.88941.991 1.00 7.21 ATOM 3773 N ASP 538 24.266 27.956 39.762 1.00 11.11ATOM 3774 CA ASP 538 25.675 27.811 39.461 1.00 10.38 ATOM 3775 CB ASP538 25.853 27.736 37.944 1.00 10.80 ATOM 3776 CG ASP 538 25.031 26.60537.329 1.00 12.13 ATOM 3777 OD1 ASP 538 24.925 25.533 37.965 1.00 11.88ATOM 3778 OD2 ASP 538 24.491 26.778 36.220 1.00 13.46 ATOM 3779 C ASP538 26.567 28.882 40.095 1.00 10.52 ATOM 3780 O ASP 538 27.694 28.59040.489 1.00 11.65 ATOM 3781 N PRO 539 26.079 30.132 40.219 1.00 10.22ATOM 3782 CD PRO 539 24.848 30.756 39.699 1.00 9.12 ATOM 3783 CA PRO 53926.951 31.138 40.841 1.00 10.73 ATOM 3784 CB PRO 539 26.076 32.39040.868 1.00 9.39 ATOM 3785 CG PRO 539 25.233 32.228 39.636 1.00 11.07ATOM 3786 C PRO 539 27.367 30.710 42.254 1.00 11.37 ATOM 3787 O PRO 53928.469 31.021 42.716 1.00 11.84 ATOM 3788 N GLY 540 26.472 30.001 42.9351.00 10.64 ATOM 3789 CA GLY 540 26.762 29.551 44.287 1.00 12.15 ATOM3790 C GLY 540 27.897 28.547 44.348 1.00 11.90 ATOM 3791 O GLY 54028.416 28.254 45.427 1.00 11.97 ATOM 3792 N ALA 541 28.285 28.022 43.1891.00 11.60 ATOM 3793 CA ALA 541 29.370 27.048 43.107 1.00 11.56 ATOM3794 CB ALA 541 29.133 26.093 41.931 1.00 13.00 ATOM 3795 C ALA 54130.737 27.725 42.965 1.00 11.57 ATOM 3796 O ALA 541 31.753 27.057 42.7601.00 11.83 ATOM 3797 N LYS 542 30.752 29.052 43.064 1.00 11.43 ATOM 3798CA LYS 542 31.992 29.824 42.984 1.00 11.78 ATOM 3799 CB LYS 542 31.89130.884 41.878 1.00 10.91 ATOM 3800 CG LYS 542 33.109 31.805 41.772 1.008.80 ATOM 3801 CD LYS 542 34.399 31.022 41.509 1.00 8.48 ATOM 3802 CELYS 542 35.618 31.946 41.540 1.00 8.38 ATOM 3803 NZ LYS 542 36.90931.210 41.407 1.00 9.81 ATOM 3804 C LYS 542 32.199 30.484 44.353 1.0012.26 ATOM 3805 O LYS 542 31.374 31.280 44.803 1.00 11.13 ATOM 3806 NPHE 543 33.305 30.137 45.004 1.00 13.11 ATOM 3807 CA PHE 543 33.63730.632 46.343 1.00 13.89 ATOM 3808 CB PHE 543 35.152 30.580 46.561 1.0013.28 ATOM 3809 CG PHE 543 35.591 31.133 47.890 1.00 15.40 ATOM 3810 CD1PHE 543 35.490 30.363 49.048 1.00 14.58 ATOM 3811 CD2 PHE 543 36.08232.435 47.990 1.00 13.56 ATOM 3812 CE1 PHE 543 35.873 30.883 50.289 1.0012.64 ATOM 3813 CE2 PHE 543 36.465 32.961 49.223 1.00 14.52 ATOM 3814 CZPHE 543 36.360 32.182 50.376 1.00 12.86 ATOM 3815 C PHE 543 33.14632.028 46.734 1.00 13.70 ATOM 3816 O PHE 543 32.413 32.183 47.714 1.0014.70 ATOM 3817 N HIS 544 33.564 33.035 45.973 1.00 11.85 ATOM 3818 CAHIS 544 33.230 34.430 46.257 1.00 12.43 ATOM 3819 CB HIS 544 33.89935.330 45.216 1.00 11.22 ATOM 3820 CG HIS 544 35.380 35.131 45.129 1.0012.39 ATOM 3821 CD2 HIS 544 36.412 35.944 45.460 1.00 10.77 ATOM 3822ND1 HIS 544 35.945 33.952 44.694 1.00 12.50 ATOM 3823 CE1 HIS 544 37.26234.045 44.762 1.00 12.26 ATOM 3824 NE2 HIS 544 37.570 35.243 45.223 1.0012.30 ATOM 3825 C HIS 544 31.754 34.791 46.389 1.00 12.49 ATOM 3826 OHIS 544 31.414 35.774 47.053 1.00 13.33 ATOM 3827 N ILE 545 30.88034.004 45.773 1.00 12.62 ATOM 3828 CA ILE 545 29.455 34.278 45.848 1.0011.82 ATOM 3829 CB ILE 545 28.685 33.471 44.772 1.00 12.66 ATOM 3830 CG2ILE 545 27.178 33.627 44.955 1.00 11.69 ATOM 3831 CG1 ILE 545 29.11733.943 43.380 1.00 13.17 ATOM 3832 CD1 ILE 545 28.898 35.423 43.130 1.0013.67 ATOM 3833 C ILE 545 28.926 33.980 47.251 1.00 13.02 ATOM 3834 OILE 545 28.437 34.880 47.933 1.00 12.86 ATOM 3835 N PRO 546 29.02132.719 47.712 1.00 12.59 ATOM 3836 CD PRO 546 29.404 31.462 47.045 1.0010.20 ATOM 3837 CA PRO 546 28.511 32.463 49.064 1.00 11.85 ATOM 3838 CBPRO 546 28.527 30.932 49.162 1.00 14.53 ATOM 3839 CG PRO 546 29.62930.530 48.217 1.00 11.49 ATOM 3840 C PRO 546 29.346 33.146 50.154 1.0013.09 ATOM 3841 O PRO 546 28.848 33.420 51.248 1.00 11.43 ATOM 3842 NSER 547 30.611 33.433 49.850 1.00 11.87 ATOM 3843 CA SER 547 31.48834.090 50.817 1.00 12.43 ATOM 3844 CB SER 547 32.950 33.734 50.550 1.0014.52 ATOM 3845 OG SER 547 33.188 32.370 50.842 1.00 18.88 ATOM 3846 CSER 547 31.332 35.601 50.811 1.00 10.80 ATOM 3847 O SER 547 31.94636.294 51.617 1.00 10.64 ATOM 3848 N SER 548 30.515 36.105 49.891 1.0011.41 ATOM 3849 CA SER 548 30.259 37.538 49.777 1.00 11.67 ATOM 3850 CBSER 548 29.419 38.020 50.968 1.00 12.24 ATOM 3851 OG SER 548 28.97739.360 50.781 1.00 11.61 ATOM 3852 C SER 548 31.537 38.380 49.669 1.0013.36 ATOM 3853 O SER 548 31.711 39.366 50.396 1.00 13.15 ATOM 3854 NVAL 549 32.430 37.978 48.768 1.00 11.75 ATOM 3855 CA VAL 549 33.67238.714 48.529 1.00 11.24 ATOM 3856 CB VAL 549 34.911 37.786 48.533 1.0011.58 ATOM 3857 CG1 VAL 549 36.169 38.594 48.199 1.00 10.79 ATOM 3858CG2 VAL 549 35.058 37.105 49.888 1.00 12.34 ATOM 3859 C VAL 549 33.55039.347 47.139 1.00 9.01 ATOM 3860 O VAL 549 33.356 38.637 46.149 1.009.01 ATOM 3861 N PRO 550 33.651 40.687 47.049 1.00 7.69 ATOM 3862 CD PRO550 33.852 41.644 48.152 1.00 8.15 ATOM 3863 CA PRO 550 33.547 41.38845.757 1.00 9.25 ATOM 3864 CB PRO 550 33.846 42.841 46.127 1.00 8.76ATOM 3865 CG PRO 550 33.325 42.934 47.551 1.00 8.40 ATOM 3866 C PRO 55034.546 40.819 44.747 1.00 8.58 ATOM 3867 O PRO 550 35.645 40.411 45.1221.00 8.68 ATOM 3868 N TYR 551 34.179 40.813 43.469 1.00 8.90 ATOM 3869CA TYR 551 35.050 40.234 42.452 1.00 8.19 ATOM 3870 CB TYR 551 34.28239.168 41.661 1.00 8.98 ATOM 3871 CG TYR 551 35.155 38.019 41.221 1.008.00 ATOM 3872 CD1 TYR 551 35.496 37.008 42.119 1.00 7.60 ATOM 3873 CE1TYR 551 36.367 35.985 41.759 1.00 8.68 ATOM 3874 CD2 TYR 551 35.70537.978 39.935 1.00 8.09 ATOM 3875 CE2 TYR 551 36.589 36.948 39.562 1.008.21 ATOM 3876 CZ TYR 551 36.913 35.960 40.486 1.00 8.67 ATOM 3877 OHTYR 551 37.794 34.955 40.160 1.00 9.65 ATOM 3878 C TYR 551 35.706 41.18241.452 1.00 9.16 ATOM 3879 O TYR 551 36.728 40.839 40.865 1.00 9.22 ATOM3880 N ILE 552 35.124 42.358 41.243 1.00 8.84 ATOM 3881 CA ILE 55235.676 43.299 40.275 1.00 9.21 ATOM 3882 CB ILE 552 34.790 44.576 40.1891.00 9.04 ATOM 3883 CG2 ILE 552 35.055 45.494 41.365 1.00 9.74 ATOM 3884CG1 ILE 552 35.028 45.280 38.851 1.00 8.56 ATOM 3885 CD1 ILE 552 34.58744.457 37.637 1.00 5.07 ATOM 3886 C ILE 552 37.141 43.652 40.565 1.0010.06 ATOM 3887 O ILE 552 37.892 44.025 39.664 1.00 11.40 ATOM 3888 NARG 553 37.549 43.508 41.821 1.00 10.58 ATOM 3889 CA ARG 553 38.92843.775 42.217 1.00 9.70 ATOM 3890 CB ARG 553 39.106 43.467 43.708 1.0010.44 ATOM 3891 CG ARG 553 38.642 42.058 44.103 1.00 11.05 ATOM 3892 CDARG 553 38.629 41.861 45.620 1.00 10.48 ATOM 3893 NE ARG 553 37.81542.881 46.274 1.00 9.50 ATOM 3894 CZ ARG 553 37.562 42.928 47.577 1.009.87 ATOM 3895 NH1 ARG 553 38.059 42.002 48.389 1.00 9.94 ATOM 3896 NH2ARG 553 36.816 43.909 48.071 1.00 9.97 ATOM 3897 C ARG 553 39.910 42.92041.396 1.00 10.71 ATOM 3898 O ARG 553 41.049 43.331 41.151 1.00 9.61ATOM 3899 N TYR 554 39.468 41.739 40.967 1.00 8.53 ATOM 3900 CA TYR 55440.334 40.844 40.195 1.00 10.58 ATOM 3901 CB TYR 554 39.815 39.40140.264 1.00 9.50 ATOM 3902 CG TYR 554 39.759 38.865 41.679 1.00 10.20ATOM 3903 CD1 TYR 554 38.534 38.602 42.297 1.00 9.83 ATOM 3904 CE1 TYR554 38.471 38.161 43.620 1.00 9.58 ATOM 3905 CD2 TYR 554 40.930 38.67042.421 1.00 9.15 ATOM 3906 CE2 TYR 554 40.881 38.229 43.747 1.00 8.88ATOM 3907 CZ TYR 554 39.645 37.977 44.339 1.00 10.44 ATOM 3908 OH TYR554 39.572 37.561 45.648 1.00 8.38 ATOM 3909 C TYR 554 40.472 41.28638.746 1.00 10.64 ATOM 3910 O TYR 554 41.518 41.083 38.122 1.00 11.41ATOM 3911 N PHE 555 39.414 41.884 38.209 1.00 10.46 ATOM 3912 CA PHE 55539.452 42.393 36.842 1.00 10.84 ATOM 3913 CB PHE 555 38.060 42.85536.400 1.00 10.26 ATOM 3914 CG PHE 555 38.046 43.526 35.061 1.00 10.17ATOM 3915 CD1 PHE 555 38.027 42.776 33.889 1.00 11.11 ATOM 3916 CD2 PHE555 38.081 44.911 34.968 1.00 11.00 ATOM 3917 CE1 PHE 555 38.044 43.40232.641 1.00 10.56 ATOM 3918 CE2 PHE 555 38.101 45.547 33.723 1.00 11.95ATOM 3919 CZ PHE 555 38.083 44.792 32.560 1.00 10.41 ATOM 3920 C PHE 55540.417 43.586 36.850 1.00 10.22 ATOM 3921 O PHE 555 41.309 43.689 36.0071.00 9.16 ATOM 3922 N VAL 556 40.225 44.483 37.810 1.00 8.84 ATOM 3923CA VAL 556 41.083 45.652 37.947 1.00 10.41 ATOM 3924 CB VAL 556 40.65746.515 39.163 1.00 11.27 ATOM 3925 CG1 VAL 556 41.651 47.663 39.377 1.0011.42 ATOM 3926 CG2 VAL 556 39.256 47.074 38.934 1.00 10.95 ATOM 3927 CVAL 556 42.530 45.183 38.135 1.00 10.85 ATOM 3928 O VAL 556 43.44845.679 37.485 1.00 9.24 ATOM 3929 N SER 557 42.722 44.213 39.021 1.0010.92 ATOM 3930 CA SER 557 44.055 43.681 39.283 1.00 12.23 ATOM 3931 CBSER 557 43.986 42.547 40.311 1.00 12.25 ATOM 3932 OG SER 557 45.24241.895 40.418 1.00 11.90 ATOM 3933 C SER 557 44.781 43.167 38.042 1.0010.88 ATOM 3934 O SER 557 45.944 43.491 37.823 1.00 11.61 ATOM 3935 NPHE 558 44.108 42.358 37.233 1.00 11.01 ATOM 3936 CA PHE 558 44.76041.805 36.054 1.00 12.87 ATOM 3937 CB PHE 558 43.874 40.728 35.419 1.0013.39 ATOM 3938 CG PHE 558 44.053 39.374 36.041 1.00 14.43 ATOM 3939 CD1PHE 558 43.973 39.217 37.425 1.00 16.42 ATOM 3940 CD2 PHE 558 44.34338.263 35.254 1.00 14.78 ATOM 3941 CE1 PHE 558 44.185 37.969 38.017 1.0016.88 ATOM 3942 CE2 PHE 558 44.554 37.016 35.830 1.00 15.76 ATOM 3943 CZPHE 558 44.476 36.868 37.218 1.00 17.97 ATOM 3944 C PHE 558 45.19142.844 35.032 1.00 13.85 ATOM 3945 O PHE 558 46.164 42.640 34.308 1.0012.86 ATOM 3946 N ILE 559 44.479 43.963 34.979 1.00 14.42 ATOM 3947 CAILE 559 44.840 45.028 34.051 1.00 13.66 ATOM 3948 CB ILE 559 43.67746.038 33.853 1.00 14.20 ATOM 3949 CG2 ILE 559 44.179 47.274 33.112 1.0012.67 ATOM 3950 CG1 ILE 559 42.513 45.381 33.098 1.00 15.77 ATOM 3951CD1 ILE 559 42.788 45.101 31.635 1.00 17.17 ATOM 3952 C ILE 559 46.03945.796 34.611 1.00 12.63 ATOM 3953 O ILE 559 47.080 45.907 33.964 1.0012.70 ATOM 3954 N ILE 560 45.892 46.304 35.831 1.00 11.72 ATOM 3955 CAILE 560 46.946 47.104 36.441 1.00 10.69 ATOM 3956 CB ILE 560 46.43647.844 37.706 1.00 10.54 ATOM 3957 CG2 ILE 560 45.153 48.614 37.370 1.008.48 ATOM 3958 CG1 ILE 560 46.206 46.858 38.854 1.00 8.80 ATOM 3959 CD1ILE 560 45.770 47.529 40.158 1.00 8.36 ATOM 3960 C ILE 560 48.227 46.35536.793 1.00 12.09 ATOM 3961 O ILE 560 49.296 46.962 36.854 1.00 10.94ATOM 3962 N GLN 561 48.144 45.049 37.023 1.00 10.67 ATOM 3963 CA GLN 56149.364 44.324 37.354 1.00 11.49 ATOM 3964 CB GLN 561 49.060 42.88237.778 1.00 10.52 ATOM 3965 CG GLN 561 48.500 41.975 36.701 1.00 9.92ATOM 3966 CD GLN 561 48.154 40.604 37.254 1.00 12.40 ATOM 3967 OE1 GLN561 48.678 39.589 36.799 1.00 11.82 ATOM 3968 NE2 GLN 561 47.269 40.57138.250 1.00 10.71 ATOM 3969 C GLN 561 50.341 44.363 36.176 1.00 11.50ATOM 3970 O GLN 561 51.554 44.347 36.372 1.00 11.27 ATOM 3971 N PHE 56249.817 44.424 34.953 1.00 11.69 ATOM 3972 CA PHE 562 50.691 44.50333.790 1.00 11.21 ATOM 3973 CB PHE 562 49.956 44.080 32.510 1.00 11.05ATOM 3974 CG PHE 562 49.863 42.591 32.352 1.00 11.29 ATOM 3975 CD1 PHE562 48.793 41.884 32.890 1.00 9.06 ATOM 3976 CD2 PHE 562 50.913 41.88031.768 1.00 12.56 ATOM 3977 CE1 PHE 562 48.772 40.488 32.858 1.00 12.27ATOM 3978 CE2 PHE 562 50.903 40.485 31.732 1.00 12.36 ATOM 3979 CZ PHE562 49.831 39.787 32.280 1.00 11.90 ATOM 3980 C PHE 562 51.231 45.92533.675 1.00 12.75 ATOM 3981 O PHE 562 52.351 46.140 33.199 1.00 11.93ATOM 3982 N GLN 563 50.437 46.897 34.117 1.00 10.72 ATOM 3983 CA GLN 56350.891 48.281 34.097 1.00 12.88 ATOM 3984 CB GLN 563 49.767 49.23434.519 1.00 11.19 ATOM 3985 CG GLN 563 48.737 49.532 33.435 1.00 11.49ATOM 3986 CD GLN 563 47.675 50.507 33.912 1.00 12.70 ATOM 3987 OE1 GLN563 46.589 50.107 34.331 1.00 12.32 ATOM 3988 NE2 GLN 563 47.997 51.79933.872 1.00 11.50 ATOM 3989 C GLN 563 52.047 48.395 35.092 1.00 12.39ATOM 3990 O GLN 563 53.025 49.093 34.839 1.00 13.44 ATOM 3991 N PHE 56451.925 47.706 36.225 1.00 11.63 ATOM 3992 CA PHE 564 52.963 47.74037.252 1.00 13.10 ATOM 3993 CB PHE 564 52.464 47.095 38.554 1.00 11.20ATOM 3994 CG PHE 564 51.333 47.841 39.221 1.00 12.19 ATOM 3995 CD1 PHE564 50.907 49.082 38.746 1.00 14.04 ATOM 3996 CD2 PHE 564 50.687 47.29440.329 1.00 12.60 ATOM 3997 CE1 PHE 564 49.852 49.766 39.365 1.00 13.68ATOM 3998 CE2 PHE 564 49.634 47.967 40.956 1.00 11.39 ATOM 3999 CZ PHE564 49.215 49.203 40.473 1.00 11.65 ATOM 4000 C PHE 564 54.216 47.01336.768 1.00 12.91 ATOM 4001 O PHE 564 55.333 47.480 36.971 1.00 12.87ATOM 4002 N HIS 565 54.019 45.865 36.132 1.00 13.20 ATOM 4003 CA HIS 56555.121 45.070 35.599 1.00 14.27 ATOM 4004 CB HIS 565 54.560 43.82534.906 1.00 12.73 ATOM 4005 CG HIS 565 55.607 42.908 34.354 1.00 15.74ATOM 4006 CD2 HIS 565 55.857 42.500 33.086 1.00 12.69 ATOM 4007 ND1 HIS565 56.545 42.283 35.148 1.00 14.29 ATOM 4008 CE1 HIS 565 57.326 41.53234.394 1.00 14.80 ATOM 4009 NE2 HIS 565 56.930 41.647 33.138 1.00 14.33ATOM 4010 C HIS 565 55.923 45.920 34.600 1.00 14.86 ATOM 4011 O HIS 56557.153 45.973 34.652 1.00 14.50 ATOM 4012 N GLU 566 55.213 46.593 33.7021.00 13.69 ATOM 4013 CA GLU 566 55.848 47.443 32.702 1.00 15.17 ATOM4014 CB GLU 566 54.778 48.065 31.797 1.00 15.39 ATOM 4015 CG GLU 56655.313 48.964 30.695 1.00 15.92 ATOM 4016 CD GLU 566 54.202 49.65229.931 1.00 15.19 ATOM 4017 OE1 GLU 566 53.539 50.538 30.505 1.00 17.62ATOM 4018 OE2 GLU 566 53.980 49.295 28.758 1.00 18.81 ATOM 4019 C GLU566 56.695 48.551 33.339 1.00 15.89 ATOM 4020 O GLU 566 57.859 48.73732.976 1.00 14.18 ATOM 4021 N ALA 567 56.112 49.282 34.287 1.00 15.39ATOM 4022 CA ALA 567 56.828 50.372 34.948 1.00 16.88 ATOM 4023 CB ALA567 55.865 51.183 35.819 1.00 14.89 ATOM 4024 C ALA 567 58.019 49.89735.784 1.00 16.62 ATOM 4025 O ALA 567 59.096 50.488 35.727 1.00 15.99ATOM 4026 N LEU 568 57.825 48.833 36.557 1.00 15.41 ATOM 4027 CA LEU 56858.893 48.309 37.398 1.00 16.13 ATOM 4028 CB LEU 568 58.359 47.20138.314 1.00 17.30 ATOM 4029 CG LEU 568 57.250 47.612 39.299 1.00 20.05ATOM 4030 CD1 LEU 568 56.889 46.432 40.190 1.00 18.53 ATOM 4031 CD2 LEU568 57.711 48.778 40.145 1.00 18.19 ATOM 4032 C LEU 568 60.048 47.78436.552 1.00 18.07 ATOM 4033 O LEU 568 61.214 47.911 36.929 1.00 17.90ATOM 4034 N CYS 569 59.720 47.202 35.403 1.00 18.05 ATOM 4035 CA CYS 56960.732 46.672 34.502 1.00 18.25 ATOM 4036 C CYS 569 61.549 47.820 33.9231.00 20.30 ATOM 4037 O CYS 569 62.773 47.723 33.798 1.00 20.29 ATOM 4038CB CYS 569 60.067 45.860 33.388 1.00 16.73 ATOM 4039 SG CYS 569 59.39044.286 34.002 1.00 19.14 ATOM 4040 N GLN 570 60.868 48.905 33.571 1.0020.33 ATOM 4041 CA GLN 570 61.543 50.077 33.035 1.00 23.99 ATOM 4042 CBGLN 570 60.520 51.120 32.572 1.00 26.88 ATOM 4043 CG GLN 570 61.12852.411 32.026 1.00 33.15 ATOM 4044 CD GLN 570 61.464 53.420 33.112 1.0038.69 ATOM 4045 OE1 GLN 570 62.144 54.418 32.859 1.00 42.37 ATOM 4046NE2 GLN 570 60.979 53.172 34.327 1.00 41.47 ATOM 4047 C GLN 570 62.43350.659 34.135 1.00 23.86 ATOM 4048 O GLN 570 63.580 51.019 33.890 1.0024.65 ATOM 4049 N ALA 571 61.902 50.730 35.351 1.00 24.19 ATOM 4050 CAALA 571 62.656 51.266 36.479 1.00 24.23 ATOM 4051 CB ALA 571 61.76051.366 37.707 1.00 22.96 ATOM 4052 C ALA 571 63.864 50.384 36.783 1.0025.45 ATOM 4053 O ALA 571 64.875 50.860 37.305 1.00 25.42 ATOM 4054 NALA 572 63.750 49.099 36.459 1.00 24.84 ATOM 4055 CA ALA 572 64.82748.147 36.699 1.00 25.13 ATOM 4056 CB ALA 572 64.254 46.750 36.870 1.0023.83 ATOM 4057 C ALA 572 65.863 48.152 35.573 1.00 25.94 ATOM 4058 OALA 572 66.867 47.442 35.642 1.00 26.07 ATOM 4059 N GLY 573 65.60948.947 34.537 1.00 26.23 ATOM 4060 CA GLY 573 66.532 49.025 33.419 1.0027.16 ATOM 4061 C GLY 573 66.339 47.967 32.344 1.00 28.15 ATOM 4062 OGLY 573 67.187 47.812 31.460 1.00 27.38 ATOM 4063 N HIS 574 65.22947.238 32.400 1.00 28.43 ATOM 4064 CA HIS 574 64.969 46.204 31.406 1.0027.36 ATOM 4065 CB HIS 574 63.768 45.348 31.814 1.00 27.79 ATOM 4066 CGHIS 574 63.425 44.284 30.818 1.00 27.40 ATOM 4067 CD2 HIS 574 62.48344.244 29.845 1.00 26.79 ATOM 4068 ND1 HIS 574 64.132 43.105 30.714 1.0028.45 ATOM 4069 CE1 HIS 574 63.643 42.386 29.720 1.00 27.27 ATOM 4070NE2 HIS 574 62.642 43.055 29.175 1.00 26.73 ATOM 4071 C HIS 574 64.70246.794 30.025 1.00 27.12 ATOM 4072 O HIS 574 64.038 47.820 29.886 1.0026.50 ATOM 4073 N THR 575 65.226 46.130 29.004 1.00 27.68 ATOM 4074 CATHR 575 65.036 46.562 27.630 1.00 28.87 ATOM 4075 CB THR 575 66.32647.153 27.038 1.00 29.42 ATOM 4076 OG1 THR 575 67.310 46.121 26.914 1.0030.33 ATOM 4077 CG2 THR 575 66.864 48.254 27.942 1.00 30.67 ATOM 4078 CTHR 575 64.640 45.336 26.821 1.00 28.31 ATOM 4079 O THR 575 64.94044.204 27.205 1.00 28.82 ATOM 4080 N GLY 576 63.969 45.560 25.700 1.0028.44 ATOM 4081 CA GLY 576 63.539 44.448 24.875 1.00 27.18 ATOM 4082 CGLY 576 62.119 44.050 25.230 1.00 25.91 ATOM 4083 O GLY 576 61.46544.737 26.018 1.00 24.77 ATOM 4084 N PRO 577 61.619 42.933 24.678 1.0024.95 ATOM 4085 CD PRO 577 62.349 41.978 23.827 1.00 23.68 ATOM 4086 CAPRO 577 60.258 42.457 24.946 1.00 22.59 ATOM 4087 CB PRO 577 60.25941.056 24.341 1.00 22.99 ATOM 4088 CG PRO 577 61.219 41.191 23.196 1.0024.60 ATOM 4089 C PRO 577 59.910 42.446 26.431 1.00 21.80 ATOM 4090 OPRO 577 60.659 41.917 27.254 1.00 19.91 ATOM 4091 N LEU 578 58.76643.033 26.762 1.00 20.01 ATOM 4092 CA LEU 578 58.307 43.099 28.140 1.0019.37 ATOM 4093 CB LEU 578 56.978 43.849 28.201 1.00 19.91 ATOM 4094 CGLEU 578 56.331 44.032 29.575 1.00 20.71 ATOM 4095 CD1 LEU 578 57.28944.770 30.506 1.00 19.94 ATOM 4096 CD2 LEU 578 55.027 44.807 29.412 1.0019.01 ATOM 4097 C LEU 578 58.155 41.723 28.792 1.00 19.24 ATOM 4098 OLEU 578 58.455 41.558 29.977 1.00 19.94 ATOM 4099 N HIS 579 57.70740.731 28.025 1.00 18.28 ATOM 4100 CA HIS 579 57.506 39.399 28.584 1.0017.96 ATOM 4101 CB HIS 579 56.750 38.496 27.598 1.00 17.78 ATOM 4102 CGHIS 579 57.550 38.091 26.397 1.00 19.87 ATOM 4103 CD2 HIS 579 58.26136.967 26.140 1.00 19.63 ATOM 4104 ND1 HIS 579 57.660 38.881 25.272 1.0020.33 ATOM 4105 CE1 HIS 579 58.403 38.259 24.372 1.00 21.49 ATOM 4106NE2 HIS 579 58.781 37.096 24.873 1.00 21.52 ATOM 4107 C HIS 579 58.78838.703 29.038 1.00 18.92 ATOM 4108 O HIS 579 58.736 37.704 29.753 1.0018.97 ATOM 4109 N LYS 580 59.939 39.227 28.628 1.00 19.36 ATOM 4110 CALYS 580 61.213 38.633 29.024 1.00 20.72 ATOM 4111 CB LYS 580 62.24938.793 27.906 1.00 22.61 ATOM 4112 CG LYS 580 61.921 38.033 26.637 1.0026.07 ATOM 4113 CD LYS 580 63.026 38.210 25.603 1.00 30.62 ATOM 4114 CELYS 580 62.691 37.498 24.303 1.00 32.64 ATOM 4115 NZ LYS 580 63.73937.735 23.272 1.00 36.23 ATOM 4116 C LYS 580 61.759 39.261 30.304 1.0019.60 ATOM 4117 O LYS 580 62.820 38.868 30.791 1.00 19.03 ATOM 4118 NCYS 581 61.035 40.231 30.850 1.00 18.42 ATOM 4119 CA CYS 581 61.48140.906 32.064 1.00 17.07 ATOM 4120 C CYS 581 61.314 40.101 33.347 1.0017.10 ATOM 4121 O CYS 581 60.304 39.418 33.547 1.00 15.04 ATOM 4122 CBCYS 581 60.760 42.250 32.216 1.00 18.37 ATOM 4123 SG CYS 581 60.96943.013 33.857 1.00 17.47 ATOM 4124 N ASP 582 62.326 40.198 34.207 1.0015.09 ATOM 4125 CA ASP 582 62.349 39.536 35.508 1.00 16.68 ATOM 4126 CBASP 582 63.280 38.317 35.483 1.00 17.27 ATOM 4127 CG ASP 582 63.34637.599 36.823 1.00 17.46 ATOM 4128 OD1 ASP 582 62.896 38.168 37.840 1.0020.34 ATOM 4129 OD2 ASP 582 63.863 36.464 36.864 1.00 18.13 ATOM 4130 CASP 582 62.905 40.596 36.455 1.00 17.47 ATOM 4131 O ASP 582 64.09040.934 36.391 1.00 17.45 ATOM 4132 N ILE 583 62.053 41.128 37.326 1.0016.24 ATOM 4133 CA ILE 583 62.486 42.171 38.250 1.00 15.41 ATOM 4134 CBILE 583 61.307 43.072 38.690 1.00 14.68 ATOM 4135 CG2 ILE 583 60.63243.673 37.470 1.00 14.39 ATOM 4136 CG1 ILE 583 60.311 42.260 39.523 1.0015.92 ATOM 4137 CD1 ILE 583 59.269 43.108 40.237 1.00 14.64 ATOM 4138 CILE 583 63.153 41.641 39.510 1.00 14.69 ATOM 4139 O ILE 583 63.33942.393 40.461 1.00 15.92 ATOM 4140 N TYR 584 63.515 40.361 39.525 1.0014.71 ATOM 4141 CA TYR 584 64.159 39.793 40.707 1.00 16.16 ATOM 4142 CBTYR 584 64.674 38.379 40.435 1.00 17.42 ATOM 4143 CG TYR 584 65.20137.707 41.687 1.00 20.19 ATOM 4144 CD1 TYR 584 64.335 37.319 42.710 1.0019.90 ATOM 4145 CE1 TYR 584 64.818 36.736 43.882 1.00 22.35 ATOM 4146CD2 TYR 584 66.569 37.496 41.868 1.00 21.27 ATOM 4147 CE2 TYR 584 67.06236.917 43.040 1.00 21.55 ATOM 4148 CZ TYR 584 66.182 36.540 44.040 1.0023.16 ATOM 4149 OH TYR 584 66.667 35.970 45.197 1.00 24.33 ATOM 4150 CTYR 584 65.313 40.665 41.203 1.00 17.22 ATOM 4151 O TYR 584 66.18141.077 40.430 1.00 15.46 ATOM 4152 N GLN 585 65.280 40.919 42.511 1.0019.21 ATOM 4153 CA GLN 565 66.220 41.732 43.291 1.00 20.56 ATOM 4154 CBGLN 585 67.547 40.975 43.537 1.00 22.86 ATOM 4155 CG GLN 585 68.71441.237 42.615 1.00 25.28 ATOM 4156 CD GLN 585 70.041 40.759 43.227 1.0025.98 ATOM 4157 OE1 GLN 585 70.858 41.563 43.688 1.00 27.46 ATOM 4158NE2 GLN 585 70.246 39.449 43.244 1.00 21.75 ATOM 4159 C GLN 585 66.47343.182 42.874 1.00 20.42 ATOM 4160 O GLN 585 67.461 43.798 43.278 1.0021.28 ATOM 4161 N SER 586 65.550 43.745 42.102 1.00 19.19 ATOM 4162 CASER 586 65.660 45.139 41.690 1.00 19.32 ATOM 4163 CB SER 586 64.78645.414 40.471 1.00 18.80 ATOM 4164 OG SER 586 64.601 46.811 40.310 1.0018.57 ATOM 4165 C SER 586 65.189 46.029 42.843 1.00 19.72 ATOM 4166 OSER 586 64.024 45.974 43.242 1.00 19.41 ATOM 4167 N LYS 587 66.08946.850 43.373 1.00 19.62 ATOM 4168 CA LYS 587 65.732 47.732 44.478 1.0019.54 ATOM 4169 CB LYS 587 66.993 48.220 45.201 1.00 19.75 ATOM 4170 CGLYS 587 67.817 47.097 45.824 1.00 19.70 ATOM 4171 CD LYS 587 66.99646.278 46.807 1.00 19.79 ATOM 4172 CE LYS 587 67.818 45.169 47.454 1.0018.62 ATOM 4173 NZ LYS 587 68.332 44.187 46.455 1.00 17.59 ATOM 4174 CLYS 587 64.903 48.918 43.998 1.00 18.61 ATOM 4175 O LYS 587 64.07949.442 44.746 1.00 18.91 ATOM 4176 N GLU 588 65.125 49.340 42.756 1.0017.99 ATOM 4177 CA GLU 588 64.368 50.453 42.189 1.00 19.42 ATOM 4178 CBGLU 588 64.886 50.814 40.793 1.00 21.76 ATOM 4179 CG GLU 588 66.27251.445 40.746 1.00 27.43 ATOM 4180 CD GLU 588 67.376 50.476 41.117 1.0029.76 ATOM 4181 OE1 GLU 588 67.323 49.311 40.666 1.00 30.34 ATOM 4182OE2 GLU 588 68.304 50.885 41.849 1.00 33.88 ATOM 4183 C GLU 588 62.89850.048 42.081 1.00 19.93 ATOM 4184 O GLU 588 61.995 50.836 42.376 1.0017.54 ATOM 4185 N ALA 589 62.669 48.813 41.645 1.00 19.54 ATOM 4186 CAALA 589 61.315 48.292 41.503 1.00 19.77 ATOM 4187 CB ALA 589 61.35146.904 40.875 1.00 19.22 ATOM 4188 C ALA 589 60.657 48.231 42.879 1.0019.77 ATOM 4189 O ALA 589 59.564 48.756 43.081 1.00 18.88 ATOM 4190 NGLY 590 61.339 47.596 43.825 1.00 19.84 ATOM 4191 CA GLY 590 60.80247.485 45.169 1.00 20.54 ATOM 4192 C GLY 590 60.463 48.824 45.808 1.0021.45 ATOM 4193 O GLY 590 59.471 48.940 46.527 1.00 21.87 ATOM 4194 NGLN 591 61.274 49.842 45.541 1.00 21.62 ATOM 4195 CA GLN 591 61.03951.156 46.125 1.00 23.40 ATOM 4196 CB GLN 591 62.209 52.093 45.822 1.0027.20 ATOM 4197 CG GLN 591 62.105 53.431 46.537 1.00 33.72 ATOM 4198 CDGLN 591 62.006 53.271 48.049 1.00 37.72 ATOM 4199 OE1 GLN 591 62.94252.804 48.701 1.00 40.06 ATOM 4200 NE2 GLN 591 60.862 53.650 48.610 1.0040.38 ATOM 4201 C GLN 591 59.734 51.797 45.657 1.00 22.75 ATOM 4202 OGLN 591 59.049 52.458 46.436 1.00 22.38 ATOM 4203 N ARG 592 59.38351.612 44.391 1.00 21.41 ATOM 4204 CA ARG 592 58.141 52.189 43.900 1.0023.04 ATOM 4205 CB ARG 592 58.056 52.092 42.380 1.00 24.83 ATOM 4206 CGARG 592 59.000 53.041 41.678 1.00 27.16 ATOM 4207 CD ARG 592 58.67253.136 40.216 1.00 30.01 ATOM 4208 NE ARG 592 59.631 53.965 39.500 1.0030.87 ATOM 4209 CZ ARG 592 59.574 54.207 38.197 1.00 33.37 ATOM 4210 NH1ARG 592 58.597 53.680 37.468 1.00 33.76 ATOM 4211 NH2 ARG 592 60.49854.961 37.620 1.00 33.43 ATOM 4212 C ARG 592 56.940 51.501 44.529 1.0022.47 ATOM 4213 O ARG 592 55.957 52.151 44.884 1.00 23.13 ATOM 4214 NLEU 593 57.022 50.183 44.670 1.00 20.30 ATOM 4215 CA LEU 593 55.92849.439 45.268 1.00 19.74 ATOM 4216 CB LEU 593 56.173 47.932 45.147 1.0019.55 ATOM 4217 CG LEU 593 55.936 47.315 43.765 1.00 21.26 ATOM 4218 CD1LEU 593 56.137 45.807 43.847 1.00 20.22 ATOM 4219 CD2 LEU 593 54.51847.639 43.289 1.00 18.77 ATOM 4220 C LEU 593 55.756 49.819 46.734 1.0018.89 ATOM 4221 O LEU 593 54.633 49.946 47.218 1.00 17.61 ATOM 4222 NALA 594 56.872 50.003 47.434 1.00 17.55 ATOM 4223 CA ALA 594 56.82750.358 48.851 1.00 19.25 ATOM 4224 CB ALA 594 58.236 50.327 49.449 1.0017.33 ATOM 4225 C ALA 594 56.184 51.724 49.091 1.00 18.56 ATOM 4226 OALA 594 55.281 51.852 49.914 1.00 19.48 ATOM 4227 N THR 595 56.64752.744 48.378 1.00 19.12 ATOM 4228 CA THR 595 56.091 54.081 48.558 1.0020.47 ATOM 4229 CB THR 595 56.754 55.105 47.602 1.00 22.14 ATOM 4230 OG1THR 595 56.482 54.744 46.242 1.00 27.28 ATOM 4231 CG2 THR 595 58.25555.134 47.814 1.00 22.28 ATOM 4232 C THR 595 54.584 54.067 48.306 1.0020.42 ATOM 4233 O THR 595 53.823 54.741 49.006 1.00 20.17 ATOM 4234 NALA 596 54.158 53.286 47.315 1.00 17.08 ATOM 4235 CA ALA 596 52.74453.191 46.972 1.00 15.64 ATOM 4236 CB ALA 596 52.577 52.497 45.619 1.0014.14 ATOM 4237 C ALA 596 51.948 52.448 48.043 1.00 14.88 ATOM 4238 OALA 596 50.891 52.914 48.474 1.00 15.10 ATOM 4239 N MET 597 52.45151.294 48.472 1.00 12.78 ATOM 4240 CA MET 597 51.762 50.511 49.488 1.0014.01 ATOM 4241 CB MET 597 52.464 49.162 49.702 1.00 13.50 ATOM 4242 CGMET 597 52.266 48.171 48.562 1.00 14.73 ATOM 4243 SD MET 597 52.87846.512 48.914 1.00 17.16 ATOM 4244 CE MET 597 54.598 46.708 48.490 1.0016.02 ATOM 4245 C MET 597 51.644 51.249 50.820 1.00 14.90 ATOM 4246 OMET 597 50.648 51.108 51.525 1.00 13.57 ATOM 4247 N LYS 598 52.65952.037 51.157 1.00 15.99 ATOM 4248 CA LYS 598 52.660 52.786 52.412 1.0017.02 ATOM 4249 CB LYS 598 53.998 53.509 52.588 1.00 17.91 ATOM 4250 CGLYS 598 55.146 52.592 52.970 1.00 22.00 ATOM 4251 CD LYS 598 56.43953.374 53.127 1.00 25.95 ATOM 4252 CE LYS 598 57.505 52.545 53.830 1.0028.04 ATOM 4253 NZ LYS 598 57.829 51.285 53.106 1.00 28.00 ATOM 4254 CLYS 598 51.512 53.790 52.513 1.00 17.35 ATOM 4255 O LYS 598 51.09854.155 53.613 1.00 19.76 ATOM 4256 N LEU 599 51.000 54.234 51.369 1.0015.18 ATOM 4257 CA LEU 599 49.892 55.184 51.355 1.00 14.61 ATOM 4258 CBLEU 599 49.652 55.722 49.940 1.00 15.70 ATOM 4259 CG LEU 599 50.70156.621 49.288 1.00 15.36 ATOM 4260 CD1 LEU 599 50.234 56.968 47.888 1.0015.46 ATOM 4261 CD2 LEU 599 50.911 57.884 50.113 1.00 15.35 ATOM 4262 CLEU 599 48.607 54.534 51.845 1.00 14.55 ATOM 4263 O LEU 599 47.68655.222 52.285 1.00 16.32 ATOM 4264 N GLY 600 48.544 53.209 51.767 1.0013.23 ATOM 4265 CA GLY 600 47.341 52.517 52.184 1.00 14.20 ATOM 4266 CGLY 600 46.128 53.091 51.468 1.00 14.55 ATOM 4267 O GLY 600 46.11653.212 50.240 1.00 14.07 ATOM 4268 N PHE 601 45.117 53.468 52.242 1.0015.08 ATOM 4269 CA PHE 601 43.883 54.031 51.700 1.00 16.39 ATOM 4270 CBPHE 601 42.684 53.251 52.271 1.00 16.50 ATOM 4271 CG PHE 601 41.37653.527 51.574 1.00 18.08 ATOM 4272 CD1 PHE 601 41.221 53.255 50.217 1.0018.28 ATOM 4273 CD2 PHE 601 40.290 54.033 52.284 1.00 18.21 ATOM 4274CE1 PHE 601 40.002 53.478 49.577 1.00 19.49 ATOM 4275 CE2 PHE 601 39.06054.262 51.653 1.00 19.93 ATOM 4276 CZ PHE 601 38.918 53.982 50.297 1.0018.56 ATOM 4277 C PHE 601 43.786 55.518 52.079 1.00 16.63 ATOM 4278 OPHE 601 42.698 56.083 52.144 1.00 16.35 ATOM 4279 N SER 602 44.93456.152 52.302 1.00 18.17 ATOM 4280 CA SER 602 44.968 57.561 52.699 1.0019.16 ATOM 4281 CB SER 602 46.294 57.868 53.395 1.00 19.08 ATOM 4282 OGSER 602 47.375 57.759 52.484 1.00 16.23 ATOM 4283 C SER 602 44.75158.593 51.590 1.00 21.31 ATOM 4284 O SER 602 44.388 59.735 51.874 1.0019.96 ATOM 4285 N ARG 603 44.973 58.199 50.337 1.00 20.09 ATOM 4286 CAARG 603 44.816 59.118 49.207 1.00 21.67 ATOM 4287 CB ARG 603 46.20159.533 48.685 1.00 22.66 ATOM 4288 CG ARG 603 47.124 60.184 49.711 1.0026.63 ATOM 4289 CD ARG 603 46.639 61.574 50.087 1.00 28.83 ATOM 4290 NEARG 603 46.453 62.415 48.908 1.00 33.44 ATOM 4291 CZ ARG 603 45.95563.648 48.939 1.00 35.92 ATOM 4292 NH1 ARG 603 45.594 64.189 50.096 1.0035.88 ATOM 4293 NH2 ARG 603 45.808 64.337 47.816 1.00 35.28 ATOM 4294 CARG 603 44.037 58.471 48.058 1.00 20.33 ATOM 4295 O ARG 603 43.92657.257 47.987 1.00 21.14 ATOM 4296 N PRO 604 43.486 59.283 47.141 1.0021.16 ATOM 4297 CD PRO 604 43.484 60.757 47.074 1.00 20.84 ATOM 4298 CAPRO 604 42.742 58.700 46.016 1.00 20.12 ATOM 4299 CB PRO 604 42.38059.920 45.171 1.00 21.00 ATOM 4300 CG PRO 604 42.288 61.033 46.199 1.0022.41 ATOM 4301 C PRO 604 43.717 57.765 45.294 1.00 18.21 ATOM 4302 OPRO 604 44.879 58.123 45.108 1.00 16.62 ATOM 4303 N TRP 605 43.25656.588 44.871 1.00 16.20 ATOM 4304 CA TRP 605 44.155 55.631 44.222 1.0014.88 ATOM 4305 CB TRP 605 43.404 54.352 43.807 1.00 11.66 ATOM 4306 CGTRP 605 42.419 54.500 42.687 1.00 11.73 ATOM 4307 CD2 TRP 605 42.71254.543 41.285 1.00 10.38 ATOM 4308 CE2 TRP 605 41.478 54.643 40.605 1.009.76 ATOM 4309 CE3 TRP 605 43.897 54.513 40.537 1.00 11.00 ATOM 4310 CD1TRP 605 41.059 54.575 42.797 1.00 11.94 ATOM 4311 NE1 TRP 605 40.48754.657 41.551 1.00 12.01 ATOM 4312 CZ2 TRP 605 41.393 54.706 39.211 1.0010.56 ATOM 4313 CZ3 TRP 605 43.813 54.577 39.147 1.00 12.40 ATOM 4314CH2 TRP 605 42.569 54.675 38.500 1.00 10.93 ATOM 4315 C TRP 605 44.99056.138 43.048 1.00 14.01 ATOM 4316 O TRP 605 46.088 55.639 42.819 1.0014.77 ATOM 4317 N PRO 606 44.491 57.132 42.287 1.00 14.29 ATOM 4318 CDPRO 606 43.145 57.734 42.275 1.00 12.19 ATOM 4319 CA PRO 606 45.28657.629 41.158 1.00 15.72 ATOM 4320 CB PRO 606 44.432 58.770 40.613 1.0015.01 ATOM 4321 CG PRO 606 43.046 58.272 40.859 1.00 14.40 ATOM 4322 CPRO 606 46.687 58.091 41.559 1.00 17.03 ATOM 4323 O PRO 606 47.60058.098 40.740 1.00 16.15 ATOM 4324 N GLU 607 46.852 58.481 42.818 1.0017.28 ATOM 4325 CA GLU 607 48.157 58.925 43.298 1.00 19.19 ATOM 4326 CBGLU 607 48.017 59.648 44.639 1.00 21.09 ATOM 4327 CG GLU 607 47.45661.060 44.503 1.00 25.25 ATOM 4328 CD GLU 607 47.359 61.785 45.837 1.0027.88 ATOM 4329 OE1 GLU 607 48.311 61.683 46.641 1.00 28.02 ATOM 4330OE2 GLU 607 46.334 62.462 46.075 1.00 29.69 ATOM 4331 C GLU 607 49.10657.739 43.430 1.00 17.57 ATOM 4332 O GLU 607 50.268 57.828 43.052 1.0018.96 ATOM 4333 N ALA 608 48.611 56.626 43.962 1.00 16.29 ATOM 4334 CAALA 608 49.438 55.434 44.094 1.00 16.79 ATOM 4335 CB ALA 608 48.69354.353 44.871 1.00 14.91 ATOM 4336 C ALA 608 49.775 54.947 42.683 1.0016.09 ATOM 4337 O ALA 608 50.886 54.488 42.425 1.00 16.14 ATOM 4338 NMET 609 48.810 55.056 41.772 1.00 15.85 ATOM 4339 CA MET 609 49.02454.649 40.383 1.00 15.49 ATOM 4340 CB MET 609 47.742 54.841 39.569 1.0014.89 ATOM 4341 CG MET 609 47.885 54.548 38.068 1.00 12.61 ATOM 4342 SDMET 609 48.373 52.846 37.686 1.00 14.89 ATOM 4343 CE MET 609 46.75252.007 37.746 1.00 9.67 ATOM 4344 C MET 609 50.152 55.486 39.769 1.0017.04 ATOM 4345 O MET 609 51.018 54.963 39.063 1.00 16.25 ATOM 4346 NGLN 610 50.131 56.787 40.044 1.00 16.65 ATOM 4347 CA GLN 610 51.14957.697 39.527 1.00 17.56 ATOM 4348 CB GLN 610 50.798 59.148 39.865 1.0021.08 ATOM 4349 CG GLN 610 51.631 60.167 39.093 1.00 24.06 ATOM 4350 CDGLN 610 50.775 61.060 38.219 1.00 27.95 ATOM 4351 OE1 GLN 610 50.22762.066 38.675 1.00 30.67 ATOM 4352 NE2 GLN 610 50.637 60.684 36.959 1.0031.02 ATOM 4353 C GLN 610 52.521 57.362 40.103 1.00 18.21 ATOM 4354 OGLN 610 53.513 57.324 39.375 1.00 17.58 ATOM 4355 N LEU 611 52.57457.120 41.410 1.00 17.37 ATOM 4356 CA LEU 611 53.831 56.775 42.069 1.0019.20 ATOM 4357 CB LEU 611 53.593 56.498 43.560 1.00 20.05 ATOM 4358 CGLEU 611 53.385 57.741 44.430 1.00 22.61 ATOM 4359 CD1 LEU 611 53.02057.324 45.839 1.00 22.10 ATOM 4360 CD2 LEU 611 54.660 58.580 44.431 1.0021.77 ATOM 4361 C LEU 611 54.517 55.567 41.434 1.00 18.06 ATOM 4362 OLEU 611 55.743 55.524 41.319 1.00 17.10 ATOM 4363 N ILE 612 53.72854.585 41.019 1.00 17.78 ATOM 4364 CA ILE 612 54.289 53.384 40.408 1.0015.89 ATOM 4365 CB ILE 612 53.356 52.167 40.609 1.00 17.36 ATOM 4366 CG2ILE 612 53.944 50.944 39.917 1.00 17.31 ATOM 4367 CG1 ILE 612 53.15851.888 42.099 1.00 17.99 ATOM 4368 CD1 ILE 612 52.075 50.865 42.391 1.0016.14 ATOM 4369 C ILE 612 54.562 53.505 38.907 1.00 16.86 ATOM 4370 OILE 612 55.643 53.151 38.440 1.00 18.03 ATOM 4371 N THR 613 53.58654.018 38.162 1.00 16.36 ATOM 4372 CA THR 613 53.684 54.108 36.707 1.0015.96 ATOM 4373 CB THR 613 52.368 53.622 36.079 1.00 14.90 ATOM 4374 OG1THR 613 51.341 54.594 36.320 1.00 12.04 ATOM 4375 CG2 THR 613 51.94152.289 36.701 1.00 12.12 ATOM 4376 C THR 613 54.035 55.452 36.059 1.0017.25 ATOM 4377 O THR 613 54.323 55.502 34.860 1.00 16.91 ATOM 4378 NGLY 614 54.000 56.538 36.826 1.00 16.88 ATOM 4379 CA GLY 614 54.31557.836 36.251 1.00 16.24 ATOM 4380 C GLY 614 53.126 58.496 35.572 1.0017.22 ATOM 4381 O GLY 614 53.256 59.556 34.962 1.00 16.05 ATOM 4382 NGLN 615 51.965 57.854 35.659 1.00 17.32 ATOM 4383 CA GLN 615 50.73658.391 35.086 1.00 15.68 ATOM 4384 CB GLN 615 50.551 57.895 33.644 1.0015.80 ATOM 4385 CG GLN 615 50.422 56.397 33.467 1.00 16.06 ATOM 4386 CDGLN 615 49.041 55.919 33.822 1.00 14.47 ATOM 4387 OE1 GLN 615 48.04556.448 33.322 1.00 14.28 ATOM 4388 NE2 GLN 615 48.966 54.919 34.686 1.0012.42 ATOM 4389 C GLN 615 49.622 57.957 36.048 1.00 14.75 ATOM 4390 OGLN 615 49.815 57.042 36.837 1.00 14.61 ATOM 4391 N PRO 616 48.44358.599 35.994 1.00 14.37 ATOM 4392 CD PRO 616 48.129 59.856 35.288 1.0015.57 ATOM 4393 CA PRO 616 47.357 58.248 36.917 1.00 14.41 ATOM 4394 CBPRO 616 46.829 59.617 37.298 1.00 15.41 ATOM 4395 CG PRO 616 46.80060.287 35.933 1.00 14.41 ATOM 4396 C PRO 616 46.202 57.320 36.543 1.0014.55 ATOM 4397 O PRO 616 45.390 56.988 37.409 1.00 13.74 ATOM 4398 NASN 617 46.108 56.904 35.289 1.00 14.76 ATOM 4399 CA ASN 617 44.98556.072 34.869 1.00 16.09 ATOM 4400 CB ASN 617 44.495 56.545 33.501 1.0017.02 ATOM 4401 CG ASN 617 44.216 58.029 33.462 1.00 18.18 ATOM 4402 OD1ASN 617 44.489 58.692 32.463 1.00 22.94 ATOM 4403 ND2 ASN 617 43.65858.557 34.542 1.00 18.54 ATOM 4404 C ASN 617 45.226 54.573 34.777 1.0014.02 ATOM 4405 O ASN 617 46.364 54.105 34.776 1.00 13.88 ATOM 4406 NMET 618 44.124 53.829 34.710 1.00 13.32 ATOM 4407 CA MET 618 44.17952.387 34.516 1.00 14.06 ATOM 4408 CB MET 618 42.868 51.709 34.929 1.0011.91 ATOM 4409 CG MET 618 42.667 51.565 36.425 1.00 12.29 ATOM 4410 SDMET 618 41.194 50.589 36.832 1.00 13.39 ATOM 4411 CE MET 618 39.92751.842 36.691 1.00 14.36 ATOM 4412 C MET 618 44.316 52.322 32.997 1.0014.48 ATOM 4413 O MET 618 43.788 53.187 32.291 1.00 13.59 ATOM 4414 NSER 619 45.013 51.318 32.488 1.00 12.87 ATOM 4415 CA SER 619 45.19451.215 31.049 1.00 13.47 ATOM 4416 CB SER 619 46.309 52.168 30.599 1.0013.34 ATOM 4417 OG SER 619 46.562 52.039 29.215 1.00 16.20 ATOM 4418 CSER 619 45.540 49.797 30.631 1.00 12.99 ATOM 4419 O SER 619 46.33849.131 31.288 1.00 12.36 ATOM 4420 N ALA 620 44.937 49.350 29.533 1.0012.12 ATOM 4421 CA ALA 620 45.177 48.012 29.001 1.00 13.20 ATOM 4422 CBALA 620 43.968 47.555 28.189 1.00 9.78 ATOM 4423 C ALA 620 46.433 47.97128.125 1.00 13.52 ATOM 4424 O ALA 620 46.845 46.901 27.672 1.00 12.99ATOM 4425 N SER 621 47.036 49.135 27.886 1.00 14.24 ATOM 4426 CA SER 62148.239 49.219 27.049 1.00 14.97 ATOM 4427 CB SER 621 48.788 50.64927.037 1.00 15.46 ATOM 4428 OG SER 621 47.972 51.485 26.239 1.00 22.97ATOM 4429 C SER 621 49.361 48.266 27.446 1.00 13.26 ATOM 4430 O SER 62149.919 47.576 26.600 1.00 12.69 ATOM 4431 N ALA 622 49.697 48.241 28.7301.00 12.55 ATOM 4432 CA ALA 622 50.761 47.374 29.220 1.00 12.62 ATOM4433 CB ALA 622 50.945 47.576 30.718 1.00 13.96 ATOM 4434 C ALA 62250.476 45.902 28.917 1.00 13.74 ATOM 4435 O ALA 622 51.344 45.181 28.4121.00 13.46 ATOM 4436 N MET 623 49.261 45.458 29.227 1.00 12.23 ATOM 4437CA MET 623 48.882 44.074 28.977 1.00 11.27 ATOM 4438 CB MET 623 47.50143.792 29.578 1.00 11.37 ATOM 4439 CG MET 623 47.048 42.354 29.452 1.0012.71 ATOM 4440 SD MET 623 45.490 42.044 30.308 1.00 16.84 ATOM 4441 CEMET 623 45.878 40.541 31.173 1.00 14.59 ATOM 4442 C MET 623 48.89243.767 27.476 1.00 11.91 ATOM 4443 O MET 623 49.352 42.706 27.058 1.0013.42 ATOM 4444 N LEU 624 48.397 44.694 26.662 1.00 13.23 ATOM 4445 CALEU 624 48.392 44.486 25.212 1.00 15.53 ATOM 4446 CB LEU 624 47.62245.611 24.505 1.00 15.98 ATOM 4447 CG LEU 624 46.108 45.644 24.741 1.0019.16 ATOM 4448 CD1 LEU 624 45.483 46.800 23.970 1.00 18.76 ATOM 4449CD2 LEU 624 45.496 44.322 24.302 1.00 21.48 ATOM 4450 C LEU 624 49.82444.419 24.674 1.00 15.45 ATOM 4451 O LEU 624 50.141 43.602 23.808 1.0015.14 ATOM 4452 N SER 625 50.688 45.281 25.198 1.00 15.79 ATOM 4453 CASER 625 52.088 45.315 24.788 1.00 16.37 ATOM 4454 CB SER 625 52.78846.502 25.462 1.00 16.92 ATOM 4455 OG SER 625 54.196 46.404 25.354 1.0022.26 ATOM 4456 C SER 625 52.777 43.995 25.168 1.00 16.55 ATOM 4457 OSER 625 53.544 43.426 24.385 1.00 17.40 ATOM 4458 N TYR 626 52.49043.511 26.372 1.00 14.61 ATOM 4459 CA TYR 626 53.055 42.253 26.858 1.0013.80 ATOM 4460 CB TYR 626 52.487 41.939 28.251 1.00 13.59 ATOM 4461 CGTYR 626 53.024 40.679 28.896 1.00 14.23 ATOM 4462 CD1 TYR 626 54.06140.733 29.827 1.00 15.51 ATOM 4463 CE1 TYR 626 54.538 39.574 30.438 1.0014.52 ATOM 4464 CD2 TYR 626 52.481 39.431 28.587 1.00 12.73 ATOM 4465CE2 TYR 626 52.951 38.275 29.186 1.00 12.06 ATOM 4466 CZ TYR 626 53.97538.348 30.111 1.00 14.06 ATOM 4467 OH TYR 626 54.425 37.193 30.713 1.0013.54 ATOM 4468 C TYR 626 52.721 41.101 25.901 1.00 13.64 ATOM 4469 OTYR 626 53.585 40.287 25.567 1.00 12.40 ATOM 4470 N PHE 627 51.46741.039 25.461 1.00 12.53 ATOM 4471 CA PHE 627 51.021 39.969 24.567 1.0014.30 ATOM 4472 CB PHE 627 49.608 39.515 24.955 1.00 11.92 ATOM 4473 CGPHE 627 49.534 38.832 26.285 1.00 12.27 ATOM 4474 CD1 PHE 627 49.08739.517 27.414 1.00 12.27 ATOM 4475 CD2 PHE 627 49.902 37.497 26.410 1.0010.91 ATOM 4476 CE1 PHE 627 49.008 38.880 28.649 1.00 12.53 ATOM 4477CE2 PHE 627 49.829 36.848 27.639 1.00 11.87 ATOM 4478 CZ PHE 627 49.37937.539 28.762 1.00 13.01 ATOM 4479 C PHE 627 51.030 40.267 23.066 1.0014.21 ATOM 4480 O PHE 627 50.575 39.446 22.274 1.00 15.37 ATOM 4481 NLYS 628 51.538 41.430 22.671 1.00 15.87 ATOM 4482 CA LYS 628 51.57041.801 21.258 1.00 15.56 ATOM 4483 CB LYS 628 52.415 43.065 21.065 1.0018.34 ATOM 4484 CG LYS 628 52.689 43.436 19.608 1.00 20.03 ATOM 4485 CDLYS 628 51.421 43.755 18.835 1.00 21.75 ATOM 4486 CE LYS 628 51.75444.104 17.378 1.00 25.43 ATOM 4487 NZ LYS 628 50.542 44.288 16.531 1.0024.46 ATOM 4488 C LYS 628 52.080 40.682 20.345 1.00 15.60 ATOM 4489 OLYS 628 51.462 40.383 19.324 1.00 17.04 ATOM 4490 N PRO 629 53.21540.054 20.693 1.00 15.51 ATOM 4491 CD PRO 629 54.172 40.346 21.775 1.0016.28 ATOM 4492 CA PRO 629 53.715 38.978 19.830 1.00 16.88 ATOM 4493 CBPRO 629 54.987 38.522 20.545 1.00 17.11 ATOM 4494 CG PRO 629 55.46339.781 21.218 1.00 16.67 ATOM 4495 C PRO 629 52.690 37.848 19.676 1.0017.03 ATOM 4496 O PRO 629 52.496 37.320 18.579 1.00 17.38 ATOM 4497 NLEU 630 52.027 37.486 20.771 1.00 16.19 ATOM 4498 CA LEU 630 51.03336.424 20.718 1.00 15.34 ATOM 4499 CB LEU 630 50.570 36.044 22.126 1.0014.76 ATOM 4500 CG LEU 630 49.601 34.856 22.206 1.00 15.06 ATOM 4501 CD1LEU 630 50.308 33.587 21.767 1.00 15.11 ATOM 4502 CD2 LEU 630 49.08634.696 23.623 1.00 14.11 ATOM 4503 C LEU 630 49.831 36.835 19.872 1.0015.75 ATOM 4504 O LEU 630 49.308 36.035 19.098 1.00 15.82 ATOM 4505 NLEU 631 49.389 38.081 20.018 1.00 16.88 ATOM 4506 CA LEU 631 48.24938.564 19.245 1.00 17.64 ATOM 4507 CB LEU 631 47.959 40.036 19.556 1.0017.22 ATOM 4508 CG LEU 631 46.810 40.681 18.765 1.00 20.26 ATOM 4509 CD1LEU 631 45.498 39.989 19.100 1.00 20.21 ATOM 4510 CD2 LEU 631 46.71942.161 19.093 1.00 19.79 ATOM 4511 C LEU 631 48.533 38.405 17.753 1.0018.65 ATOM 4512 O LEU 631 47.681 37.929 17.005 1.00 18.10 ATOM 4513 NASP 632 49.731 38.802 17.326 1.00 17.92 ATOM 4514 CA ASP 632 50.10938.692 15.920 1.00 18.59 ATOM 4515 CB ASP 632 51.485 39.326 15.671 1.0019.38 ATOM 4516 CG ASP 632 51.480 40.827 15.866 1.00 19.25 ATOM 4517 OD1ASP 632 50.445 41.457 15.585 1.00 23.41 ATOM 4518 OD2 ASP 632 52.51441.385 16.283 1.00 23.91 ATOM 4519 C ASP 632 50.138 37.234 15.476 1.0017.19 ATOM 4520 O ASP 632 49.677 36.898 14.385 1.00 15.78 ATOM 4521 NTRP 633 50.682 36.368 16.326 1.00 16.49 ATOM 4522 CA TRP 633 50.75634.950 15.997 1.00 16.56 ATOM 4523 CB TRP 633 51.565 34.194 17.057 1.0016.10 ATOM 4524 CG TRP 633 51.804 32.763 16.687 1.00 17.24 ATOM 4525 CD2TRP 633 50.971 31.645 17.015 1.00 17.80 ATOM 4526 CE2 TRP 633 51.52330.510 16.380 1.00 18.16 ATOM 4527 CE3 TRP 633 49.807 31.491 17.782 1.0017.82 ATOM 4528 CD1 TRP 633 52.804 32.273 15.892 1.00 17.18 ATOM 4529NE1 TRP 633 52.641 30.922 15.703 1.00 17.98 ATOM 4530 CZ2 TRP 633 50.95229.240 16.486 1.00 17.93 ATOM 4531 CZ3 TRP 633 49.240 30.226 17.889 1.0019.24 ATOM 4532 CH2 TRP 633 49.815 29.117 17.243 1.00 17.03 ATOM 4533 CTRP 633 49.347 34.359 15.912 1.00 16.87 ATOM 4534 O TRP 633 49.04833.559 15.024 1.00 15.40 ATOM 4535 N LEU 634 48.480 34.770 16.833 1.0016.10 ATOM 4536 CA LEU 634 47.108 34.275 16.872 1.00 15.03 ATOM 4537 CBLEU 634 46.406 34.749 18.151 1.00 13.27 ATOM 4538 CG LEU 634 46.72033.957 19.419 1.00 14.68 ATOM 4539 CD1 LEU 634 46.010 34.593 20.609 1.0011.99 ATOM 4540 CD2 LEU 634 46.276 32.498 19.240 1.00 15.41 ATOM 4541 CLEU 634 46.291 34.686 15.655 1.00 14.79 ATOM 4542 O LEU 634 45.50933.896 15.130 1.00 13.57 ATOM 4543 N ARG 635 46.460 35.923 15.208 1.0014.72 ATOM 4544 CA ARG 635 45.720 36.385 14.041 1.00 16.48 ATOM 4545 CBARG 635 45.919 37.888 13.839 1.00 16.73 ATOM 4546 CG ARG 635 45.03038.742 14.722 1.00 20.60 ATOM 4547 CD ARG 635 45.367 40.211 14.574 1.0025.55 ATOM 4548 NE ARG 635 44.462 41.063 15.340 1.00 29.96 ATOM 4549 CZARG 635 44.726 42.325 15.659 1.00 31.82 ATOM 4550 NH1 ARG 635 45.87142.880 15.280 1.00 31.36 ATOM 4551 NH2 ARG 635 43.846 43.034 16.353 1.0034.01 ATOM 4552 C ARG 635 46.158 35.618 12.797 1.00 16.36 ATOM 4553 OARG 635 45.327 35.194 11.997 1.00 16.07 ATOM 4554 N THR 636 47.46335.430 12.645 1.00 16.74 ATOM 4555 CA THR 636 47.983 34.698 11.494 1.0016.97 ATOM 4556 CB THR 636 49.524 34.739 11.463 1.00 17.36 ATOM 4557 OG1THR 636 49.956 36.094 11.282 1.00 18.76 ATOM 4558 CG2 THR 636 50.06433.874 10.324 1.00 17.64 ATOM 4559 C THR 636 47.513 33.243 11.522 1.0015.76 ATOM 4560 O THR 636 47.099 32.707 10.501 1.00 14.02 ATOM 4561 NGLU 637 47.568 32.615 12.695 1.00 15.46 ATOM 4562 CA GLU 637 47.13731.223 12.842 1.00 15.45 ATOM 4563 CB GLU 637 47.484 30.695 14.241 1.0015.84 ATOM 4564 CG GLU 637 46.905 29.309 14.562 1.00 17.40 ATOM 4565 CDGLU 637 47.626 28.165 13.849 1.00 21.20 ATOM 4566 OE1 GLU 637 48.41728.429 12.922 1.00 20.76 ATOM 4567 OE2 GLU 637 47.394 26.992 14.217 1.0024.25 ATOM 4568 C GLU 637 45.638 31.059 12.601 1.00 14.61 ATOM 4569 OGLU 637 45.224 30.163 11.869 1.00 14.03 ATOM 4570 N ASN 638 44.82531.911 13.222 1.00 15.50 ATOM 4571 CA ASN 638 43.378 31.824 13.046 1.0015.74 ATOM 4572 CB ASN 638 42.643 32.768 14.006 1.00 15.40 ATOM 4573 CGASN 638 42.690 32.288 15.447 1.00 15.23 ATOM 4574 OD1 ASN 638 42.76531.084 15.713 1.00 12.88 ATOM 4575 ND2 ASN 638 42.633 33.228 16.387 1.0011.63 ATOM 4576 C ASN 638 42.972 32.146 11.617 1.00 17.16 ATOM 4577 OASN 638 42.029 31.563 11.086 1.00 16.41 ATOM 4578 N GLU 639 43.69133.076 10.996 1.00 18.19 ATOM 4579 CA GLU 639 43.402 33.476 9.628 1.0020.22 ATOM 4580 CB GLU 639 44.260 34.686 9.240 1.00 20.36 ATOM 4581 CGGLU 639 44.222 35.028 7.756 1.00 25.06 ATOM 4582 CD GLU 639 45.15636.172 7.400 1.00 26.81 ATOM 4583 OE1 GLU 639 44.849 37.324 7.773 1.0029.07 ATOM 4584 OE2 GLU 639 46.201 35.917 6.759 1.00 25.74 ATOM 4585 CGLU 639 43.635 32.343 8.630 1.00 20.09 ATOM 4586 O GLU 639 42.799 32.0927.763 1.00 18.73 ATOM 4587 N LEU 640 44.760 31.647 8.751 1.00 20.74 ATOM4588 CA LEU 640 45.044 30.572 7.811 1.00 20.59 ATOM 4589 CB LEU 64046.506 30.127 7.936 1.00 22.92 ATOM 4590 CG LEU 640 47.008 29.340 9.1391.00 24.43 ATOM 4591 CD1 LEU 640 46.740 27.859 8.916 1.00 25.30 ATOM4592 CD2 LEU 640 48.508 29.571 9.297 1.00 25.43 ATOM 4593 C LEU 64044.086 29.393 7.976 1.00 19.55 ATOM 4594 O LEU 640 43.888 28.610 7.0471.00 17.75 ATOM 4595 N HIS 641 43.474 29.280 9.151 1.00 19.69 ATOM 4596CA HIS 641 42.518 28.208 9.400 1.00 19.52 ATOM 4597 CB HIS 641 42.65527.687 10.832 1.00 18.00 ATOM 4598 CG HIS 641 43.861 26.829 11.038 1.0020.33 ATOM 4599 CD2 HIS 641 44.212 25.645 10.485 1.00 19.67 ATOM 4600ND1 HIS 641 44.902 27.188 11.867 1.00 22.38 ATOM 4601 CE1 HIS 641 45.84326.264 11.814 1.00 19.87 ATOM 4602 NE2 HIS 641 45.450 25.317 10.982 1.0023.55 ATOM 4603 C HIS 642 41.088 28.668 9.139 1.00 18.42 ATOM 4604 O HIS641 40.144 27.894 9.282 1.00 19.70 ATOM 4605 N GLY 642 40.941 29.9318.749 1.00 18.10 ATOM 4606 CA GLY 642 39.627 30.480 8.456 1.00 19.31ATOM 4607 C GLY 642 38.673 30.513 9.638 1.00 20.19 ATOM 4608 O GLY 64237.473 30.272 9.482 1.00 20.13 ATOM 4609 N GLU 643 39.192 30.817 10.8201.00 18.07 ATOM 4610 CA GLU 643 38.353 30.866 12.013 1.00 18.39 ATOM4611 CB GLU 643 39.216 30.975 13.275 1.00 16.96 ATOM 4612 CG GLU 64340.297 29.914 13.395 1.00 17.41 ATOM 4613 CD GLU 643 39.741 28.51913.602 1.00 15.36 ATOM 4614 OE1 GLU 643 38.504 28.345 13.574 1.00 15.16ATOM 4615 OE2 GLU 643 40.554 27.595 13.794 1.00 18.49 ATOM 4616 C GLU643 37.395 32.048 11.980 1.00 18.65 ATOM 4617 O GLU 643 37.744 33.13611.516 1.00 20.72 ATOM 4618 N LYS 644 36.181 31.818 12.469 1.00 18.08ATOM 4619 CA LYS 644 35.168 32.859 12.560 1.00 17.63 ATOM 4620 CB LYS644 33.796 32.312 12.169 1.00 21.41 ATOM 4621 CG LYS 644 32.658 33.30412.356 1.00 27.52 ATOM 4622 CD LYS 644 31.314 32.656 12.064 1.00 33.74ATOM 4623 CE LYS 644 30.179 33.660 12.149 1.00 36.34 ATOM 4624 NZ LYS644 28.880 33.042 11.750 1.00 39.29 ATOM 4625 C LYS 644 35.165 33.26214.030 1.00 17.75 ATOM 4626 O LYS 644 34.652 32.527 14.876 1.00 17.16ATOM 4627 N LEU 645 35.753 34.417 14.330 1.00 16.17 ATOM 4628 CA LEU 64535.841 34.899 15.705 1.00 16.77 ATOM 4629 CB LEU 645 36.665 36.18615.767 1.00 15.16 ATOM 4630 CG LEU 645 38.096 36.118 15.230 1.00 16.86ATOM 4631 CD1 LEU 645 38.773 37.464 15.445 1.00 16.62 ATOM 4632 CD2 LEU645 38.865 35.008 15.924 1.00 15.25 ATOM 4633 C LEU 645 34.479 35.14916.328 1.00 16.42 ATOM 4634 O LEU 645 33.562 35.621 15.668 1.00 15.27ATOM 4635 N GLY 646 34.352 34.832 17.611 1.00 16.60 ATOM 4636 CA GLY 64633.089 35.048 18.287 1.00 16.22 ATOM 4637 C GLY 646 32.126 33.881 18.1831.00 17.80 ATOM 4638 O GLY 646 32.501 32.773 17.793 1.00 17.07 ATOM 4639N TRP 647 30.872 34.142 18.529 1.00 18.98 ATOM 4640 CA TRP 647 29.84033.116 18.516 1.00 25.11 ATOM 4641 CB TRP 647 29.775 32.464 19.896 1.0021.13 ATOM 4642 CG TRP 647 29.941 33.462 21.022 1.00 17.17 ATOM 4643 CD2TRP 647 31.178 33.914 21.590 1.00 14.61 ATOM 4644 CE2 TRP 647 30.85734.870 22.583 1.00 14.82 ATOM 4645 CE3 TRP 647 32.526 33.609 21.354 1.0012.25 ATOM 4646 CD1 TRP 647 28.950 34.139 21.676 1.00 16.56 ATOM 4647NE1 TRP 647 29.491 34.984 22.616 1.00 15.68 ATOM 4648 CZ2 TRP 647 31.83835.523 23.343 1.00 12.54 ATOM 4649 CZ3 TRP 647 33.504 34.258 22.110 1.0013.82 ATOM 4650 CH2 TRP 647 33.151 35.206 23.094 1.00 13.80 ATOM 4651 CTRP 647 28.480 33.697 18.135 1.00 31.34 ATOM 4652 O TRP 647 27.67534.038 18.995 1.00 31.85 ATOM 4653 N PRO 648 28.207 33.807 16.823 1.0037.87 ATOM 4654 CD PRO 648 29.017 33.206 15.747 1.00 39.60 ATOM 4655 CAPRO 648 26.951 34.344 16.284 1.00 41.15 ATOM 4656 CB PRO 648 27.11734.156 14.778 1.00 42.26 ATOM 4657 CG PRO 648 27.978 32.919 14.693 1.0041.09 ATOM 4658 C PRO 648 25.709 33.627 16.822 1.00 43.83 ATOM 4659 OPRO 648 24.732 34.318 17.183 1.00 45.84 ATOM 4660 OXT PRO 648 25.72532.377 16.859 1.00 46.26 ATOM 4661 OH2 WAT 705 33.593 46.605 44.423 1.009.31 ATOM 4662 OH2 WAT 706 32.965 26.053 34.132 1.00 8.96 ATOM 4663 OH2WAT 707 24.287 47.413 42.078 1.00 8.51 ATOM 4664 OH2 WAT 708 41.49222.684 37.822 1.00 11.40 ATOM 4665 OH2 WAT 709 57.508 41.508 37.660 1.0013.76 ATOM 4666 OH2 WAT 710 39.412 23.942 39.181 1.00 8.91 ATOM 4667 OH2WAT 711 51.091 36.475 38.087 1.00 10.07 ATOM 4668 OH2 WAT 712 53.04251.060 33.144 1.00 16.13 ATOM 4669 OH2 WAT 713 52.228 34.436 36.844 1.0010.52 ATOM 4670 OH2 WAT 714 16.492 44.739 50.912 1.00 12.73 ATOM 4671OH2 WAT 715 47.496 46.775 31.239 1.00 10.24 ATOM 4672 OH2 WAT 716 33.68554.185 42.672 1.00 16.09 ATOM 4673 OH2 WAT 717 33.197 41.542 38.210 1.0012.21 ATOM 4674 OH2 WAT 718 37.259 27.514 46.151 1.00 11.50 ATOM 4675OH2 WAT 719 17.570 40.507 43.225 1.00 12.99 ATOM 4676 OH2 WAT 720 40.86249.469 48.991 1.00 9.86 ATOM 4677 OH2 WAT 721 37.202 32.888 29.681 1.009.25 ATOM 4678 OH2 WAT 722 48.308 52.095 48.720 1.00 13.18 ATOM 4679 OH2WAT 723 44.174 25.251 17.566 1.00 11.48 ATOM 4680 OH2 WAT 724 37.63528.226 16.249 1.00 13.61 ATOM 4681 OH2 WAT 725 31.657 44.896 43.119 1.008.30 ATOM 4682 OH2 WAT 726 48.823 40.553 46.220 1.00 14.22 ATOM 4683 OH2WAT 727 43.137 28.430 14.664 1.00 15.95 ATOM 4684 OH2 WAT 728 36.28833.431 19.194 1.00 9.04 ATOM 4685 OH2 WAT 729 45.181 39.323 41.443 1.0015.73 ATOM 4686 OH2 WAT 730 19.065 49.680 43.390 1.00 14.42 ATOM 4687OH2 WAT 731 18.532 48.145 47.790 1.00 14.97 ATOM 4688 OH2 WAT 732 16.29139.074 47.581 1.00 12.27 ATOM 4689 OH2 WAT 734 27.683 37.166 46.929 1.009.69 ATOM 4690 OH2 WAT 735 43.137 42.880 22.592 1.00 14.48 ATOM 4691 OH2WAT 736 23.024 50.329 41.657 1.00 17.32 ATOM 4692 OH2 WAT 737 40.66728.535 40.057 1.00 16.00 ATOM 4693 OH2 WAT 738 44.387 45.117 56.435 1.0014.17 ATOM 4694 OH2 WAT 739 42.945 25.383 33.384 1.00 13.52 ATOM 4695OH2 WAT 740 36.456 23.986 32.241 1.00 8.95 ATOM 4696 OH2 WAT 741 39.95039.788 48.186 1.00 12.78 ATOM 4697 OH2 WAT 742 47.924 45.637 61.414 1.0020.16 ATOM 4698 OH2 WAT 743 48.523 42.505 62.565 1.00 17.18 ATOM 4699OH2 WAT 744 16.710 44.022 47.985 1.00 15.86 ATOM 4700 OH2 WAT 745 50.72252.452 33.013 1.00 14.62 ATOM 4701 OH2 WAT 746 42.905 51.202 39.594 1.0014.40 ATOM 4702 OH2 WAT 747 43.215 36.931 50.988 1.00 16.61 ATOM 4703OH2 WAT 748 37.286 29.700 43.929 1.00 19.60 ATOM 4704 OH2 WAT 749 31.74523.237 13.527 1.00 19.26 ATOM 4705 OH2 WAT 750 50.872 32.438 13.257 1.0013.65 ATOM 4706 OH2 WAT 751 23.924 24.786 40.648 1.00 14.00 ATOM 4707OH2 WAT 752 46.065 55.788 48.966 1.00 12.21 ATOM 4708 OH2 WAT 753 17.35938.412 45.074 1.00 16.22 ATOM 4709 OH2 WAT 754 30.402 54.271 37.540 1.0019.90 ATOM 4710 OH2 WAT 755 30.166 28.862 39.171 1.00 11.86 ATOM 4711OH2 WAT 756 40.401 56.296 45.617 1.00 19.60 ATOM 4712 OH2 WAT 757 48.25046.266 58.848 1.00 15.18 ATOM 4713 OH2 WAT 758 23.481 22.074 39.456 1.0013.04 ATOM 4714 OH2 WAT 759 39.537 29.868 42.153 1.00 13.71 ATOM 4715OH2 WAT 760 41.465 55.169 34.794 1.00 16.56 ATOM 4716 OH2 WAT 761 50.21132.756 35.889 1.00 22.03 ATOM 4717 OH2 WAT 762 55.270 39.776 52.027 1.0016.82 ATOM 4718 OH2 WAT 763 17.787 47.082 45.179 1.00 17.96 ATOM 4719OH2 WAT 764 41.349 43.344 47.624 1.00 13.85 ATOM 4720 OH2 WAT 765 31.36548.033 33.699 1.00 17.60 ATOM 4721 OH2 WAT 766 35.820 29.185 13.398 1.0014.60 ATOM 4722 OH2 WAT 767 42.075 46.950 49.736 1.00 18.28 ATOM 4723OH2 WAT 768 40.009 19.530 28.487 1.00 17.39 ATOM 4724 OH2 WAT 770 52.87828.814 13.591 1.00 22.84 ATOM 4725 OH2 WAT 771 39.380 57.861 40.522 1.0020.88 ATOM 4726 OH2 WAT 772 34.750 20.720 49.137 1.00 24.09 ATOM 4727OH2 WAT 773 17.366 31.093 38.464 1.00 23.54 ATOM 4728 OH2 WAT 774 44.80423.924 14.000 1.00 19.88 ATOM 4729 OH2 WAT 775 31.146 56.380 49.556 1.0021.05 ATOM 4730 OH2 WAT 776 46.715 56.401 46.506 1.00 19.22 ATOM 4731OH2 WAT 777 42.869 58.288 37.166 1.00 15.61 ATOM 4732 OH2 WAT 778 40.83133.557 7.130 1.00 24.79 ATOM 4733 OH2 WAT 779 35.162 52.317 73.577 1.0020.05 ATOM 4734 OH2 WAT 780 14.809 39.247 36.520 1.00 18.70 ATOM 4735OH2 WAT 781 39.527 31.879 53.125 1.00 13.72 ATOM 4736 OH2 WAT 782 27.75750.041 53.223 1.00 27.53 ATOM 4737 OH2 WAT 783 49.394 26.247 11.787 1.0019.81 ATOM 4738 OH2 WAT 784 44.777 26.399 15.119 1.00 21.30 ATOM 4739OH2 WAT 785 57.867 38.875 52.198 1.00 18.47 ATOM 4740 OH2 WAT 786 34.15551.047 61.985 1.00 19.93 ATOM 4741 OH2 WAT 787 45.141 27.154 46.412 1.0022.42 ATOM 4742 OH2 WAT 788 43.475 51.366 28.087 1.00 18.86 ATOM 4743OH2 WAT 789 20.668 25.724 29.782 1.00 24.21 ATOM 4744 OH2 WAT 790 32.08332.320 15.051 1.00 19.38 ATOM 4745 OH2 WAT 791 49.913 48.449 23.710 1.0018.63 ATOM 4746 OH2 WAT 792 42.785 27.563 47.669 1.00 25.09 ATOM 4747OH2 WAT 793 39.850 53.780 46.033 1.00 22.72 ATOM 4748 OH2 WAT 794 27.46613.978 27.601 1.00 20.70 ATOM 4749 OH2 WAT 795 40.190 34.656 11.736 1.0032.79 ATOM 4750 OH2 WAT 796 39.109 10.985 33.519 1.00 22.45 ATOM 4751OH2 WAT 797 27.558 21.410 51.556 1.00 17.72 ATOM 4752 OH2 WAT 798 66.16340.174 37.797 1.00 19.68 ATOM 4753 OH2 WAT 799 22.819 49.816 39.224 1.0023.29 ATOM 4754 OH2 WAT 800 25.950 37.105 65.162 1.00 25.58 ATOM 4755OH2 WAT 801 34.253 10.439 28.187 1.00 25.36 ATOM 4756 OH2 WAT 802 59.84033.669 44.222 1.00 19.20 ATOM 4757 OH2 WAT 803 38.496 20.697 31.902 1.0016.24 ATOM 4758 OH2 WAT 804 40.729 21.319 12.133 1.00 28.36 ATOM 4759OH2 WAT 805 56.117 41.173 25.206 1.00 19.73 ATOM 4760 OH2 WAT 806 37.04726.923 50.890 1.00 22.30 ATOM 4761 OH2 WAT 807 42.476 46.612 21.569 1.0021.24 ATOM 4762 OH2 WAT 808 35.171 28.146 10.829 1.00 23.83 ATOM 4763OH2 WAT 809 29.225 19.649 23.377 1.00 20.44 ATOM 4764 OH2 WAT 810 52.75351.832 57.912 1.00 24.14 ATOM 4765 OH2 WAT 811 53.307 37.708 61.763 1.0020.90 ATOM 4766 OH2 WAT 812 11.971 34.982 48.268 1.00 25.05 ATOM 4767OH2 WAT 813 24.990 48.789 37.974 1.00 24.58 ATOM 4768 OH2 WAT 814 43.95119.262 20.770 1.00 21.14 ATOM 4769 OH2 WAT 815 36.259 14.934 14.740 1.0022.42 ATOM 4770 OH2 WAT 816 35.820 12.642 25.488 1.00 20.65 ATOM 4771OH2 WAT 817 39.436 55.386 36.440 1.00 12.53 ATOM 4772 OH2 WAT 818 62.58334.233 30.419 1.00 22.07 ATOM 4773 OH2 WAT 819 19.790 54.852 50.868 1.0029.06 ATOM 4774 OH2 WAT 820 50.697 29.832 12.471 1.00 22.39 ATOM 4775OH2 WAT 821 27.847 56.381 70.315 1.00 23.46 ATOM 4776 OH2 WAT 823 27.94917.733 50.193 1.00 31.12 ATOM 4777 OH2 WAT 824 55.965 37.522 32.909 1.0017.65 ATOM 4778 OH2 WAT 825 9.432 31.570 48.180 1.00 32.33 ATOM 4779 OH2WAT 826 41.473 54.399 62.185 1.00 30.40 ATOM 4780 OH2 WAT 827 50.99218.343 24.030 1.00 25.41 ATOM 4781 OH2 WAT 828 26.053 14.477 12.460 1.0020.39 ATOM 4782 OH2 WAT 829 69.827 44.579 41.736 1.00 22.45 ATOM 4783OH2 WAT 830 56.552 22.658 16.664 1.00 27.42 ATOM 4784 OH2 WAT 831 26.28820.159 49.712 1.00 24.06 ATOM 4785 OH2 WAT 832 16.705 33.141 51.058 1.0019.06 ATOM 4786 OH2 WAT 833 21.271 53.952 59.470 1.00 23.51 ATOM 4787OH2 WAT 834 47.427 53.353 64.227 1.00 34.99 ATOM 4788 OH2 WAT 835 45.81726.456 42.450 1.00 37.42 ATOM 4789 OH2 WAT 836 49.720 39.114 12.538 1.0029.15 ATOM 4790 OH2 WAT 837 36.955 41.394 51.137 1.00 26.94 ATOM 4791OH2 WAT 838 42.624 25.634 37.851 1.00 23.28 ATOM 4792 OH2 WAT 839 51.31524.980 58.259 1.00 30.21 ATOM 4793 OH2 WAT 840 54.566 56.838 50.490 1.0030.20 ATOM 4794 OH2 WAT 841 40.512 53.418 32.693 1.00 26.12 ATOM 4795OH2 WAT 842 26.362 47.983 54.146 1.00 26.40 ATOM 4796 OH2 WAT 843 37.20132.434 54.478 1.00 19.11 ATOM 4797 OH2 WAT 844 57.961 39.008 32.080 1.0020.99 ATOM 4798 OH2 WAT 845 18.271 24.342 44.501 1.00 22.93 ATOM 4799OH2 WAT 846 41.486 21.860 67.124 1.00 40.66 ATOM 4800 OH2 WAT 847 13.91729.508 37.265 1.00 42.07 ATOM 4801 OH2 WAT 848 17.295 33.378 57.585 1.0024.15 ATOM 4802 OH2 WAT 849 22.558 38.571 32.120 1.00 36.71 ATOM 4803OH2 WAT 850 35.628 59.228 37.704 1.00 24.98 ATOM 4804 OH2 WAT 851 24.24159.727 65.168 1.00 27.57 ATOM 4805 OH2 WAT 852 30.466 55.002 34.566 1.0020.81 ATOM 4806 OH2 WAT 853 39.487 26.456 44.048 1.00 27.56 ATOM 4807OH2 WAT 854 32.107 46.093 71.751 1.00 28.54 ATOM 4808 OH2 WAT 855 48.70024.975 15.218 1.00 27.62 ATOM 4809 OH2 WAT 856 71.051 37.353 44.254 1.0024.64 ATOM 4810 OH2 WAT 857 18.705 30.001 40.624 1.00 24.61 ATOM 4811OH2 WAT 858 67.822 43.137 39.600 1.00 24.92 ATOM 4812 OH2 WAT 859 28.87964.576 58.006 1.00 30.86 ATOM 4813 OH2 WAT 860 50.121 23.822 38.157 1.0029.74 ATOM 4814 OH2 WAT 861 50.504 23.835 16.516 1.00 41.06 ATOM 4815OH2 WAT 862 50.897 18.482 46.813 1.00 28.35 ATOM 4816 OH2 WAT 863 54.68137.002 16.795 1.00 25.10 ATOM 4817 OH2 WAT 864 23.493 23.940 53.772 1.0022.53 ATOM 4818 OH2 WAT 865 33.356 54.985 26.024 1.00 43.50 ATOM 4819OH2 WAT 866 43.404 31.760 41.951 1.00 21.02 ATOM 4820 OH2 WAT 867 28.23142.794 54.526 1.00 30.76 ATOM 4821 OH2 WAT 868 14.847 43.548 34.779 1.0034.44 ATOM 4822 OH2 WAT 869 14.659 39.207 57.645 1.00 33.41 ATOM 4823OH2 WAT 870 57.510 37.601 64.872 1.00 30.64 ATOM 4824 OH2 WAT 871 20.65132.033 29.682 1.00 28.82 ATOM 4825 OH2 WAT 872 52.056 50.326 27.360 1.0024.49 ATOM 4826 OH2 WAT 873 51.657 35.863 62.500 1.00 26.14 ATOM 4827OH2 WAT 874 47.279 21.024 51.484 1.00 23.69 ATOM 4828 OH2 WAT 875 29.57644.197 56.830 1.00 26.36 ATOM 4829 OH2 WAT 876 40.524 18.980 31.059 1.0025.48 ATOM 4830 OH2 WAT 877 56.572 42.868 23.278 1.00 31.20 ATOM 4831OH2 WAT 878 34.210 18.018 53.038 1.00 32.11 ATOM 4832 OH2 WAT 879 27.25818.647 26.109 1.00 26.96 ATOM 4833 OH2 WAT 880 62.773 54.373 39.531 1.0036.25 ATOM 4834 OH2 WAT 881 35.089 9.269 50.485 1.00 38.55 ATOM 4835 OH2WAT 882 38.082 57.888 33.414 1.00 23.60 ATOM 4836 OH2 WAT 883 20.57020.572 35.734 1.00 30.32 ATOM 4837 OH2 WAT 884 64.060 48.729 47.598 1.0025.68 ATOM 4838 OH2 WAT 885 61.993 33.237 54.293 1.00 38.10 ATOM 4839OH2 WAT 886 46.176 15.310 31.633 1.00 32.63 ATOM 4840 OH2 WAT 887 14.96850.857 53.881 1.00 42.97 ATOM 4841 OH2 WAT 888 21.704 24.366 51.887 1.0036.24 ATOM 4842 OH2 WAT 889 39.839 19.775 14.153 1.00 24.51 ATOM 4843OH2 WAT 890 44.365 68.561 56.122 1.00 31.90 ATOM 4844 OH2 WAT 891 47.55330.301 39.926 1.00 25.30 ATOM 4845 OH2 WAT 892 32.268 20.759 14.108 1.0023.29 ATOM 4846 OH2 WAT 893 69.343 41.988 48.078 1.00 32.22 ATOM 4847OH2 WAT 894 24.297 15.185 41.737 1.00 31.91 ATOM 4848 OH2 WAT 895 30.65511.104 25.446 1.00 26.78 ATOM 4849 OH2 WAT 896 42.362 40.299 57.293 1.0020.70 ATOM 4850 OH2 WAT 898 41.774 36.340 13.554 1.00 34.25 ATOM 4851OH2 WAT 899 39.152 38.465 60.315 1.00 25.51 ATOM 4852 OH2 WAT 900 41.14724.781 9.266 1.00 37.67 ATOM 4853 OH2 WAT 901 69.407 36.691 46.483 1.0026.53 ATOM 4854 OH2 WAT 902 55.637 47.942 26.959 1.00 32.37 ATOM 4855OH2 WAT 903 33.913 34.460 58.201 1.00 38.45 ATOM 4856 OH2 WAT 904 56.26958.664 39.628 1.00 38.97 ATOM 4857 OH2 WAT 905 57.309 45.050 24.747 1.0030.45 ATOM 4858 OH2 WAT 906 67.831 30.631 34.349 1.00 30.40 ATOM 4859OH2 WAT 907 17.422 51.937 47.071 1.00 26.07 ATOM 4860 OH2 WAT 908 35.63330.975 66.612 1.00 24.07 ATOM 4861 OH2 WAT 910 61.975 46.612 53.486 1.0026.87 ATOM 4862 OH2 WAT 911 47.029 38.251 67.425 1.00 30.22 ATOM 4863OH2 WAT 912 60.210 33.638 26.728 1.00 31.35 ATOM 4864 OH2 WAT 913 17.48236.558 63.602 1.00 44.50 ATOM 4865 OH2 WAT 914 24.128 36.324 26.146 1.0020.37 ATOM 4866 OH2 WAT 915 15.719 30.346 47.149 1.00 24.17 ATOM 4867OH2 WAT 916 23.359 62.099 63.265 1.00 40.09 ATOM 4868 OH2 WAT 917 50.74048.721 64.156 1.00 39.37 ATOM 4869 OH2 WAT 918 64.987 41.178 33.243 1.0037.88 ATOM 4870 OH2 WAT 919 47.126 55.164 71.884 1.00 33.61 ATOM 4871OH2 WAT 920 15.488 43.883 65.882 1.00 23.44 ATOM 4872 OH2 WAT 921 37.70650.611 24.676 1.00 33.21 ATOM 4873 OH2 WAT 922 37.379 23.810 9.516 1.0034.84 ATOM 4874 OH2 WAT 923 38.957 20.044 55.559 1.00 43.10 ATOM 4875OH2 WAT 924 24.959 16.071 14.898 1.00 34.26 ATOM 4876 OH2 WAT 925 22.42916.629 37.874 1.00 31.87 ATOM 4877 OH2 WAT 926 29.356 53.921 43.835 1.0038.69 ATOM 4878 OH2 WAT 927 60.523 35.360 57.102 1.00 40.12 ATOM 4879OH2 WAT 928 29.303 20.134 16.704 1.00 26.85 ATOM 4880 OH2 WAT 929 19.79933.303 59.063 1.00 32.03 ATOM 4881 OH2 WAT 930 19.367 18.997 32.033 1.0030.19 ATOM 4882 OH2 WAT 931 48.165 22.382 58.513 1.00 36.12 ATOM 4883OH2 WAT 932 43.741 63.487 53.233 1.00 33.28 ATOM 4884 OH2 WAT 933 33.86320.218 11.695 1.00 26.21 ATOM 4885 OH2 WAT 934 49.235 59.976 52.718 1.0028.98 ATOM 4886 OH2 WAT 935 63.989 32.978 44.987 1.00 35.98 ATOM 4887OH2 WAT 936 38.155 21.333 49.259 1.00 27.87 ATOM 4888 OH2 WAT 937 28.08014.345 39.095 1.00 31.98 ATOM 4889 OH2 WAT 938 15.034 38.648 61.496 1.0035.94 ATOM 4890 OH2 WAT 939 58.771 42.322 58.976 1.00 26.19 ATOM 4891OH2 WAT 940 47.485 42.154 69.878 1.00 35.48 ATOM 4892 OH2 WAT 941 26.60232.519 69.106 1.00 23.36 ATOM 4893 OH2 WAT 942 28.022 17.338 22.711 1.0031.24 ATOM 4894 OH2 WAT 943 26.711 49.956 71.239 1.00 38.80 ATOM 4895OH2 WAT 944 64.021 22.891 42.685 1.00 33.14 ATOM 4896 OH2 WAT 945 47.67733.744 7.930 1.00 25.60 ATOM 4897 OH2 WAT 946 34.908 23.405 49.212 1.0024.56 ATOM 4898 OH2 WAT 947 46.968 46.697 68.856 1.00 35.00 ATOM 4899OH2 WAT 948 41.692 11.412 30.635 1.00 31.37 ATOM 4900 OH2 WAT 949 34.42348.837 63.936 1.00 25.42 ATOM 4901 OH2 WAT 950 38.612 61.793 51.417 1.0033.87 ATOM 4902 OH2 WAT 951 45.067 50.306 71.708 1.00 44.52 ATOM 4903OH2 WAT 952 46.249 23.672 42.556 1.00 31.95 ATOM 4904 OH2 WAT 953 22.94857.447 63.178 1.00 39.30 ATOM 4905 OH2 WAT 954 53.305 20.101 34.868 1.0041.13 ATOM 4906 OH2 WAT 955 39.320 63.985 53.074 1.00 28.86 ATOM 4907OH2 WAT 956 20.574 21.558 47.751 1.00 30.99 ATOM 4908 OH2 WAT 957 70.49044.479 44.539 1.00 22.23 ATOM 4909 OH2 WAT 958 13.638 23.050 34.936 1.0028.58 ATOM 4910 OH2 WAT 959 61.304 38.113 59.657 1.00 31.77 ATOM 4911OH2 WAT 960 70.418 49.240 43.244 1.00 47.36 ATOM 4912 OH2 WAT 961 27.27213.615 45.529 1.00 35.16 ATOM 4913 OH2 WAT 962 40.595 52.830 28.676 1.0035.25 ATOM 4914 OH2 WAT 963 41.406 39.978 15.308 1.00 23.02 ATOM 4915OH2 WAT 964 47.358 18.488 60.102 1.00 48.76 ATOM 4916 OH2 WAT 965 30.06144.962 27.407 1.00 28.02 ATOM 4917 OH2 WAT 966 69.978 22.947 32.361 1.0035.17 ATOM 4918 OH2 WAT 967 54.106 56.970 32.477 1.00 27.90 ATOM 4919OH2 WAT 968 48.115 18.063 53.954 1.00 37.64 ATOM 4920 OH2 WAT 969 38.32016.416 14.841 1.00 28.53 ATOM 4921 OH2 WAT 970 29.037 12.266 32.860 1.0024.29 ATOM 4922 OH2 WAT 971 29.314 35.536 60.124 1.00 39.44 ATOM 4923OH2 WAT 972 47.444 23.555 12.870 1.00 36.87 ATOM 4924 OH2 WAT 973 40.38949.471 57.522 1.00 28.51 ATOM 4925 OH2 WAT 974 47.998 48.009 65.323 1.0045.77 ATOM 4926 OH2 WAT 975 38.192 25.689 48.335 1.00 36.54 ATOM 4927OH2 WAT 976 22.607 20.057 46.747 1.00 33.16 ATOM 4928 OH2 WAT 977 37.37223.697 52.106 1.00 21.54 ATOM 4929 OH2 WAT 978 33.554 55.985 48.705 1.0026.17 ATOM 4930 OH2 WAT 979 48.510 43.090 21.681 1.00 30.35 ATOM 4931OH2 WAT 980 47.263 49.883 23.397 1.00 41.75 ATOM 4932 OH2 WAT 981 19.51918.617 44.162 1.00 42.73 ATOM 4933 OH2 WAT 982 37.700 6.935 33.344 1.0044.09 ATOM 4934 OH2 WAT 983 44.887 20.648 40.251 1.00 45.35 ATOM 4935OH2 WAT 984 67.007 44.355 29.244 1.00 44.80 ATOM 4936 OH2 WAT 985 65.45835.373 34.954 1.00 44.52 ATOM 4937 OH2 WAT 986 30.989 20.633 65.111 1.0035.79 ATOM 4938 OH2 WAT 987 26.918 36.574 22.781 1.00 35.02 ATOM 4939OH2 WAT 988 19.103 25.427 48.338 1.00 25.31 ATOM 4940 OH2 WAT 989 47.80158.546 30.861 1.00 32.01 ATOM 4941 OH2 WAT 990 33.665 57.659 31.778 1.0036.66 ATOM 4942 OH2 WAT 991 60.170 48.247 52.476 1.00 32.47 ATOM 4943OH2 WAT 993 63.978 36.551 52.728 1.00 34.68 ATOM 4944 OH2 WAT 994 29.80456.958 72.469 1.00 49.60 ATOM 4945 OH2 WAT 995 9.989 39.449 62.826 1.0044.68 ATOM 4946 OH2 WAT 996 36.235 28.967 7.281 1.00 44.34 ATOM 4947 OH2WAT 997 49.505 50.913 30.172 1.00 29.44 ATOM 4948 OH2 WAT 998 11.06237.216 34.519 1.00 29.29 ATOM 4949 OH2 WAT 999 44.702 22.987 39.107 1.0036.93 ATOM 4950 OH2 WAT 1000 50.857 38.850 67.888 1.00 36.37 ATOM 4951OH2 WAT 1002 60.252 35.317 28.988 1.00 29.45 ATOM 4952 OH2 WAT 100320.726 30.784 57.864 1.00 29.69 ATOM 4953 OH2 WAT 1004 20.309 29.02931.082 1.00 23.76 ATOM 4954 OH2 WAT 1005 21.059 52.048 61.212 1.00 28.93ATOM 4955 OH2 WAT 1006 44.854 20.536 43.319 1.00 44.76 ATOM 4956 OH2 WAT1007 19.996 28.678 33.868 1.00 30.03 ATOM 4957 OH2 WAT 1008 33.82236.086 54.053 1.00 31.99 ATOM 4958 OH2 WAT 1009 53.120 30.359 35.5011.00 32.80 ATOM 4959 OH2 WAT 1010 54.882 53.339 33.303 1.00 30.28 ATOM4960 OH2 WAT 1012 55.781 39.618 64.945 1.00 34.34 ATOM 4961 OH2 WAT 101348.371 45.507 17.871 1.00 36.20 ATOM 4962 OH2 WAT 1014 66.334 38.11749.319 1.00 23.90 ATOM 4963 OH2 WAT 1015 16.758 47.920 39.004 1.00 37.89ATOM 4964 OH2 WAT 1016 54.280 18.755 56.686 1.00 52.80 ATOM 4965 OH2 WAT1017 31.023 49.906 52.390 1.00 45.47 ATOM 4966 OH2 WAT 1018 12.05542.758 50.614 1.00 49.35 ATOM 4967 OH2 WAT 1019 31.945 53.747 53.0151.00 35.87 ATOM 4968 OH2 WAT 1020 13.807 43.996 63.471 1.00 38.90 ATOM4969 OH2 WAT 1021 55.521 22.445 54.252 1.00 28.52 ATOM 4970 OH2 WAT 102217.175 28.274 38.843 1.00 32.21 ATOM 4971 OH2 WAT 1024 36.313 20.40251.637 1.00 43.69 ATOM 4972 OH2 WAT 1025 48.801 20.762 30.306 1.00 24.61ATOM 4973 OH2 WAT 1026 40.208 59.687 47.657 1.00 44.52 ATOM 4974 OH2 WAT1027 14.148 45.044 52.430 1.00 40.64 ATOM 4975 OH2 WAT 1028 38.75517.199 55.396 1.00 42.40 ATOM 4976 OH2 WAT 1029 62.000 22.562 29.6361.00 43.07 ATOM 4977 OH2 WAT 1030 20.078 45.714 34.052 1.00 44.28 ATOM4978 OH2 WAT 1031 63.279 47.962 24.894 1.00 31.08 ATOM 4979 OH2 WAT 103235.585 5.069 31.352 1.00 35.03 ATOM 4980 OH2 WAT 1033 29.682 34.10853.939 1.00 26.25 ATOM 4981 OH2 WAT 1034 46.780 38.540 9.889 1.00 51.06ATOM 4982 OH2 WAT 1035 44.882 34.636 67.334 1.00 46.95 ATOM 4983 OH2 WAT1036 37.415 12.859 50.188 0.50 42.02 ATOM 4984 OH2 WAT 1037 25.98144.789 34.946 1.00 24.59 ATOM 4985 OH2 WAT 1038 43.445 29.058 41.2611.00 45.80 ATOM 4986 OH2 WAT 1039 12.090 30.084 45.723 1.00 38.62 ATOM4987 OH2 WAT 1040 11.364 36.356 54.939 1.00 40.96 ATOM 4988 OH2 WAT 104129.272 41.003 52.730 1.00 42.87 ATOM 4989 OH2 WAT 1042 37.324 27.0428.738 1.00 46.28 ATOM 4990 OH2 WAT 1043 57.492 28.350 30.232 1.00 46.70ATOM 4991 OH2 WAT 1044 15.052 49.656 56.840 1.00 37.66 ATOM 4992 OH2 WAT1045 46.768 51.835 70.126 1.00 51.14 ATOM 4993 OH2 WAT 1046 33.16257.841 46.992 1.00 41.63 ATOM 4994 OH2 WAT 1047 44.092 26.222 49.1371.00 40.14 ATOM 4995 OH2 WAT 1048 42.496 32.208 38.770 1.00 40.63 ATOM4996 OH2 WAT 1049 58.978 48.444 30.591 1.00 27.79 ATOM 4997 OH2 WAT 105055.619 13.932 32.119 1.00 39.09 ATOM 4998 OH2 WAT 1051 46.458 60.89555.459 1.00 37.85 ATOM 4999 OH2 WAT 1052 42.873 26.465 64.734 1.00 39.73ATOM 5000 OH2 WAT 1053 56.101 17.530 47.784 1.00 39.99 ATOM 5001 OH2 WAT1054 31.203 38.751 53.971 1.00 30.66 ATOM 5002 OH2 WAT 1055 47.56317.129 46.637 1.00 45.01 ATOM 5003 OH2 WAT 1056 58.815 30.610 63.3721.00 32.58 ATOM 5004 OH2 WAT 1057 26.459 10.748 26.222 1.00 46.82 ATOM5005 OH2 WAT 1058 45.017 29.344 39.141 1.00 43.86 ATOM 5006 OH2 WAT 105926.313 26.119 59.271 1.00 36.72 ATOM 5007 OH2 WAT 1061 28.236 58.74855.454 1.00 30.55 ATOM 5008 OH2 WAT 1062 61.906 32.814 43.031 1.00 29.09ATOM 5009 OH2 WAT 1063 69.011 47.015 42.506 1.00 28.30 ATOM 5010 OH2 WAT1066 52.729 54.024 56.720 1.00 49.30 ATOM 5011 OH2 WAT 1068 44.43916.568 20.527 1.00 40.67 ATOM 5012 OH2 WAT 1070 45.820 25.970 61.8871.00 41.07 ATOM 5013 OH2 WAT 1071 60.712 46.310 28.186 0.50 40.28 ATOM5014 OH2 WAT 1072 36.208 36.373 12.341 1.00 29.35 ATOM 5015 OH2 WAT 107335.114 41.414 67.958 1.00 46.06 ATOM 5016 OH2 WAT 1074 65.518 34.72751.474 1.00 29.02 ATOM 5017 OH2 WAT 1075 13.571 35.140 58.001 1.00 38.14ATOM 5018 OH2 WAT 1076 34.047 38.447 58.618 1.00 35.93 ATOM 5019 OH2 WAT1077 48.507 37.783 69.502 1.00 45.44 ATOM 5020 OH2 WAT 1078 41.21038.536 55.002 0.50 37.11 ATOM 5021 OH2 WAT 1079 29.344 38.728 22.9881.00 40.16 ATOM 5022 OH2 WAT 1080 14.136 37.604 50.804 1.00 38.19 ATOM5023 OH2 WAT 1081 48.142 54.501 25.745 1.00 36.15 ATOM 5024 OH2 WAT 108240.910 25.680 40.947 1.00 20.33 ATOM 5025 OH2 WAT 1083 40.233 57.74637.797 1.00 16.93 ATOM 5026 OH2 WAT 1084 54.670 59.272 48.665 1.00 32.72ATOM 5027 OH2 WAT 1085 53.699 57.790 52.915 1.00 30.15 ATOM 5028 OH2 WAT1086 16.670 32.247 54.833 1.00 41.51 ATOM 5029 OH2 WAT 1087 22.29631.936 27.500 1.00 28.36 ATOM 5030 OH2 WAT 1088 47.914 17.001 32.4541.00 37.63 ATOM 5031 OH2 WAT 1089 57.985 47.492 28.231 1.00 32.60 ATOM5032 OH2 WAT 1090 35.749 34.442 55.271 1.00 34.51 ATOM 5033 OH2 WAT 109131.476 35.919 55.030 1.00 29.00 ATOM 5034 OH2 WAT 1092 57.549 59.85042.071 1.00 37.12 ATOM 5035 OH2 WAT 1093 37.244 31.058 68.548 1.00 28.12ATOM 5036 OH2 WAT 1094 37.707 33.592 70.255 1.00 33.05 ATOM 5037 OH2 WAT1095 65.341 43.727 34.421 1.00 39.40 ATOM 5038 OH2 WAT 1096 29.57156.164 45.104 1.00 27.27 ATOM 5039 OH2 WAT 1097 28.460 20.997 19.1681.00 29.57 ATOM 5040 OH2 WAT 1098 18.695 33.000 61.504 1.00 27.80 ATOM5041 OH2 WAT 1099 19.269 34.045 63.767 1.00 40.98 ATOM 5042 OH2 WAT 110050.893 61.236 50.969 1.00 35.01 ATOM 5043 OH2 WAT 1101 56.400 43.89459.831 1.00 32.48 ATOM 5044 OH2 WAT 1102 56.721 41.861 63.860 1.00 30.95ATOM 5045 OH2 WAT 1103 34.429 49.906 71.937 1.00 27.35 ATOM 5046 OH2 WAT1104 41.246 9.747 32.571 1.00 29.28 ATOM 5047 OH2 WAT 1105 20.981 21.79850.939 1.00 39.38 ATOM 5048 OH2 WAT 1106 23.739 19.876 50.550 1.00 40.52ATOM 5049 OH2 WAT 1107 38.769 41.131 17.011 1.00 45.24 ATOM 5050 OH2 WAT1108 29.718 9.526 34.248 1.00 37.08 ATOM 5051 OH2 WAT 1109 27.449 9.01535.782 1.00 29.46 ATOM 5052 OH2 WAT 1110 26.205 9.875 37.838 1.00 37.18ATOM 5053 OH2 WAT 1111 24.669 47.026 35.553 1.00 25.36 ATOM 5054 OH2 WAT1112 31.450 56.875 43.413 1.00 35.79 ATOM 5055 OH2 WAT 1113 29.19357.847 41.895 1.00 28.59 ATOM 5056 OH2 WAT 1114 48.270 62.126 54.0571.00 47.11 ATOM 5057 OH2 WAT 1115 25.062 58.442 56.552 1.00 44.02 ATOM5058 OH2 WAT 1116 22.740 60.186 60.488 1.00 34.22 ATOM 5059 OH2 WAT 111739.213 37.453 56.336 1.00 40.31 ATOM 5060 OH2 WAT 1118 38.121 40.79859.573 1.00 43.24 ATOM 5061 OH2 WAT 1119 37.346 43.433 61.501 1.00 37.73ATOM 5062 OH2 WAT 1120 37.001 39.773 55.197 1.00 42.52 ATOM 5063 OH2 WAT1121 18.157 30.227 56.161 1.00 37.69 ATOM 5064 OH2 WAT 1122 33.76210.574 25.544 1.00 23.70 ATOM 5065 OH2 WAT 1123 37.474 59.970 39.7571.00 21.11 ATOM 5066 OH2 WAT 1124 41.061 44.584 49.861 1.00 25.81 ATOM5067 OH2 WAT 1125 70.442 38.041 48.255 1.00 29.55 ATOM 5068 OH2 WAT 112615.491 41.776 47.873 1.00 30.31 ATOM 5069 OH2 WAT 1127 25.212 43.11632.288 1.00 28.62 ATOM 5070 OH2 WAT 1128 26.383 21.154 54.156 1.00 29.70ATOM 5071 OH2 WAT 1129 50.740 60.798 47.331 1.00 38.19 ATOM 5072 OH2 WAT1130 41.735 39.836 50.778 1.00 37.70 ATOM 5073 OH2 WAT 1131 42.70160.987 37.812 1.00 41.12 ATOM 5074 OH2 WAT 1132 14.659 29.765 44.8941.00 33.95 ATOM 5075 OH2 WAT 1133 34.102 38.199 24.717 1.00 27.35 ATOM5076 OH2 WAT 1134 45.354 44.890 68.080 1.00 31.32 ATOM 5077 OH2 WAT 113535.915 44.195 50.574 1.00 32.69 ATOM 5078 OH2 WAT 1136 15.867 48.66359.058 1.00 34.96 ATOM 5079 OH2 WAT 1137 15.232 36.067 62.441 1.00 39.53ATOM 5080 OH2 WAT 1138 24.046 35.123 64.133 1.00 33.21 ATOM 5081 OH2 WAT1140 42.820 43.043 56.106 1.00 40.38 ATOM 5082 OH2 WAT 1142 30.16446.247 60.234 1.00 27.89 ATOM 5083 OH2 WAT 1143 36.787 20.701 62.5131.00 40.11 ATOM 5084 OH2 WAT 1144 55.849 49.287 57.410 1.00 29.15 ATOM5085 OH2 WAT 1145 50.753 46.872 21.712 1.00 35.52 ATOM 5086 OH2 WAT 114645.737 64.613 61.498 1.00 44.87 ATOM 5087 OH2 WAT 1147 28.723 16.49152.376 1.00 48.22 ATOM 5088 OH2 WAT 1148 41.105 13.562 41.818 1.00 29.30ATOM 5089 OH2 WAT 1149 26.685 14.349 42.039 1.00 42.43 ATOM 5090 OH2 WAT1150 38.358 50.484 49.443 1.00 35.16 ATOM 5091 OH2 WAT 1151 69.92042.965 37.954 1.00 40.56 ATOM 5092 OH2 WAT 1152 52.738 59.405 31.4531.00 35.45 ATOM 5093 OH2 WAT 1153 32.404 39.258 22.528 1.00 39.05 ATOM5094 OH2 WAT 1154 22.666 50.694 36.768 1.00 36.83 ATOM 5095 OH2 WAT 115514.698 50.360 47.308 1.00 38.90 ATOM 5096 OH2 WAT 1156 39.143 11.15536.210 1.00 39.07 ATOM 5097 OH2 WAT 1157 55.657 18.795 54.147 1.00 34.85ATOM 5098 OH2 WAT 1158 62.362 32.941 24.043 1.00 41.87 ATOM 5099 OH2 WAT1159 29.902 43.547 51.918 1.00 32.04 ATOM 5100 OH2 WAT 1160 26.17130.161 18.201 1.00 39.60 ATOM 5101 OH2 WAT 1161 41.218 21.756 70.3701.00 41.36 ATOM 5102 OH2 WAT 1162 26.190 30.492 28.185 1.00 27.88 ATOM5103 OH2 WAT 1163 50.602 53.898 30.780 1.00 30.62 ATOM 5104 OH2 WAT 116426.955 17.640 16.849 1.00 31.56 ATOM 5105 OH2 WAT 1165 41.691 10.37428.028 1.00 32.37 ATOM 5106 OH2 WAT 1166 57.418 56.385 51.476 1.00 35.94ATOM 5107 OH2 WAT 1167 55.642 43.654 62.253 1.00 41.27 ATOM 5108 OH2 WAT1168 41.479 56.703 63.461 1.00 34.93 ATOM 5109 OH2 WAT 1169 39.61358.154 43.178 1.00 35.49 ATOM 5110 OH2 WAT 1170 45.356 56.475 68.4961.00 37.27 ATOM 5111 OH2 WAT 1171 44.916 53.775 27.876 1.00 31.35 ATOM5112 OH2 WAT 1172 25.722 27.696 18.138 1.00 38.58 ATOM 5113 OH2 WAT 117343.375 49.025 22.195 1.00 33.80 ATOM 5114 OH2 WAT 1174 21.889 34.53126.210 1.00 36.18 ATOM 5115 OH2 WAT 1175 41.736 39.433 59.697 1.00 36.02ATOM 5116 OH2 WAT 1176 47.436 28.894 63.907 1.00 33.93 ATOM 5117 OH2 WAT1177 28.538 47.783 33.721 1.00 39.02 ATOM 5118 OH2 WAT 1178 45.54119.730 50.210 1.00 43.10 ATOM 5119 OH2 WAT 1179 68.291 39.466 47.5971.00 37.89 ATOM 5120 OH2 WAT 1180 66.025 32.351 42.560 1.00 35.69 ATOM5121 OH2 WAT 1181 61.703 29.189 16.524 1.00 36.27 ATOM 5122 OH2 WAT 118214.548 30.540 42.421 1.00 42.06 ATOM 5123 OH2 WAT 1183 15.496 27.27047.838 1.00 46.85 ATOM 5124 OH2 WAT 1184 14.095 47.673 48.381 1.00 47.62ATOM 5125 OH2 WAT 1185 47.204 19.227 33.252 1.00 36.81 ATOM 5126 OH2 WAT1186 15.661 33.106 31.093 1.00 46.85 ATOM 5127 OH2 WAT 1187 67.15047.220 39.295 1.00 36.46 ATOM 5128 OH2 WAT 1188 29.557 22.635 20.9461.00 41.67 ATOM 5129 OH2 WAT 1189 28.682 26.265 60.679 1.00 46.57 ATOM5130 OH2 WAT 1190 17.693 23.606 49.850 1.00 36.98 ATOM 5131 OH2 WAT 119151.486 56.952 54.132 1.00 32.03 ATOM 5132 OH2 WAT 1192 55.843 23.20925.565 1.00 44.63 ATOM 5133 OH2 WAT 1193 43.669 45.262 17.620 1.00 41.89ATOM 5134 OH2 WAT 1194 36.029 14.373 12.084 1.00 39.33 ATOM 5135 OH2 WAT1195 14.318 32.026 49.337 1.00 35.36 ATOM 5136 OH2 WAT 1196 13.22235.202 50.716 1.00 45.32 ATOM 5137 OH2 WAT 1197 54.042 24.106 57.2471.00 47.39 ATOM 5138 OH2 WAT 1198 34.685 14.060 23.512 1.00 39.90 ATOM5139 OH2 WAT 1199 45.704 57.109 65.615 1.00 46.14 ATOM 5140 OH2 WAT 120044.873 24.284 46.545 1.00 34.57 ATOM 5141 OH2 WAT 1201 35.967 56.59450.557 1.00 39.33 ATOM 5142 OH2 WAT 1202 30.036 57.668 47.644 1.00 37.79ATOM 5143 OH2 WAT 1203 49.131 18.854 41.508 1.00 42.53 ATOM 5144 OH2 WAT1204 30.102 43.586 25.149 1.00 40.72 ATOM 5145 OH2 WAT 1205 16.99853.914 48.758 1.00 48.89 ATOM 5146 OH2 WAT 1207 22.805 15.462 43.8881.00 41.37 ATOM 5147 OH2 WAT 1208 21.497 24.519 27.314 1.00 37.24 ATOM5148 OH2 WAT 1209 17.651 41.303 33.491 1.00 42.96 ATOM 5149 OH2 WAT 121060.654 28.310 58.903 1.00 50.25 ATOM 5150 OH2 WAT 1212 46.533 63.56552.672 1.00 46.38 ATOM 5151 OH2 WAT 1213 46.413 53.655 68.053 1.00 39.92ATOM 5152 OH2 WAT 1214 14.311 46.777 37.971 1.00 50.08 ATOM 5153 OH2 WAT1216 55.429 29.530 33.565 1.00 45.03 ATOM 5154 OH2 WAT 1217 53.47835.792 14.453 1.00 40.11 ATOM 5155 OH2 WAT 1218 40.345 43.339 56.6271.00 47.78 ATOM 5156 OH2 WAT 1219 36.529 52.046 58.807 1.00 38.42 ATOM5157 OH2 WAT 1220 24.511 41.919 29.518 1.00 41.70 ATOM 5158 OH2 WAT 122217.693 27.672 35.440 1.00 43.96 ATOM 5159 OH2 WAT 1223 23.641 21.25253.576 1.00 44.70 ATOM 5160 OH2 WAT 1224 51.161 18.080 43.110 1.00 37.11ATOM 5161 OH2 WAT 1225 44.467 44.673 20.294 1.00 44.46 ATOM 5162 OH2 WAT1226 50.788 19.723 49.959 1.00 37.29 ATOM 5163 OH2 WAT 1227 54.75225.906 65.096 1.00 46.67 ATOM 5164 OH2 WAT 1228 63.418 32.799 51.9221.00 39.05 ATOM 5165 OH2 WAT 1229 49.352 29.893 33.234 1.00 44.01 ATOM5166 OH2 WAT 1230 31.202 38.938 20.335 1.00 49.64 ATOM 5167 OH2 WAT 123133.715 51.957 58.093 1.00 40.80 ATOM 5168 OH2 WAT 1232 23.578 22.34127.377 1.00 33.04 ATOM 5169 OH2 WAT 1233 48.877 30.829 37.399 1.00 42.38ATOM 5170 OH2 WAT 1235 52.077 39.927 11.643 1.00 50.91 ATOM 5171 OH2 WAT1236 46.727 47.936 20.766 1.00 39.36 ATOM 5172 OH2 WAT 1237 19.93216.273 39.489 1.00 39.93 ATOM 5173 OH2 WAT 1239 40.814 60.178 74.5991.00 41.48 ATOM 5174 OH2 WAT 1240 51.750 29.763 9.713 1.00 41.37 ATOM5175 OH2 WAT 1241 38.610 58.856 35.877 1.00 44.28 ATOM 5176 OH2 WAT 124221.432 26.708 58.173 1.00 37.52 ATOM 5177 OH2 WAT 1243 46.966 33.87068.743 1.00 45.93 ATOM 5178 OH2 WAT 1244 61.246 43.773 58.961 1.00 40.96ATOM 5179 OH2 WAT 1246 64.751 48.614 51.387 1.00 40.01 ATOM 5180 OH2 WAT1249 28.908 23.979 70.000 1.00 50.21 ATOM 5181 OH2 WAT 1250 35.09250.916 23.964 1.00 43.45 ATOM 5182 OH2 WAT 1251 40.260 47.302 20.0711.00 39.21 ATOM 5183 OH2 WAT 1252 35.991 60.939 52.084 1.00 42.26 ATOM5184 OH2 WAT 1253 27.391 37.137 20.202 1.00 43.08 ATOM 5185 OH2 WAT 125512.393 50.408 52.301 0.50 37.03 ATOM 5186 OH2 WAT 1256 23.608 55.16264.150 1.00 41.77 ATOM 5187 OH2 WAT 1258 47.269 17.174 22.065 1.00 46.22ATOM 5188 OH2 WAT 1259 28.456 62.543 55.786 1.00 41.70 ATOM 5189 OH2 WAT1260 18.167 46.909 66.948 1.00 43.73 ATOM 5190 OH2 WAT 1261 26.96645.286 26.641 1.00 48.72 ATOM 5191 OH2 WAT 1264 17.101 45.276 33.4251.00 43.21 ATOM 5192 OH2 WAT 1265 63.613 36.746 57.666 1.00 42.19 ATOM5193 OH2 WAT 1266 24.775 12.094 44.611 1.00 43.78 ATOM 5194 OH2 WAT 126714.567 43.639 54.809 1.00 43.19 ATOM 5195 OH2 WAT 1268 62.111 49.25049.919 1.00 45.57 ATOM 5196 OH2 WAT 1269 50.495 37.209 8.544 1.00 41.23ATOM 5197 OH2 WAT 1270 25.496 43.939 68.768 1.00 38.89 ATOM 5198 OH2 WAT1271 46.561 47.854 71.850 1.00 47.32 ATOM 5199 OH2 WAT 1272 34.62440.398 52.220 1.00 40.23 ATOM 5200 OH2 WAT 1273 23.826 29.701 27.1121.00 37.37 ATOM 5201 OH2 WAT 1275 58.487 56.076 44.456 1.00 49.60 ATOM5202 OH2 WAT 1276 47.004 19.336 65.956 1.00 44.67 ATOM 5203 OH2 WAT 127735.331 60.688 71.296 1.00 49.05 ATOM 5204 OH2 WAT 1278 64.248 43.85253.276 1.00 45.61 ATOM 5205 OH2 WAT 1279 38.265 60.125 44.267 1.00 40.24ATOM 5206 OH2 WAT 1280 32.716 19.954 61.811 1.00 48.51 ATOM 5207 OH2 WAT1282 37.969 28.502 70.587 1.00 45.47 ATOM 5208 OH2 WAT 1283 45.14943.238 70.422 1.00 51.48 ATOM 5209 OH2 WAT 1284 59.891 53.118 51.5391.00 48.96 ATOM 5210 OH2 WAT 1285 34.867 45.533 72.885 1.00 47.50 ATOM5211 OH2 WAT 1286 21.880 52.964 63.592 1.00 43.17 ATOM 5212 OH2 WAT 128849.993 22.986 32.101 1.00 43.19 ATOM 5213 OH2 WAT 1289 46.808 19.42138.578 1.00 44.53 ATOM 5214 OH2 WAT 1290 30.906 19.264 11.986 1.00 42.77ATOM 5215 OH2 WAT 1293 9.566 38.464 32.587 1.00 48.38 ATOM 5216 OH2 WAT1294 42.359 12.879 35.960 1.00 39.40 ATOM 5217 OH2 WAT 1296 43.73554.908 30.034 1.00 43.21 ATOM 5218 OH2 WAT 1298 38.663 10.988 25.0181.00 37.95 ATOM 5219 OH2 WAT 1299 32.861 26.550 10.296 1.00 46.61 ATOM5220 OH2 WAT 1300 43.628 37.637 11.420 1.00 44.84 ATOM 5221 OH2 WAT 130247.573 23.475 60.712 1.00 38.95 ATOM 5222 OH2 WAT 1303 64.973 53.33138.090 1.00 38.57 ATOM 5223 OH2 WAT 1304 16.881 19.232 30.969 1.00 47.01ATOM 5224 OH2 WAT 1306 48.262 21.848 19.919 1.00 44.43 ATOM 5225 OH2 WAT1307 11.425 37.923 51.890 1.00 34.09 ATOM 5226 OH2 WAT 1308 63.09629.357 20.027 1.00 40.25 ATOM 5227 OH2 WAT 1309 23.170 21.317 25.1281.00 38.17 ATOM 5228 OH2 WAT 1310 20.030 19.255 25.175 1.00 29.39 ATOM5229 OH2 WAT 1311 51.597 27.670 8.159 1.00 42.04 ATOM 5230 OH2 WAT 131248.948 36.803 6.527 1.00 41.43 ATOM 5231 O1 LIS 702 40.291 33.743 45.1201.00 13.04 ATOM 5232 O2 LIS 702 43.369 36.201 48.269 1.00 15.16 ATOM5233 O3 LIS 702 41.939 37.283 47.069 1.00 13.89 ATOM 5234 O4 LIS 70238.843 33.368 41.867 1.00 13.99 ATOM 5235 O5 LIS 702 40.703 32.27242.326 1.00 11.94 ATOM 5236 N1 LIS 702 41.897 34.063 47.266 1.00 14.83ATOM 5237 N2 LIS 702 41.810 34.533 43.599 1.00 13.77 ATOM 5238 N3 LIS702 43.329 27.774 44.087 1.00 21.85 ATOM 5239 C1 LIS 702 41.502 34.05244.840 1.00 13.99 ATOM 5240 C2 LIS 702 42.612 33.852 45.943 1.00 12.80ATOM 5241 C3 LIS 702 42.259 36.267 47.654 1.00 13.57 ATOM 5242 C4 LIS702 41.315 35.065 47.682 1.00 14.83 ATOM 5243 C5 LIS 702 40.715 34.68542.559 1.00 14.91 ATOM 5244 C6 LIS 702 41.505 35.237 41.353 1.00 14.97ATOM 5245 C7 LIS 702 42.826 35.369 41.680 1.00 16.22 ATOM 5246 C8 LIS702 43.138 34.956 43.062 1.00 12.52 ATOM 5247 C9 LIS 702 40.081 33.28442.224 1.00 13.82 ATOM 5248 C10 LIS 702 43.252 32.473 45.784 1.00 14.69ATOM 5249 C11 LIS 702 42.484 31.248 45.536 1.00 16.12 ATOM 5250 C12 LIS702 43.296 30.062 44.842 1.00 17.50 ATOM 5251 C13 LIS 702 42.487 28.89544.629 1.00 20.10 ATOM 5252 C14 LIS 702 40.586 35.365 48.932 1.00 12.04ATOM 5253 C15 LIS 702 39.408 36.299 49.163 1.00 13.87 ATOM 5254 C16 LIS702 38.847 36.401 50.549 1.00 15.99 ATOM 5255 C17 LIS 702 38.566 35.20651.331 1.00 14.59 ATOM 5256 C18 LIS 702 38.016 35.319 52.656 1.00 17.75ATOM 5257 C19 LIS 702 37.737 36.627 53.218 1.00 18.68 ATOM 5258 C20 LIS702 38.014 37.822 52.443 1.00 18.46 ATOM 5259 C21 LIS 702 38.568 37.71051.112 1.00 16.62 ATOM 5260 N GLY 2000 46.347 33.778 41.598 1.00 29.94ATOM 5261 CA GLY 2000 46.605 34.757 40.562 1.00 28.86 ATOM 5262 C GLY2000 46.815 34.072 39.230 1.00 29.89 ATOM 5263 O GLY 2000 47.218 34.69538.260 1.00 28.89 ATOM 5264 ZN + 2 ZN2 701 43.821 38.240 46.712 1.0025.11 ATOM 5265 CL CL 703 29.172 28.069 36.210 1.00 12.41 ATOM 5266 CLCL 704 36.272 45.081 44.766 1.00 15.28 END

Sequences Seq ID No. 1 WT-ACESQQVTVTHGTSSQATTSSQTTTHQATAHQTSAQSPNLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRH S Seq ID No. 2ACE-Δ36NJ LVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNS

1. A method of preparing a crystal of ACE protein comprising the stepsof: (a) culturing host cells comprising an underglycosylated ACEprotein; (b) purifying the underglycosylated ACE protein; and (c)crystallising the underglycosylated ACE protein.
 2. A method accordingto claim 1 wherein the ACE protein is underglycosylated by removing oneor more glycosylation sites and/or one or more partially glycosylatedsites.
 3. A method according to claim 1 wherein the underglycosylatedACE protein comprises a mutation at amino acid 337 of SEQ ID No 2 oramino acids 90, 109, 155, 337 and 586 of SEQ ID No
 2. 4. A methodaccording claim 1 wherein the ACE protein is crystallised using about 10mM HEPES and about 0.1% PMSF with an equal volume of a reservoirsolution containing about 15% PEG 4000, about 50 mM CH₃COONa.3H₂O pH 4.7and about 10 μM ZnSO₄.7H₂O.
 5. A method according claim 1 wherein thecrystal that is prepared has a structure defined by at least a portionof the structure co-ordinates of Table A.
 6. A method according claim 1wherein the crystal belongs to the space group P2₁2₁2₁ or wherein thecrystal has the unit cell dimensions: a=56.47 Å, b=84.90 Å and c=133.99Å.
 7. A method according to claim 1 wherein the ACE protein is human ACEprotein.
 8. A method according to claim 1 wherein the ACE protein iscrystallised in the presence of an entity.
 9. A method according toclaim 8 wherein the entity is a modulator of ACE.
 10. A method accordingto claim 9 wherein the entity is an inhibitor of ACE.
 11. A methodaccording to claim 10 wherein the inhibitor of ACE is lisinopril or aderivative thereof.
 12. A method according to claim 11 wherein thecrystal that is prepared has a structure defined by at least a portionof the structure co-ordinates of Table B.